Details for: H2AZ1

Gene ID: 3015

Symbol: H2AZ1

Ensembl ID: ENSG00000164032

Description: H2A.Z variant histone 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.38
    Marker Score: 4215
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.72
    Marker Score: 3775
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.56
    Marker Score: 3053
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.28
    Marker Score: 6596
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 4.06
    Marker Score: 4401
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.05
    Marker Score: 8555.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.03
    Marker Score: 1484
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.9
    Marker Score: 2941
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.66
    Marker Score: 49211
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.66
    Marker Score: 3118
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.62
    Marker Score: 3231
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.59
    Marker Score: 47408
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.54
    Marker Score: 2594
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.31
    Marker Score: 8083.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.29
    Marker Score: 32617
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.2
    Marker Score: 108722
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.14
    Marker Score: 108906
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.13
    Marker Score: 5710
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.11
    Marker Score: 1603
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.08
    Marker Score: 4007
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.06
    Marker Score: 2035
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.06
    Marker Score: 1035
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.02
    Marker Score: 967
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.01
    Marker Score: 34937.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.99
    Marker Score: 1878
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 2.98
    Marker Score: 1161
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.97
    Marker Score: 1235
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.96
    Marker Score: 8187
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.96
    Marker Score: 741
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.95
    Marker Score: 1571
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.94
    Marker Score: 2307
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.91
    Marker Score: 3513.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.89
    Marker Score: 8247
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.85
    Marker Score: 2682
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.83
    Marker Score: 5310
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.82
    Marker Score: 2664
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.81
    Marker Score: 2217
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.81
    Marker Score: 1762
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.81
    Marker Score: 20888
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.8
    Marker Score: 3377
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.79
    Marker Score: 2002
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.79
    Marker Score: 4574
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.77
    Marker Score: 661
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.77
    Marker Score: 2873
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.75
    Marker Score: 2962
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.74
    Marker Score: 5575
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.74
    Marker Score: 3877.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.73
    Marker Score: 152846
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.72
    Marker Score: 8064
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.71
    Marker Score: 989
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.7
    Marker Score: 1854
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.7
    Marker Score: 1214
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.69
    Marker Score: 2264
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.69
    Marker Score: 2872
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.68
    Marker Score: 5357
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.68
    Marker Score: 68641
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.68
    Marker Score: 2861.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.67
    Marker Score: 10945
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.67
    Marker Score: 3553
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.65
    Marker Score: 5529
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.64
    Marker Score: 1137.5
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.64
    Marker Score: 918
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.63
    Marker Score: 7676
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.63
    Marker Score: 2948
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.61
    Marker Score: 2220
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.59
    Marker Score: 1885
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.58
    Marker Score: 1377
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.58
    Marker Score: 136410
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.57
    Marker Score: 1859
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.57
    Marker Score: 1320
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.57
    Marker Score: 1109
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.57
    Marker Score: 665
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.56
    Marker Score: 9875
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.56
    Marker Score: 3699
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.56
    Marker Score: 841
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.55
    Marker Score: 16614
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.54
    Marker Score: 672
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.54
    Marker Score: 1506
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.53
    Marker Score: 1152
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.52
    Marker Score: 4917
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.52
    Marker Score: 2803.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.52
    Marker Score: 1825
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.51
    Marker Score: 16344
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.49
    Marker Score: 2495
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.49
    Marker Score: 1117
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.49
    Marker Score: 6975
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.48
    Marker Score: 1171
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.47
    Marker Score: 651
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.47
    Marker Score: 4186
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.47
    Marker Score: 3424
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.47
    Marker Score: 5601
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.47
    Marker Score: 1216
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.47
    Marker Score: 3924
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.47
    Marker Score: 958
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.46
    Marker Score: 2209
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.46
    Marker Score: 1130
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.46
    Marker Score: 1167
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.46
    Marker Score: 3171
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.46
    Marker Score: 3948
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.46
    Marker Score: 1440

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Other Information

**Key characteristics:** - H2AZ1 is a member of the H2A.Z family of histone proteins, which are characterized by their ability to interact with DNA and influence gene expression. - It is a highly conserved gene with similar sequences found in mammals, birds, and fish. - The protein encoded by H2AZ1 is a core histone that plays a central role in maintaining the structure and integrity of chromatin. **Pathways and functions:** - H2AZ1 is involved in various cellular processes, including: - Amyloid fiber formation: H2AZ1 is a key factor in the assembly and maintenance of amyloid fibers, which are abnormal protein aggregates associated with several neurodegenerative diseases. - Barr body: H2AZ1 is expressed in cells that contain a Barr body, a condensed structure involved in DNA repair and maintenance. - Cellular response to estradiol stimulus: In estrogen-responsive cells, H2AZ1 is essential for the proper regulation of gene expression in response to estradiol, a hormone that promotes the development and maintenance of female reproductive organs. - Chromatin DNA binding: H2AZ1 is a key chromatin remodeling factor that binds to DNA and facilitates the opening of chromatin for transcription and other genetic processes. - Chromatin organization: H2AZ1 plays a role in organizing and packaging DNA into higher-order chromatin structures, such as heterochromatin and euchromatin. - Euchromatin: H2AZ1 is involved in the maintenance of euchromatin, the accessible chromatin region for transcription. - Heterochromatin: H2AZ1 helps to establish and maintain heterochromatin, a condensed and transcriptionally inactive form of chromatin found in certain cell types. - Metabolism of proteins: H2AZ1 is involved in the metabolism of proteins by helping to regulate the stability and trafficking of histone variants. - Nucleosomal DNA binding: H2AZ1 can bind to DNA and facilitate the formation of nucleosomes, which are protein complexes that assemble around DNA to form chromatin. - Rna polymerase ii cis-regulatory region sequence-specific DNA binding: H2AZ1 is a key cis-regulatory factor that binds to specific DNA sequences to regulate the expression of genes involved in RNA polymerase II-mediated transcription. - Rna polymerase ii core promoter sequence-specific DNA binding: H2AZ1 also binds to a DNA sequence known as the Rna polymerase II core promoter, which is essential for the initiation of RNA polymerase II-mediated transcription. **Clinical significance:** - Mutations in H2AZ1 have been linked to several human diseases, including Alzheimer's disease, Parkinson's disease, and cancer. - In these diseases, mutations in H2AZ1 are associated with the formation of amyloid fibers, which are characterized by the abnormal aggregation of misfolded proteins. - Targeting H2AZ1 has emerged as a potential therapeutic strategy for these diseases, as it could be used to inhibit the formation of amyloid fibers and slow down the progression of the disease.

Genular Protein ID: 3343180047

Symbol: H2AZ_HUMAN

Name: Histone H2A.Z

UniProtKB Accession Codes:

P0C0S5 B2RD56 P17317 Q6I9U0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 15 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3344202

Title: Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.

PubMed ID: 3344202

DOI: 10.1093/nar/16.3.1113

PubMed ID: 1697587

Title: The human histone H2A.Z gene. Sequence and regulation.

PubMed ID: 1697587

DOI: 10.1016/s0021-9258(18)77243-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11835281

Title: Histone ubiquitination: a tagging tail unfolds?

PubMed ID: 11835281

DOI: 10.1002/bies.10038

PubMed ID: 15878876

Title: Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z.

PubMed ID: 15878876

DOI: 10.1074/jbc.m501784200

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20473270

Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.

PubMed ID: 20473270

DOI: 10.1038/emboj.2010.85

PubMed ID: 26237645

Title: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

PubMed ID: 26237645

DOI: 10.1038/ncb3209

PubMed ID: 28645917

Title: Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.

PubMed ID: 28645917

DOI: 10.15252/embj.201695757

PubMed ID: 30327463

Title: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.

PubMed ID: 30327463

DOI: 10.1038/s41467-018-06665-5

PubMed ID: 11101893

Title: Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.

PubMed ID: 11101893

DOI: 10.1038/81971

PubMed ID: 24463511

Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.

PubMed ID: 24463511

DOI: 10.1038/nature12922

PubMed ID: 23324626

Title: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.

PubMed ID: 23324626

DOI: 10.4161/epi.23416

PubMed ID: 31527837

Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.

PubMed ID: 31527837

DOI: 10.1038/s41589-019-0354-y

PubMed ID: 26974126

Title: Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.

PubMed ID: 26974126

DOI: 10.1038/nsmb.3189

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

Sequence Information:

  • Length: 128
  • Mass: 13553
  • Checksum: E024E53818230371
  • Sequence:
    • MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE 
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG 
KKGQQKTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.