Details for: H2AZ1

Gene ID: 3015

Symbol: H2AZ1

Ensembl ID: ENSG00000164032

Description: H2A.Z variant histone 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 5.38
    Marker Score: 4,215
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.72
    Marker Score: 3,775
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 4.56
    Marker Score: 3,053
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.28
    Marker Score: 6,596
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 4.06
    Marker Score: 4,401
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.05
    Marker Score: 8,556
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.03
    Marker Score: 1,484
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.9
    Marker Score: 2,941
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.66
    Marker Score: 49,211
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.66
    Marker Score: 3,118
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.62
    Marker Score: 3,231
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.59
    Marker Score: 47,408
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.54
    Marker Score: 2,594
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.31
    Marker Score: 8,084
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.29
    Marker Score: 32,617
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.2
    Marker Score: 108,722
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.14
    Marker Score: 108,906
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.13
    Marker Score: 5,710
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.11
    Marker Score: 1,603
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.08
    Marker Score: 4,007
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.06
    Marker Score: 2,035
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.06
    Marker Score: 1,035
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.02
    Marker Score: 967
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.01
    Marker Score: 34,938
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.99
    Marker Score: 1,878
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 2.98
    Marker Score: 1,161
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.97
    Marker Score: 1,235
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.96
    Marker Score: 8,187
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.96
    Marker Score: 741
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.95
    Marker Score: 1,571
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.94
    Marker Score: 2,307
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.91
    Marker Score: 3,514
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.89
    Marker Score: 8,247
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.85
    Marker Score: 2,682
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.83
    Marker Score: 5,310
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.82
    Marker Score: 2,664
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.81
    Marker Score: 2,217
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.81
    Marker Score: 1,762
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.81
    Marker Score: 20,888
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.8
    Marker Score: 3,377
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.79
    Marker Score: 2,002
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.79
    Marker Score: 4,574
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.77
    Marker Score: 661
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.77
    Marker Score: 2,873
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.75
    Marker Score: 2,962
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.74
    Marker Score: 5,575
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.74
    Marker Score: 3,878
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.73
    Marker Score: 152,846
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.72
    Marker Score: 8,064
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.71
    Marker Score: 989
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.7
    Marker Score: 1,854
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.7
    Marker Score: 1,214
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.69
    Marker Score: 2,264
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.69
    Marker Score: 2,872
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.68
    Marker Score: 5,357
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.68
    Marker Score: 68,641
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.68
    Marker Score: 2,862
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.67
    Marker Score: 10,945
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.67
    Marker Score: 3,553
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.65
    Marker Score: 5,529
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.64
    Marker Score: 1,138
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.64
    Marker Score: 918
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.63
    Marker Score: 7,676
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.63
    Marker Score: 2,948
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.61
    Marker Score: 2,220
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.59
    Marker Score: 1,885
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.58
    Marker Score: 1,377
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.58
    Marker Score: 136,410
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.57
    Marker Score: 1,859
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.57
    Marker Score: 1,320
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.57
    Marker Score: 1,109
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.57
    Marker Score: 665
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.56
    Marker Score: 9,875
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.56
    Marker Score: 3,699
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.56
    Marker Score: 841
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.55
    Marker Score: 16,614
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.54
    Marker Score: 672
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.54
    Marker Score: 1,506
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.53
    Marker Score: 1,152
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.52
    Marker Score: 4,917
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.52
    Marker Score: 2,804
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.52
    Marker Score: 1,825
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.51
    Marker Score: 16,344
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.49
    Marker Score: 2,495
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.49
    Marker Score: 1,117
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.49
    Marker Score: 6,975
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.48
    Marker Score: 1,171
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.47
    Marker Score: 651
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.47
    Marker Score: 4,186
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.47
    Marker Score: 3,424
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.47
    Marker Score: 5,601
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.47
    Marker Score: 1,216
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.47
    Marker Score: 3,924
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.47
    Marker Score: 958
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.46
    Marker Score: 2,209
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 2.46
    Marker Score: 1,130
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.46
    Marker Score: 1,167
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.46
    Marker Score: 3,171
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.46
    Marker Score: 3,948
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.46
    Marker Score: 1,440

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** H2AZ1 is a histone variant that is distinct from the canonical histone H2A due to its unique amino acid composition and post-translational modifications. It is highly expressed in various cell types, including thyroid follicular cells, early promyelocytes, and mesenchymal stem cells, suggesting its importance in regulating gene expression and chromatin organization. **Pathways and Functions:** H2AZ1 is involved in various chromatin-related pathways, including: 1. **Chromatin DNA binding:** H2AZ1 interacts with DNA-binding proteins to regulate chromatin structure and gene expression. 2. **Euchromatin organization:** H2AZ1 is essential for maintaining the open chromatin structure of euchromatin, which is necessary for gene activation. 3. **Heterochromatin organization:** H2AZ1 also plays a role in regulating heterochromatin, the compact and transcriptionally inactive chromatin structure. 4. **Protein binding and heterodimerization:** H2AZ1 interacts with other proteins to form heterodimers that regulate chromatin structure and gene expression. 5. **Transcriptional regulation:** H2AZ1 is involved in the regulation of transcription by RNA polymerase II, a key enzyme responsible for gene expression. **Clinical Significance:** Dysregulation of H2AZ1 has been implicated in various human diseases, including: 1. **Cancer:** H2AZ1 is overexpressed in various types of cancer, suggesting its potential role as an oncogene. 2. **Neurological disorders:** H2AZ1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where chromatin dysregulation is a hallmark. 3. **Autoimmune diseases:** H2AZ1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where chromatin dysregulation contributes to disease pathology. In conclusion, H2AZ1 is a critical histone variant that plays a key role in maintaining chromatin organization and regulating gene expression. Its dysregulation has significant implications for human disease, highlighting the need for further research into the mechanisms underlying its function and its potential therapeutic applications. **Future Directions:** 1. **Investigating the role of H2AZ1 in cancer:** Elucidating the mechanisms by which H2AZ1 contributes to cancer development and progression. 2. **Exploring the link between H2AZ1 and neurological disorders:** Investigating the relationship between H2AZ1 dysregulation and neurological disorders, such as Alzheimer's and Parkinson's disease. 3. **Developing therapeutic strategies:** Targeting H2AZ1 or its interacting proteins to develop novel therapeutic approaches for diseases associated with chromatin dysregulation. By further understanding the role of H2AZ1 in chromatin organization and regulation, we can uncover new avenues for therapeutic intervention and improve our understanding of the complex relationships between chromatin, gene expression, and human disease.

Genular Protein ID: 3343180047

Symbol: H2AZ_HUMAN

Name: Histone H2A.Z

UniProtKB Accession Codes:

P0C0S5 B2RD56 P17317 Q6I9U0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 1 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 15 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3344202

Title: Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species.

PubMed ID: 3344202

DOI: 10.1093/nar/16.3.1113

PubMed ID: 1697587

Title: The human histone H2A.Z gene. Sequence and regulation.

PubMed ID: 1697587

DOI: 10.1016/s0021-9258(18)77243-8

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11835281

Title: Histone ubiquitination: a tagging tail unfolds?

PubMed ID: 11835281

DOI: 10.1002/bies.10038

PubMed ID: 15878876

Title: Transcription-induced chromatin remodeling at the c-myc gene involves the local exchange of histone H2A.Z.

PubMed ID: 15878876

DOI: 10.1074/jbc.m501784200

PubMed ID: 16457589

Title: Precise characterization of human histones in the H2A gene family by top down mass spectrometry.

PubMed ID: 16457589

DOI: 10.1021/pr050269n

PubMed ID: 16627869

Title: Quantitative proteomic analysis of post-translational modifications of human histones.

PubMed ID: 16627869

DOI: 10.1074/mcp.m600007-mcp200

PubMed ID: 16319397

Title: Characterization of histones H2A and H2B variants and their post-translational modifications by mass spectrometry.

PubMed ID: 16319397

DOI: 10.1074/mcp.m500288-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20473270

Title: Essential role of p18Hamlet/SRCAP-mediated histone H2A.Z chromatin incorporation in muscle differentiation.

PubMed ID: 20473270

DOI: 10.1038/emboj.2010.85

PubMed ID: 26237645

Title: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

PubMed ID: 26237645

DOI: 10.1038/ncb3209

PubMed ID: 28645917

Title: Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation.

PubMed ID: 28645917

DOI: 10.15252/embj.201695757

PubMed ID: 30327463

Title: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.

PubMed ID: 30327463

DOI: 10.1038/s41467-018-06665-5

PubMed ID: 11101893

Title: Crystal structure of a nucleosome core particle containing the variant histone H2A.Z.

PubMed ID: 11101893

DOI: 10.1038/81971

PubMed ID: 24463511

Title: ANP32E is a histone chaperone that removes H2A.Z from chromatin.

PubMed ID: 24463511

DOI: 10.1038/nature12922

PubMed ID: 23324626

Title: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal.

PubMed ID: 23324626

DOI: 10.4161/epi.23416

PubMed ID: 31527837

Title: DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription.

PubMed ID: 31527837

DOI: 10.1038/s41589-019-0354-y

PubMed ID: 26974126

Title: Molecular basis and specificity of H2A.Z-H2B recognition and deposition by the histone chaperone YL1.

PubMed ID: 26974126

DOI: 10.1038/nsmb.3189

PubMed ID: 31645732

Title: Metabolic regulation of gene expression by histone lactylation.

PubMed ID: 31645732

DOI: 10.1038/s41586-019-1678-1

Sequence Information:

  • Length: 128
  • Mass: 13553
  • Checksum: E024E53818230371
  • Sequence:
    • MAGGKAGKDS GKAKTKAVSR SQRAGLQFPV GRIHRHLKSR TTSHGRVGAT AAVYSAAILE 
YLTAEVLELA GNASKDLKVK RITPRHLQLA IRGDEELDSL IKATIAGGGV IPHIHKSLIG 
KKGQQKTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.