ELOB | ENSG00000103363 | NCBI 6923

Details for: ELOB

Gene ID: 6923

Symbol: ELOB

Ensembl ID: ENSG00000103363

Description: elongin B

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Axon guidance
(R-HSA-422475)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Evasion by rsv of host interferon responses
(R-HSA-9833109)
Formation of hiv-1 elongation complex containing hiv-1 tat
(R-HSA-167200)
Formation of hiv elongation complex in the absence of hiv tat
(R-HSA-167152)
Formation of rna pol ii elongation complex
(R-HSA-112382)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hiv elongation arrest and recovery
(R-HSA-167287)
Hiv infection
(R-HSA-162906)
Hiv life cycle
(R-HSA-162587)
Hiv transcription elongation
(R-HSA-167169)
Host interactions of hiv factors
(R-HSA-162909)
Immune system
(R-HSA-168256)
Inactivation of csf3 (g-csf) signaling
(R-HSA-9705462)
Infectious disease
(R-HSA-5663205)
Late phase of hiv life cycle
(R-HSA-162599)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pausing and recovery of hiv elongation
(R-HSA-167290)
Pausing and recovery of tat-mediated hiv elongation
(R-HSA-167238)
Post-translational protein modification
(R-HSA-597592)
Regulation of expression of slits and robos
(R-HSA-9010553)
Respiratory syncytial virus infection pathway
(R-HSA-9820952)
Rna polymerase ii pre-transcription events
(R-HSA-674695)
Rna polymerase ii transcription
(R-HSA-73857)
Rna polymerase ii transcription elongation
(R-HSA-75955)
Rsv-host interactions
(R-HSA-9833110)
Signaling by csf3 (g-csf)
(R-HSA-9674555)
Signaling by robo receptors
(R-HSA-376176)
Tat-mediated elongation of the hiv-1 transcript
(R-HSA-167246)
Tat-mediated hiv elongation arrest and recovery
(R-HSA-167243)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Transcriptional regulation by tp53
(R-HSA-3700989)
Transcription of the hiv genome
(R-HSA-167172)
Vif-mediated degradation of apobec3g
(R-HSA-180585)
Viral infection pathways
(R-HSA-9824446)
Cul2-ring ubiquitin ligase complex
(GO:0031462)
Cul5-ring ubiquitin ligase complex
(GO:0031466)
Cytosol
(GO:0005829)
Elongin complex
(GO:0070449)
Nucleoplasm
(GO:0005654)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Target-directed mirna degradation
(GO:0140958)
Transcription corepressor binding
(GO:0001222)
Transcription elongation by rna polymerase ii
(GO:0006368)
Transcription initiation at rna polymerase ii promoter
(GO:0006367)
Ubiquitin protein ligase binding
(GO:0031625)
Vcb complex
(GO:0030891)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: embryonic stem cell (CL0002322)
Fold Change: 383.8595
Cell Significance Index: -158.1300
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 328.4250
Cell Significance Index: -133.4300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 319.9169
Cell Significance Index: -151.0400
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 289.0149
Cell Significance Index: -148.6700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 225.9687
Cell Significance Index: -151.6300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 141.4307
Cell Significance Index: -135.0300
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 35.5935
Cell Significance Index: -95.3500
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 34.9997
Cell Significance Index: -107.5000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 20.2551
Cell Significance Index: -44.3300
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 8.4970
Cell Significance Index: 396.1700
Cell Name: peg cell (CL4033014)
Fold Change: 6.5932
Cell Significance Index: 152.3300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 5.7879
Cell Significance Index: 106.9800
Cell Name: granulosa cell (CL0000501)
Fold Change: 4.6134
Cell Significance Index: 121.3100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.5756
Cell Significance Index: 628.3600
Cell Name: cell in vitro (CL0001034)
Fold Change: 4.5216
Cell Significance Index: 2469.3600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.1024
Cell Significance Index: 739.5300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 4.0035
Cell Significance Index: 83.8000
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 3.9646
Cell Significance Index: 487.4900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.5336
Cell Significance Index: 185.5300
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 3.2372
Cell Significance Index: 381.7600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 3.0569
Cell Significance Index: 227.8300
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 2.9556
Cell Significance Index: 79.0600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 2.9286
Cell Significance Index: 137.6400
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.8987
Cell Significance Index: 32.9300
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.8806
Cell Significance Index: 1273.6000
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.7196
Cell Significance Index: 192.3400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.7113
Cell Significance Index: 73.8000
Cell Name: kidney cell (CL1000497)
Fold Change: 2.6815
Cell Significance Index: 21.4100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.5605
Cell Significance Index: 75.2000
Cell Name: lactocyte (CL0002325)
Fold Change: 2.5200
Cell Significance Index: 325.5700
Cell Name: odontoblast (CL0000060)
Fold Change: 2.2609
Cell Significance Index: 289.8300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.1458
Cell Significance Index: 19.7600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.1363
Cell Significance Index: 137.8300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.0544
Cell Significance Index: 59.1900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.0065
Cell Significance Index: 90.9500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.9798
Cell Significance Index: 321.9900
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.3135
Cell Significance Index: 14.2800
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1285
Cell Significance Index: 58.6200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.7767
Cell Significance Index: 26.9900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.7689
Cell Significance Index: 131.3000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.4804
Cell Significance Index: 363.6000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.4560
Cell Significance Index: 5.8400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.4289
Cell Significance Index: 12.3000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.3570
Cell Significance Index: 261.7300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3349
Cell Significance Index: 63.7400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.2550
Cell Significance Index: 51.1600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1933
Cell Significance Index: 19.1200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1401
Cell Significance Index: 8.4100
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0941
Cell Significance Index: 1.5800
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0894
Cell Significance Index: 1.3400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0427
Cell Significance Index: 1.1400
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0227
Cell Significance Index: 1.1800
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0059
Cell Significance Index: 2.1000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0308
Cell Significance Index: -6.1200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0414
Cell Significance Index: -4.2300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0491
Cell Significance Index: -92.5400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0995
Cell Significance Index: -183.5500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.1189
Cell Significance Index: -182.9800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1390
Cell Significance Index: -189.0200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1578
Cell Significance Index: -116.8900
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1692
Cell Significance Index: -8.5500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1826
Cell Significance Index: -115.9600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2009
Cell Significance Index: -12.6600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.2144
Cell Significance Index: -148.3200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.2362
Cell Significance Index: -133.1900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2618
Cell Significance Index: -9.2000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2757
Cell Significance Index: -125.1400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.3295
Cell Significance Index: -205.7600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3470
Cell Significance Index: -14.2200
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4399
Cell Significance Index: -126.5800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4578
Cell Significance Index: -36.2600
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5799
Cell Significance Index: -66.4400
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.7447
Cell Significance Index: -13.1600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.8180
Cell Significance Index: -172.3000
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.9088
Cell Significance Index: -132.1000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.9285
Cell Significance Index: -108.2100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.9450
Cell Significance Index: -26.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.9947
Cell Significance Index: -21.5500
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.0264
Cell Significance Index: -26.2200
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -1.0972
Cell Significance Index: -67.4400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.1399
Cell Significance Index: -36.5100
Cell Name: Sertoli cell (CL0000216)
Fold Change: -1.3553
Cell Significance Index: -19.0100
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.4331
Cell Significance Index: -149.2200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.9082
Cell Significance Index: -146.4400
Cell Name: seromucus secreting cell (CL0000159)
Fold Change: -1.9208
Cell Significance Index: -40.0600
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.9556
Cell Significance Index: -109.7400
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.9780
Cell Significance Index: -133.0000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.0476
Cell Significance Index: -35.0900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.0500
Cell Significance Index: -27.9700
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -2.4416
Cell Significance Index: -42.0900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.4743
Cell Significance Index: -151.7000
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -2.5274
Cell Significance Index: -21.2300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.6112
Cell Significance Index: -76.9100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -3.2621
Cell Significance Index: -144.2900
Cell Name: retinal rod cell (CL0000604)
Fold Change: -3.2834
Cell Significance Index: -39.1400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -3.4318
Cell Significance Index: -125.9800
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -3.6330
Cell Significance Index: -21.9500
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -3.8368
Cell Significance Index: -145.2900
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -3.9290
Cell Significance Index: -24.1800
Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -4.0270
Cell Significance Index: -31.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The ELOB gene is a member of the elongin family of proteins, which are known to interact with other proteins to regulate ubiquitination and degradation processes. The Elongin B protein is a key component of the Elongin complex, which consists of three subunits: Elongin A, Elongin B, and CUL4. The Elongin complex is involved in the ubiquitination and degradation of target proteins, including histones, transcription factors, and other regulatory proteins. **Pathways and Functions** The ELOB gene is involved in various cellular pathways, including: 1. **Adaptive Immune System**: The ELOB gene is expressed in immune cells, such as CD8-positive T cells and classical monocytes, and plays a crucial role in the regulation of immune responses, including T cell activation and cytokine production. 2. **Antigen Processing and Presentation**: The ELOB gene is involved in the regulation of antigen processing and presentation, including the ubiquitination and degradation of MHC class I molecules. 3. **Cellular Responses to Stimuli**: The ELOB gene is involved in the regulation of cellular responses to stimuli, including stress, hypoxia, and cytokine signaling. 4. **Cytokine Signaling**: The ELOB gene is involved in the regulation of cytokine signaling, including the ubiquitination and degradation of cytokine receptors. **Clinical Significance** The ELOB gene has been implicated in various diseases, including: 1. **Cancer**: The ELOB gene is overexpressed in certain types of cancer, including breast cancer and lung cancer, and is associated with poor prognosis. 2. **Autoimmune Diseases**: The ELOB gene is involved in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious Diseases**: The ELOB gene is involved in the regulation of immune responses to infectious diseases, such as HIV and tuberculosis. 4. **Neurological Disorders**: The ELOB gene is involved in the regulation of immune responses in neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, the ELOB gene is a critical component in the regulation of gene expression and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Elongin 18 kDa subunit
A0A384MDL3_HUMAN

Genular Protein ID: 2125149385

Symbol: ELOB_HUMAN

Name: Elongin 18 kDa subunit

UniProtKB Accession Codes:

Q15370 B7WPD3

Database IDs:

Citations:

PubMed ID: 7638163

Title: Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog.

PubMed ID: 7638163

DOI: 10.1073/pnas.92.16.7172

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11006129

Title: Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity.

PubMed ID: 11006129

DOI: 10.1006/bbrc.2000.3451

PubMed ID: 15574592

Title: Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation.

PubMed ID: 15574592

DOI: 10.1101/gad.1249904

PubMed ID: 17189197

Title: Structural basis for protein recognition by B30.2/SPRY domains.

PubMed ID: 17189197

DOI: 10.1016/j.molcel.2006.11.009

PubMed ID: 15590694

Title: Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.

PubMed ID: 15590694

DOI: 10.1074/jbc.m408575200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19920177

Title: Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation.

PubMed ID: 19920177

DOI: 10.1073/pnas.0907052106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21119685

Title: Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.

PubMed ID: 21119685

DOI: 10.1038/cr.2010.165

PubMed ID: 21697472

Title: Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.

PubMed ID: 21697472

DOI: 10.1128/jvi.00733-11

PubMed ID: 20532212

Title: The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex.

PubMed ID: 20532212

DOI: 10.1371/journal.ppat.1000925

PubMed ID: 22190037

Title: Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection.

PubMed ID: 22190037

DOI: 10.1038/nature10693

PubMed ID: 22510880

Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

PubMed ID: 22510880

DOI: 10.1038/emboj.2012.91

PubMed ID: 23102700

Title: The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5.

PubMed ID: 23102700

DOI: 10.1016/j.molcel.2012.09.018

PubMed ID: 22286099

Title: The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

PubMed ID: 22286099

DOI: 10.1038/ncb2424

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24337577

Title: Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase.

PubMed ID: 24337577

DOI: 10.1074/jbc.m113.534602

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26041281

Title: Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation.

PubMed ID: 26041281

DOI: 10.1128/jvi.00799-15

PubMed ID: 21980433

Title: The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.

PubMed ID: 21980433

DOI: 10.1371/journal.pone.0025358

PubMed ID: 25505247

Title: Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).

PubMed ID: 25505247

DOI: 10.1074/jbc.m114.616664

PubMed ID: 26138980

Title: SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

PubMed ID: 26138980

DOI: 10.1126/science.aab0515

PubMed ID: 26906416

Title: Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.

PubMed ID: 26906416

DOI: 10.1242/jcs.181784

PubMed ID: 29779948

Title: The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons.

PubMed ID: 29779948

DOI: 10.1016/j.cell.2018.04.028

PubMed ID: 29775578

Title: C-terminal end-directed protein elimination by CRL2 ubiquitin ligases.

PubMed ID: 29775578

DOI: 10.1016/j.molcel.2018.04.006

PubMed ID: 31387940

Title: BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.

PubMed ID: 31387940

DOI: 10.1083/jcb.201901156

PubMed ID: 33268465

Title: The mechanism of NEDD8 activation of CUL5 Ubiquitin E3 ligases.

PubMed ID: 33268465

DOI: 10.1074/mcp.ra120.002414

PubMed ID: 35486881

Title: Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins.

PubMed ID: 35486881

DOI: 10.1021/acs.biochem.2c00130

PubMed ID: 10205047

Title: Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.

PubMed ID: 10205047

DOI: 10.1126/science.284.5413.455

PubMed ID: 12050673

Title: Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.

PubMed ID: 12050673

DOI: 10.1038/nature00767

PubMed ID: 12004076

Title: Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling.

PubMed ID: 12004076

DOI: 10.1126/science.1073440

PubMed ID: 17997974

Title: Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation.

PubMed ID: 17997974

DOI: 10.1016/j.str.2007.09.016

PubMed ID: 18562529

Title: Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly.

PubMed ID: 18562529

DOI: 10.1128/jvi.00767-08

PubMed ID: 23837592

Title: Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.

PubMed ID: 23837592

DOI: 10.1021/bi400758h

PubMed ID: 24225024

Title: Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.

PubMed ID: 24225024

DOI: 10.1098/rsob.130100

PubMed ID: 24402281

Title: Structural basis for hijacking CBF-beta and CUL5 E3 ligase complex by HIV-1 Vif.

PubMed ID: 24402281

DOI: 10.1038/nature12884

PubMed ID: 31182716

Title: Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase.

PubMed ID: 31182716

DOI: 10.1038/s41467-019-10190-4

PubMed ID: 32513959

Title: Structure and dynamics of the ASB9 CUL-RING E3 ligase.

PubMed ID: 32513959

DOI: 10.1038/s41467-020-16499-9

PubMed ID: 34857742

Title: Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.

PubMed ID: 34857742

DOI: 10.1038/s41467-021-26983-5

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 36754086

Title: The structural basis for HIV-1 Vif antagonism of human APOBEC3G.

PubMed ID: 36754086

DOI: 10.1038/s41586-023-05779-1

PubMed ID: 37816714

Title: Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.

PubMed ID: 37816714

DOI: 10.1038/s41467-023-41894-3

PubMed ID: 37640699

Title: Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.

PubMed ID: 37640699

DOI: 10.1038/s41467-023-40955-x

PubMed ID: 38418882

Title: The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.

PubMed ID: 38418882

DOI: 10.1038/s41586-024-07112-w

Sequence Information:

Length: 118
Mass: 13133
Checksum: C045F58FBED0EC47
Sequence:

MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC 
GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVQ

Genular Protein ID: 1136609304

Symbol: A0A384MDL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A384MDL3

Database IDs:

Sequence Information:

Length: 161
Mass: 17911
Checksum: 72277A4ACF21429F
Sequence:

MDVFLMIRRH KTTIFTDAKE SSTVFELKRI VEGILKRPPD EQRLYKDDQL LDDGKTLGEC 
GFTSQTARPQ APATVGLAFR ADDTFEALCI EPFSSPPELP DVMKPQDSGS SANEQAVHLH 
VHSQTMAKSR NTSWSQCPGL TACSTREPQD GPTQVHPRWG L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ELOB

Associated with

Cells (max top 100)

Other Information

Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. PubMed ID: 7638163

The sequence and analysis of duplication-rich human chromosome 16. PubMed ID: 15616553

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity. PubMed ID: 11006129

Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation. PubMed ID: 15574592

Structural basis for protein recognition by B30.2/SPRY domains. PubMed ID: 17189197

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. PubMed ID: 15590694

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation. PubMed ID: 19920177

Initial characterization of the human central proteome. PubMed ID: 21269460

Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. PubMed ID: 21119685

Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65. PubMed ID: 21697472

The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex. PubMed ID: 20532212

Vif hijacks CBF-beta to degrade APOBEC3G and promote HIV-1 infection. PubMed ID: 22190037

Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation. PubMed ID: 22510880

The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. PubMed ID: 23102700

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. PubMed ID: 22286099

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. PubMed ID: 24337577

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Poxvirus protein MC132 from molluscum contagiosum virus inhibits NF-B activation by targeting p65 for degradation. PubMed ID: 26041281

The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels. PubMed ID: 21980433

Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). PubMed ID: 25505247

SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding. PubMed ID: 26138980

Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. PubMed ID: 26906416

The eukaryotic proteome is shaped by E3 ubiquitin ligases targeting C-terminal degrons. PubMed ID: 29779948

C-terminal end-directed protein elimination by CRL2 ubiquitin ligases. PubMed ID: 29775578

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. PubMed ID: 31387940

The mechanism of NEDD8 activation of CUL5 Ubiquitin E3 ligases. PubMed ID: 33268465

Human Protein-l-isoaspartate O-Methyltransferase Domain-Containing Protein 1 (PCMTD1) Associates with Cullin-RING Ligase Proteins. PubMed ID: 35486881

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. PubMed ID: 10205047

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. PubMed ID: 12050673

Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. PubMed ID: 12004076

Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation. PubMed ID: 17997974

Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly. PubMed ID: 18562529

Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases. PubMed ID: 23837592

Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction. PubMed ID: 24225024

Structural basis for hijacking CBF-beta and CUL5 E3 ligase complex by HIV-1 Vif. PubMed ID: 24402281

Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase. PubMed ID: 31182716

Structure and dynamics of the ASB9 CUL-RING E3 ligase. PubMed ID: 32513959

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands. PubMed ID: 34857742

A conserved mechanism for regulating replisome disassembly in eukaryotes. PubMed ID: 34700328

The structural basis for HIV-1 Vif antagonism of human APOBEC3G. PubMed ID: 36754086

Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2. PubMed ID: 37816714

Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H. PubMed ID: 37640699

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation. PubMed ID: 38418882