Details for: ISL1

Gene ID: 3670

Symbol: ISL1

Ensembl ID: ENSG00000016082

Description: ISL LIM homeobox 1

Associated with

  • Axon guidance
    (R-HSA-422475)
  • Cardiogenesis
    (R-HSA-9733709)
  • Developmental biology
    (R-HSA-1266738)
  • Incretin synthesis, secretion, and inactivation
    (R-HSA-400508)
  • Metabolism of proteins
    (R-HSA-392499)
  • Nervous system development
    (R-HSA-9675108)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Regulation of expression of slits and robos
    (R-HSA-9010553)
  • Signaling by robo receptors
    (R-HSA-376176)
  • Synthesis, secretion, and inactivation of glucose-dependent insulinotropic polypeptide (gip)
    (R-HSA-400511)
  • Atrial septum morphogenesis
    (GO:0060413)
  • Axonogenesis
    (GO:0007409)
  • Bhlh transcription factor binding
    (GO:0043425)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cardiac cell fate determination
    (GO:0060913)
  • Cardiac muscle cell myoblast differentiation
    (GO:0060379)
  • Cardiac right ventricle morphogenesis
    (GO:0003215)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Chromatin
    (GO:0000785)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endocardial cushion morphogenesis
    (GO:0003203)
  • Heart development
    (GO:0007507)
  • Innervation
    (GO:0060384)
  • Mesenchymal cell differentiation
    (GO:0048762)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of intracellular estrogen receptor signaling pathway
    (GO:0033147)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of protein-containing complex assembly
    (GO:0031333)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neural crest cell migration
    (GO:0001755)
  • Neuron fate specification
    (GO:0048665)
  • Nuclear estrogen receptor binding
    (GO:0030331)
  • Nuclear receptor binding
    (GO:0016922)
  • Nucleus
    (GO:0005634)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Outflow tract septum morphogenesis
    (GO:0003148)
  • Pancreas development
    (GO:0031016)
  • Peripheral nervous system neuron axonogenesis
    (GO:0048936)
  • Pharyngeal system development
    (GO:0060037)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of granulocyte colony-stimulating factor production
    (GO:0071657)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of interleukin-1 alpha production
    (GO:0032730)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of macrophage colony-stimulating factor production
    (GO:1901258)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of secondary heart field cardioblast proliferation
    (GO:0003266)
  • Retinal ganglion cell axon guidance
    (GO:0031290)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secondary heart field specification
    (GO:0003139)
  • Sensory system development
    (GO:0048880)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Sinoatrial node cell development
    (GO:0060931)
  • Spinal cord motor neuron cell fate specification
    (GO:0021520)
  • Spinal cord motor neuron differentiation
    (GO:0021522)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Trigeminal nerve development
    (GO:0021559)
  • Ventricular cardiac muscle tissue morphogenesis
    (GO:0055010)
  • Visceral motor neuron differentiation
    (GO:0021524)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 4.84
    Marker Score: 6956
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 3.49
    Marker Score: 1805
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.86
    Marker Score: 4021
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.62
    Marker Score: 1367
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.2
    Marker Score: 2216
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.57
    Marker Score: 6531
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.45
    Marker Score: 606
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.42
    Marker Score: 5264
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.34
    Marker Score: 463
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.26
    Marker Score: 507
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 851
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.15
    Marker Score: 427
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4802
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 499
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.08
    Marker Score: 1206
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.06
    Marker Score: 238
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48037
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.97
    Marker Score: 264
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.96
    Marker Score: 1573
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.94
    Marker Score: 454
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.82
    Marker Score: 474
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.8
    Marker Score: 1523
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.79
    Marker Score: 329
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1257
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 497
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.75
    Marker Score: 2943
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.74
    Marker Score: 214
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.74
    Marker Score: 322
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.73
    Marker Score: 916
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.7
    Marker Score: 601
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.68
    Marker Score: 350
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.67
    Marker Score: 1177
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.65
    Marker Score: 576
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.63
    Marker Score: 163
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1227
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.6
    Marker Score: 181
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 337
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.55
    Marker Score: 4075
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.55
    Marker Score: 149
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.52
    Marker Score: 506
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.51
    Marker Score: 211
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.5
    Marker Score: 474
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.46
    Marker Score: 1352
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.46
    Marker Score: 117
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.44
    Marker Score: 638
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.44
    Marker Score: 184
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.44
    Marker Score: 567
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 137.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 246
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.42
    Marker Score: 135
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.42
    Marker Score: 417
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.42
    Marker Score: 109
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.42
    Marker Score: 6542
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 396
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.4
    Marker Score: 132
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.39
    Marker Score: 666
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.38
    Marker Score: 261
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.37
    Marker Score: 303
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.37
    Marker Score: 91
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.35
    Marker Score: 109
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.35
    Marker Score: 2081
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.35
    Marker Score: 344
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.34
    Marker Score: 161
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.32
    Marker Score: 730
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.32
    Marker Score: 336
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.31
    Marker Score: 191
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.31
    Marker Score: 580
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.31
    Marker Score: 89
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.3
    Marker Score: 149
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.29
    Marker Score: 604.5
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.29
    Marker Score: 459
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.28
    Marker Score: 114
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.28
    Marker Score: 80
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.27
    Marker Score: 127
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.27
    Marker Score: 66
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 139

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Other Information

**Key characteristics:** * The ISL1 gene is located on chromosome 17q21.1. * It is a relatively large gene with a length of approximately 1.5 million base pairs. * The protein encoded by the ISL1 gene is a transcription factor with a molecular weight of approximately 160 kDa. * ISL1 is a member of the LIM family of transcription factors, which are known for their role in regulating cell fate and differentiation. **Pathways and functions:** * ISL1 is a key regulator of the development and survival of various cell types. * It is involved in embryonic development, where it promotes the proliferation and survival of neural and cardiovascular progenitor cells. * In adult tissues, ISL1 plays a role in maintaining tissue homeostasis and preventing tumor formation. * It is also involved in the regulation of metabolism, insulin signaling, and inflammation. **Clinical significance:** * Mutations in the ISL1 gene have been linked to several human diseases, including diabetes, cardiovascular disease, and cancer. * Studies of ISL1 function have potential implications for the development of novel therapeutic strategies for these diseases. **Additional notes:** * ISL1 is a highly conserved gene with similar sequences in mammals. * It is a key target for the treatment of type 1 diabetes. * The expression of ISL1 is regulated by various hormones, including insulin, growth hormone, and thyroid hormone.

Genular Protein ID: 2828262339

Symbol: ISL1_HUMAN

Name: Insulin gene enhancer protein ISL-1

UniProtKB Accession Codes:

P61371 P20663 P47894

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 68 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7907017

Title: The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage.

PubMed ID: 7907017

DOI: 10.1210/endo.134.3.7907017

PubMed ID: 7912209

Title: Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism.

PubMed ID: 7912209

DOI: 10.2337/diab.43.7.935

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21403123

Title: Formation of the building plan of the human heart: morphogenesis, growth, and differentiation.

PubMed ID: 21403123

DOI: 10.1161/circulationaha.110.980607

Sequence Information:

  • Length: 349
  • Mass: 39036
  • Checksum: 4DB82FD09154F404
  • Sequence:
    • MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDESCTCFV 
RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY HIECFRCVAC SRQLIPGDEF 
ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK 
TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS 
IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.