Details for: COX1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 999.4013
Cell Significance Index: -471.8400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 972.8117
Cell Significance Index: -500.4000 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 705.4313
Cell Significance Index: -473.3600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 74.7990
Cell Significance Index: 2745.8200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 73.5985
Cell Significance Index: -197.1600 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 69.4805
Cell Significance Index: 974.5700 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 57.6649
Cell Significance Index: 458.8100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 51.5472
Cell Significance Index: 4082.5400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 50.6454
Cell Significance Index: 37133.0100 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 44.0893
Cell Significance Index: 118.1100 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 34.4447
Cell Significance Index: 508.4000 - Cell Name: abnormal cell (CL0001061)
Fold Change: 20.2695
Cell Significance Index: 2070.5200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 19.3005
Cell Significance Index: 1013.3500 - Cell Name: pro-T cell (CL0000827)
Fold Change: 15.1362
Cell Significance Index: 386.6800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 13.5837
Cell Significance Index: 1477.5000 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 13.0419
Cell Significance Index: 354.9900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 12.8993
Cell Significance Index: 7044.6400 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 11.7927
Cell Significance Index: 217.9600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 11.3540
Cell Significance Index: 104.5600 - Cell Name: granulosa cell (CL0000501)
Fold Change: 11.0160
Cell Significance Index: 289.6700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 10.4765
Cell Significance Index: 474.8700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 9.6175
Cell Significance Index: 1182.5600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 9.3041
Cell Significance Index: 268.0700 - Cell Name: lactocyte (CL0002325)
Fold Change: 9.0873
Cell Significance Index: 1174.0100 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 9.0239
Cell Significance Index: 188.2000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 9.0016
Cell Significance Index: 1236.1700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 8.8419
Cell Significance Index: 658.9800 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 8.8302
Cell Significance Index: 6683.7400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 8.5534
Cell Significance Index: 398.8000 - Cell Name: peg cell (CL4033014)
Fold Change: 7.9430
Cell Significance Index: 183.5100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 7.9209
Cell Significance Index: 372.2800 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 7.8004
Cell Significance Index: 271.0600 - Cell Name: enterocyte (CL0000584)
Fold Change: 7.5919
Cell Significance Index: 47.1000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 7.5812
Cell Significance Index: 1366.6500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.9047
Cell Significance Index: 445.4600 - Cell Name: odontoblast (CL0000060)
Fold Change: 6.7120
Cell Significance Index: 860.4400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 6.2784
Cell Significance Index: 621.0700 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 5.1989
Cell Significance Index: 66.5800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 4.6151
Cell Significance Index: 132.3000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.0553
Cell Significance Index: 46.0700 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 3.8470
Cell Significance Index: 3473.5200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.8097
Cell Significance Index: 57.4100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 3.5320
Cell Significance Index: 103.7300 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.5249
Cell Significance Index: 62.2900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 3.0035
Cell Significance Index: 1077.3100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.5573
Cell Significance Index: 507.5100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.4513
Cell Significance Index: 398.6800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6082
Cell Significance Index: 322.6100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.4345
Cell Significance Index: 273.0000 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.3048
Cell Significance Index: 21.9800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.2370
Cell Significance Index: 43.4700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.4738
Cell Significance Index: 12.6500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1881
Cell Significance Index: -354.2100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.3448
Cell Significance Index: -635.9000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.4138
Cell Significance Index: -636.9800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.4737
Cell Significance Index: -644.1000 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.5509
Cell Significance Index: -94.0700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.6055
Cell Significance Index: -448.4900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.6711
Cell Significance Index: -34.8600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.6834
Cell Significance Index: -434.0600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.8106
Cell Significance Index: -457.1400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.8697
Cell Significance Index: -394.7400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.9071
Cell Significance Index: -566.4800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -1.1343
Cell Significance Index: -326.3700 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -1.1443
Cell Significance Index: -68.7000 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.7579
Cell Significance Index: -13.5500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.8299
Cell Significance Index: -209.6500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.9930
Cell Significance Index: -137.8300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -2.1866
Cell Significance Index: -45.7700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -2.4727
Cell Significance Index: -166.2700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -2.5070
Cell Significance Index: -528.0300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.5309
Cell Significance Index: -81.0600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.8707
Cell Significance Index: -71.7600 - Cell Name: preadipocyte (CL0002334)
Fold Change: -2.9897
Cell Significance Index: -58.3500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -3.1886
Cell Significance Index: -178.9300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -3.3263
Cell Significance Index: -483.5100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -3.3790
Cell Significance Index: -56.5500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -3.4517
Cell Significance Index: -264.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -3.8456
Cell Significance Index: -236.3700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -4.1103
Cell Significance Index: -427.9800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -4.2991
Cell Significance Index: -93.1400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -5.4361
Cell Significance Index: -342.6200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -5.8055
Cell Significance Index: -86.9900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -6.5347
Cell Significance Index: -400.6400 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -7.2998
Cell Significance Index: -125.8400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -7.4444
Cell Significance Index: -212.4400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -7.5400
Cell Significance Index: -160.5800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -8.8138
Cell Significance Index: -91.2400 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -9.2138
Cell Significance Index: -465.6400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -9.4627
Cell Significance Index: -253.1200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -9.4911
Cell Significance Index: -419.8200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -9.7337
Cell Significance Index: -286.7000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -11.5793
Cell Significance Index: -438.4800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -11.7430
Cell Significance Index: -481.1700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -11.7945
Cell Significance Index: -160.9200 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -11.7960
Cell Significance Index: -140.6200 - Cell Name: kidney cell (CL1000497)
Fold Change: -11.7982
Cell Significance Index: -94.2000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -12.7615
Cell Significance Index: -264.7300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -13.3424
Cell Significance Index: -467.4100 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -13.8440
Cell Significance Index: -105.8300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2059656603
Symbol: COX1_HUMAN
Name: Cytochrome c oxidase subunit 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 7530363
Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
PubMed ID: 7530363
PubMed ID: 12949126
Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.
PubMed ID: 12949126
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 12840039
Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
PubMed ID: 12840039
DOI: 10.1101/gr.686603
PubMed ID: 14760490
Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
PubMed ID: 14760490
PubMed ID: 6260957
Title: Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.
PubMed ID: 6260957
PubMed ID: 10577941
Title: Heterogenous point mutations in the mitochondrial tRNA Ser(UCN) precursor coexisting with the A1555G mutation in deaf students from Mongolia.
PubMed ID: 10577941
DOI: 10.1086/302658
PubMed ID: 26321642
Title: MITRAC7 acts as a COX1-specific chaperone and reveals a checkpoint during cytochrome c oxidase assembly.
PubMed ID: 26321642
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 29154948
Title: The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis.
PubMed ID: 29154948
PubMed ID: 28844695
Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.
PubMed ID: 28844695
PubMed ID: 30030519
Title: Structure of the intact 14-subunit human cytochrome c oxidase.
PubMed ID: 30030519
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 1322638
Title: A mitochondrial DNA variant, identified in Leber hereditary optic neuropathy patients, which extends the amino acid sequence of cytochrome c oxidase subunit I.
PubMed ID: 1322638
PubMed ID: 9389715
Title: Heteroplasmic point mutations of mitochondrial DNA affecting subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia.
PubMed ID: 9389715
PubMed ID: 9851701
Title: MtDNA mutations associated with sideroblastic anaemia cause a defect of mitochondrial cytochrome c oxidase.
PubMed ID: 9851701
PubMed ID: 10980727
Title: Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mitochondrial DNA.
PubMed ID: 10980727
DOI: 10.1212/wnl.55.5.644
PubMed ID: 12140182
Title: Metabolic consequences of a novel missense mutation of the mtDNA CO I gene.
PubMed ID: 12140182
PubMed ID: 16284789
Title: Introducing a novel human mtDNA mutation into the Paracoccus denitrificans COX I gene explains functional deficits in a patient.
PubMed ID: 16284789
PubMed ID: 16407113
Title: Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.
PubMed ID: 16407113
PubMed ID: 19218458
Title: A mitochondrial DNA mutation linked to colon cancer results in proton leaks in cytochrome c oxidase.
PubMed ID: 19218458
Sequence Information:
- Length: 513
- Mass: 57041
- Checksum: DBCBFE808650AE0D
- Sequence:
MFADRWLFST NHKDIGTLYL LFGAWAGVLG TALSLLIRAE LGQPGNLLGN DHIYNVIVTA HAFVMIFFMV MPIMIGGFGN WLVPLMIGAP DMAFPRMNNM SFWLLPPSLL LLLASAMVEA GAGTGWTVYP PLAGNYSHPG ASVDLTIFSL HLAGVSSILG AINFITTIIN MKPPAMTQYQ TPLFVWSVLI TAVLLLLSLP VLAAGITMLL TDRNLNTTFF DPAGGGDPIL YQHLFWFFGH PEVYILILPG FGMISHIVTY YSGKKEPFGY MGMVWAMMSI GFLGFIVWAH HMFTVGMDVD TRAYFTSATM IIAIPTGVKV FSWLATLHGS NMKWSAAVLW ALGFIFLFTV GGLTGIVLAN SSLDIVLHDT YYVVAHFHYV LSMGAVFAIM GGFIHWFPLF SGYTLDQTYA KIHFTIMFIG VNLTFFPQHF LGLSGMPRRY SDYPDAYTTW NILSSVGSFI SLTAVMLMIF MIWEAFASKR KVLMVEEPSM NLEWLYGCPP PYHTFEEPVY MKS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.