Details for: HNRNPA1

Gene ID: 3178

Symbol: HNRNPA1

Ensembl ID: ENSG00000135486

Description: heterogeneous nuclear ribonucleoprotein A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 9.25
    Marker Score: 6981
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 5.06
    Marker Score: 4298
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 5.06
    Marker Score: 1482
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.95
    Marker Score: 48987
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.86
    Marker Score: 7478.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.84
    Marker Score: 10152
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.8
    Marker Score: 20013
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.72
    Marker Score: 3328
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.61
    Marker Score: 3610
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.55
    Marker Score: 13284
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.55
    Marker Score: 59994
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.53
    Marker Score: 1671
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.53
    Marker Score: 2748
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.42
    Marker Score: 150410
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.27
    Marker Score: 3058
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.19
    Marker Score: 17397.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.18
    Marker Score: 7167
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.17
    Marker Score: 2538
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.13
    Marker Score: 3684
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.1
    Marker Score: 11315
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.09
    Marker Score: 54908
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.02
    Marker Score: 9822
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.99
    Marker Score: 17130
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.93
    Marker Score: 45644
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.91
    Marker Score: 1759.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.84
    Marker Score: 3320
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.83
    Marker Score: 3700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.83
    Marker Score: 3769
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.82
    Marker Score: 4084
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.81
    Marker Score: 10692
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.8
    Marker Score: 4589
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.75
    Marker Score: 9138
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.74
    Marker Score: 24314
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.73
    Marker Score: 3321
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.71
    Marker Score: 196052
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.69
    Marker Score: 5432
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.69
    Marker Score: 6586
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.64
    Marker Score: 3433.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.63
    Marker Score: 6828
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.63
    Marker Score: 11444
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.62
    Marker Score: 3051
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.62
    Marker Score: 2557
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.62
    Marker Score: 4713
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.61
    Marker Score: 1857
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.6
    Marker Score: 2613
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.59
    Marker Score: 2314
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.57
    Marker Score: 2802
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.53
    Marker Score: 3013
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.52
    Marker Score: 3309
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.44
    Marker Score: 4059.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.41
    Marker Score: 25366
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.4
    Marker Score: 2988
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.38
    Marker Score: 1885
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.37
    Marker Score: 2114
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.36
    Marker Score: 19929
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.35
    Marker Score: 2747
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.34
    Marker Score: 5482.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.34
    Marker Score: 2526.5
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.33
    Marker Score: 1836
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.31
    Marker Score: 2195
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.31
    Marker Score: 1075
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.3
    Marker Score: 4675
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.28
    Marker Score: 1080
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.25
    Marker Score: 2029.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.25
    Marker Score: 2349
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.25
    Marker Score: 1043
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.24
    Marker Score: 12495
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.24
    Marker Score: 1596
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.23
    Marker Score: 16993.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.23
    Marker Score: 1891
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.22
    Marker Score: 4450
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.22
    Marker Score: 1607
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.22
    Marker Score: 2671
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.21
    Marker Score: 1440
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.19
    Marker Score: 2986
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.18
    Marker Score: 20742
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.18
    Marker Score: 1109
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.17
    Marker Score: 2088
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.17
    Marker Score: 1789
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 3.16
    Marker Score: 1878
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.16
    Marker Score: 1316
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.15
    Marker Score: 7155
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.14
    Marker Score: 2472
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.13
    Marker Score: 5302
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.13
    Marker Score: 748
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.12
    Marker Score: 1664
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.12
    Marker Score: 9251
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.11
    Marker Score: 1339
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.11
    Marker Score: 1913
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.11
    Marker Score: 6212
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.1
    Marker Score: 1785
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.08
    Marker Score: 3216.5
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.07
    Marker Score: 2326.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.07
    Marker Score: 3407
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.06
    Marker Score: 6211.5
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.05
    Marker Score: 3374
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.04
    Marker Score: 1031
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.04
    Marker Score: 808
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 3.04
    Marker Score: 1093
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.03
    Marker Score: 7649

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Other Information

**Key characteristics:** * HNRNPA1 is a protein encoded by the ENSG00000135486 gene. * It is a large protein with a molecular weight of approximately 170 kDa. * It is found in a variety of cell types, including blood cells, epithelial cells, and immune cells. **Pathways and functions:** * HNRNPA1 is involved in the processing of capped intron-containing pre-mRNA. * It interacts with the SRF protein, which is responsible for the recognition and removal of introns from pre-mRNA. * HNRNPA1 is also involved in the regulation of mRNA splicing, where it can facilitate the inclusion or exclusion of specific exons in the final mRNA product. * It plays a role in the initiation of translation by binding to the 5' cap of pre-mRNA and facilitating the interaction between the cap-binding complex and the ribosome. **Clinical significance:** * Mutations in HNRNPA1 have been linked to several human diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. * In cancer, HNRNPA1 mutations can lead to the activation of oncogenes, resulting in uncontrolled cell growth and proliferation. * HNRNPA1 inhibitors are being investigated as potential therapeutic agents for cancer and other diseases where HNRNPA1 is involved. **Additional notes:** * HNRNPA1 is a highly conserved protein with significant expression in immune cells. * It is a key regulator of gene expression and plays a role in maintaining cellular homeostasis and preventing the initiation of uncontrolled cell growth. * Dysregulation of HNRNPA1 has been linked to various diseases, highlighting its importance in maintaining cellular health and preventing disease.

Genular Protein ID: 1882053567

Symbol: ROA1_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein A1

UniProtKB Accession Codes:

P09651 A8K4Z8 Q3MIB7 Q6PJZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 15 EMDB 2 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 30 PDBsum 26 PIR 2 PRIDE 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2760922

Title: Isolation of an active gene encoding human hnRNP protein A1. Evidence for alternative splicing.

PubMed ID: 2760922

DOI: 10.1016/0022-2836(89)90459-2

PubMed ID: 2836799

Title: cDNA cloning of human hnRNP protein A1 reveals the existence of multiple mRNA isoforms.

PubMed ID: 2836799

DOI: 10.1093/nar/16.9.3751

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3023065

Title: Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1.

PubMed ID: 3023065

DOI: 10.1002/j.1460-2075.1986.tb04494.x

PubMed ID: 1691095

Title: Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.

PubMed ID: 1691095

DOI: 10.1002/j.1460-2075.1990.tb08230.x

PubMed ID: 7730395

Title: A nuclear localization domain in the hnRNP A1 protein.

PubMed ID: 7730395

DOI: 10.1083/jcb.129.3.551

PubMed ID: 8521471

Title: A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway.

PubMed ID: 8521471

DOI: 10.1016/0092-8674(95)90119-1

PubMed ID: 7769000

Title: Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP A1.

PubMed ID: 7769000

DOI: 10.1242/jcs.108.2.545

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 15161980

Title: Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis.

PubMed ID: 15161980

DOI: 10.1073/pnas.0402889101

PubMed ID: 16111636

Title: The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.

PubMed ID: 16111636

DOI: 10.1016/j.immuni.2005.06.009

PubMed ID: 15862300

Title: The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1.

PubMed ID: 15862300

DOI: 10.1016/j.febslet.2005.03.080

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17371836

Title: The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.

PubMed ID: 17371836

DOI: 10.1083/jcb.200701005

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17229681

Title: An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.

PubMed ID: 17229681

DOI: 10.1128/jvi.01311-06

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20010808

Title: HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.

PubMed ID: 20010808

DOI: 10.1038/nature08697

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24549040

Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

PubMed ID: 24549040

DOI: 10.1093/hmg/ddu068

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25678563

Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

PubMed ID: 25678563

DOI: 10.1093/brain/awv005

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28431233

Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

PubMed ID: 28431233

DOI: 10.1016/j.molcel.2017.03.014

PubMed ID: 28985503

Title: A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.

PubMed ID: 28985503

DOI: 10.1016/j.molcel.2017.09.015

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31498791

Title: EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.

PubMed ID: 31498791

DOI: 10.1371/journal.pone.0221048

PubMed ID: 33360543

Title: Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.

PubMed ID: 33360543

DOI: 10.1016/j.bbrc.2020.11.115

PubMed ID: 2176620

Title: Modeling by homology of RNA binding domain in A1 hnRNP protein.

PubMed ID: 2176620

DOI: 10.1016/0014-5793(90)80863-e

PubMed ID: 9164463

Title: Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75-A resolution.

PubMed ID: 9164463

DOI: 10.1038/nsb0397-215

PubMed ID: 9115444

Title: Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs.

PubMed ID: 9115444

DOI: 10.1016/s0969-2126(97)00211-6

PubMed ID: 23455423

Title: Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

PubMed ID: 23455423

DOI: 10.1038/nature11922

PubMed ID: 25616961

Title: ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1.

PubMed ID: 25616961

DOI: 10.1093/hmg/ddv020

PubMed ID: 27694260

Title: Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.

PubMed ID: 27694260

DOI: 10.1212/wnl.0000000000003256

Sequence Information:

  • Length: 372
  • Mass: 38747
  • Checksum: A06683571C6C109F
  • Sequence:
    • MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV 
TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH 
LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA 
LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS 
GDGYNGFGND GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG 
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK PRNQGGYGGS 
SSSSSYGSGR RF

Genular Protein ID: 96568368

Symbol: A0A024RB53_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RB53

Database IDs:

ARBA 14 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 5 Gene3D 1 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 320
  • Mass: 34196
  • Checksum: 59485C9FA1FF8AE1
  • Sequence:
    • MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV 
TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH 
LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA 
LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS 
GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR 
NQGGYGGSSS SSSYGSGRRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.