Details for: TBCB

Gene ID: 1155

Symbol: TBCB

Ensembl ID: ENSG00000105254

Description: tubulin folding cofactor B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.53
    Marker Score: 2835
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.26
    Marker Score: 22417
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.23
    Marker Score: 1684
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.18
    Marker Score: 13931
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.17
    Marker Score: 730
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.16
    Marker Score: 4515.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.15
    Marker Score: 9283
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.14
    Marker Score: 28268
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.14
    Marker Score: 4341.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.08
    Marker Score: 5751
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.08
    Marker Score: 1235.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.03
    Marker Score: 3443
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.02
    Marker Score: 5495
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.01
    Marker Score: 20253.5
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2
    Marker Score: 944.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.98
    Marker Score: 11752.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.98
    Marker Score: 1738
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.98
    Marker Score: 4653
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.96
    Marker Score: 1844
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.95
    Marker Score: 1221.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.94
    Marker Score: 12636
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.94
    Marker Score: 1829
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.94
    Marker Score: 2075
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.9
    Marker Score: 2919
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.89
    Marker Score: 5962
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.88
    Marker Score: 907
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.88
    Marker Score: 25253
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.88
    Marker Score: 2700
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.88
    Marker Score: 1368
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.87
    Marker Score: 7667
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.87
    Marker Score: 463
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.87
    Marker Score: 2260
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.87
    Marker Score: 1764
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.87
    Marker Score: 1982
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.86
    Marker Score: 7989
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.86
    Marker Score: 20976
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.86
    Marker Score: 2738
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.86
    Marker Score: 2552.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.85
    Marker Score: 18743
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.84
    Marker Score: 7242
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.84
    Marker Score: 3581
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.82
    Marker Score: 1831
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.82
    Marker Score: 2981.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.81
    Marker Score: 1951
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.78
    Marker Score: 1885
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.77
    Marker Score: 842
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.77
    Marker Score: 1795
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.76
    Marker Score: 1175
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.75
    Marker Score: 15228
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.75
    Marker Score: 3291
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.74
    Marker Score: 959
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.72
    Marker Score: 3000
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.72
    Marker Score: 913
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.71
    Marker Score: 14770
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.7
    Marker Score: 2820
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.69
    Marker Score: 4939
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.69
    Marker Score: 4046
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.69
    Marker Score: 478
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.69
    Marker Score: 94355
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.69
    Marker Score: 1157
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.69
    Marker Score: 43156
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.68
    Marker Score: 483
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.67
    Marker Score: 19434
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.67
    Marker Score: 3339
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.66
    Marker Score: 1735
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.66
    Marker Score: 856
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.66
    Marker Score: 470
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.66
    Marker Score: 970
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.64
    Marker Score: 962
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.63
    Marker Score: 563
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.63
    Marker Score: 486
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.63
    Marker Score: 1334
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.63
    Marker Score: 4102
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.62
    Marker Score: 1068
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.62
    Marker Score: 603
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.61
    Marker Score: 836
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.61
    Marker Score: 2016
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.61
    Marker Score: 4770
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6
    Marker Score: 55485
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.57
    Marker Score: 867
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.57
    Marker Score: 375
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.57
    Marker Score: 2222
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.56
    Marker Score: 2077
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.56
    Marker Score: 1131
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.55
    Marker Score: 5754
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.55
    Marker Score: 1460
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.55
    Marker Score: 2286
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.54
    Marker Score: 4034
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.54
    Marker Score: 621
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.53
    Marker Score: 3740
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.53
    Marker Score: 1089
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.53
    Marker Score: 4357
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.52
    Marker Score: 621
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.52
    Marker Score: 1362
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.51
    Marker Score: 524
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.51
    Marker Score: 679
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.51
    Marker Score: 521
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.51
    Marker Score: 1535
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.51
    Marker Score: 2670
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.51
    Marker Score: 1722

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a chaperone protein that helps to protect alpha-tubulin from degradation. * It is involved in the post-chaperonin tubulin folding pathway. * It is also involved in the assembly of the cell cortex. **Pathways and functions:** * The TBCB gene is expressed in neurons, where it is required for the assembly of alpha-tubulin into microtubules. * Microtubules are essential for a variety of cellular processes, including cell migration, organelle transport, and signal transduction. * Dysfunction of the TBCB gene has been linked to a number of neurological disorders, including Alzheimer's disease and autism. **Clinical significance:** * Mutations in the TBCB gene have been linked to a number of neurological disorders, including Alzheimer's disease and autism. * Targeting the TBCB gene has been explored as a therapeutic strategy for these disorders. * A drug called Tirosyl-tyrosine methyltransferase inhibitor (TTMIs) is currently being tested in clinical trials for the treatment of Alzheimer's disease. **Additional information:** * The TBCB gene is also expressed in other cell types, including epithelial cells, hematopoietic stem cells, and germ cells. * It is a highly conserved gene, with a similar sequence in humans, mice, and rats. * The protein is also expressed in the testes, where it is involved in the production of seminal fluid.

Genular Protein ID: 2789051735

Symbol: TBCB_HUMAN

Name: Tubulin-folding cofactor B

UniProtKB Accession Codes:

Q99426 O00111 O00674 O14728 Q6FGY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9265649

Title: Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors.

PubMed ID: 9265649

DOI: 10.1083/jcb.138.4.821

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8978778

Title: Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-Gly domain.

PubMed ID: 8978778

DOI: 10.1159/000134191

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16303566

Title: Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.

PubMed ID: 16303566

DOI: 10.1016/j.cub.2005.10.052

PubMed ID: 15831477

Title: p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.

PubMed ID: 15831477

DOI: 10.1128/mcb.25.9.3726-3736.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22777741

Title: Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).

PubMed ID: 22777741

DOI: 10.1007/s00441-012-1463-z

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32366039

Title: Tubulin folding cofactor TBCB is a target of the salmonella effector protein SseK1.

PubMed ID: 32366039

DOI: 10.3390/ijms21093193

Sequence Information:

  • Length: 244
  • Mass: 27326
  • Checksum: E984C7C74A105384
  • Sequence:
    • MEVTGVSAPT VTVFISSSLN TFRSEKRYSR SLTIAEFKCK LELLVGSPAS CMELELYGVD 
DKFYSKLDQE DALLGSYPVD DGCRIHVIDH SGARLGEYED VSRVEKYTIS QEAYDQRQDT 
VRSFLKRSKL GRYNEEERAQ QEAEAAQRLA EEKAQASSIP VGSRCEVRAA GQSPRRGTVM 
YVGLTDFKPG YWIGVRYDEP LGKNDGSVNG KRYFECQAKY GAFVKPAVVT VGDFPEEDYG 
LDEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.