YWHAB | ENSG00000166913 | NCBI 7529

Details for: YWHAB

Gene ID: 7529

Symbol: YWHAB

Ensembl ID: ENSG00000166913

Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta

Associated with

Activation of bad and translocation to mitochondria
(R-HSA-111447)
Activation of bh3-only proteins
(R-HSA-114452)
Adaptive immune system
(R-HSA-1280218)
Apoptosis
(R-HSA-109581)
Arms-mediated activation
(R-HSA-170984)
Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-HSA-450385)
Cell cycle
(R-HSA-1640170)
Cell cycle checkpoints
(R-HSA-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-HSA-75035)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Foxo-mediated transcription
(R-HSA-9614085)
Frs2-mediated activation
(R-HSA-170968)
G2/m checkpoints
(R-HSA-69481)
G2/m dna damage checkpoint
(R-HSA-69473)
Gain-of-function mras complexes activate raf signaling
(R-HSA-9726842)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Intrinsic pathway for apoptosis
(R-HSA-109606)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of rna
(R-HSA-8953854)
Mtorc1-mediated signalling
(R-HSA-166208)
Mtor signalling
(R-HSA-165159)
Negative regulation of mapk pathway
(R-HSA-5675221)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Programmed cell death
(R-HSA-5357801)
Prolonged erk activation events
(R-HSA-169893)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Rap1 signalling
(R-HSA-392517)
Regulation of localization of foxo transcription factors
(R-HSA-9614399)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate pkns
(R-HSA-5625740)
Rna polymerase ii transcription
(R-HSA-73857)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1 targets host intracellular signalling and regulatory pathways
(R-HSA-9735871)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov-2 infection
(R-HSA-9694516)
Sars-cov-2 targets host intracellular signalling and regulatory pathways
(R-HSA-9755779)
Sars-cov-2-host interactions
(R-HSA-9705683)
Sars-cov infections
(R-HSA-9679506)
Shoc2 m1731 mutant abolishes mras complex function
(R-HSA-9726840)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by hippo
(R-HSA-2028269)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by mras-complex mutants
(R-HSA-9660537)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signalling to erks
(R-HSA-187687)
Tp53 regulates metabolic genes
(R-HSA-5628897)
Transcriptional regulation by tp53
(R-HSA-3700989)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Tristetraprolin (ttp, zfp36) binds and destabilizes mrna
(R-HSA-450513)
Vesicle-mediated transport
(R-HSA-5653656)
Viral infection pathways
(R-HSA-9824446)
Cadherin binding
(GO:0045296)
Cytoplasm
(GO:0005737)
Cytoplasmic sequestering of protein
(GO:0051220)
Cytosol
(GO:0005829)
Enzyme binding
(GO:0019899)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Melanosome
(GO:0042470)
Membrane
(GO:0016020)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphoprotein binding
(GO:0051219)
Phosphoserine residue binding
(GO:0050815)
Positive regulation of catalytic activity
(GO:0043085)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein kinase inhibitor activity
(GO:0004860)
Protein localization
(GO:0008104)
Protein targeting
(GO:0006605)
Signal transduction
(GO:0007165)
Vacuolar membrane
(GO:0005774)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 819.4401
Cell Significance Index: -127.4600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 454.2598
Cell Significance Index: -115.2200
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 346.8888
Cell Significance Index: -142.9000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 310.9361
Cell Significance Index: -126.3200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 295.6012
Cell Significance Index: -139.5600
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 277.1464
Cell Significance Index: -142.5600
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 208.7338
Cell Significance Index: -140.0700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 134.6855
Cell Significance Index: -128.5900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 112.4128
Cell Significance Index: -138.6000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 36.2169
Cell Significance Index: -97.0200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 36.0538
Cell Significance Index: -142.2700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 35.2699
Cell Significance Index: -108.3300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.8559
Cell Significance Index: -45.6500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 5.4373
Cell Significance Index: 50.0700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 5.3396
Cell Significance Index: 280.3500
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.1648
Cell Significance Index: 95.4600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.1528
Cell Significance Index: 489.7400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.0622
Cell Significance Index: 732.2900
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.0228
Cell Significance Index: 494.6400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.6430
Cell Significance Index: 106.9900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.2805
Cell Significance Index: 154.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 3.1898
Cell Significance Index: 166.1500
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.8774
Cell Significance Index: 78.3200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.6002
Cell Significance Index: 183.9000
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.4322
Cell Significance Index: 156.9200
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.3571
Cell Significance Index: 1287.2700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.3375
Cell Significance Index: 1033.4500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 2.2642
Cell Significance Index: 78.6800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.2202
Cell Significance Index: 304.8900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.1934
Cell Significance Index: 440.0000
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.6082
Cell Significance Index: 18.2700
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.5950
Cell Significance Index: 42.5900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.5327
Cell Significance Index: 166.7200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4394
Cell Significance Index: 74.7700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.3886
Cell Significance Index: 225.8400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.3302
Cell Significance Index: 99.1400
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.3023
Cell Significance Index: 34.2500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.1586
Cell Significance Index: 54.0200
Cell Name: odontoblast (CL0000060)
Fold Change: 1.0918
Cell Significance Index: 139.9600
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0559
Cell Significance Index: 953.3700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.9908
Cell Significance Index: 355.3700
Cell Name: lactocyte (CL0002325)
Fold Change: 0.9549
Cell Significance Index: 123.3700
Cell Name: peg cell (CL4033014)
Fold Change: 0.7622
Cell Significance Index: 17.6100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5711
Cell Significance Index: 56.4900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4944
Cell Significance Index: 98.1200
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3424
Cell Significance Index: 15.5200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.2909
Cell Significance Index: 17.8800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.2904
Cell Significance Index: 8.3200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2376
Cell Significance Index: 45.2100
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.1611
Cell Significance Index: 118.1200
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1238
Cell Significance Index: 21.1400
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0951
Cell Significance Index: 3.3400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0752
Cell Significance Index: 56.9400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0515
Cell Significance Index: 3.4600
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0401
Cell Significance Index: -75.4400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0517
Cell Significance Index: -5.2800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0649
Cell Significance Index: -48.0600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0760
Cell Significance Index: -47.4300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0869
Cell Significance Index: -160.2400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0946
Cell Significance Index: -65.4500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1054
Cell Significance Index: -162.2400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1240
Cell Significance Index: -168.5500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1472
Cell Significance Index: -93.5000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1722
Cell Significance Index: -97.1200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1960
Cell Significance Index: -3.2800
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2153
Cell Significance Index: -24.5800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2274
Cell Significance Index: -6.4900
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2566
Cell Significance Index: -116.4700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2709
Cell Significance Index: -7.8000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3069
Cell Significance Index: -64.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4288
Cell Significance Index: -123.3900
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6372
Cell Significance Index: -73.0100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6435
Cell Significance Index: -74.9900
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7322
Cell Significance Index: -106.4300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.7620
Cell Significance Index: -15.9500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.7783
Cell Significance Index: -49.0600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9878
Cell Significance Index: -78.2300
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.9944
Cell Significance Index: -27.7900
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.1025
Cell Significance Index: -28.1700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.1516
Cell Significance Index: -24.9500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1757
Cell Significance Index: -37.6600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.1911
Cell Significance Index: -31.8600
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.2269
Cell Significance Index: -16.7400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.2368
Cell Significance Index: -21.8600
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.3039
Cell Significance Index: -10.0500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.3248
Cell Significance Index: -74.3400
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.3497
Cell Significance Index: -140.5400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.5068
Cell Significance Index: -66.6500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.5254
Cell Significance Index: -117.0600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.8420
Cell Significance Index: -69.7500
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -2.0674
Cell Significance Index: -44.0300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.0832
Cell Significance Index: -35.7000
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.2850
Cell Significance Index: -140.0900
Cell Name: preadipocyte (CL0002334)
Fold Change: -2.2903
Cell Significance Index: -44.7000
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -2.3282
Cell Significance Index: -62.3900
Cell Name: cortical interneuron (CL0008031)
Fold Change: -2.3496
Cell Significance Index: -56.3500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -2.5993
Cell Significance Index: -131.3600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -2.6333
Cell Significance Index: -15.9100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.7103
Cell Significance Index: -79.8300
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.8013
Cell Significance Index: -70.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** YWHAB is a member of the 14-3-3 protein family, which is characterized by its ability to bind to specific phosphoserine or phosphothreonine motifs on target proteins. This binding capacity allows YWHAB to regulate protein-protein interactions and modulate signal transduction pathways. YWHAB has been shown to interact with a wide range of proteins, including kinases, phosphatases, and transcription factors, and its binding activity is regulated by post-translational modifications. **Pathways and Functions** YWHAB is involved in various signaling pathways, including: 1. **Apoptosis**: YWHAB has been shown to regulate the activity of pro-apoptotic proteins, such as BAX and BAK, and modulate the activity of anti-apoptotic proteins, such as BCL-2. 2. **Cell Cycle**: YWHAB regulates the activity of CDKs, which are essential for cell cycle progression. 3. **Immune Response**: YWHAB has been implicated in the regulation of immune responses, including the activation of T cells and the regulation of cytokine production. 4. **Signaling by Growth Factor Receptors**: YWHAB regulates the activity of growth factor receptors, such as EGFR and PDGFR. 5. **Raf/Mapk Signaling**: YWHAB interacts with Raf and Mapk kinases, which are essential for the regulation of cell proliferation and survival. **Clinical Significance** YWHAB has been implicated in various diseases, including: 1. **Cancer**: YWHAB overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Autoimmune Diseases**: YWHAB has been implicated in the regulation of immune responses and has been observed to be overexpressed in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious Diseases**: YWHAB has been shown to regulate the activity of immune cells, such as macrophages and T cells, and has been implicated in the regulation of immune responses to viral infections, such as HIV and SARS-CoV-2. In conclusion, YWHAB is a multifunctional protein that plays a crucial role in various cellular processes, including cell signaling, apoptosis, and immune response. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the mechanisms by which YWHAB regulates cellular processes and its role in disease pathogenesis.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

14-3-3 protein beta/alpha

Genular Protein ID: 944835163

Symbol: 1433B_HUMAN

Name: 14-3-3 protein beta/alpha

UniProtKB Accession Codes:

P31946 A8K9K2 E1P616

Database IDs:

Citations:

PubMed ID: 8515476

Title: Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.

PubMed ID: 8515476

DOI: 10.1006/jmbi.1993.1346

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23572552

Title: ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding.

PubMed ID: 23572552

DOI: 10.1128/mbio.00098-13

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 11555644

Title: Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1.

PubMed ID: 11555644

DOI: 10.1074/jbc.m104620200

PubMed ID: 11260479

Title: Mammalian 14-3-3beta associates with the Chlamydia trachomatis inclusion membrane via its interaction with IncG.

PubMed ID: 11260479

DOI: 10.1046/j.1365-2958.2001.02355.x

PubMed ID: 11427721

Title: Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis.

PubMed ID: 11427721

DOI: 10.1073/pnas.141118798

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15454081

Title: The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

PubMed ID: 15454081

DOI: 10.1016/j.cell.2004.09.015

PubMed ID: 15538381

Title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.

PubMed ID: 15538381

DOI: 10.1038/sj.emboj.7600477

PubMed ID: 15159416

Title: A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.

PubMed ID: 15159416

DOI: 10.1083/jcb.200401136

PubMed ID: 15882968

Title: ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3.

PubMed ID: 15882968

DOI: 10.1016/j.bbrc.2005.03.229

PubMed ID: 15696159

Title: JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.

PubMed ID: 15696159

DOI: 10.1038/ncb1228

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 16959763

Title: Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling.

PubMed ID: 16959763

DOI: 10.1074/mcp.m600147-mcp200

PubMed ID: 17974916

Title: Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control.

PubMed ID: 17974916

DOI: 10.1101/gad.1602907

PubMed ID: 17717073

Title: Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation.

PubMed ID: 17717073

DOI: 10.1210/me.2007-0323

PubMed ID: 18249187

Title: Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.

PubMed ID: 18249187

DOI: 10.1016/j.bbrc.2008.01.114

PubMed ID: 19172738

Title: Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein.

PubMed ID: 19172738

DOI: 10.1038/emboj.2008.159

PubMed ID: 19640509

Title: SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner.

PubMed ID: 19640509

DOI: 10.1016/j.biopsych.2009.05.033

PubMed ID: 19592491

Title: Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons.

PubMed ID: 19592491

DOI: 10.1074/jbc.m109.026237

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21224381

Title: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation.

PubMed ID: 21224381

DOI: 10.1074/jbc.m110.185645

PubMed ID: 22827337

Title: RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation.

PubMed ID: 22827337

DOI: 10.1042/bj20120938

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23938468

Title: A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection.

PubMed ID: 23938468

DOI: 10.1074/mcp.m113.030866

PubMed ID: 24636949

Title: Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding.

PubMed ID: 24636949

DOI: 10.1016/j.jmb.2014.03.004

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26047703

Title: Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins.

PubMed ID: 26047703

DOI: 10.1016/j.bbrc.2015.05.105

PubMed ID: 25588844

Title: Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.

PubMed ID: 25588844

DOI: 10.1242/jcs.161497

PubMed ID: 25489052

Title: Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects.

PubMed ID: 25489052

DOI: 10.1093/hmg/ddu611

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27030597

Title: Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation.

PubMed ID: 27030597

DOI: 10.1126/scitranslmed.aaf1471

PubMed ID: 33537682

Title: Missense substitutions at a conserved 14-3-3 binding site in HDAC4 cause a novel intellectual disability syndrome.

PubMed ID: 33537682

DOI: 10.1016/j.xhgg.2020.100015

PubMed ID: 17085597

Title: Structural basis for protein-protein interactions in the 14-3-3 protein family.

PubMed ID: 17085597

DOI: 10.1073/pnas.0605779103

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

Sequence Information:

Length: 246
Mass: 28082
Checksum: 6BE1A9BF97468017
Sequence:

MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS 
WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLIPN ATQPESKVFY 
LKMKGDYFRY LSEVASGDNK QTTVSNSQQA YQEAFEISKK EMQPTHPIRL GLALNFSVFY 
YEILNSPEKA CSLAKTAFDE AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD 
AGEGEN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: YWHAB

Associated with

Cells (max top 100)

Other Information

Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway. PubMed ID: 8515476

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ACBD3 interaction with TBC1 domain 22 protein is differentially affected by enteroviral and kobuviral 3A protein binding. PubMed ID: 23572552

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1. PubMed ID: 11555644

Mammalian 14-3-3beta associates with the Chlamydia trachomatis inclusion membrane via its interaction with IncG. PubMed ID: 11260479

Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. PubMed ID: 11427721

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. PubMed ID: 15454081

The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. PubMed ID: 15538381

A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. PubMed ID: 15159416

ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3. PubMed ID: 15882968

JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. PubMed ID: 15696159

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. PubMed ID: 16959763

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. PubMed ID: 17974916

Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation. PubMed ID: 17717073

Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53. PubMed ID: 18249187

Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein. PubMed ID: 19172738

SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation-dependent manner. PubMed ID: 19640509

Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. PubMed ID: 19592491

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in alpha1-adrenergic receptor-induced p38 activation. PubMed ID: 21224381

RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. PubMed ID: 22827337

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. PubMed ID: 23938468

Crystal structure of human myosin 1c - the motor in GLUT4 exocytosis: implications for Ca(2+)-regulation and 14-3-3 binding. PubMed ID: 24636949

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins. PubMed ID: 26047703

Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. PubMed ID: 25588844

Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. PubMed ID: 25489052

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. PubMed ID: 27030597

Missense substitutions at a conserved 14-3-3 binding site in HDAC4 cause a novel intellectual disability syndrome. PubMed ID: 33537682

Structural basis for protein-protein interactions in the 14-3-3 protein family. PubMed ID: 17085597

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. PubMed ID: 21248752