Details for: H2AZ1

Gene ID: 3015

Symbol: H2AZ1

Ensembl ID: ENSG00000164032

Description: H2A.Z variant histone 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 486.3537
    Cell Significance Index: -75.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 352.1480
    Cell Significance Index: -89.3200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 318.6328
    Cell Significance Index: -131.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 281.5581
    Cell Significance Index: -114.3900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 265.9690
    Cell Significance Index: -125.5700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 243.7473
    Cell Significance Index: -125.3800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 187.7285
    Cell Significance Index: -125.9700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 121.4096
    Cell Significance Index: -115.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 91.5118
    Cell Significance Index: -112.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.5987
    Cell Significance Index: -124.6900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 21.6119
    Cell Significance Index: -66.3800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.6213
    Cell Significance Index: -32.0000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 9.4331
    Cell Significance Index: 252.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.1097
    Cell Significance Index: 281.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.8325
    Cell Significance Index: 85.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.8481
    Cell Significance Index: 122.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.7393
    Cell Significance Index: 150.9200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.6108
    Cell Significance Index: 661.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0474
    Cell Significance Index: 2210.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.2972
    Cell Significance Index: 405.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.1548
    Cell Significance Index: 165.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1225
    Cell Significance Index: 428.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.0054
    Cell Significance Index: 53.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9989
    Cell Significance Index: 140.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8278
    Cell Significance Index: 76.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.6784
    Cell Significance Index: 343.3600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6645
    Cell Significance Index: 30.2700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.6025
    Cell Significance Index: 15.2900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.3376
    Cell Significance Index: 1033.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.3027
    Cell Significance Index: 148.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2886
    Cell Significance Index: 412.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.2480
    Cell Significance Index: 64.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1810
    Cell Significance Index: 162.5500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1348
    Cell Significance Index: 275.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0987
    Cell Significance Index: 97.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0324
    Cell Significance Index: 59.6900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7512
    Cell Significance Index: 91.2200
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.6274
    Cell Significance Index: 4.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6033
    Cell Significance Index: 113.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0408
    Cell Significance Index: 206.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0074
    Cell Significance Index: 45.6600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.0068
    Cell Significance Index: 7.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9591
    Cell Significance Index: 866.0000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.8229
    Cell Significance Index: 9.8100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.8166
    Cell Significance Index: 6.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5897
    Cell Significance Index: 118.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5395
    Cell Significance Index: 53.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5207
    Cell Significance Index: 27.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4951
    Cell Significance Index: 94.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4700
    Cell Significance Index: 29.6200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4595
    Cell Significance Index: 6.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2803
    Cell Significance Index: 212.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2308
    Cell Significance Index: 12.9500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1309
    Cell Significance Index: 0.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1307
    Cell Significance Index: 3.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1165
    Cell Significance Index: 1.9500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0042
    Cell Significance Index: 1.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0013
    Cell Significance Index: -0.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0475
    Cell Significance Index: -89.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0578
    Cell Significance Index: -5.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0795
    Cell Significance Index: -146.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0906
    Cell Significance Index: -4.5800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0946
    Cell Significance Index: -145.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1099
    Cell Significance Index: -149.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1230
    Cell Significance Index: -5.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1507
    Cell Significance Index: -111.6600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1577
    Cell Significance Index: -100.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1850
    Cell Significance Index: -3.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2097
    Cell Significance Index: -118.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2194
    Cell Significance Index: -35.6900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2238
    Cell Significance Index: -5.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2429
    Cell Significance Index: -110.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2564
    Cell Significance Index: -160.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3257
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3443
    Cell Significance Index: -58.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3625
    Cell Significance Index: -10.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3683
    Cell Significance Index: -9.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3820
    Cell Significance Index: -109.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4235
    Cell Significance Index: -3.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4583
    Cell Significance Index: -9.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5503
    Cell Significance Index: -63.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6070
    Cell Significance Index: -19.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6426
    Cell Significance Index: -135.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7526
    Cell Significance Index: -109.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8478
    Cell Significance Index: -50.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9194
    Cell Significance Index: -11.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0903
    Cell Significance Index: -23.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1847
    Cell Significance Index: -123.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2122
    Cell Significance Index: -96.0100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -1.2138
    Cell Significance Index: -10.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4164
    Cell Significance Index: -95.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5443
    Cell Significance Index: -21.0700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.5608
    Cell Significance Index: -9.4300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.5726
    Cell Significance Index: -26.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.6374
    Cell Significance Index: -125.6500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.6406
    Cell Significance Index: -10.2700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.7751
    Cell Significance Index: -30.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.9705
    Cell Significance Index: -69.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0522
    Cell Significance Index: -125.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2978
    Cell Significance Index: -67.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** H2AZ1 is a histone variant that is distinct from the canonical histone H2A due to its unique amino acid composition and post-translational modifications. It is highly expressed in various cell types, including thyroid follicular cells, early promyelocytes, and mesenchymal stem cells, suggesting its importance in regulating gene expression and chromatin organization. **Pathways and Functions:** H2AZ1 is involved in various chromatin-related pathways, including: 1. **Chromatin DNA binding:** H2AZ1 interacts with DNA-binding proteins to regulate chromatin structure and gene expression. 2. **Euchromatin organization:** H2AZ1 is essential for maintaining the open chromatin structure of euchromatin, which is necessary for gene activation. 3. **Heterochromatin organization:** H2AZ1 also plays a role in regulating heterochromatin, the compact and transcriptionally inactive chromatin structure. 4. **Protein binding and heterodimerization:** H2AZ1 interacts with other proteins to form heterodimers that regulate chromatin structure and gene expression. 5. **Transcriptional regulation:** H2AZ1 is involved in the regulation of transcription by RNA polymerase II, a key enzyme responsible for gene expression. **Clinical Significance:** Dysregulation of H2AZ1 has been implicated in various human diseases, including: 1. **Cancer:** H2AZ1 is overexpressed in various types of cancer, suggesting its potential role as an oncogene. 2. **Neurological disorders:** H2AZ1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where chromatin dysregulation is a hallmark. 3. **Autoimmune diseases:** H2AZ1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where chromatin dysregulation contributes to disease pathology. In conclusion, H2AZ1 is a critical histone variant that plays a key role in maintaining chromatin organization and regulating gene expression. Its dysregulation has significant implications for human disease, highlighting the need for further research into the mechanisms underlying its function and its potential therapeutic applications. **Future Directions:** 1. **Investigating the role of H2AZ1 in cancer:** Elucidating the mechanisms by which H2AZ1 contributes to cancer development and progression. 2. **Exploring the link between H2AZ1 and neurological disorders:** Investigating the relationship between H2AZ1 dysregulation and neurological disorders, such as Alzheimer's and Parkinson's disease. 3. **Developing therapeutic strategies:** Targeting H2AZ1 or its interacting proteins to develop novel therapeutic approaches for diseases associated with chromatin dysregulation. By further understanding the role of H2AZ1 in chromatin organization and regulation, we can uncover new avenues for therapeutic intervention and improve our understanding of the complex relationships between chromatin, gene expression, and human disease.

Genular Protein ID: 3343180047

Symbol: H2AZ_HUMAN

Name: Histone H2A.Z

UniProtKB Accession Codes:

P0C0S5 B2RD56 P17317 Q6I9U0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 17 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3344202

Title: Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.

PubMed ID: 3344202

DOI: 10.1093/nar/16.3.1113

PubMed ID: 1697587

Title: The human histone H2A.Z gene. Sequence and regulation.

PubMed ID: 1697587

DOI: 10.1016/s0021-9258(18)77243-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11835281

Title: Histone ubiquitination: a tagging tail unfolds?

PubMed ID: 11835281

DOI: 10.1002/bies.10038

PubMed ID: 15878876

Title: Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z.

PubMed ID: 15878876

DOI: 10.1074/jbc.m501784200

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20473270

Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.

PubMed ID: 20473270

DOI: 10.1038/emboj.2010.85

PubMed ID: 26237645

Title: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

PubMed ID: 26237645

DOI: 10.1038/ncb3209

PubMed ID: 28645917

Title: Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.

PubMed ID: 28645917

DOI: 10.15252/embj.201695757

PubMed ID: 30327463

Title: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.

PubMed ID: 30327463

DOI: 10.1038/s41467-018-06665-5

PubMed ID: 11101893

Title: Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.

PubMed ID: 11101893

DOI: 10.1038/81971

PubMed ID: 24463511

Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.

PubMed ID: 24463511

DOI: 10.1038/nature12922

PubMed ID: 23324626

Title: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.

PubMed ID: 23324626

DOI: 10.4161/epi.23416

PubMed ID: 31527837

Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.

PubMed ID: 31527837

DOI: 10.1038/s41589-019-0354-y

PubMed ID: 26974126

Title: Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.

PubMed ID: 26974126

DOI: 10.1038/nsmb.3189

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

Sequence Information:

  • Length: 128
  • Mass: 13553
  • Checksum: E024E53818230371
  • Sequence:
    • MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE 
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG 
KKGQQKTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.