Details for: INSM1

Gene ID: 3642

Symbol: INSM1

Ensembl ID: ENSG00000173404

Description: INSM transcriptional repressor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.6610
    Cell Significance Index: 43.8500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.1881
    Cell Significance Index: 13.1900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9002
    Cell Significance Index: 21.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8833
    Cell Significance Index: 87.3800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.8576
    Cell Significance Index: 4.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8176
    Cell Significance Index: 738.2700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7233
    Cell Significance Index: 15.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6734
    Cell Significance Index: 128.1500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5548
    Cell Significance Index: 60.3500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5043
    Cell Significance Index: 82.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4766
    Cell Significance Index: 28.6200
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.3394
    Cell Significance Index: 3.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3045
    Cell Significance Index: 21.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2430
    Cell Significance Index: 3.7600
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.2244
    Cell Significance Index: 2.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1333
    Cell Significance Index: 3.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0962
    Cell Significance Index: 5.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0900
    Cell Significance Index: 1.9700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0893
    Cell Significance Index: 1.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0771
    Cell Significance Index: 2.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0547
    Cell Significance Index: 2.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0462
    Cell Significance Index: 5.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0367
    Cell Significance Index: 2.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0195
    Cell Significance Index: 13.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0092
    Cell Significance Index: 0.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0092
    Cell Significance Index: 4.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0048
    Cell Significance Index: 0.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0035
    Cell Significance Index: 2.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0024
    Cell Significance Index: -1.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0032
    Cell Significance Index: -0.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0059
    Cell Significance Index: -1.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0121
    Cell Significance Index: -4.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0126
    Cell Significance Index: -19.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0175
    Cell Significance Index: -12.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0201
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0209
    Cell Significance Index: -3.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0228
    Cell Significance Index: -0.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0228
    Cell Significance Index: -12.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0279
    Cell Significance Index: -0.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0327
    Cell Significance Index: -0.8900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0338
    Cell Significance Index: -0.2200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0497
    Cell Significance Index: -1.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0554
    Cell Significance Index: -11.0000
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.0729
    Cell Significance Index: -0.5900
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0765
    Cell Significance Index: -1.0400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0911
    Cell Significance Index: -0.9900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0916
    Cell Significance Index: -1.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0931
    Cell Significance Index: -12.7800
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0947
    Cell Significance Index: -0.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0957
    Cell Significance Index: -11.1500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.0980
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1130
    Cell Significance Index: -12.9500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1135
    Cell Significance Index: -13.3900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1296
    Cell Significance Index: -1.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1514
    Cell Significance Index: -10.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1625
    Cell Significance Index: -12.8700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1681
    Cell Significance Index: -1.0300
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.1700
    Cell Significance Index: -1.0600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1757
    Cell Significance Index: -0.9200
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.1806
    Cell Significance Index: -1.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1953
    Cell Significance Index: -12.6000
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.2029
    Cell Significance Index: -1.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2238
    Cell Significance Index: -9.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2387
    Cell Significance Index: -12.4400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2626
    Cell Significance Index: -13.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2728
    Cell Significance Index: -6.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2772
    Cell Significance Index: -10.5000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2852
    Cell Significance Index: -6.8400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.3084
    Cell Significance Index: -6.0300
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3168
    Cell Significance Index: -1.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3716
    Cell Significance Index: -12.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3905
    Cell Significance Index: -13.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3942
    Cell Significance Index: -11.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4110
    Cell Significance Index: -13.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4210
    Cell Significance Index: -11.2800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4386
    Cell Significance Index: -4.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4432
    Cell Significance Index: -20.8300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4454
    Cell Significance Index: -13.1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4699
    Cell Significance Index: -12.5700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4782
    Cell Significance Index: -11.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4841
    Cell Significance Index: -12.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4895
    Cell Significance Index: -13.0700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.5117
    Cell Significance Index: -12.7800
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: -0.5403
    Cell Significance Index: -5.0000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5419
    Cell Significance Index: -5.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.5476
    Cell Significance Index: -11.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5568
    Cell Significance Index: -13.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.5570
    Cell Significance Index: -14.1900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5788
    Cell Significance Index: -12.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5854
    Cell Significance Index: -11.5800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.5985
    Cell Significance Index: -10.2300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.5990
    Cell Significance Index: -7.2400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6048
    Cell Significance Index: -19.1300
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6055
    Cell Significance Index: -5.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6070
    Cell Significance Index: -17.4000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6072
    Cell Significance Index: -12.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6165
    Cell Significance Index: -13.0900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.6187
    Cell Significance Index: -12.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Repressor Function:** INSM1 acts as a transcriptional repressor, regulating the expression of target genes through its ability to bind to specific DNA sequences and recruit co-repressors. 2. **Cell-Specific Expression:** INSM1 is significantly expressed in various cell types, including endocrine cells, neurons, and neural crest cells, underscoring its role in regulating cell-specific developmental processes. 3. **Multiple Pathway Involvement:** INSM1 is implicated in multiple signaling pathways, including cell cycle regulation, chromatin remodeling, and transcriptional regulation, highlighting its broad impact on cellular processes. 4. **Repressor Activity in Chromatin Remodeling:** INSM1's ability to interact with histone deacetylases and other chromatin-modifying enzymes suggests its involvement in chromatin remodeling and gene expression regulation. **Pathways and Functions:** 1. **Cell Cycle Regulation:** INSM1's involvement in the cell cycle, particularly in regulating cell population proliferation, highlights its role in maintaining cellular homeostasis. 2. **Chromatin Remodeling:** INSM1's interaction with histone deacetylases and other chromatin-modifying enzymes suggests its involvement in chromatin remodeling and gene expression regulation. 3. **Neuronal Differentiation:** INSM1's expression in neurons and its role in regulating neuronal precursor cell proliferation underscore its importance in neuronal development and differentiation. 4. **Endocrine Cell Development:** INSM1's involvement in regulating endocrine cell development, including pancreatic beta-cell and adrenal chromaffin cell differentiation, highlights its role in endocrine tissue development. **Clinical Significance:** 1. **Diabetes and Pancreatic Development:** Dysregulation of INSM1 in pancreatic beta-cell development may contribute to the pathogenesis of diabetes. 2. **Neurological Disorders:** INSM1's involvement in neuronal differentiation and development suggests its potential role in neurological disorders, such as neurodegenerative diseases. 3. **Cancer and Tumor Suppression:** INSM1's role in regulating cell cycle and chromatin remodeling may also contribute to its potential as a tumor suppressor gene. 4. **Regenerative Medicine:** Understanding INSM1's role in cellular development and differentiation may provide insights into regenerative medicine strategies for tissue repair and replacement. In conclusion, INSM1 is a multifunctional gene that plays a critical role in regulating various cellular processes, including cell differentiation, proliferation, and migration. Its involvement in multiple signaling pathways highlights its importance in maintaining cellular homeostasis and regulating tissue development. Further research on INSM1's role in disease and development will provide valuable insights into its clinical significance and potential therapeutic applications.

Genular Protein ID: 2161381504

Symbol: INSM1_HUMAN

Name: Insulinoma-associated protein 1

UniProtKB Accession Codes:

Q01101

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1634555

Title: A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs.

PubMed ID: 1634555

DOI: 10.1016/s0021-9258(18)42173-4

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 8188699

Title: Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1.

PubMed ID: 8188699

DOI: 10.1016/s0021-9258(17)36770-4

PubMed ID: 11842116

Title: Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.

PubMed ID: 11842116

DOI: 10.1093/nar/30.4.1038

PubMed ID: 12890672

Title: NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.

PubMed ID: 12890672

DOI: 10.1074/jbc.m306795200

PubMed ID: 16569215

Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.

PubMed ID: 16569215

DOI: 10.1042/bj20051669

PubMed ID: 16511571

Title: IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

PubMed ID: 16511571

DOI: 10.1038/sj.emboj.7601011

PubMed ID: 18417529

Title: Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.

PubMed ID: 18417529

DOI: 10.1677/joe-08-0001

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19246490

Title: Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation.

PubMed ID: 19246490

DOI: 10.1096/fj.08-125971

PubMed ID: 23721412

Title: Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.

PubMed ID: 23721412

DOI: 10.1021/cb4001926

Sequence Information:

  • Length: 510
  • Mass: 52923
  • Checksum: 22D4E97696397365
  • Sequence:
    • MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP GPLPPPPPAE 
RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY SPTRPVSREH EKHKYFERSF 
NLGSPVSAES FPTPAALLGG GGGGGASGAG GGGTCGGDPL LFAPAELKMG TAFSAGAEAA 
RGPGPGPPLP PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV 
LGLKIKEGPV EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC 
AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD TPSPGGVSES 
GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL APPAEDLLAL YPGPDEKAPQ 
EAAGDGEGAG VLGLSASAEC HLCPVCGESF ASKGAQERHL RLLHAAQVFP CKYCPATFYS 
SPGLTRHINK CHPSENRQVI LLQVPVRPAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.