Details for: CADPS

Gene ID: 8618

Symbol: CADPS

Ensembl ID: ENSG00000163618

Description: calcium dependent secretion activator

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 9.28
    Marker Score: 6985
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 6.67
    Marker Score: 3451
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.35
    Marker Score: 20107
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 4.21
    Marker Score: 142302.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.06
    Marker Score: 21815
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.82
    Marker Score: 20039
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.77
    Marker Score: 2188
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 3.72
    Marker Score: 1946
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 3.64
    Marker Score: 5128
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.48
    Marker Score: 11673
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.4
    Marker Score: 25649.5
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.38
    Marker Score: 12017
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 3.25
    Marker Score: 1030
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.02
    Marker Score: 8624
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.99
    Marker Score: 6871
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.92
    Marker Score: 58019
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.91
    Marker Score: 4890
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 2.84
    Marker Score: 1367
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.8
    Marker Score: 21471
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.8
    Marker Score: 41846
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: 2.77
    Marker Score: 932
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.69
    Marker Score: 102270
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.63
    Marker Score: 1181
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10863
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 2.53
    Marker Score: 836
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.46
    Marker Score: 2980
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.46
    Marker Score: 90626.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.45
    Marker Score: 1028
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.36
    Marker Score: 3178
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.36
    Marker Score: 9116.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 2.34
    Marker Score: 2924
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.31
    Marker Score: 51539.5
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.26
    Marker Score: 870
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.25
    Marker Score: 1588
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20686
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.1
    Marker Score: 21637
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127651
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.03
    Marker Score: 8279
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.02
    Marker Score: 4109
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.98
    Marker Score: 1112
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18350.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16171
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.82
    Marker Score: 496
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.77
    Marker Score: 2136
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.74
    Marker Score: 1638.5
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 1.73
    Marker Score: 524
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.72
    Marker Score: 693
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.7
    Marker Score: 7132.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.66
    Marker Score: 35414
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2558.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.64
    Marker Score: 1421
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.63
    Marker Score: 3080.5
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.53
    Marker Score: 1886
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.51
    Marker Score: 6312
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168191
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.44
    Marker Score: 2929
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.36
    Marker Score: 470
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 864
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19740
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.22
    Marker Score: 806
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.19
    Marker Score: 1239
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.18
    Marker Score: 1328
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.12
    Marker Score: 673.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.1
    Marker Score: 645.5
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.07
    Marker Score: 242
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.04
    Marker Score: 1202
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251779
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71801.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.96
    Marker Score: 357.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.95
    Marker Score: 349
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.93
    Marker Score: 909
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.92
    Marker Score: 239
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5258
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.88
    Marker Score: 381
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.87
    Marker Score: 521
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.86
    Marker Score: 3624
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.83
    Marker Score: 1989
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 633
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.83
    Marker Score: 429
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.82
    Marker Score: 334
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.78
    Marker Score: 251
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.77
    Marker Score: 258
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.76
    Marker Score: 166
  • Cell Name: visceromotor neuron (CL0005025)
    Fold Change: 0.76
    Marker Score: 222
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.74
    Marker Score: 7547
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.74
    Marker Score: 895.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 663
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 344
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179

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Other Information

**Key Characteristics:** 1. **Calcium-dependent secretion activator**: CADPS is a calcium-dependent protein that regulates exocytosis by modulating the activity of calcium channels and pumps. 2. **Specific expression in photoreceptor cells, endocrine cells, and neurons**: CADPS is predominantly expressed in photoreceptor cells, endocrine cells, and neurons, indicating its involvement in sensory and motor functions. 3. **Involvement in glutamatergic synapse and synaptic vesicle exocytosis**: CADPS is implicated in the regulation of glutamatergic synapses and synaptic vesicle exocytosis, highlighting its role in neurotransmission and synaptic plasticity. 4. **Positive regulation of exocytosis**: CADPS acts as a positive regulator of exocytosis, suggesting its involvement in enhancing the release of cellular contents. **Pathways and Functions:** 1. **Dense core granule exocytosis**: CADPS regulates the exocytosis of dense core granules, which are involved in the release of hormones and neurotransmitters. 2. **Exocytosis**: CADPS modulates the activity of calcium channels and pumps, leading to the regulation of exocytosis in various cell types. 3. **Glutamatergic synapse**: CADPS is involved in the regulation of glutamatergic synapses, which are essential for synaptic plasticity and learning. 4. **Lipid binding and metal ion binding**: CADPS exhibits lipid-binding and metal ion-binding properties, suggesting its involvement in cellular membrane dynamics and protein-protein interactions. **Clinical Significance:** 1. **Neurological disorders**: CADPS dysregulation has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease. 2. **Immune system disorders**: CADPS is also involved in immune system regulation, and its dysregulation may contribute to autoimmune diseases and immunodeficiency disorders. 3. **Endocrine disorders**: CADPS plays a role in endocrine function, and its dysregulation may contribute to endocrine disorders, such as diabetes and thyroid disease. 4. **Cancer**: CADPS has been implicated in cancer progression and metastasis, highlighting its potential as a therapeutic target. In conclusion, CADPS is a critical regulator of exocytosis and cellular signaling, with significant implications for our understanding of neurological, immunological, and endocrine disorders. Further research is necessary to elucidate the mechanisms underlying CADPS dysregulation and to explore its potential as a therapeutic target.

Genular Protein ID: 1645032962

Symbol: CAPS1_HUMAN

Name: Calcium-dependent secretion activator 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12659812

Title: Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family.

PubMed ID: 12659812

DOI: 10.1016/s0888-7543(02)00040-x

PubMed ID: 10574461

Title: Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.

PubMed ID: 10574461

DOI: 10.1093/dnares/6.5.329

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 9289490

Title: Novel Ca2+-binding protein (CAPS) related to UNC-31 required for Ca2+-activated exocytosis.

PubMed ID: 9289490

DOI: 10.1074/jbc.272.32.19637

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15857609

Title: Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).

PubMed ID: 15857609

DOI: 10.1016/j.bcp.2005.02.015

Sequence Information:

  • Length: 1353
  • Mass: 152786
  • Checksum: 9911C50B3A507112
  • Sequence:
  • MLDPSSSEEE SDEIVEEESG KEVLGSAPSG ARLSPSRTSE GSAGSAGLGG GGAGAGAGVG 
    AGGGGGSGAS SGGGAGGLQP SSRAGGGRPS SPSPSVVSEK EKEELERLQK EEEERKKRLQ 
    LYVFVMRCIA YPFNAKQPTD MARRQQKISK QQLQTVKDRF QAFLNGETQI MADEAFMNAV 
    QSYYEVFLKS DRVARMVQSG GCSANDSREV FKKHIEKRVR SLPEIDGLSK ETVLSSWMAK 
    FDAIYRGEED PRKQQARMTA SAASELILSK EQLYEMFQNI LGIKKFEHQL LYNACQLDNP 
    DEQAAQIRRE LDGRLQMADQ IARERKFPKF VSKEMENMYI EELKSSVNLL MANLESMPVS 
    KGGEFKLQKL KRSHNASIID MGEESENQLS KSDVVLSFSL EVVIMEVQGL KSLAPNRIVY 
    CTMEVEGGEK LQTDQAEASK PTWGTQGDFS TTHALPAVKV KLFTESTGVL ALEDKELGRV 
    ILHPTPNSPK QSEWHKMTVS KNCPDQDLKI KLAVRMDKPQ NMKHSGYLWA IGKNVWKRWK 
    KRFFVLVQVS QYTFAMCSYR EKKAEPQELL QLDGYTVDYT DPQPGLEGGR AFFNAVKEGD 
    TVIFASDDEQ DRILWVQAMY RATGQSHKPV PPTQVQKLNA KGGNVPQLDA PISQFYADRA 
    QKHGMDEFIS SNPCNFDHAS LFEMVQRLTL DHRLNDSYSC LGWFSPGQVF VLDEYCARNG 
    VRGCHRHLCY LRDLLERAEN GAMIDPTLLH YSFAFCASHV HGNRPDGIGT VTVEEKERFE 
    EIKERLRVLL ENQITHFRYC FPFGRPEGAL KATLSLLERV LMKDIVTPVP QEEVKTVIRK 
    CLEQAALVNY SRLSEYAKIE ENQKDAENVG RLITPAKKLE DTIRLAELVI EVLQQNEEHH 
    AEPHVDKGEA FAWWSDLMVE HAETFLSLFA VDMDAALEVQ PPDTWDSFPL FQLLNDFLRT 
    DYNLCNGKFH KHLQDLFAPL VVRYVDLMES SIAQSIHRGF ERESWEPVKS LTSNLPNVNL 
    PNVNLPKVPN LPVNIPLGIP QMPTFSAPSW MAAIYDADNG SGTSEDLFWK LDALQTFIRD 
    LHWPEEEFGK HLEQRLKLMA SDMIESCVKR TRIAFEVKLQ KTSRSTDFRV PQSICTMFNV 
    MVDAKAQSTK LCSMEMGQEH QYHSKIDELI EETVKEMITL LVAKFVTILE GVLAKLSRYD 
    EGTLFSSFLS FTVKAASKYV DVPKPGMDVA DAYVTFVRHS QDVLRDKVNE EMYIERLFDQ 
    WYNSSMNVIC TWLTDRMDLQ LHIYQLKTLI RMVKKTYRDF RLQGVLDSTL NSKTYETIRN 
    RLTVEEATAS VSEGGGLQGI SMKDSDEEDE EDD

Genular Protein ID: 2553662250

Symbol: F1T0E5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

Sequence Information:

  • Length: 1344
  • Mass: 152001
  • Checksum: 1E3800FA8B52B046
  • Sequence:
  • MLDPSSSEEE SDEIVEEESG KEVLGSAPSG ARLSPSRTSE GSAGSAGLGG GGAGAGAGVG 
    AGGGGGSGAS SGGGAGGLQP SSRAGGGRPS SPSPSVVSEK EKEELERLQK EEEERKKRLQ 
    LYVFVMRCIA YPFNAKQPTD MARRQQKISK QQLQTVKDRF QAFLNGETQI MADEAFMNAV 
    QSYYEVFLKS DRVARMVQSG GCSANDSREV FKKHIEKRVR SLPEIDGLSK ETVLSSWMAK 
    FDAIYRGEED PRKQQARMTA SAASELILSK EQLYEMFQNI LGIKKFEHQL LYNACQLDNP 
    DEQAAQIRRE LDGRLQMADQ IARERKFPKF VSKEMENMYI EELKSSVNLL MANLESMPVS 
    KGGEFKLQKL KRSHNASIID MGEESENQLS KSDVVLSFSL EVVIMEVQGL KSLAPNRIVY 
    CTMEVEGGEK LQTDQAEASK PTWGTQGDFS TTHALPAVKV KLFTESTGVL ALEDKELGRV 
    ILHPTPNSPK QSEWHKMTVS KNCPDQDLKI KLAVRMDKPQ NMKHSGYLWA IGKNVWKRWK 
    KRFFVLVQVS QYTFAMCSYR EKKAEPQELL QLDGYTVDYT DPQPGLEGGR AFFNAVKEGD 
    TVIFASDDEQ DRILWVQAMY RATGQSHKPV PPTQVQKLNA KGGNVPQLDA PISQFYADRA 
    QKHGMDEFIS SNPCNFDHAS LFEMVQRLTL DHRLNDSYSC LGWFSPGQVF VLDEYCARNG 
    VRGCHRHLCY LRDLLERAEN GAMIDPTLLH YSFAFCASHV HGNSQQMHVY LSGLPPNTDP 
    EGSKTPSPPE PEAKKDTKKE SKKRKDSKTQ ANQELKRPDG IGTVTVEEKE RFEEIKERLR 
    VLLENQITHF RYCFPFGRPE GALKATLSLL ERVLMKDIVT PVPQEEVKTV IRKCLEQAAL 
    VNYSRLSEYA KIEENVGRLI TPAKKLEDTI RLAELVIEVL QQNEEHHAEA FAWWSDLMVE 
    HAETFLSLFA VDMDAALEVQ PPDTWDSFPL FQLLNDFLRT DYNLCNGKFH KHLQDLFAPL 
    VVRYVDLMES SIAQSIHRGF ERESWEPVNN GSGTSEDLFW KLDALQTFIR DLHWPEEEFG 
    KHLEQRLKLM ASDMIESCVK RTRIAFEVKL QKTSRSTDFR VPQSICTMFN VMVDAKAQST 
    KLCSMEMGQE HQYHSKIDEL IEETVKEMIT LLVAKFVTIL EGVLAKLSRY DEGTLFSSFL 
    SFTVKAASKY VDVPKPGMDV ADAYVTFVRH SQDVLRDKVN EEMYIERLFD QWYNSSMNVI 
    CTWLTDRMDL QLHIYQLKTL IRMVKKTYRD FRLQGVLDST LNSKTYETIR NRLTVEEATA 
    SVSEGGGLQG ISMKDSDEED EEDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.