Details for: CL0002394

Cell ID: CL0002394

Cell Name: CD141-positive myeloid dendritic cell

Marker Score Threshold: 340
(Derived using integrated single-cell and genomic data)

Description: A myeloid dendritic cell found in the blood, lymph nodes, tonsil, bone marrow, and spleen that is CD141-positive (BDCA-3), XCR1-positive, and Clec9A-positive. This cell-type can cross-present antigen to CD8-positive T cells and can produce inteferon-beta.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.15
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.01
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.58
    Ensembl ID: ENSG00000184009
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.57
    Ensembl ID: ENSG00000131143
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.51
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.46
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.41
    Ensembl ID: ENSG00000198668
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.35
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.3
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.17
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.16
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.14
    Ensembl ID: ENSG00000124172
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.06
    Ensembl ID: ENSG00000126267
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.03
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.01
    Ensembl ID: ENSG00000070831
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.99
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.88
    Ensembl ID: ENSG00000135404
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.88
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.85
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.84
    Ensembl ID: ENSG00000077549
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.83
    Ensembl ID: ENSG00000111775
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.82
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.8
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.79
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.75
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.69
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.67
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.67
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.66
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.65
    Ensembl ID: ENSG00000134825
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.63
    Ensembl ID: ENSG00000099624
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.62
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.57
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.56
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.53
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.53
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.51
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.46
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.46
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.45
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.44
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.41
    Ensembl ID: ENSG00000117410
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.41
    Ensembl ID: ENSG00000198931
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.4
    Ensembl ID: ENSG00000161203
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.39
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.39
    Ensembl ID: ENSG00000013441
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.37
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.37
    Ensembl ID: ENSG00000196776
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.36
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.35
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.33
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.31
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.31
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.3
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.28
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.28
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.26
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.24
    Ensembl ID: ENSG00000182718
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.23
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.21
    Ensembl ID: ENSG00000122359
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.21
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.2
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.19
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.19
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.18
    Ensembl ID: ENSG00000123505
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.17
    Ensembl ID: ENSG00000042753
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.15
    Ensembl ID: ENSG00000104765
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.15
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.14
    Ensembl ID: ENSG00000069849
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.14
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.13
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.13
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.11
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.1
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AP3S1 (ENSG00000177879)
    Fold Change: 1.1
    Ensembl ID: ENSG00000177879
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.09
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.08
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143727
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.08
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.08
    Ensembl ID: ENSG00000070961
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.07
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.06
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CLTC (ENSG00000141367)
    Fold Change: 1.06
    Ensembl ID: ENSG00000141367
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.05
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.05
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.04
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.04
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.04
    Ensembl ID: ENSG00000164615
  • Gene Symbol: CLNS1A (ENSG00000074201)
    Fold Change: 1.03
    Ensembl ID: ENSG00000074201
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.03
    Ensembl ID: ENSG00000135046
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.02
    Ensembl ID: ENSG00000142599
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.01
    Ensembl ID: ENSG00000175416
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1
    Ensembl ID: ENSG00000105254
Hovered Details

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Hovered Details

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**Key Characteristics** * CD141 (BDCA-3) positive * XCR1 positive * Clec9A positive * Found in blood, lymph nodes, tonsils, bone marrow, and spleen * Capable of cross-presenting antigens to CD8+ T cells * Produce interferon-beta * Involved in the regulation of immune responses **Clinical Significance** CD141-positive mDCs play a crucial role in the initiation of immune responses, particularly in the context of tumor immunology. These cells are involved in the recognition and processing of tumor antigens, which are then presented to CD8+ T cells. The activation of cytotoxic T cells is a critical step in the elimination of tumor cells. Additionally, CD141-positive mDCs are involved in the regulation of immune responses, including the production of interferon-beta, which can modulate the activity of immune cells. In the context of infectious diseases, CD141-positive mDCs are involved in the recognition and processing of pathogens, which are then presented to CD8+ T cells. The activation of cytotoxic T cells is a critical step in the elimination of pathogens. Furthermore, CD141-positive mDCs have been implicated in the pathogenesis of various diseases, including cancer, autoimmune diseases, and infectious diseases. For example, in cancer, CD141-positive mDCs can promote tumor progression by inducing an immunosuppressive microenvironment. In autoimmune diseases, CD141-positive mDCs can contribute to disease pathogenesis by promoting the activation of autoreactive T cells. Overall, CD141-positive mDCs are a critical component of the immune system, and their dysregulation can contribute to various diseases. Understanding the mechanisms by which these cells function can provide valuable insights into the development of novel therapeutic strategies for the treatment of immune-related disorders. **Pathways and Ontologies** CD141-positive mDCs are involved in a wide range of cellular processes, including: * Actin cytoskeleton organization * Adherens junction assembly and disassembly * Apical junction complex formation * Apical protein localization * Atp binding * Axon guidance * Axonogenesis * B-wich complex positively regulates rrna expression * Bbaf complex * Blood microparticle formation * Brahma complex * Brush border formation * Calyx of held formation * Cell-cell communication * Cell-cell junction organization * Cell-extracellular matrix interactions * Cell junction organization * Cell motility * Cellular response to cytochalasin b * Chaperonin-mediated protein folding * Chromatin organization * Chromatin remodeling * Clathrin-mediated endocytosis * Cooperation of prefoldin and tric/cct in actin and tubulin folding * Cortical cytoskeleton organization * Cytoplasmic ribonucleoprotein granule formation * Cytoskeleton formation * Cytosol organization * Dense body formation * Deubiquitination * Developmental biology * Disease * Diseases of signal transduction by growth factor receptors and second messengers * Dna damage recognition in gg-ner * Dna repair * Eph-ephrin mediated repulsion of cells * Eph-ephrin signaling * Ephb-mediated forward signaling * Epigenetic regulation of gene expression * Establishment or maintenance of cell polarity * Extracellular exosome formation * Extracellular space formation * Factors involved in megakaryocyte development and platelet production * Fcgamma receptor (fcgr) dependent phagocytosis * Fcgr3a-mediated phagocytosis * Focal adhesion formation * Folding of actin by cct/tric * Formation of annular gap junctions * Gap junction degradation * Gap junction trafficking * Gap junction trafficking and regulation * Gbaf complex * Gene expression (transcription) * Global genome nucleotide excision repair (gg-ner) * Glutamatergic synapse formation * Hats acetylate histones * Hemostasis * Hydrolase activity * Identical protein binding * Immune system * Infectious disease * Innate immune system * Interaction between l1 and ankyrins * Kinesin binding * Kinetochore formation * L1cam interactions * Lamellipodium formation * Leishmania infection * Leishmania phagocytosis * Maintenance of blood-brain barrier * Map2k and mapk activation * Mapk1/mapk3 signaling * Mapk family signaling cascades * Membrane trafficking * Metabolism of proteins * Morphogenesis of a polarized epithelium * Nbaf complex * Negative regulation of cell differentiation * Negative regulation of protein binding * Nervous system development * Nitric-oxide synthase binding * Npbaf complex * Nua4 histone acetyltransferase complex * Nuclear matrix formation * Nucleoplasm organization * Nucleosomal dna binding * Nucleosome formation * Nucleotide excision repair * Nucleus formation * Oncogenic mapk signaling * Paradoxical activation of raf signaling by kinase inactive braf * Parasite infection pathways * Plasma membrane formation * Platelet aggregation * Positive epigenetic regulation of rrna expression * Positive regulation of cell differentiation * Positive regulation of cell population proliferation * Positive regulation of dna-templated transcription * Positive regulation of double-strand break repair * Positive regulation of double-strand break repair via homologous recombination * Positive regulation of myoblast differentiation * Positive regulation of norepinephrine uptake * Positive regulation of stem cell population maintenance * Positive regulation of t cell differentiation * Post-translational protein modification * Postsynaptic actin cytoskeleton organization * Postsynaptic actin cytoskeleton formation * Prefoldin mediated transfer of substrate to cct/tric * Presynapse formation * Protein-containing complex formation * Protein binding * Protein folding * Protein kinase binding * Protein localization to adherens junction * Raf/map kinase cascade * Recycling pathway of l1 * Regulation of actin dynamics for phagocytic cup formation * Regulation of apoptotic process * Regulation of cell cycle * Regulation of cyclin-dependent protein serine/threonine kinase activity * Regulation of double-strand break repair * Regulation of g0 to g1 transition * Regulation of g1/s transition of mitotic cell cycle * Regulation of mitotic metaphase/anaphase transition * Regulation of norepinephrine uptake * Regulation of nucleotide-excision repair * Regulation of protein localization to plasma membrane * Regulation of synaptic vesicle endocytosis * Regulation of transcription by rna polymerase ii * Regulation of transepithelial transport * Regulation of transmembrane transporter activity * Rhof gtpase cycle * Rho gtpase cycle * Rho gtpase effectors * Rho gtpases activate formins * Rho gtpases activate iqgaps * Rho gtpases activate wasps and waves * Ribonucleoprotein complex formation * Rsc-type complex formation * Schaffer collateral - ca1 synapse formation * Sensory perception * Sensory processing of sound * Sensory processing of sound by inner hair cells of the cochlea * Sensory processing of sound by outer hair cells of the cochlea * Signaling by braf and raf1 fusions * Signaling by high-kinase activity braf mutants * Signaling by moderate kinase activity braf mutants * Signaling by raf1 mutants * Signaling by ras mutants * Signaling by receptor tyrosine kinases * Signaling by rho gtpases * Signaling by rho gtpases, miro gtpases and rhobtb3 * Signaling by vegf * Signaling downstream of ras mutants * Signal transduction * Structural constituent of cytoskeleton * Structural constituent of postsynaptic actin cytoskeleton * Substantia nigra development * Swi/snf complex formation * Synapse formation * Tat protein binding * Tau protein binding * Tight junction formation * Translocation of slc2a4 (glut4) to the plasma membrane * Uch proteinases * Vegfa-vegfr2 pathway * Vesicle formation * Vesicle-mediated transport