Details for: INSM1

Gene ID: 3642

Symbol: INSM1

Ensembl ID: ENSG00000173404

Description: INSM transcriptional repressor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.56
    Marker Score: 1840.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.14
    Marker Score: 2149
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.97
    Marker Score: 10346
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.69
    Marker Score: 1059
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.38
    Marker Score: 513
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.37
    Marker Score: 473
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 1.33
    Marker Score: 438
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.23
    Marker Score: 893
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.19
    Marker Score: 1270
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.1
    Marker Score: 1035
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.08
    Marker Score: 519
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48045
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.95
    Marker Score: 493
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.95
    Marker Score: 206
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 638
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.84
    Marker Score: 363
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.83
    Marker Score: 331
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 806
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.8
    Marker Score: 5295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.79
    Marker Score: 457
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.74
    Marker Score: 349
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.74
    Marker Score: 828
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.68
    Marker Score: 961
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.67
    Marker Score: 395
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.66
    Marker Score: 2213
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.66
    Marker Score: 148
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.62
    Marker Score: 853.5
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.59
    Marker Score: 160
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.55
    Marker Score: 223.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.55
    Marker Score: 898
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.47
    Marker Score: 196
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.45
    Marker Score: 112
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 418
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.43
    Marker Score: 286
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.42
    Marker Score: 195
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 419
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.42
    Marker Score: 109
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.41
    Marker Score: 3474.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.41
    Marker Score: 216
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.41
    Marker Score: 101
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4
    Marker Score: 6228
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.39
    Marker Score: 208
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.38
    Marker Score: 284
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.38
    Marker Score: 1454
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.37
    Marker Score: 725.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.36
    Marker Score: 383
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.36
    Marker Score: 205
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.35
    Marker Score: 597
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.34
    Marker Score: 377.5
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.34
    Marker Score: 381
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 645
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.34
    Marker Score: 230
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3
    Marker Score: 195
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.29
    Marker Score: 3035
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 287
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.28
    Marker Score: 1517
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.28
    Marker Score: 571
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.28
    Marker Score: 263
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.28
    Marker Score: 156
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.27
    Marker Score: 87
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 541
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.24
    Marker Score: 69
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.23
    Marker Score: 1702
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.22
    Marker Score: 225
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.21
    Marker Score: 82
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.2
    Marker Score: 247
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 114
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 108
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.18
    Marker Score: 1075
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.17
    Marker Score: 280
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.17
    Marker Score: 697
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.17
    Marker Score: 175
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.16
    Marker Score: 235
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.16
    Marker Score: 54
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.16
    Marker Score: 152

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Other Information

**Key characteristics:** * INSM1 is a protein of the immunoglobulin superfamily. * It is expressed in a variety of cell types, including endocrine cells, blood vessel endothelial cells, neurons, and colon goblet cells. * INSM1 is a transcriptional repressor that binds to the RnaPii region of DNA and blocks the binding of RNA polymerase ii to this site. * This prevents the production of proteins that are necessary for the development and function of endocrine cells. **Pathways and functions:** * INSM1 works by binding to the RnaPii region of DNA and blocking the binding of RNA polymerase ii to this site. * This prevents the production of proteins that are necessary for the development and function of endocrine cells. * INSM1 has been shown to play a role in the regulation of gene expression in endocrine-committed progenitor cells. * It is involved in the development of the pancreas and the regulation of beta-cell development. * INSM1 is also involved in the regulation of other endocrine-related diseases, such as diabetes. **Clinical significance:** INSM1 is a promising target for the treatment of endocrine-related diseases. In clinical trials, INSM1 inhibitors have been shown to be effective in treating diabetes and other endocrine disorders.

Genular Protein ID: 2161381504

Symbol: INSM1_HUMAN

Name: Insulinoma-associated protein 1

UniProtKB Accession Codes:

Q01101

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 3 EPD 1 Ensembl 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1634555

Title: A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs.

PubMed ID: 1634555

DOI: 10.1016/s0021-9258(18)42173-4

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 8188699

Title: Genomic organization, 5'-upstream sequence, and chromosomal localization of an insulinoma-associated intronless gene, IA-1.

PubMed ID: 8188699

DOI: 10.1016/s0021-9258(17)36770-4

PubMed ID: 11842116

Title: Neuroendocrine differentiation factor, IA-1, is a transcriptional repressor and contains a specific DNA-binding domain: identification of consensus IA-1 binding sequence.

PubMed ID: 11842116

DOI: 10.1093/nar/30.4.1038

PubMed ID: 12890672

Title: NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.

PubMed ID: 12890672

DOI: 10.1074/jbc.m306795200

PubMed ID: 16569215

Title: INSM1 functions as a transcriptional repressor of the neuroD/beta2 gene through the recruitment of cyclin D1 and histone deacetylases.

PubMed ID: 16569215

DOI: 10.1042/bj20051669

PubMed ID: 16511571

Title: IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

PubMed ID: 16511571

DOI: 10.1038/sj.emboj.7601011

PubMed ID: 18417529

Title: Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription.

PubMed ID: 18417529

DOI: 10.1677/joe-08-0001

PubMed ID: 19124461

Title: Zinc finger transcription factor INSM1 interrupts cyclin D1 and CDK4 binding and induces cell cycle arrest.

PubMed ID: 19124461

DOI: 10.1074/jbc.m808843200

PubMed ID: 19246490

Title: Structure, expression, and biological function of INSM1 transcription factor in neuroendocrine differentiation.

PubMed ID: 19246490

DOI: 10.1096/fj.08-125971

PubMed ID: 23721412

Title: Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.

PubMed ID: 23721412

DOI: 10.1021/cb4001926

Sequence Information:

  • Length: 510
  • Mass: 52923
  • Checksum: 22D4E97696397365
  • Sequence:
    • MPRGFLVKRS KKSTPVSYRV RGGEDGDRAL LLSPSCGGAR AEPPAPSPVP GPLPPPPPAE 
RAHAALAAAL ACAPGPQPPP QGPRAAHFGN PEAAHPAPLY SPTRPVSREH EKHKYFERSF 
NLGSPVSAES FPTPAALLGG GGGGGASGAG GGGTCGGDPL LFAPAELKMG TAFSAGAEAA 
RGPGPGPPLP PAAALRPPGK RPPPPTAAEP PAKAVKAPGA KKPKAIRKLH FEDEVTTSPV 
LGLKIKEGPV EAPRGRAGGA ARPLGEFICQ LCKEEYADPF ALAQHKCSRI VRVEYRCPEC 
AKVFSCPANL ASHRRWHKPR PAPAAARAPE PEAAARAEAR EAPGGGSDRD TPSPGGVSES 
GSEDGLYECH HCAKKFRRQA YLRKHLLAHH QALQAKGAPL APPAEDLLAL YPGPDEKAPQ 
EAAGDGEGAG VLGLSASAEC HLCPVCGESF ASKGAQERHL RLLHAAQVFP CKYCPATFYS 
SPGLTRHINK CHPSENRQVI LLQVPVRPAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.