Details for: TPT1

Gene ID: 7178

Symbol: TPT1

Ensembl ID: ENSG00000133112

Description: tumor protein, translationally-controlled 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1771.9605
    Cell Significance Index: -275.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 1031.9016
    Cell Significance Index: -261.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 854.5261
    Cell Significance Index: -352.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 795.7276
    Cell Significance Index: -323.2700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 718.6692
    Cell Significance Index: -339.3000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 688.1710
    Cell Significance Index: -353.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 507.9862
    Cell Significance Index: -340.8700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 346.0408
    Cell Significance Index: -330.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 255.3457
    Cell Significance Index: -314.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 89.7002
    Cell Significance Index: -275.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 87.7688
    Cell Significance Index: -346.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 65.5988
    Cell Significance Index: -175.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 55.2594
    Cell Significance Index: -120.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 14.6364
    Cell Significance Index: 338.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 14.2671
    Cell Significance Index: 665.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 13.7854
    Cell Significance Index: 254.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 13.7153
    Cell Significance Index: 644.6100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 12.8164
    Cell Significance Index: 367.3900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 9.9055
    Cell Significance Index: 269.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 9.7169
    Cell Significance Index: 1194.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 9.6522
    Cell Significance Index: 1739.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 9.5677
    Cell Significance Index: 1313.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.5388
    Cell Significance Index: 108.3700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 9.4656
    Cell Significance Index: 5169.4100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.8060
    Cell Significance Index: 112.7800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 8.6955
    Cell Significance Index: 181.3500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 8.5638
    Cell Significance Index: 552.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 8.5090
    Cell Significance Index: 601.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 8.0646
    Cell Significance Index: 3565.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 8.0135
    Cell Significance Index: 1035.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 7.9355
    Cell Significance Index: 413.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.7224
    Cell Significance Index: 268.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.2483
    Cell Significance Index: 540.2100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 7.0829
    Cell Significance Index: 186.2500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.0606
    Cell Significance Index: 124.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.0240
    Cell Significance Index: 828.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 6.5141
    Cell Significance Index: 515.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.9177
    Cell Significance Index: 758.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.6986
    Cell Significance Index: 167.3600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 5.3020
    Cell Significance Index: 45.5600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 4.8080
    Cell Significance Index: 12.8800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.6999
    Cell Significance Index: 43.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.5331
    Cell Significance Index: 121.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 4.5094
    Cell Significance Index: 3413.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.7647
    Cell Significance Index: 170.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.6356
    Cell Significance Index: 76.1000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 3.4208
    Cell Significance Index: 3088.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.4184
    Cell Significance Index: 678.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 2.6618
    Cell Significance Index: 1951.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5786
    Cell Significance Index: 133.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2805
    Cell Significance Index: 243.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.7954
    Cell Significance Index: 4.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2308
    Cell Significance Index: 12.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1687
    Cell Significance Index: 33.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0436
    Cell Significance Index: -4.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0594
    Cell Significance Index: -111.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1225
    Cell Significance Index: -2.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1685
    Cell Significance Index: -310.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1947
    Cell Significance Index: -299.7200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.2671
    Cell Significance Index: -363.1400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3362
    Cell Significance Index: -120.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.3726
    Cell Significance Index: -236.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4070
    Cell Significance Index: -69.5000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.4256
    Cell Significance Index: -315.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4596
    Cell Significance Index: -45.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.5617
    Cell Significance Index: -316.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.6194
    Cell Significance Index: -281.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.6489
    Cell Significance Index: -405.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.9578
    Cell Significance Index: -275.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2014
    Cell Significance Index: -38.4800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.2804
    Cell Significance Index: -13.9200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.5889
    Cell Significance Index: -9.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.7657
    Cell Significance Index: -256.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -1.7907
    Cell Significance Index: -291.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -1.8059
    Cell Significance Index: -380.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.9715
    Cell Significance Index: -124.2600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.0738
    Cell Significance Index: -59.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -2.1036
    Cell Significance Index: -228.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.1349
    Cell Significance Index: -54.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -2.1642
    Cell Significance Index: -252.2100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.2999
    Cell Significance Index: -57.4900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.3044
    Cell Significance Index: -39.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -2.4306
    Cell Significance Index: -278.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.4852
    Cell Significance Index: -152.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.7229
    Cell Significance Index: -188.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.9837
    Cell Significance Index: -167.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -3.2409
    Cell Significance Index: -337.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.4228
    Cell Significance Index: -46.7000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.4750
    Cell Significance Index: -52.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -3.6641
    Cell Significance Index: -281.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -3.6856
    Cell Significance Index: -247.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -3.8409
    Cell Significance Index: -107.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.9818
    Cell Significance Index: -305.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -5.0299
    Cell Significance Index: -59.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -5.1162
    Cell Significance Index: -137.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -5.1464
    Cell Significance Index: -210.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -5.5713
    Cell Significance Index: -120.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -5.9209
    Cell Significance Index: -115.5600
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -6.1251
    Cell Significance Index: -43.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -6.5943
    Cell Significance Index: -333.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TPT1 is a small, cytosolic protein with a molecular weight of approximately 22 kDa. It is characterized by its ability to bind to various cellular components, including microtubules, DNA, and RNA, and regulate their functions. TPT1 is also known for its anti-apoptotic properties, as it can inhibit the activation of caspases and promote cell survival. Furthermore, TPT1 has been implicated in the regulation of cell proliferation, differentiation, and migration, making it a potential biomarker for cancer diagnosis and treatment. **Pathways and Functions** TPT1 is involved in various cellular pathways, including: 1. **Intracellular calcium ion homeostasis**: TPT1 regulates the influx and efflux of calcium ions, which is essential for cellular signaling and survival. 2. **Apoptosis regulation**: TPT1 inhibits the activation of caspases, promoting cell survival and preventing apoptosis. 3. **Cell proliferation and differentiation**: TPT1 regulates the expression of genes involved in cell growth and differentiation, influencing cancer progression. 4. **Immune evasion**: TPT1 can inhibit the activation of immune cells, such as T cells and natural killer cells, allowing cancer cells to evade immune surveillance. **Clinical Significance** TPT1 has significant clinical implications, particularly in the context of cancer. Overexpression of TPT1 has been observed in various types of cancer, including thyroid, breast, and lung cancer. This overexpression can contribute to cancer progression, metastasis, and resistance to therapy. Moreover, TPT1 has been implicated in the regulation of immune responses, making it a potential target for immunotherapy. In addition to its role in cancer, TPT1 has also been implicated in other diseases, including autoimmune disorders and neurodegenerative diseases. For example, TPT1 has been shown to contribute to the pathogenesis of multiple sclerosis, a chronic autoimmune disease. **Conclusion** In conclusion, TPT1 is a multifunctional protein that plays a crucial role in various cellular processes, including regulation of apoptosis, cell proliferation, and differentiation. Its significant expression in various cell types, including malignant cells, highlights its potential role in cancer progression and immune evasion. Further research is needed to fully elucidate the immunological significance of TPT1 and its potential applications in cancer therapy and other diseases.

Genular Protein ID: 3169250586

Symbol: TCTP_HUMAN

Name: Translationally-controlled tumor protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2813067

Title: cDNA sequence coding for a translationally controlled human tumor protein.

PubMed ID: 2813067

DOI: 10.1093/nar/17.20.8367

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 7542803

Title: Molecular identification of an IgE-dependent histamine-releasing factor.

PubMed ID: 7542803

DOI: 10.1126/science.7542803

PubMed ID: 9059837

Title: Translationally controlled tumor protein: a protein identified in several nontumoral cells including erythrocytes.

PubMed ID: 9059837

DOI: 10.1002/elps.1150180127

PubMed ID: 12167714

Title: Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.

PubMed ID: 12167714

DOI: 10.1128/mcb.22.17.6209-6221.2002

PubMed ID: 15319436

Title: TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway.

PubMed ID: 15319436

DOI: 10.1074/jbc.m404850200

PubMed ID: 15162379

Title: Translationally controlled tumor protein (TCTP) in the human prostate and prostate cancer cells: expression, distribution, and calcium binding activity.

PubMed ID: 15162379

DOI: 10.1002/pros.20054

PubMed ID: 15958728

Title: The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells.

PubMed ID: 15958728

DOI: 10.1095/biolreprod.105.042077

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 18325344

Title: Interaction between fortilin and transforming growth factor-beta stimulated clone-22 (TSC-22) prevents apoptosis via the destabilization of TSC-22.

PubMed ID: 18325344

DOI: 10.1016/j.febslet.2008.01.066

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 172
  • Mass: 19595
  • Checksum: BD31399B71CA62F9
  • Sequence:
  • MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE 
    GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE 
    QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KC

Genular Protein ID: 537369394

Symbol: A0A0B4J2C3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 197
  • Mass: 22574
  • Checksum: 5D2ED551B8E0C177
  • Sequence:
  • MIIYRDLISH DEMFSDIYKI REIADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE 
    GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE 
    QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KCDAKERNPC 
    AFCLSLWRPR LNWGIHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.