Details for: TBCB

Gene ID: 1155

Symbol: TBCB

Ensembl ID: ENSG00000105254

Description: tubulin folding cofactor B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 365.4886
    Cell Significance Index: -56.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 196.6541
    Cell Significance Index: -49.8800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 148.6354
    Cell Significance Index: -61.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.9485
    Cell Significance Index: -51.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.8299
    Cell Significance Index: -58.9400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 112.0172
    Cell Significance Index: -57.6200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 88.4844
    Cell Significance Index: -59.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.1562
    Cell Significance Index: -52.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.3408
    Cell Significance Index: -60.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.8032
    Cell Significance Index: -62.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.8529
    Cell Significance Index: -45.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.1681
    Cell Significance Index: -24.5600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.2330
    Cell Significance Index: -15.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.7751
    Cell Significance Index: 72.9700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6681
    Cell Significance Index: 78.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.1071
    Cell Significance Index: 73.2200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.9209
    Cell Significance Index: 100.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7792
    Cell Significance Index: 244.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7777
    Cell Significance Index: 37.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.5920
    Cell Significance Index: 102.7100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2758
    Cell Significance Index: 163.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2572
    Cell Significance Index: 204.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1673
    Cell Significance Index: 137.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.0908
    Cell Significance Index: 51.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0611
    Cell Significance Index: 579.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0231
    Cell Significance Index: 125.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0004
    Cell Significance Index: 63.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8786
    Cell Significance Index: 158.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7889
    Cell Significance Index: 41.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.7762
    Cell Significance Index: 57.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7151
    Cell Significance Index: 92.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6625
    Cell Significance Index: 132.9100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.6584
    Cell Significance Index: 7.4800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.6550
    Cell Significance Index: 5.2300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6522
    Cell Significance Index: 7.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5309
    Cell Significance Index: 234.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4787
    Cell Significance Index: 13.0300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4377
    Cell Significance Index: 5.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3681
    Cell Significance Index: 132.0500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3561
    Cell Significance Index: 18.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3199
    Cell Significance Index: 7.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2221
    Cell Significance Index: 3.0300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.2212
    Cell Significance Index: 1.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1974
    Cell Significance Index: 37.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1445
    Cell Significance Index: 10.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1127
    Cell Significance Index: 6.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0948
    Cell Significance Index: 1.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0914
    Cell Significance Index: 1.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0839
    Cell Significance Index: 1.5500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0547
    Cell Significance Index: 9.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0528
    Cell Significance Index: 10.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0406
    Cell Significance Index: 0.6800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0067
    Cell Significance Index: 5.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0045
    Cell Significance Index: -3.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0076
    Cell Significance Index: -0.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0097
    Cell Significance Index: -0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0180
    Cell Significance Index: -27.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0186
    Cell Significance Index: -13.6300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0204
    Cell Significance Index: -38.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0252
    Cell Significance Index: -0.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0256
    Cell Significance Index: -47.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0264
    Cell Significance Index: -2.7000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0437
    Cell Significance Index: -59.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0492
    Cell Significance Index: -30.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0695
    Cell Significance Index: -44.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0745
    Cell Significance Index: -42.0000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0777
    Cell Significance Index: -53.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0901
    Cell Significance Index: -4.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1110
    Cell Significance Index: -50.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1219
    Cell Significance Index: -25.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1413
    Cell Significance Index: -4.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1593
    Cell Significance Index: -2.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1657
    Cell Significance Index: -47.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2107
    Cell Significance Index: -24.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2340
    Cell Significance Index: -26.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2376
    Cell Significance Index: -10.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2982
    Cell Significance Index: -9.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3172
    Cell Significance Index: -46.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3415
    Cell Significance Index: -12.0000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3562
    Cell Significance Index: -9.1000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4057
    Cell Significance Index: -46.3100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5169
    Cell Significance Index: -4.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5544
    Cell Significance Index: -43.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5946
    Cell Significance Index: -61.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6015
    Cell Significance Index: -12.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6099
    Cell Significance Index: -41.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7257
    Cell Significance Index: -40.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7382
    Cell Significance Index: -56.6500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7683
    Cell Significance Index: -22.6300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8569
    Cell Significance Index: -10.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9554
    Cell Significance Index: -58.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.0356
    Cell Significance Index: -29.6900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.1024
    Cell Significance Index: -9.2600
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -1.1230
    Cell Significance Index: -7.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.1319
    Cell Significance Index: -16.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2385
    Cell Significance Index: -54.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2577
    Cell Significance Index: -35.8900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.2863
    Cell Significance Index: -30.8500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3995
    Cell Significance Index: -45.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TBCB is a protein that interacts with alpha-tubulin, a key component of microtubules, to facilitate the proper folding and assembly of tubulins. This interaction is critical for the formation of stable microtubules, which are essential for various cellular processes, including cell division, movement, and intracellular transport. TBCB is also involved in the regulation of microtubule dynamics, influencing the assembly and disassembly of microtubules. **Pathways and Functions** TBCB is involved in several cellular pathways, including: 1. **Microtubule cytoskeleton organization**: TBCB plays a crucial role in the assembly and disassembly of microtubules, regulating their dynamics and stability. 2. **Protein binding**: TBCB interacts with various proteins, including alpha-tubulin, to facilitate the proper folding and assembly of tubulins. 3. **Cell differentiation**: TBCB is involved in the regulation of cell differentiation, influencing the development and maturation of cells in the nervous system and immune system. 4. **Nervous system development**: TBCB is essential for the development and maturation of neurons, influencing the formation of neural connections and synapses. 5. **Immune system function**: TBCB is involved in the regulation of immune cell function, influencing the activation and proliferation of T cells and other immune cells. **Clinical Significance** Dysregulation of TBCB has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: TBCB dysfunction has been linked to neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 2. **Immune system disorders**: TBCB dysfunction has been implicated in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: TBCB has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. In conclusion, TBCB is a critical gene that plays a pivotal role in the regulation of microtubule dynamics and cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of TBCB function and its potential as a therapeutic target.

Genular Protein ID: 2789051735

Symbol: TBCB_HUMAN

Name: Tubulin-folding cofactor B

UniProtKB Accession Codes:

Q99426 O00111 O00674 O14728 Q6FGY5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9265649

Title: Tubulin subunits exist in an activated conformational state generated and maintained by protein cofactors.

PubMed ID: 9265649

DOI: 10.1083/jcb.138.4.821

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8978778

Title: Cloning, expression, and mapping of CKAPI, which encodes a putative cytoskeleton-associated protein containing a CAP-Gly domain.

PubMed ID: 8978778

DOI: 10.1159/000134191

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 16303566

Title: Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway.

PubMed ID: 16303566

DOI: 10.1016/j.cub.2005.10.052

PubMed ID: 15831477

Title: p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor B.

PubMed ID: 15831477

DOI: 10.1128/mcb.25.9.3726-3736.2005

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22777741

Title: Tubulin-binding cofactor B is a direct interaction partner of the dynactin subunit p150(Glued).

PubMed ID: 22777741

DOI: 10.1007/s00441-012-1463-z

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 32366039

Title: Tubulin folding cofactor TBCB is a target of the salmonella effector protein SseK1.

PubMed ID: 32366039

DOI: 10.3390/ijms21093193

Sequence Information:

  • Length: 244
  • Mass: 27326
  • Checksum: E984C7C74A105384
  • Sequence:
    • MEVTGVSAPT VTVFISSSLN TFRSEKRYSR SLTIAEFKCK LELLVGSPAS CMELELYGVD 
DKFYSKLDQE DALLGSYPVD DGCRIHVIDH SGARLGEYED VSRVEKYTIS QEAYDQRQDT 
VRSFLKRSKL GRYNEEERAQ QEAEAAQRLA EEKAQASSIP VGSRCEVRAA GQSPRRGTVM 
YVGLTDFKPG YWIGVRYDEP LGKNDGSVNG KRYFECQAKY GAFVKPAVVT VGDFPEEDYG 
LDEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.