Details for: ISL1

Gene ID: 3670

Symbol: ISL1

Ensembl ID: ENSG00000016082

Description: ISL LIM homeobox 1

Associated with

  • Axon guidance
    (R-HSA-422475)
  • Cardiogenesis
    (R-HSA-9733709)
  • Developmental biology
    (R-HSA-1266738)
  • Incretin synthesis, secretion, and inactivation
    (R-HSA-400508)
  • Metabolism of proteins
    (R-HSA-392499)
  • Nervous system development
    (R-HSA-9675108)
  • Peptide hormone metabolism
    (R-HSA-2980736)
  • Regulation of expression of slits and robos
    (R-HSA-9010553)
  • Signaling by robo receptors
    (R-HSA-376176)
  • Synthesis, secretion, and inactivation of glucose-dependent insulinotropic polypeptide (gip)
    (R-HSA-400511)
  • Atrial septum morphogenesis
    (GO:0060413)
  • Axonogenesis
    (GO:0007409)
  • Bhlh transcription factor binding
    (GO:0043425)
  • Canonical wnt signaling pathway
    (GO:0060070)
  • Cardiac cell fate determination
    (GO:0060913)
  • Cardiac muscle cell myoblast differentiation
    (GO:0060379)
  • Cardiac right ventricle morphogenesis
    (GO:0003215)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to glucocorticoid stimulus
    (GO:0071385)
  • Chromatin
    (GO:0000785)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endocardial cushion morphogenesis
    (GO:0003203)
  • Heart development
    (GO:0007507)
  • Innervation
    (GO:0060384)
  • Mesenchymal cell differentiation
    (GO:0048762)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of intracellular estrogen receptor signaling pathway
    (GO:0033147)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of protein-containing complex assembly
    (GO:0031333)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neural crest cell migration
    (GO:0001755)
  • Neuron fate specification
    (GO:0048665)
  • Nuclear estrogen receptor binding
    (GO:0030331)
  • Nuclear receptor binding
    (GO:0016922)
  • Nucleus
    (GO:0005634)
  • Outflow tract morphogenesis
    (GO:0003151)
  • Outflow tract septum morphogenesis
    (GO:0003148)
  • Pancreas development
    (GO:0031016)
  • Peripheral nervous system neuron axonogenesis
    (GO:0048936)
  • Pharyngeal system development
    (GO:0060037)
  • Pituitary gland development
    (GO:0021983)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of cell differentiation
    (GO:0045597)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of granulocyte colony-stimulating factor production
    (GO:0071657)
  • Positive regulation of granulocyte macrophage colony-stimulating factor production
    (GO:0032725)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of interleukin-1 alpha production
    (GO:0032730)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of macrophage colony-stimulating factor production
    (GO:1901258)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of vascular endothelial growth factor production
    (GO:0010575)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Protein binding
    (GO:0005515)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of secondary heart field cardioblast proliferation
    (GO:0003266)
  • Retinal ganglion cell axon guidance
    (GO:0031290)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Secondary heart field specification
    (GO:0003139)
  • Sensory system development
    (GO:0048880)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Sinoatrial node cell development
    (GO:0060931)
  • Spinal cord motor neuron cell fate specification
    (GO:0021520)
  • Spinal cord motor neuron differentiation
    (GO:0021522)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Trigeminal nerve development
    (GO:0021559)
  • Ventricular cardiac muscle tissue morphogenesis
    (GO:0055010)
  • Visceral motor neuron differentiation
    (GO:0021524)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.5902
    Cell Significance Index: 281.4200
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 3.5397
    Cell Significance Index: 20.1200
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 3.0267
    Cell Significance Index: 2.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9505
    Cell Significance Index: 94.5000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.5862
    Cell Significance Index: 26.9400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.4232
    Cell Significance Index: 10.9700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.3845
    Cell Significance Index: 11.4500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.0997
    Cell Significance Index: 13.3300
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.9882
    Cell Significance Index: 8.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7079
    Cell Significance Index: 70.0300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6946
    Cell Significance Index: 36.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6757
    Cell Significance Index: 610.1300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.6037
    Cell Significance Index: 6.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5357
    Cell Significance Index: 101.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4735
    Cell Significance Index: 10.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4173
    Cell Significance Index: 45.3900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4040
    Cell Significance Index: 65.7100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3511
    Cell Significance Index: 9.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2935
    Cell Significance Index: 17.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2221
    Cell Significance Index: 27.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2181
    Cell Significance Index: 15.0800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1608
    Cell Significance Index: 18.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1589
    Cell Significance Index: 28.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1239
    Cell Significance Index: 85.7000
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.1212
    Cell Significance Index: 1.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0686
    Cell Significance Index: 3.8500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0662
    Cell Significance Index: 0.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0378
    Cell Significance Index: 1.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0349
    Cell Significance Index: 1.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.0168
    Cell Significance Index: 3.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0161
    Cell Significance Index: 0.7300
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.0157
    Cell Significance Index: 0.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0045
    Cell Significance Index: 3.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0041
    Cell Significance Index: -2.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0069
    Cell Significance Index: -3.0500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0071
    Cell Significance Index: -4.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -10.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0162
    Cell Significance Index: -10.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0180
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0192
    Cell Significance Index: -3.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0226
    Cell Significance Index: -10.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0339
    Cell Significance Index: -9.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0415
    Cell Significance Index: -0.8600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0469
    Cell Significance Index: -9.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0472
    Cell Significance Index: -9.3800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0523
    Cell Significance Index: -0.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0589
    Cell Significance Index: -6.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0684
    Cell Significance Index: -9.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0744
    Cell Significance Index: -8.5200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0785
    Cell Significance Index: -10.1400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0884
    Cell Significance Index: -5.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1032
    Cell Significance Index: -5.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1179
    Cell Significance Index: -8.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1277
    Cell Significance Index: -7.8500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1363
    Cell Significance Index: -10.1600
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.1570
    Cell Significance Index: -1.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1744
    Cell Significance Index: -8.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2038
    Cell Significance Index: -3.4100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2196
    Cell Significance Index: -10.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2197
    Cell Significance Index: -9.7200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2201
    Cell Significance Index: -6.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2280
    Cell Significance Index: -6.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2466
    Cell Significance Index: -6.1700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2487
    Cell Significance Index: -9.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2515
    Cell Significance Index: -8.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2517
    Cell Significance Index: -6.8500
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.2528
    Cell Significance Index: -2.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2706
    Cell Significance Index: -9.4800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2835
    Cell Significance Index: -4.0600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2843
    Cell Significance Index: -7.0900
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.2921
    Cell Significance Index: -3.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2924
    Cell Significance Index: -10.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2945
    Cell Significance Index: -7.5700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2961
    Cell Significance Index: -7.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2970
    Cell Significance Index: -9.4600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3024
    Cell Significance Index: -6.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3072
    Cell Significance Index: -4.6300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3084
    Cell Significance Index: -8.1100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3162
    Cell Significance Index: -9.0700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3164
    Cell Significance Index: -4.2700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3223
    Cell Significance Index: -8.6200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.3235
    Cell Significance Index: -2.8500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3429
    Cell Significance Index: -10.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3671
    Cell Significance Index: -7.6900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3724
    Cell Significance Index: -10.6300
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.3732
    Cell Significance Index: -6.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3796
    Cell Significance Index: -4.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3862
    Cell Significance Index: -9.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3885
    Cell Significance Index: -9.4800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3891
    Cell Significance Index: -9.7100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3907
    Cell Significance Index: -9.3700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4341
    Cell Significance Index: -9.0600
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.4351
    Cell Significance Index: -5.5100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4355
    Cell Significance Index: -10.5500
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.4452
    Cell Significance Index: -6.1800
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.4465
    Cell Significance Index: -3.6200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4586
    Cell Significance Index: -9.7300
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.4655
    Cell Significance Index: -5.1100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4698
    Cell Significance Index: -9.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcription Factor:** ISL1 is a transcription factor that regulates gene expression by binding to specific DNA sequences. 2. **Developmental Expression:** ISL1 is expressed in various tissues during development, including the heart, nervous system, and immune cells. 3. **Cell Fate Determination:** ISL1 plays a critical role in determining the fate of cells, including cardiac cell fate determination, neural crest cell migration, and immune cell differentiation. 4. **Signal Transduction:** ISL1 interacts with other signaling pathways, including the canonical Wnt signaling pathway, to regulate cell proliferation, differentiation, and survival. **Pathways and Functions:** ISL1 is involved in several key pathways, including: 1. **Cardiac Development:** ISL1 regulates cardiac cell fate determination, cardiac muscle cell myoblast differentiation, and heart development. 2. **Nervous System Development:** ISL1 is involved in neural crest cell migration, neuron fate specification, and neuron differentiation. 3. **Immune System Function:** ISL1 regulates immune cell differentiation, proliferation, and function, including granulocyte colony-stimulating factor production and insulin secretion. 4. **Wnt Signaling Pathway:** ISL1 negatively regulates the canonical Wnt signaling pathway, which is involved in cell proliferation, differentiation, and survival. **Clinical Significance:** Dysregulation of ISL1 has been implicated in various diseases, including: 1. **Congenital Heart Defects:** Mutations in ISL1 have been associated with congenital heart defects, including atrial septal defects and ventricular septal defects. 2. **Neurological Disorders:** ISL1 mutations have been linked to neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Immunological Disorders:** ISL1 dysregulation has been implicated in immunological disorders, including autoimmune diseases and cancer. In conclusion, the ISL1 gene is a critical regulator of development and function in the immune system and beyond. Its dysregulation has been implicated in various diseases, highlighting the importance of ISL1 in maintaining tissue homeostasis and overall health. Further research is needed to fully understand the mechanisms by which ISL1 regulates development and function, as well as its role in disease pathogenesis.

Genular Protein ID: 2828262339

Symbol: ISL1_HUMAN

Name: Insulin gene enhancer protein ISL-1

UniProtKB Accession Codes:

P61371 P20663 P47894

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 69 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7907017

Title: The LIM domain homeobox gene isl-1: conservation of human, hamster, and rat complementary deoxyribonucleic acid sequences and expression in cell types of nonneuroendocrine lineage.

PubMed ID: 7907017

DOI: 10.1210/endo.134.3.7907017

PubMed ID: 7912209

Title: Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism.

PubMed ID: 7912209

DOI: 10.2337/diab.43.7.935

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 21403123

Title: Formation of the building plan of the human heart: morphogenesis, growth, and differentiation.

PubMed ID: 21403123

DOI: 10.1161/circulationaha.110.980607

Sequence Information:

  • Length: 349
  • Mass: 39036
  • Checksum: 4DB82FD09154F404
  • Sequence:
    • MGDMGDPPKK KRLISLCVGC GNQIHDQYIL RVSPDLEWHA ACLKCAECNQ YLDESCTCFV 
RDGKTYCKRD YIRLYGIKCA KCSIGFSKND FVMRARSKVY HIECFRCVAC SRQLIPGDEF 
ALREDGLFCR ADHDVVERAS LGAGDPLSPL HPARPLQMAA EPISARQPAL RPHVHKQPEK 
TTRVRTVLNE KQLHTLRTCY AANPRPDALM KEQLVEMTGL SPRVIRVWFQ NKRCKDKKRS 
IMMKQLQQQQ PNDKTNIQGM TGTPMVAASP ERHDGGLQAN PVEVQSYQPP WKVLSDFALQ 
SDIDQPAFQQ LVNFSEGGPG SNSTGSEVAS MSSQLPDTPN SMVASPIEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.