Details for: H2AZ1
Gene ID: 3015
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: H2AZ1
Ensembl ID: ENSG00000164032
Description: H2A.Z variant histone 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 114.76rCSI 99.37%PRS 3.35
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CSI 114.49rCSI 92.57%PRS 2.94
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CSI 96.45rCSI 87.1%PRS 2.63
-
CSI 94.19rCSI 100%PRS 2.78
-
CSI 90.03rCSI 75.46%PRS 3.61
-
CSI 86.95rCSI 72.01%PRS 3
-
CSI 84.98rCSI 56.49%PRS 3.57
-
CSI 73.95rCSI 86.85%PRS 3.66
-
CSI 72.18rCSI 63.4%PRS 3.35
-
CSI 68.96rCSI 86.55%PRS 3.8
-
CSI 68.86rCSI 95.67%PRS 3.19
-
CSI 68.63rCSI 98.98%PRS 4.16
-
CSI 67.54rCSI 65.01%PRS 3.13
-
CSI 67.45rCSI 77.21%PRS 6.25
-
CSI 65.62rCSI 54.4%PRS 2.81
-
CSI 65.17rCSI 50.21%PRS 2.7
-
CSI 63.74rCSI 63.61%PRS 2.53
-
CSI 62.42rCSI 54.89%PRS 2.18
-
CSI 61.29rCSI 48.21%PRS 3.56
-
CSI 60.37rCSI 63.25%PRS 3.24
-
CSI 59.48rCSI 81.32%PRS 5.46
-
CSI 58.4rCSI 57.44%PRS 3.32
-
CSI 56.66rCSI 68.01%PRS 3
-
CSI 54.93rCSI 74.85%PRS 2.71
-
CSI 54.65rCSI 43.2%PRS 2.08
-
CSI 52.18rCSI 89.4%PRS 4
-
CSI 51.73rCSI 79.93%PRS 2.82
-
CSI 50.47rCSI 72.03%PRS 3.43
-
CSI 48.5rCSI 50.69%PRS 3.2
-
CSI 47.4rCSI 58.64%PRS 2.63
-
CSI 46.64rCSI 69.32%PRS 3.98
-
CSI 44.73rCSI 68.42%PRS 4.91
-
CSI 42.22rCSI 54.19%PRS 3.01
-
CSI 40.14rCSI 64.03%PRS 2.64
-
CSI 39.66rCSI 29.37%PRS 2.84
-
CSI 38.73rCSI 34.38%PRS 3
-
CSI 38rCSI 35.06%PRS 3.03
-
CSI 37.14rCSI 49.63%PRS 5.74
-
CSI 36.06rCSI 45.91%PRS 3.51
-
CSI 35.25rCSI 32.37%PRS 3.41
-
CSI 34.23rCSI 28.58%PRS 9.96
-
CSI 33.25rCSI 34.84%PRS 2.8
-
CSI 31.16rCSI 42.57%PRS 3.32
-
CSI 30.95rCSI 88.35%PRS 5.32
-
CSI 29.7rCSI 45.61%PRS 3.47
-
CSI 29.56rCSI 55.88%PRS 6.83
-
CSI 29.31rCSI 62.34%PRS 5.98
-
CSI 28.67rCSI 41.32%PRS 4.88
-
CSI 28.43rCSI 43.69%PRS 4.37
-
CSI 28.28rCSI 24.77%PRS 4.05
-
CSI 28.27rCSI 90.72%PRS 4.59
-
CSI 27.98rCSI 61.95%PRS 2.82
-
CSI 27.44rCSI 41.91%PRS 5.26
-
CSI 27.22rCSI 92.02%PRS 5.18
-
CSI 26.48rCSI 57.81%PRS 6.16
-
CSI 25.02rCSI 45.46%PRS 4.61
-
CSI 24.18rCSI 39.83%PRS 3.47
-
CSI 24.15rCSI 30.97%PRS 3.46
-
CSI 23.64rCSI 64.96%PRS 5.08
-
CSI 23.63rCSI 24.48%PRS 3.51
-
CSI 23.59rCSI 31.35%PRS 3.29
-
CSI 23.35rCSI 69.64%PRS 8.25
-
CSI 22.92rCSI 27.69%PRS 3.46
-
CSI 22.63rCSI 23.07%PRS 4.36
-
CSI 22.51rCSI 66.8%PRS 5.31
-
CSI 22.34rCSI 64.68%PRS 3.41
-
CSI 21.36rCSI 43.85%PRS 7.35
-
CSI 21.25rCSI 45.23%PRS 4.9
-
CSI 21.02rCSI 40.12%PRS 7.43
-
CSI 20.81rCSI 37.1%PRS 5.21
-
CSI 20.16rCSI 70.72%PRS 5.46
-
CSI 19.74rCSI 18.65%PRS 3.13
-
CSI 19.57rCSI 29.89%PRS 3.03
-
CSI 18.53rCSI 34.98%PRS 3.73
-
CSI 18.44rCSI 80.96%PRS 5.94
-
CSI 17.62rCSI 13.33%PRS 4.2
-
CSI 17.53rCSI 41.66%PRS 4.59
-
CSI 17.52rCSI 47.22%PRS 3.95
-
CSI 17.16rCSI 45.18%PRS 5.9
-
CSI 17.15rCSI 50.62%PRS 3.94
-
CSI 16.81rCSI 12.63%PRS 3.08
-
CSI 16.54rCSI 81.53%PRS 4.12
-
CSI 16.32rCSI 20.11%PRS 10.01
-
CSI 15.88rCSI 25.56%PRS 2.37
-
CSI 15.88rCSI 13.69%PRS 5.02
-
CSI 15.77rCSI 84.14%PRS 7.75
-
CSI 15.52rCSI 60.42%PRS 4.97
-
CSI 15.34rCSI 100%PRS 7.92
-
CSI 15.27rCSI 40.52%PRS 5.23
-
CSI 15.26rCSI 18.57%PRS 3.8
-
CSI 15.2rCSI 11.38%PRS 4.92
-
CSI 15.11rCSI 60.15%PRS 5.49
-
CSI 15.03rCSI 68.34%PRS 11.47
-
CSI 14.96rCSI 85.8%PRS 4.73
-
CSI 14.9rCSI 52.9%PRS 4.96
-
CSI 14.35rCSI 63.12%PRS 3.12
-
CSI 14.27rCSI 34.35%PRS 4.75
-
CSI 14.25rCSI 25.11%PRS 3.42
-
CSI 14.21rCSI 33.14%PRS 8.24
-
CSI 14.06rCSI 35.71%PRS 3.07
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CSI -53.3rCSI -62.4%PRS 5.0%
-
CSI -33.3rCSI -41.5%PRS 1.7%
-
CSI -16.0rCSI -28.0%PRS 2.4%
-
CSI -10.7rCSI -18.9%PRS 1.9%
-
CSI -10.5rCSI -23.5%PRS 2.0%
-
CSI -8.0rCSI -33.3%PRS 9.4%
-
CSI -7.3rCSI -16.8%PRS 2.9%
-
CSI -7.2rCSI -26.1%PRS 1.6%
-
CSI -6.7rCSI -15.1%PRS 7.8%
-
CSI -6.7rCSI -4.7%PRS 4.4%
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CSI -6.5rCSI -24.2%PRS 2.6%
-
CSI -6.0rCSI -30.1%PRS 15.9%
-
CSI -5.7rCSI -9.2%PRS 2.2%
-
CSI -4.9rCSI -18.5%PRS 6.8%
-
CSI -4.7rCSI -14.7%PRS 2.0%
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CSI -4.6rCSI -7.7%PRS 1.9%
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CSI -4.5rCSI -5.4%PRS 5.3%
-
CSI -4.3rCSI -71.9%PRS 16.4%
-
CSI -4.0rCSI -11.5%PRS 4.2%
-
CSI -3.9rCSI -14.7%PRS 2.0%
-
CSI -3.8rCSI -8.8%PRS 2.9%
-
CSI -3.4rCSI -4.3%PRS 2.0%
-
CSI -3.2rCSI -8.4%PRS 3.6%
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CSI -2.9rCSI -11.8%PRS 3.8%
-
CSI -2.7rCSI -8.4%PRS 2.2%
-
CSI -2.5rCSI -14.9%PRS 2.1%
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CSI -2.2rCSI -2.8%PRS 4.0%
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CSI -2.0rCSI -15.2%PRS 6.6%
-
CSI -1.8rCSI -1.7%PRS 4.7%
-
CSI -1.5rCSI -6.9%PRS 6.6%
-
CSI -1.5rCSI -9.6%PRS 6.4%
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CSI -1.4rCSI -1.7%PRS 1.9%
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CSI -1.3rCSI -2.4%PRS 2.4%
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CSI -1.1rCSI -22.2%PRS 3.4%
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CSI -1.1rCSI -22.1%PRS 3.7%
-
CSI -0.9rCSI -1.0%PRS 3.5%
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CSI -0.8rCSI -2.0%PRS 1.9%
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CSI -0.8rCSI -1.2%PRS 3.0%
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CSI -0.7rCSI -13.9%PRS 63.0%
-
CSI -0.5rCSI -3.6%PRS 6.3%
-
CSI -0.4rCSI -1.9%PRS 5.4%
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CSI -0.2rCSI -1.1%PRS 15.8%
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CSI -0.1rCSI -0.4%PRS 4.0%
-
CSI -0.1rCSI -0.3%PRS 7.7%
-
CSI 0.1rCSI 0.8%PRS 21.5%
-
CSI 0.1rCSI 3.0%PRS 19.6%
-
CSI 0.2rCSI 4.9%PRS 29.3%
-
CSI 0.2rCSI 1.2%PRS 7.8%
-
CSI 0.3rCSI 0.5%PRS 8.9%
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CSI 0.3rCSI 1.1%PRS 14.3%
-
CSI 0.4rCSI 5.7%PRS 8.1%
-
CSI 0.4rCSI 1.7%PRS 6.8%
-
CSI 0.4rCSI 5.4%PRS 46.4%
-
CSI 0.4rCSI 4.0%PRS 28.9%
-
CSI 0.5rCSI 2.6%PRS 17.9%
-
CSI 0.5rCSI 11.5%PRS 18.3%
-
CSI 0.5rCSI 1.2%PRS 2.4%
-
CSI 0.5rCSI 1.0%PRS 2.2%
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CSI 0.5rCSI 9.1%PRS 27.3%
-
CSI 0.5rCSI 1.2%PRS 3.8%
-
CSI 0.6rCSI 3.2%PRS 4.8%
-
CSI 0.6rCSI 1.0%PRS 4.0%
-
CSI 0.6rCSI 1.6%PRS 4.4%
-
CSI 0.7rCSI 3.4%PRS 3.9%
-
CSI 0.7rCSI 6.4%PRS 19.9%
-
CSI 0.8rCSI 4.4%PRS 8.0%
-
CSI 0.8rCSI 1.8%PRS 18.1%
-
CSI 0.9rCSI 2.4%PRS 6.0%
-
CSI 0.9rCSI 2.8%PRS 3.8%
-
CSI 1.0rCSI 2.7%PRS 4.4%
-
CSI 1.0rCSI 7.8%PRS 3.2%
-
CSI 1.0rCSI 6.6%PRS 23.9%
-
CSI 1.0rCSI 5.8%PRS 17.7%
-
CSI 1.2rCSI 2.2%PRS 4.3%
-
CSI 1.2rCSI 11.1%PRS 29.5%
-
CSI 1.3rCSI 3.6%PRS 24.4%
-
CSI 1.3rCSI 2.2%PRS 2.3%
-
CSI 1.3rCSI 2.1%PRS 2.4%
-
CSI 1.3rCSI 5.7%PRS 3.1%
-
CSI 1.3rCSI 3.1%PRS 4.9%
-
CSI 1.3rCSI 25.7%PRS 26.0%
-
CSI 1.4rCSI 6.3%PRS 12.5%
-
CSI 1.5rCSI 14.7%PRS 12.6%
-
CSI 1.6rCSI 7.6%PRS 8.5%
-
CSI 1.7rCSI 3.4%PRS 3.6%
-
CSI 1.7rCSI 6.1%PRS 15.7%
-
CSI 1.7rCSI 18.1%PRS 5.3%
-
CSI 1.7rCSI 7.7%PRS 14.6%
-
CSI 1.7rCSI 45.7%PRS 17.1%
-
CSI 1.8rCSI 2.5%PRS 2.9%
-
CSI 1.8rCSI 3.0%PRS 3.1%
-
CSI 1.9rCSI 6.3%PRS 3.0%
-
CSI 1.9rCSI 6.2%PRS 9.5%
-
CSI 2.0rCSI 47.3%PRS 3.4%
-
CSI 2.0rCSI 10.5%PRS 14.6%
-
CSI 2.1rCSI 5.3%PRS 4.5%
-
CSI 2.1rCSI 8.0%PRS 6.6%
-
CSI 2.2rCSI 4.2%PRS 6.9%
-
CSI 2.2rCSI 35.4%PRS 20.5%
-
CSI 2.3rCSI 1.4%PRS 4.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3343180047
Symbol: H2AZ_HUMAN
Name: Histone H2A.Z
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3344202
Title: Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.
PubMed ID: 3344202
PubMed ID: 1697587
Title: The human histone H2A.Z gene. Sequence and regulation.
PubMed ID: 1697587
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11835281
PubMed ID: 15878876
Title: Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z.
PubMed ID: 15878876
PubMed ID: 16457589
Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.
PubMed ID: 16457589
DOI: 10.1021/pr050269n
PubMed ID: 16627869
Title: Quantitative proteomic analysis of post-translational modifications of human histones.
PubMed ID: 16627869
PubMed ID: 16319397
Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.
PubMed ID: 16319397
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20473270
Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.
PubMed ID: 20473270
PubMed ID: 26237645
Title: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.
PubMed ID: 26237645
DOI: 10.1038/ncb3209
PubMed ID: 28645917
Title: Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.
PubMed ID: 28645917
PubMed ID: 30327463
Title: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.
PubMed ID: 30327463
PubMed ID: 11101893
Title: Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.
PubMed ID: 11101893
DOI: 10.1038/81971
PubMed ID: 24463511
Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.
PubMed ID: 24463511
DOI: 10.1038/nature12922
PubMed ID: 23324626
Title: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.
PubMed ID: 23324626
DOI: 10.4161/epi.23416
PubMed ID: 31527837
Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.
PubMed ID: 31527837
PubMed ID: 26974126
Title: Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.
PubMed ID: 26974126
DOI: 10.1038/nsmb.3189
PubMed ID: 31645732
Title: Metabolic regulation of gene expression by histone lactylation.
PubMed ID: 31645732
Sequence Information:
- Length: 128
- Mass: 13553
- Checksum: E024E53818230371
- Sequence:
MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG KKGQQKTV