Details for: PGC

Gene ID: 5225

Symbol: PGC

Ensembl ID: ENSG00000096088

Description: progastricsin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 4.4189
    Cell Significance Index: 21.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 3.8317
    Cell Significance Index: 134.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9374
    Cell Significance Index: 48.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8115
    Cell Significance Index: 161.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6749
    Cell Significance Index: 510.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.5984
    Cell Significance Index: 68.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4931
    Cell Significance Index: 93.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2887
    Cell Significance Index: 28.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2459
    Cell Significance Index: 222.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1772
    Cell Significance Index: 3.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1558
    Cell Significance Index: 25.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0779
    Cell Significance Index: 8.4800
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.0731
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0703
    Cell Significance Index: 12.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0491
    Cell Significance Index: 30.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0408
    Cell Significance Index: 1.1100
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0339
    Cell Significance Index: 0.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0117
    Cell Significance Index: 0.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0088
    Cell Significance Index: 0.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0008
    Cell Significance Index: 0.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0008
    Cell Significance Index: 0.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0002
    Cell Significance Index: 0.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0036
    Cell Significance Index: -0.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0146
    Cell Significance Index: -0.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0173
    Cell Significance Index: -0.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0175
    Cell Significance Index: -32.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0198
    Cell Significance Index: -1.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0208
    Cell Significance Index: -13.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0208
    Cell Significance Index: -32.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0234
    Cell Significance Index: -2.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0234
    Cell Significance Index: -31.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0240
    Cell Significance Index: -4.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0292
    Cell Significance Index: -15.9500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0297
    Cell Significance Index: -0.3300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0320
    Cell Significance Index: -1.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0358
    Cell Significance Index: -12.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0453
    Cell Significance Index: -5.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0465
    Cell Significance Index: -5.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0498
    Cell Significance Index: -14.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0512
    Cell Significance Index: -23.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0578
    Cell Significance Index: -1.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0610
    Cell Significance Index: -12.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0616
    Cell Significance Index: -1.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0873
    Cell Significance Index: -12.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1018
    Cell Significance Index: -3.2600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1036
    Cell Significance Index: -1.5500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.1052
    Cell Significance Index: -1.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1223
    Cell Significance Index: -16.8000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1233
    Cell Significance Index: -1.6200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1266
    Cell Significance Index: -1.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1302
    Cell Significance Index: -16.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1312
    Cell Significance Index: -13.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1561
    Cell Significance Index: -3.7800
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.1567
    Cell Significance Index: -0.9700
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1598
    Cell Significance Index: -1.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1633
    Cell Significance Index: -1.8600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1728
    Cell Significance Index: -0.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1843
    Cell Significance Index: -9.6000
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1896
    Cell Significance Index: -1.7100
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.2019
    Cell Significance Index: -2.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2057
    Cell Significance Index: -15.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2104
    Cell Significance Index: -1.4300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2322
    Cell Significance Index: -14.9800
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2327
    Cell Significance Index: -2.5400
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.2336
    Cell Significance Index: -2.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2374
    Cell Significance Index: -15.9600
  • Cell Name: CD141-positive myeloid dendritic cell (CL0002394)
    Fold Change: -0.2405
    Cell Significance Index: -2.6000
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.2436
    Cell Significance Index: -2.5200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2498
    Cell Significance Index: -3.5500
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.2536
    Cell Significance Index: -2.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2574
    Cell Significance Index: -5.3400
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2853
    Cell Significance Index: -1.8600
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.3084
    Cell Significance Index: -1.6200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3112
    Cell Significance Index: -2.2400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3266
    Cell Significance Index: -3.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3474
    Cell Significance Index: -21.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3480
    Cell Significance Index: -16.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3554
    Cell Significance Index: -9.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3583
    Cell Significance Index: -3.0100
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.4249
    Cell Significance Index: -4.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4644
    Cell Significance Index: -26.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4761
    Cell Significance Index: -21.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4788
    Cell Significance Index: -11.9400
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: -0.4799
    Cell Significance Index: -4.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4801
    Cell Significance Index: -16.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4807
    Cell Significance Index: -14.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5228
    Cell Significance Index: -27.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5232
    Cell Significance Index: -13.3300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.5318
    Cell Significance Index: -5.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5446
    Cell Significance Index: -17.8300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5482
    Cell Significance Index: -14.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5548
    Cell Significance Index: -21.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5595
    Cell Significance Index: -17.8200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5759
    Cell Significance Index: -16.5100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5782
    Cell Significance Index: -16.5000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5973
    Cell Significance Index: -14.9000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6081
    Cell Significance Index: -11.8900
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: -0.6183
    Cell Significance Index: -1.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Aspartic-type endopeptidase activity**: Progastricin is a member of the aspartic-type endopeptidase family, which is responsible for cleaving peptide bonds in the C-terminal region of proteins. 2. **Multifunctional gene**: The progastricin gene exhibits expression in various cell types, including mucous neck cells, foveolar cells, and enteroendocrine cells, indicating its involvement in multiple physiological processes. 3. **Regulation of antibacterial peptide production**: Progastricin is involved in the positive regulation of antibacterial peptide production, which is essential for maintaining gut homeostasis and preventing infections. **Pathways and Functions:** 1. **Digestion**: Progastricin is involved in the degradation of peptides, including antibacterial peptides, which are essential for protecting the gastrointestinal tract from pathogens. 2. **Extracellular space**: The progastricin gene is expressed in cells that interact with the extracellular space, suggesting its involvement in regulating the composition of the gut lumen. 3. **Positive regulation of antibacterial peptide production**: Progastricin stimulates the production of antibacterial peptides, which are essential for maintaining gut homeostasis and preventing infections. 4. **Proteolysis**: As an aspartic-type endopeptidase, progastricin is involved in the degradation of proteins, which is essential for regulating various physiological processes. **Clinical Significance:** The progastricin gene's involvement in regulating immune responses and maintaining gut homeostasis makes it a potential target for therapeutic interventions in various diseases, including: 1. **Inflammatory bowel disease (IBD)**: Alterations in progastricin expression may contribute to the development of IBD, and targeting this gene may provide a novel therapeutic approach. 2. **Gastrointestinal infections**: The progastricin gene's role in regulating antibacterial peptide production makes it a potential target for developing novel antimicrobial therapies. 3. **Cancer**: The progastricin gene's expression in enteroendocrine cells suggests its involvement in regulating cell growth and differentiation, which may be relevant in cancer development and progression. In conclusion, the progastricin gene is a multifaceted immunomodulatory gene that plays a crucial role in maintaining gut homeostasis and regulating immune responses. Further research is needed to fully elucidate the gene's functions and clinical significance, but its potential as a therapeutic target in various diseases makes it an exciting area of investigation.

Genular Protein ID: 78651517

Symbol: PEPC_HUMAN

Name: Gastricsin

UniProtKB Accession Codes:

P20142 B4DVZ3 Q5T3D7 Q5T3D8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 22 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3335549

Title: Primary structure of human pepsinogen C gene.

PubMed ID: 3335549

DOI: 10.1016/s0021-9258(19)57314-8

PubMed ID: 2909526

Title: Human pepsinogen C (progastricsin). Isolation of cDNA clones, localization to chromosome 6, and sequence homology with pepsinogen A.

PubMed ID: 2909526

DOI: 10.1016/s0021-9258(17)31268-1

PubMed ID: 2567697

Title: Human pepsinogen C (progastricsin) polymorphism: evidence for a single locus located at 6p21.1-pter.

PubMed ID: 2567697

DOI: 10.1016/0888-7543(89)90292-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2515193

Title: A comparative study on the NH2-terminal amino acid sequences and some other properties of six isozymic forms of human pepsinogens and pepsins.

PubMed ID: 2515193

DOI: 10.1093/oxfordjournals.jbchem.a122952

PubMed ID: 6816595

Title: Human progastricsin. Analysis of intermediates during activation into gastricsin and determination of the amino acid sequence of the propart.

PubMed ID: 6816595

PubMed ID: 7714902

Title: Crystal and molecular structures of human progastricsin at 1.62-A resolution.

PubMed ID: 7714902

DOI: 10.1006/jmbi.1994.0154

PubMed ID: 9406551

Title: Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.

PubMed ID: 9406551

DOI: 10.1038/nsb1297-1010

Sequence Information:

  • Length: 388
  • Mass: 42426
  • Checksum: F862DFDC1438BB92
  • Sequence:
    • MKWMVVVLVC LQLLEAAVVK VPLKKFKSIR ETMKEKGLLG EFLRTHKYDP AWKYRFGDLS 
VTYEPMAYMD AAYFGEISIG TPPQNFLVLF DTGSSNLWVP SVYCQSQACT SHSRFNPSES 
STYSTNGQTF SLQYGSGSLT GFFGYDTLTV QSIQVPNQEF GLSENEPGTN FVYAQFDGIM 
GLAYPALSVD EATTAMQGMV QEGALTSPVF SVYLSNQQGS SGGAVVFGGV DSSLYTGQIY 
WAPVTQELYW QIGIEEFLIG GQASGWCSEG CQAIVDTGTS LLTVPQQYMS ALLQATGAQE 
DEYGQFLVNC NSIQNLPSLT FIINGVEFPL PPSSYILSNN GYCTVGVEPT YLSSQNGQPL 
WILGDVFLRS YYSVYDLGNN RVGFATAA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.