Details for: H2AZ1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 486.3537
Cell Significance Index: -75.6500 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 352.1480
Cell Significance Index: -89.3200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 318.6328
Cell Significance Index: -131.2600 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 281.5581
Cell Significance Index: -114.3900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 265.9690
Cell Significance Index: -125.5700 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 243.7473
Cell Significance Index: -125.3800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 187.7285
Cell Significance Index: -125.9700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 121.4096
Cell Significance Index: -115.9200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 91.5118
Cell Significance Index: -112.8300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 31.5987
Cell Significance Index: -124.6900 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.6119
Cell Significance Index: -66.3800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 14.6213
Cell Significance Index: -32.0000 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 9.4331
Cell Significance Index: 252.3300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 8.1097
Cell Significance Index: 281.8100 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 7.8325
Cell Significance Index: 85.1500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 5.8481
Cell Significance Index: 122.4100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 5.7393
Cell Significance Index: 150.9200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 5.6108
Cell Significance Index: 661.6800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 4.0474
Cell Significance Index: 2210.3600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.2972
Cell Significance Index: 405.4200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.1548
Cell Significance Index: 165.6400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.1225
Cell Significance Index: 428.8100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.0054
Cell Significance Index: 53.1100 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.9989
Cell Significance Index: 140.9500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.8278
Cell Significance Index: 76.9700 - Cell Name: odontoblast (CL0000060)
Fold Change: 2.6784
Cell Significance Index: 343.3600 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.6645
Cell Significance Index: 30.2700 - Cell Name: theca cell (CL0000503)
Fold Change: 2.6025
Cell Significance Index: 15.2900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.3376
Cell Significance Index: 1033.5100 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.3027
Cell Significance Index: 148.5600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2886
Cell Significance Index: 412.5600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.2480
Cell Significance Index: 64.4400 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.1810
Cell Significance Index: 162.5500 - Cell Name: lactocyte (CL0002325)
Fold Change: 2.1348
Cell Significance Index: 275.8000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.0987
Cell Significance Index: 97.8500 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.0324
Cell Significance Index: 59.6900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.7512
Cell Significance Index: 91.2200 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.6274
Cell Significance Index: 4.8400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.6033
Cell Significance Index: 113.3900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0408
Cell Significance Index: 206.5500 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0074
Cell Significance Index: 45.6600 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 1.0068
Cell Significance Index: 7.7600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.9591
Cell Significance Index: 866.0000 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.8229
Cell Significance Index: 9.8100 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.8166
Cell Significance Index: 6.5200 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.5897
Cell Significance Index: 118.3000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5395
Cell Significance Index: 53.3700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5207
Cell Significance Index: 27.0500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4951
Cell Significance Index: 94.2200 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4700
Cell Significance Index: 29.6200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.4595
Cell Significance Index: 6.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2803
Cell Significance Index: 212.1400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2308
Cell Significance Index: 12.9500 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 0.1309
Cell Significance Index: 0.9400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.1307
Cell Significance Index: 3.4900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1165
Cell Significance Index: 1.9500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0042
Cell Significance Index: 1.5200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0013
Cell Significance Index: -0.9500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0475
Cell Significance Index: -89.4500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0578
Cell Significance Index: -5.9000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0795
Cell Significance Index: -146.6100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0906
Cell Significance Index: -4.5800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0946
Cell Significance Index: -145.5600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1099
Cell Significance Index: -149.4500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1230
Cell Significance Index: -5.0400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1507
Cell Significance Index: -111.6600 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1577
Cell Significance Index: -100.1500 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1850
Cell Significance Index: -3.4200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2097
Cell Significance Index: -118.2600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.2194
Cell Significance Index: -35.6900 - Cell Name: peg cell (CL4033014)
Fold Change: -0.2238
Cell Significance Index: -5.1700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2429
Cell Significance Index: -110.2600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.2564
Cell Significance Index: -160.1300 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.3257
Cell Significance Index: -9.3900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3443
Cell Significance Index: -58.7900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.3625
Cell Significance Index: -10.1300 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3683
Cell Significance Index: -9.4100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3820
Cell Significance Index: -109.9100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4235
Cell Significance Index: -3.9000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.4583
Cell Significance Index: -9.7600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5503
Cell Significance Index: -63.0500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6070
Cell Significance Index: -19.4400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.6426
Cell Significance Index: -135.3400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7526
Cell Significance Index: -109.4000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.8478
Cell Significance Index: -50.9000 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.9194
Cell Significance Index: -11.7800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.0903
Cell Significance Index: -23.6200 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.1847
Cell Significance Index: -123.3600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.2122
Cell Significance Index: -96.0100 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.2138
Cell Significance Index: -10.4300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.4164
Cell Significance Index: -95.2400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.5443
Cell Significance Index: -21.0700 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.5608
Cell Significance Index: -9.4300 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.5726
Cell Significance Index: -26.9500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.6374
Cell Significance Index: -125.6500 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -1.6406
Cell Significance Index: -10.2700 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.7751
Cell Significance Index: -30.6000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.9705
Cell Significance Index: -69.2400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.0522
Cell Significance Index: -125.8200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.2978
Cell Significance Index: -67.6800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3343180047
Symbol: H2AZ_HUMAN
Name: Histone H2A.Z
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3344202
Title: Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.
PubMed ID: 3344202
PubMed ID: 1697587
Title: The human histone H2A.Z gene. Sequence and regulation.
PubMed ID: 1697587
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11835281
PubMed ID: 15878876
Title: Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z.
PubMed ID: 15878876
PubMed ID: 16457589
Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.
PubMed ID: 16457589
DOI: 10.1021/pr050269n
PubMed ID: 16627869
Title: Quantitative proteomic analysis of post-translational modifications of human histones.
PubMed ID: 16627869
PubMed ID: 16319397
Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.
PubMed ID: 16319397
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20473270
Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
PubMed ID: 20473270
PubMed ID: 26237645
Title: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.
PubMed ID: 26237645
DOI: 10.1038/ncb3209
PubMed ID: 28645917
Title: Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.
PubMed ID: 28645917
PubMed ID: 30327463
Title: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.
PubMed ID: 30327463
PubMed ID: 11101893
Title: Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.
PubMed ID: 11101893
DOI: 10.1038/81971
PubMed ID: 24463511
Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.
PubMed ID: 24463511
DOI: 10.1038/nature12922
PubMed ID: 23324626
Title: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.
PubMed ID: 23324626
DOI: 10.4161/epi.23416
PubMed ID: 31527837
Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.
PubMed ID: 31527837
PubMed ID: 26974126
Title: Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
PubMed ID: 26974126
DOI: 10.1038/nsmb.3189
PubMed ID: 31645732
Title: Metabolic regulation of gene expression by histone lactylation.
PubMed ID: 31645732
Sequence Information:
- Length: 128
- Mass: 13553
- Checksum: E024E53818230371
- Sequence:
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG KKGQQKTV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.