Details for: SRP14

Gene ID: 6727

Symbol: SRP14

Ensembl ID: ENSG00000140319

Description: signal recognition particle 14

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1051.5270
    Cell Significance Index: -163.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 635.4197
    Cell Significance Index: -161.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 499.9908
    Cell Significance Index: -205.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 423.5976
    Cell Significance Index: -199.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 386.5780
    Cell Significance Index: -198.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 299.3418
    Cell Significance Index: -200.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 155.4557
    Cell Significance Index: -191.6700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 52.5361
    Cell Significance Index: -207.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 45.9294
    Cell Significance Index: -141.0700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.9934
    Cell Significance Index: -99.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 33.8940
    Cell Significance Index: -74.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 8.7458
    Cell Significance Index: 229.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 6.8844
    Cell Significance Index: 239.2300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 6.5499
    Cell Significance Index: 74.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.2112
    Cell Significance Index: 326.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 6.0331
    Cell Significance Index: 283.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.9892
    Cell Significance Index: 822.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 5.6515
    Cell Significance Index: 130.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.4231
    Cell Significance Index: 666.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.3850
    Cell Significance Index: 401.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 5.3264
    Cell Significance Index: 94.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.2428
    Cell Significance Index: 672.1000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.2043
    Cell Significance Index: 108.9400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.1709
    Cell Significance Index: 932.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.0587
    Cell Significance Index: 145.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 5.0415
    Cell Significance Index: 2753.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7835
    Cell Significance Index: 223.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.7395
    Cell Significance Index: 129.0100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.9447
    Cell Significance Index: 465.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.8113
    Cell Significance Index: 1685.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.7725
    Cell Significance Index: 243.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.6117
    Cell Significance Index: 466.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.0428
    Cell Significance Index: 28.0200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.0173
    Cell Significance Index: 88.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.9112
    Cell Significance Index: 205.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3897
    Cell Significance Index: 19.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.3390
    Cell Significance Index: 29.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.0078
    Cell Significance Index: 37.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.9108
    Cell Significance Index: 549.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.8865
    Cell Significance Index: 11.6100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.6778
    Cell Significance Index: 18.2400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.3362
    Cell Significance Index: 7.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3307
    Cell Significance Index: 131.6400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1843
    Cell Significance Index: 235.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9094
    Cell Significance Index: 47.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8838
    Cell Significance Index: 23.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8393
    Cell Significance Index: 143.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.7276
    Cell Significance Index: 533.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6953
    Cell Significance Index: 132.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6498
    Cell Significance Index: 491.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5065
    Cell Significance Index: 101.6100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2581
    Cell Significance Index: 92.5800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2110
    Cell Significance Index: 13.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.2011
    Cell Significance Index: 15.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1730
    Cell Significance Index: 2.9000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0132
    Cell Significance Index: -2.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0243
    Cell Significance Index: -45.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0713
    Cell Significance Index: -52.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0770
    Cell Significance Index: -7.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1064
    Cell Significance Index: -196.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1185
    Cell Significance Index: -182.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1509
    Cell Significance Index: -205.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1548
    Cell Significance Index: -96.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2113
    Cell Significance Index: -134.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2522
    Cell Significance Index: -142.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.2940
    Cell Significance Index: -203.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3645
    Cell Significance Index: -165.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3718
    Cell Significance Index: -78.3200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4619
    Cell Significance Index: -3.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8351
    Cell Significance Index: -95.6800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8741
    Cell Significance Index: -22.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9973
    Cell Significance Index: -113.8500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1264
    Cell Significance Index: -131.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1299
    Cell Significance Index: -164.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.4475
    Cell Significance Index: -65.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.6308
    Cell Significance Index: -112.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.8539
    Cell Significance Index: -40.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.9359
    Cell Significance Index: -62.0100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.9519
    Cell Significance Index: -33.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.9608
    Cell Significance Index: -204.1700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.0296
    Cell Significance Index: -54.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.0904
    Cell Significance Index: -117.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.0981
    Cell Significance Index: -73.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.1087
    Cell Significance Index: -129.6100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.1147
    Cell Significance Index: -59.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.4037
    Cell Significance Index: -184.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.4151
    Cell Significance Index: -162.3900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.4198
    Cell Significance Index: -14.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.5162
    Cell Significance Index: -34.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.6068
    Cell Significance Index: -39.0600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.6705
    Cell Significance Index: -160.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.8170
    Cell Significance Index: -33.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.2493
    Cell Significance Index: -199.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.5533
    Cell Significance Index: -104.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.7290
    Cell Significance Index: -107.4400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -3.8628
    Cell Significance Index: -66.5900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -4.1508
    Cell Significance Index: -183.6000
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -4.7120
    Cell Significance Index: -39.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -4.7805
    Cell Significance Index: -122.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -4.7961
    Cell Significance Index: -176.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SRP14 is a 14-kDa protein that belongs to the signal recognition particle (SRP) family. SRP14 is a component of the SRP complex, which recognizes and binds to the signal sequence of proteins destined for the ER. The SRP complex is composed of three subunits: SRP54, SRP68, and SRP14, which form a heterotrimeric complex. SRP14 is unique in its ability to bind to the 7S RNA, a small RNA molecule that plays a crucial role in the recognition of the signal sequence. **Pathways and Functions:** SRP14 plays a pivotal role in the cotranslational targeting of proteins to the ER. The SRP complex recognizes the signal sequence of proteins at the ribosome and facilitates their targeting to the ER. Once bound to the ER, SRP14 acts as a chaperone, helping to unfold and refold the protein, ensuring proper folding and assembly. In addition to its role in protein targeting, SRP14 has been implicated in the regulation of immune responses. Its expression is upregulated in immune cells, such as mature T cells, and it has been shown to interact with other immune-related proteins, including Ficolin-1. SRP14 has also been implicated in the regulation of neutrophil degranulation, a process critical for the clearance of pathogens. **Clinical Significance:** Dysregulation of SRP14 has been implicated in various diseases, including autoimmune disorders and cancer. For example, alterations in SRP14 expression have been observed in patients with rheumatoid arthritis and lupus. Furthermore, SRP14 has been shown to interact with other proteins involved in cancer progression, including those involved in the regulation of cell growth and apoptosis. In conclusion, SRP14 is a multifunctional protein that plays a critical role in the endoplasmic reticulum targeting of proteins and the regulation of immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying SRP14 function and its role in human disease. **Future Directions:** Future research should focus on the molecular mechanisms underlying SRP14 function, including its interactions with other proteins and its role in the regulation of immune responses. Additionally, the clinical significance of SRP14 dysregulation should be further explored, with a focus on developing novel therapeutic strategies for diseases associated with SRP14 dysfunction. In summary, SRP14 is a critical protein that plays a pivotal role in the endoplasmic reticulum targeting of proteins and the regulation of immune responses. Further research into the mechanisms underlying SRP14 function and its role in human disease will be essential for the development of novel therapeutic strategies and a deeper understanding of the complex relationships between SRP14 and the immune system.

Genular Protein ID: 3787667003

Symbol: SRP14_HUMAN

Name: Signal recognition particle 14 kDa protein

UniProtKB Accession Codes:

P37108 B5BUF5 Q6B0K5 Q96Q14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7542942

Title: The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs.

PubMed ID: 7542942

DOI: 10.1091/mbc.6.4.471

PubMed ID: 8196634

Title: A human Alu RNA-binding protein whose expression is associated with accumulation of small cytoplasmic Alu RNA.

PubMed ID: 8196634

DOI: 10.1128/mcb.14.6.3949-3959.1994

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11089964

Title: Structure and assembly of the Alu domain of the mammalian signal recognition particle.

PubMed ID: 11089964

DOI: 10.1038/35041507

PubMed ID: 34020957

Title: Receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.

PubMed ID: 34020957

DOI: 10.1126/sciadv.abg0942

Sequence Information:

  • Length: 136
  • Mass: 14570
  • Checksum: 2B5B2D1D62AF5E8E
  • Sequence:
    • MVLLESEQFL TELTRLFQKC RTSGSVYITL KKYDGRTKPI PKKGTVEGFE PADNKCLLRA 
TDGKKKISTV VSSKEVNKFQ MAYSNLLRAN MDGLKKRDKK NKTKKTKAAA AAAAAAPAAA 
ATAPTTAATT AATAAQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.