Details for: SCT

Gene ID: 6343

Symbol: SCT

Ensembl ID: ENSG00000070031

Description: secretin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.9172
    Cell Significance Index: -3.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.8711
    Cell Significance Index: -3.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1258
    Cell Significance Index: 210.2900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.8003
    Cell Significance Index: 22.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9963
    Cell Significance Index: 899.6000
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.9553
    Cell Significance Index: 7.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8082
    Cell Significance Index: 48.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7792
    Cell Significance Index: 84.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7289
    Cell Significance Index: 21.0000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6212
    Cell Significance Index: 101.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6078
    Cell Significance Index: 3.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5852
    Cell Significance Index: 68.2000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.4980
    Cell Significance Index: 5.1600
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.4497
    Cell Significance Index: 3.4100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4327
    Cell Significance Index: 29.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3715
    Cell Significance Index: 70.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3637
    Cell Significance Index: 7.8800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2600
    Cell Significance Index: 3.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2581
    Cell Significance Index: 9.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2460
    Cell Significance Index: 6.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.2449
    Cell Significance Index: 1.9600
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2431
    Cell Significance Index: 2.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2005
    Cell Significance Index: 9.0900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.0852
    Cell Significance Index: 0.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0791
    Cell Significance Index: 1.6400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0777
    Cell Significance Index: 0.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0460
    Cell Significance Index: 0.9800
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.0208
    Cell Significance Index: 0.0900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0197
    Cell Significance Index: 0.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0158
    Cell Significance Index: 0.2500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0071
    Cell Significance Index: 0.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0057
    Cell Significance Index: 0.7300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0005
    Cell Significance Index: 0.0200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0014
    Cell Significance Index: -0.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0016
    Cell Significance Index: -2.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.5300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0030
    Cell Significance Index: -0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0035
    Cell Significance Index: -1.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0048
    Cell Significance Index: -3.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0055
    Cell Significance Index: -4.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0058
    Cell Significance Index: -3.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0060
    Cell Significance Index: -3.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5400
  • Cell Name: lung perichondrial fibroblast (CL4033026)
    Fold Change: -0.0069
    Cell Significance Index: -0.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0086
    Cell Significance Index: -3.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0103
    Cell Significance Index: -2.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0104
    Cell Significance Index: -1.4300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0121
    Cell Significance Index: -0.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0140
    Cell Significance Index: -0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0145
    Cell Significance Index: -2.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0159
    Cell Significance Index: -3.1600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0172
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0202
    Cell Significance Index: -3.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0205
    Cell Significance Index: -2.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0205
    Cell Significance Index: -0.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0206
    Cell Significance Index: -3.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0207
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0218
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0221
    Cell Significance Index: -2.5300
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0236
    Cell Significance Index: -0.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0294
    Cell Significance Index: -1.0200
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0301
    Cell Significance Index: -0.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0310
    Cell Significance Index: -1.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0315
    Cell Significance Index: -0.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0320
    Cell Significance Index: -4.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0321
    Cell Significance Index: -3.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0347
    Cell Significance Index: -3.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0394
    Cell Significance Index: -4.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0401
    Cell Significance Index: -4.1000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0424
    Cell Significance Index: -0.3200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.0506
    Cell Significance Index: -0.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0518
    Cell Significance Index: -3.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0560
    Cell Significance Index: -3.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0580
    Cell Significance Index: -4.3200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0625
    Cell Significance Index: -1.5200
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.0651
    Cell Significance Index: -0.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0684
    Cell Significance Index: -3.1900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0689
    Cell Significance Index: -0.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0794
    Cell Significance Index: -1.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0801
    Cell Significance Index: -2.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0806
    Cell Significance Index: -2.0600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0822
    Cell Significance Index: -1.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0830
    Cell Significance Index: -4.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0845
    Cell Significance Index: -4.4400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0936
    Cell Significance Index: -3.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0936
    Cell Significance Index: -3.2800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0941
    Cell Significance Index: -1.2800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0968
    Cell Significance Index: -4.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0968
    Cell Significance Index: -5.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0997
    Cell Significance Index: -1.5000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1004
    Cell Significance Index: -1.3700
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1020
    Cell Significance Index: -1.4100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1031
    Cell Significance Index: -3.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1040
    Cell Significance Index: -4.6000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1087
    Cell Significance Index: -0.5200
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.1124
    Cell Significance Index: -1.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1136
    Cell Significance Index: -2.8400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1143
    Cell Significance Index: -1.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1151
    Cell Significance Index: -2.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor Binding:** Secretin binds to specific GPCRs, triggering a cascade of downstream signaling events that regulate various cellular processes. 2. **Hormone Activity:** Secretin is a hormone that regulates the secretion of pancreatic juice, gastric acid, and other digestive enzymes. 3. **Regulation of Appetite and Metabolism:** Secretin influences appetite and metabolism by modulating the activity of neurons in the hypothalamus and the pancreas. 4. **Neuroprotective Effects:** Secretin has been shown to have neuroprotective properties, particularly in the context of neurodegenerative diseases. 5. **Expression in Multiple Tissues:** The SCT gene is expressed in various tissues, including the pancreas, intestine, brain, and reproductive organs. **Pathways and Functions:** 1. **Cellular Component Signaling:** Secretin binding to GPCRs triggers a signaling cascade that regulates cellular processes, including gene expression, protein synthesis, and cell proliferation. 2. **G alpha (s) Signaling Events:** Secretin stimulates the activation of G alpha (s) proteins, which in turn activate downstream effectors, such as adenylate cyclase, leading to increased cAMP levels. 3. **Glucagon-type Ligand Receptors:** Secretin binds to glucagon-type ligand receptors, which are involved in regulating glucose metabolism and energy homeostasis. 4. **Pancreatic Juice Secretion:** Secretin stimulates the release of pancreatic juice, which contains digestive enzymes, bicarbonate, and other nutrients that facilitate digestion. 5. **Negative Regulation of Gastrin-induced Gastric Acid Secretion:** Secretin inhibits the release of gastrin, a hormone that stimulates gastric acid secretion, thereby regulating gastric acid production. **Clinical Significance:** 1. **Digestive Disorders:** Alterations in secretin secretion or signaling have been implicated in various digestive disorders, including pancreatitis, gastritis, and gastroesophageal reflux disease (GERD). 2. **Metabolic Disorders:** Secretin's role in regulating appetite and metabolism makes it a potential target for the treatment of metabolic disorders, such as obesity and type 2 diabetes. 3. **Neurological Disorders:** Secretin's neuroprotective effects suggest its potential as a therapeutic agent for neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Cancer:** Secretin has been shown to have anti-tumor effects, particularly in the context of pancreatic cancer. 5. **Gastrointestinal Motility:** Secretin regulates gastrointestinal motility, and alterations in its signaling can contribute to gastrointestinal motility disorders, such as irritable bowel syndrome (IBS). In conclusion, the secretin gene (SCT) plays a critical role in regulating various physiological processes, including digestion, metabolism, and neurology. Its multifaceted functions highlight its importance in maintaining overall health and homeostasis, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the mechanisms by which secretin regulates its various functions and to explore its potential as a therapeutic agent for various diseases.

Genular Protein ID: 1687430772

Symbol: SECR_HUMAN

Name: N/A

UniProtKB Accession Codes:

P09683

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 1 EMDB 3 Ensembl 2 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 11060443

Title: Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA.

PubMed ID: 11060443

DOI: 10.1159/000015658

PubMed ID: 25332973

Title: The physiological roles of secretin and its receptor.

PubMed ID: 25332973

DOI: 10.3978/j.issn.2305-5839.2012.12.01

PubMed ID: 30449620

Title: Secretin-activated brown fat mediates prandial thermogenesis to induce satiation.

PubMed ID: 30449620

DOI: 10.1016/j.cell.2018.10.016

Sequence Information:

  • Length: 121
  • Mass: 13016
  • Checksum: 44BDB4EFC0E161CF
  • Sequence:
    • MAPRPLLLLL LLLGGSAARP APPRARRHSD GTFTSELSRL REGARLQRLL QGLVGKRSEQ 
DAENSMAWTR LSAGLLCPSG SNMPILQAWM PLDGTWSPWL PPGPMVSEPA GAAAEGTLRP 
R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.