Details for: HNRNPA1

Gene ID: 3178

Symbol: HNRNPA1

Ensembl ID: ENSG00000135486

Description: heterogeneous nuclear ribonucleoprotein A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 897.2310
    Cell Significance Index: -139.5600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 451.9992
    Cell Significance Index: -186.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 434.0346
    Cell Significance Index: -110.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 390.1317
    Cell Significance Index: -184.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 363.6963
    Cell Significance Index: -187.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 275.2964
    Cell Significance Index: -184.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 134.0681
    Cell Significance Index: -165.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 46.1905
    Cell Significance Index: -182.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.7158
    Cell Significance Index: -90.3200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.6095
    Cell Significance Index: -103.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.2407
    Cell Significance Index: -42.1100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 16.4306
    Cell Significance Index: 96.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 15.6772
    Cell Significance Index: 544.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 15.1917
    Cell Significance Index: 194.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 15.1836
    Cell Significance Index: 121.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 13.4380
    Cell Significance Index: 281.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 13.1653
    Cell Significance Index: 346.1800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 12.8945
    Cell Significance Index: 140.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.0806
    Cell Significance Index: 332.7800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.6233
    Cell Significance Index: 909.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 6.5932
    Cell Significance Index: 116.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.1224
    Cell Significance Index: 722.0200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.6272
    Cell Significance Index: 295.4500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.5973
    Cell Significance Index: 688.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.5048
    Cell Significance Index: 711.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.0015
    Cell Significance Index: 143.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.8622
    Cell Significance Index: 876.5000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.8470
    Cell Significance Index: 142.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.7736
    Cell Significance Index: 611.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.7109
    Cell Significance Index: 351.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.5296
    Cell Significance Index: 320.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.4127
    Cell Significance Index: 50.1300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.2900
    Cell Significance Index: 1896.7200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.2883
    Cell Significance Index: 276.6600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: 4.1980
    Cell Significance Index: 56.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.0020
    Cell Significance Index: 108.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.5879
    Cell Significance Index: 1959.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.8200
    Cell Significance Index: 131.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.2867
    Cell Significance Index: 52.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.1223
    Cell Significance Index: 209.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.9622
    Cell Significance Index: 1771.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.7989
    Cell Significance Index: 307.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.7080
    Cell Significance Index: 49.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.4617
    Cell Significance Index: 40.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.9522
    Cell Significance Index: 720.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7350
    Cell Significance Index: 38.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6608
    Cell Significance Index: 131.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5375
    Cell Significance Index: 4.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4248
    Cell Significance Index: 23.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3515
    Cell Significance Index: 66.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3221
    Cell Significance Index: 5.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2225
    Cell Significance Index: 7.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1136
    Cell Significance Index: 40.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0628
    Cell Significance Index: 46.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0489
    Cell Significance Index: 9.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0316
    Cell Significance Index: 9.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0075
    Cell Significance Index: 5.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0203
    Cell Significance Index: -15.0600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0332
    Cell Significance Index: -1.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0580
    Cell Significance Index: -5.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0798
    Cell Significance Index: -150.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1085
    Cell Significance Index: -200.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1277
    Cell Significance Index: -196.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1504
    Cell Significance Index: -204.4400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1569
    Cell Significance Index: -98.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2075
    Cell Significance Index: -5.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2391
    Cell Significance Index: -134.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2651
    Cell Significance Index: -168.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.3043
    Cell Significance Index: -49.5000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3858
    Cell Significance Index: -175.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3914
    Cell Significance Index: -82.4300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4022
    Cell Significance Index: -10.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4028
    Cell Significance Index: -16.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5593
    Cell Significance Index: -34.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6165
    Cell Significance Index: -37.0100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.6438
    Cell Significance Index: -4.0000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.6766
    Cell Significance Index: -73.5900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6934
    Cell Significance Index: -22.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8432
    Cell Significance Index: -96.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1492
    Cell Significance Index: -72.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.2148
    Cell Significance Index: -141.5700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.2165
    Cell Significance Index: -176.8300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.3458
    Cell Significance Index: -23.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3630
    Cell Significance Index: -107.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.4081
    Cell Significance Index: -160.7300
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.4811
    Cell Significance Index: -9.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.7415
    Cell Significance Index: -37.7300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.7550
    Cell Significance Index: -182.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.8640
    Cell Significance Index: -143.0400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.9068
    Cell Significance Index: -86.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.4508
    Cell Significance Index: -164.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.6121
    Cell Significance Index: -65.3000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -2.6890
    Cell Significance Index: -49.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.7775
    Cell Significance Index: -38.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.7967
    Cell Significance Index: -171.4700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -2.8828
    Cell Significance Index: -22.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.9728
    Cell Significance Index: -79.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.3301
    Cell Significance Index: -98.0900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -3.4925
    Cell Significance Index: -47.6500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.6229
    Cell Significance Index: -93.1300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** hnRNP A1 is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which is composed of RNA-binding proteins that regulate RNA metabolism. This gene is characterized by its ability to bind to specific RNA sequences, including G-rich strand telomeric DNA and mRNA 3'-UTRs, and its involvement in various cellular pathways, including the regulation of telomere maintenance, alternative splicing, and immune responses. hnRNP A1 is also known to interact with other proteins, including the FGF receptor 2 (FGFR2) and the receptor tyrosine kinase (RTK), to modulate signaling pathways. **Pathways and Functions** hnRNP A1 is involved in several key pathways, including: 1. **Alternative RNA Splicing**: HnRNP A1 regulates alternative splicing by binding to specific RNA sequences and influencing the recruitment of spliceosomal components to the RNA. 2. **Telomere Maintenance**: HnRNP A1 interacts with telomerase to regulate telomere length and maintain genome stability. 3. **Immune Response**: HnRNP A1 is expressed in immune cells, including T cells and natural killer cells, and is involved in regulating immune responses to viral infections. 4. **Cellular Response to Glucose Starvation**: HnRNP A1 is involved in regulating cellular responses to glucose starvation by modulating the expression of genes involved in glucose metabolism. 5. **Cytoskeleton Organization**: HnRNP A1 interacts with actin-binding proteins to regulate cytoskeleton organization and cell migration. **Clinical Significance** Dysregulation of hnRNP A1 has been implicated in various diseases, including: 1. **Cancer**: Aberrant expression of hnRNP A1 has been observed in several types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative Diseases**: HnRNP A1 has been implicated in the regulation of alternative splicing in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 3. **Immune Disorders**: HnRNP A1 is involved in regulating immune responses, and dysregulation of this gene has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cardiovascular Disease**: HnRNP A1 has been implicated in regulating cellular responses to glucose starvation, which is a key factor in the development of cardiovascular disease. In conclusion, hnRNP A1 is a multifunctional protein that plays a critical role in regulating RNA metabolism, immune responses, and cellular homeostasis. Understanding the functions and dysregulation of this gene has important implications for the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 1882053567

Symbol: ROA1_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein A1

UniProtKB Accession Codes:

P09651 A8K4Z8 Q3MIB7 Q6PJZ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 15 EMDB 2 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 68 PDBsum 68 PIR 2 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 3 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2760922

Title: Isolation of an active gene encoding human hnRNP protein A1. Evidence for alternative splicing.

PubMed ID: 2760922

DOI: 10.1016/0022-2836(89)90459-2

PubMed ID: 2836799

Title: cDNA cloning of human hnRNP protein A1 reveals the existence of multiple mRNA isoforms.

PubMed ID: 2836799

DOI: 10.1093/nar/16.9.3751

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3023065

Title: Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1.

PubMed ID: 3023065

DOI: 10.1002/j.1460-2075.1986.tb04494.x

PubMed ID: 1691095

Title: Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein.

PubMed ID: 1691095

DOI: 10.1002/j.1460-2075.1990.tb08230.x

PubMed ID: 7730395

Title: A nuclear localization domain in the hnRNP A1 protein.

PubMed ID: 7730395

DOI: 10.1083/jcb.129.3.551

PubMed ID: 8521471

Title: A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway.

PubMed ID: 8521471

DOI: 10.1016/0092-8674(95)90119-1

PubMed ID: 7769000

Title: Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP A1.

PubMed ID: 7769000

DOI: 10.1242/jcs.108.2.545

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 15161980

Title: Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis.

PubMed ID: 15161980

DOI: 10.1073/pnas.0402889101

PubMed ID: 16111636

Title: The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.

PubMed ID: 16111636

DOI: 10.1016/j.immuni.2005.06.009

PubMed ID: 15862300

Title: The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1.

PubMed ID: 15862300

DOI: 10.1016/j.febslet.2005.03.080

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17371836

Title: The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x.

PubMed ID: 17371836

DOI: 10.1083/jcb.200701005

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17229681

Title: An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.

PubMed ID: 17229681

DOI: 10.1128/jvi.01311-06

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20010808

Title: HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.

PubMed ID: 20010808

DOI: 10.1038/nature08697

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24549040

Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

PubMed ID: 24549040

DOI: 10.1093/hmg/ddu068

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25678563

Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

PubMed ID: 25678563

DOI: 10.1093/brain/awv005

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28431233

Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.

PubMed ID: 28431233

DOI: 10.1016/j.molcel.2017.03.014

PubMed ID: 28985503

Title: A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.

PubMed ID: 28985503

DOI: 10.1016/j.molcel.2017.09.015

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31498791

Title: EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation.

PubMed ID: 31498791

DOI: 10.1371/journal.pone.0221048

PubMed ID: 33360543

Title: Overexpression of SARS-CoV-2 protein ORF6 dislocates RAE1 and NUP98 from the nuclear pore complex.

PubMed ID: 33360543

DOI: 10.1016/j.bbrc.2020.11.115

PubMed ID: 2176620

Title: Modeling by homology of RNA binding domain in A1 hnRNP protein.

PubMed ID: 2176620

DOI: 10.1016/0014-5793(90)80863-e

PubMed ID: 9164463

Title: Crystal structure of the two RNA binding domains of human hnRNP A1 at 1.75-A resolution.

PubMed ID: 9164463

DOI: 10.1038/nsb0397-215

PubMed ID: 9115444

Title: Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs.

PubMed ID: 9115444

DOI: 10.1016/s0969-2126(97)00211-6

PubMed ID: 23455423

Title: Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

PubMed ID: 23455423

DOI: 10.1038/nature11922

PubMed ID: 25616961

Title: ALS-linked mutations in ubiquilin-2 or hnRNPA1 reduce interaction between ubiquilin-2 and hnRNPA1.

PubMed ID: 25616961

DOI: 10.1093/hmg/ddv020

PubMed ID: 27694260

Title: Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.

PubMed ID: 27694260

DOI: 10.1212/wnl.0000000000003256

PubMed ID: 34722876

Title: Dominant Distal Myopathy 3 (MPD3) Caused by a Deletion in the HNRNPA1 Gene.

PubMed ID: 34722876

DOI: 10.1212/nxg.0000000000000632

Sequence Information:

  • Length: 372
  • Mass: 38747
  • Checksum: A06683571C6C109F
  • Sequence:
    • MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV 
TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH 
LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA 
LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS 
GDGYNGFGND GGYGGGGPGY SGGSRGYGSG GQGYGNQGSG YGGSGSYDSY NNGGGGGFGG 
GSGSNFGGGG SYNDFGNYNN QSSNFGPMKG GNFGGRSSGP YGGGGQYFAK PRNQGGYGGS 
SSSSSYGSGR RF

Genular Protein ID: 96568368

Symbol: A0A024RB53_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RB53

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 320
  • Mass: 34196
  • Checksum: 59485C9FA1FF8AE1
  • Sequence:
    • MSKSESPKEP EQLRKLFIGG LSFETTDESL RSHFEQWGTL TDCVVMRDPN TKRSRGFGFV 
TYATVEEVDA AMNARPHKVD GRVVEPKRAV SREDSQRPGA HLTVKKIFVG GIKEDTEEHH 
LRDYFEQYGK IEVIEIMTDR GSGKKRGFAF VTFDDHDSVD KIVIQKYHTV NGHNCEVRKA 
LSKQEMASAS SSQRGRSGSG NFGGGRGGGF GGNDNFGRGG NFSGRGGFGG SRGGGGYGGS 
GDGYNGFGND GSNFGGGGSY NDFGNYNNQS SNFGPMKGGN FGGRSSGPYG GGGQYFAKPR 
NQGGYGGSSS SSSYGSGRRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.