Details for: TMBIM6
Gene ID: 7009
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: TMBIM6
Ensembl ID: ENSG00000139644
Description: transmembrane BAX inhibitor motif containing 6
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 106.59rCSI 83.85%PRS 3.42
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CSI 106.08rCSI 100%PRS 2.43
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CSI 94.78rCSI 91.24%PRS 3.01
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CSI 92.53rCSI 100%PRS 2.09
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CSI 91.26rCSI 70.75%PRS 2.74
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CSI 91.16rCSI 95.5%PRS 3.11
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CSI 91.14rCSI 80.14%PRS 2.09
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CSI 89.16rCSI 93.4%PRS 2.69
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CSI 89.02rCSI 68.59%PRS 2.6
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CSI 86.54rCSI 79.46%PRS 3.28
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CSI 83.61rCSI 87.39%PRS 3.08
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CSI 82.01rCSI 87.14%PRS 5.23
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CSI 79.48rCSI 92.18%PRS 4.31
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CSI 77.76rCSI 64.47%PRS 2.7
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CSI 75.96rCSI 63.67%PRS 3.47
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CSI 74.55rCSI 49.55%PRS 3.43
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CSI 73.97rCSI 91.51%PRS 2.53
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CSI 73.34rCSI 70.71%PRS 1.18
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CSI 72.61rCSI 75.76%PRS 2.95
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CSI 71.54rCSI 57.84%PRS 2.82
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CSI 71.24rCSI 70.07%PRS 3.19
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CSI 68.59rCSI 47.89%PRS 3.03
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CSI 68.02rCSI 79.89%PRS 3.52
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CSI 67.1rCSI 61.9%PRS 2.92
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CSI 66.45rCSI 58.98%PRS 2.89
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CSI 66.37rCSI 97.1%PRS 3.05
-
CSI 65.78rCSI 56.96%PRS 3.22
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CSI 65.46rCSI 61.85%PRS 3.01
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CSI 62.31rCSI 41.53%PRS 8.18
-
CSI 59.92rCSI 86.36%PRS 4.7
-
CSI 58.27rCSI 85.36%PRS 3.41
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CSI 58.18rCSI 93.82%PRS 4.69
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CSI 58.17rCSI 77.32%PRS 3.16
-
CSI 57.37rCSI 38.65%PRS 3.5
-
CSI 56.75rCSI 81.35%PRS 4.05
-
CSI 56.73rCSI 74.35%PRS 15.74
-
CSI 56.33rCSI 86.04%PRS 2.92
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CSI 54.96rCSI 84.93%PRS 2.71
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CSI 54rCSI 47.43%PRS 3.22
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CSI 53.84rCSI 55.12%PRS 5.45
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CSI 53.65rCSI 48.45%PRS 2.53
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CSI 53.04rCSI 100%PRS 2.94
-
CSI 52.86rCSI 64.34%PRS 3.65
-
CSI 52.41rCSI 54.29%PRS 3.37
-
CSI 50.93rCSI 78.99%PRS 4.62
-
CSI 50.7rCSI 82.15%PRS 2.93
-
CSI 50.66rCSI 77.85%PRS 4.2
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CSI 50.53rCSI 43.56%PRS 4.82
-
CSI 50.01rCSI 37.58%PRS 2.96
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CSI 49.92rCSI 90.7%PRS 4.43
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CSI 49.83rCSI 53.4%PRS 2.65
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CSI 47.73rCSI 59.9%PRS 3.65
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CSI 47.54rCSI 37.58%PRS 2
-
CSI 45.81rCSI 58.75%PRS 3.33
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CSI 45.78rCSI 66.02%PRS 4
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CSI 45.6rCSI 37.05%PRS 3.02
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CSI 44.18rCSI 88.08%PRS 4.97
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CSI 44.1rCSI 72.64%PRS 3.33
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CSI 43.06rCSI 98.16%PRS 3.02
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CSI 42.85rCSI 80.89%PRS 3.59
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CSI 41.45rCSI 34.6%PRS 9.63
-
CSI 41.15rCSI 87.59%PRS 4.71
-
CSI 41.1rCSI 47.05%PRS 6.01
-
CSI 41.09rCSI 51.1%PRS 3.09
-
CSI 40.67rCSI 51.13%PRS 4.44
-
CSI 40.09rCSI 37.31%PRS 2.87
-
CSI 39.15rCSI 47.29%PRS 3.33
-
CSI 38.82rCSI 66.5%PRS 3.85
-
CSI 38.47rCSI 52.57%PRS 3.19
-
CSI 38.43rCSI 57.98%PRS 2.82
-
CSI 37.43rCSI 66.99%PRS 2.79
-
CSI 37.34rCSI 88.77%PRS 4.41
-
CSI 37.09rCSI 63.46%PRS 6.33
-
CSI 37.06rCSI 48.56%PRS 4.03
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CSI 37.02rCSI 81.95%PRS 2.71
-
CSI 36.96rCSI 37.67%PRS 4.19
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CSI 36.93rCSI 56.49%PRS 4.72
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CSI 36.87rCSI 70.38%PRS 7.14
-
CSI 36.7rCSI 50.18%PRS 5.24
-
CSI 36.37rCSI 28.88%PRS 5.13
-
CSI 35.87rCSI 53.18%PRS 33.95
-
CSI 35.73rCSI 78.01%PRS 5.92
-
CSI 35.11rCSI 56.27%PRS 9.63
-
CSI 33.88rCSI 54.04%PRS 2.54
-
CSI 33.78rCSI 81.05%PRS 5.52
-
CSI 33.46rCSI 78.53%PRS 5.2
-
CSI 33.28rCSI 24.65%PRS 2.73
-
CSI 32.58rCSI 47.78%PRS 3.82
-
CSI 32.48rCSI 51.59%PRS 3.78
-
CSI 31.85rCSI 38.16%PRS 5
-
CSI 31.73rCSI 26.28%PRS 2.88
-
CSI 31.62rCSI 45.8%PRS 4.23
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CSI 31.3rCSI 76.45%PRS 3.03
-
CSI 30.94rCSI 45.33%PRS 17.81
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CSI 30.62rCSI 72.66%PRS 3.88
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CSI 30.32rCSI 79.84%PRS 5.67
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CSI 30.22rCSI 47.72%PRS 2.89
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CSI 30.01rCSI 36.97%PRS 9.63
-
CSI 28.94rCSI 44.2%PRS 5.05
-
CSI 28.91rCSI 39.52%PRS 3.29
-
CSI -20.7rCSI -24.2%PRS 4.8%
-
CSI -18.2rCSI -36.6%PRS 2.2%
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CSI -15.5rCSI -27.3%PRS 3.9%
-
CSI -14.9rCSI -71.3%PRS 5.1%
-
CSI -14.1rCSI -26.4%PRS 2.3%
-
CSI -13.7rCSI -11.0%PRS 5.4%
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CSI -12.5rCSI -59.6%PRS 1.3%
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CSI -12.2rCSI -43.9%PRS 1.6%
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CSI -11.0rCSI -19.3%PRS 2.3%
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CSI -8.5rCSI -37.3%PRS 3.0%
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CSI -8.4rCSI -31.7%PRS 6.6%
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CSI -8.1rCSI -18.2%PRS 1.9%
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CSI -8.1rCSI -21.0%PRS 3.6%
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CSI -7.2rCSI -44.8%PRS 2.4%
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CSI -6.2rCSI -7.7%PRS 1.7%
-
CSI -6.2rCSI -7.4%PRS 1.8%
-
CSI -5.7rCSI -97.1%PRS 15.6%
-
CSI -5.1rCSI -4.9%PRS 6.3%
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CSI -5.0rCSI -20.1%PRS 14.4%
-
CSI -4.9rCSI -20.4%PRS 9.0%
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CSI -4.7rCSI -10.8%PRS 2.7%
-
CSI -4.1rCSI -30.2%PRS 1.3%
-
CSI -3.9rCSI -12.5%PRS 2.1%
-
CSI -3.8rCSI -40.5%PRS 36.8%
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CSI -3.8rCSI -19.5%PRS 1.6%
-
CSI -3.8rCSI -6.3%PRS 1.8%
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CSI -3.4rCSI -6.7%PRS 8.6%
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CSI -3.4rCSI -5.4%PRS 2.1%
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CSI -3.3rCSI -6.7%PRS 3.4%
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CSI -3.2rCSI -16.0%PRS 22.8%
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CSI -3.1rCSI -11.6%PRS 1.9%
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CSI -3.0rCSI -58.3%PRS 25.0%
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CSI -2.8rCSI -7.8%PRS 3.4%
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CSI -2.4rCSI -8.1%PRS 2.8%
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CSI -2.0rCSI -20.4%PRS 2.8%
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CSI -2.0rCSI -25.7%PRS 25.6%
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CSI -1.9rCSI -7.7%PRS 3.7%
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CSI -1.9rCSI -8.1%PRS 7.0%
-
CSI -1.8rCSI -5.7%PRS 2.1%
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CSI -1.4rCSI -2.5%PRS 4.1%
-
CSI -1.4rCSI -12.6%PRS 11.5%
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CSI -1.1rCSI -34.2%PRS 48.2%
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CSI -0.9rCSI -1.2%PRS 1.9%
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CSI -0.8rCSI -8.1%PRS 36.2%
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CSI -0.8rCSI -2.7%PRS 3.9%
-
CSI -0.5rCSI -13.0%PRS 1.3%
-
CSI -0.5rCSI -4.9%PRS 27.9%
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CSI -0.4rCSI -1.3%PRS 1.9%
-
CSI -0.4rCSI -1.0%PRS 10.7%
-
CSI -0.3rCSI -0.6%PRS 1.8%
-
CSI -0.3rCSI -0.7%PRS 1.1%
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CSI -0.3rCSI -3.4%PRS 33.3%
-
CSI -0.2rCSI -2.5%PRS 32.1%
-
CSI -0.1rCSI -0.3%PRS 1.6%
-
CSI 0.2rCSI 0.6%PRS 13.7%
-
CSI 0.4rCSI 1.2%PRS 5.1%
-
CSI 0.6rCSI 8.3%PRS 2.3%
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CSI 0.7rCSI 2.7%PRS 3.2%
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CSI 0.7rCSI 1.8%PRS 1.8%
-
CSI 0.8rCSI 4.9%PRS 4.5%
-
CSI 0.8rCSI 13.4%PRS 33.0%
-
CSI 0.9rCSI 4.9%PRS 17.2%
-
CSI 0.9rCSI 5.1%PRS 2.0%
-
CSI 0.9rCSI 3.9%PRS 12.0%
-
CSI 0.9rCSI 22.5%PRS 17.7%
-
CSI 0.9rCSI 5.3%PRS 4.7%
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CSI 1.0rCSI 1.5%PRS 2.7%
-
CSI 1.0rCSI 14.1%PRS 44.7%
-
CSI 1.0rCSI 5.9%PRS 6.1%
-
CSI 1.1rCSI 15.3%PRS 37.6%
-
CSI 1.1rCSI 2.3%PRS 7.1%
-
CSI 1.1rCSI 2.9%PRS 4.2%
-
CSI 1.2rCSI 15.4%PRS 19.1%
-
CSI 1.2rCSI 13.8%PRS 11.4%
-
CSI 1.2rCSI 1.8%PRS 2.5%
-
CSI 1.2rCSI 18.4%PRS 9.1%
-
CSI 1.3rCSI 5.3%PRS 3.4%
-
CSI 1.4rCSI 29.7%PRS 18.8%
-
CSI 1.5rCSI 16.4%PRS 39.7%
-
CSI 1.6rCSI 3.4%PRS 17.5%
-
CSI 1.6rCSI 37.4%PRS 21.8%
-
CSI 1.7rCSI 43.5%PRS 16.5%
-
CSI 1.7rCSI 13.5%PRS 34.6%
-
CSI 1.8rCSI 8.8%PRS 5.2%
-
CSI 1.9rCSI 21.0%PRS 21.0%
-
CSI 2.0rCSI 7.3%PRS 15.1%
-
CSI 2.1rCSI 43.1%PRS 26.8%
-
CSI 2.1rCSI 13.6%PRS 22.8%
-
CSI 2.1rCSI 12.3%PRS 16.6%
-
CSI 2.1rCSI 5.7%PRS 3.5%
-
CSI 2.2rCSI 13.0%PRS 6.5%
-
CSI 2.2rCSI 54.7%PRS 28.3%
-
CSI 2.2rCSI 16.1%PRS 38.3%
-
CSI 2.3rCSI 6.7%PRS 3.8%
-
CSI 2.3rCSI 54.0%PRS 15.8%
-
CSI 2.3rCSI 13.0%PRS 15.1%
-
CSI 2.4rCSI 2.1%PRS 3.9%
-
CSI 2.6rCSI 58.8%PRS 17.2%
-
CSI 2.6rCSI 7.5%PRS 2.6%
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CSI 2.6rCSI 49.7%PRS 26.6%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Comma-separated if multiple.
Comma-separated if multiple.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.
Genular Protein ID: 1132490018
Symbol: BI1_HUMAN
Name: Bax inhibitor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8530040
Title: Identification of a novel conserved human gene, TEGT.
PubMed ID: 8530040
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16541075
Title: The finished DNA sequence of human chromosome 12.
PubMed ID: 16541075
DOI: 10.1038/nature04569
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9660918
Title: Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.
PubMed ID: 9660918
PubMed ID: 21075086
Title: Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury.
PubMed ID: 21075086
PubMed ID: 22128171
Title: The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.
PubMed ID: 22128171
PubMed ID: 22418439
Title: Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.
PubMed ID: 22418439
Sequence Information:
- Length: 237
- Mass: 26538
- Checksum: 6567E73A1AD6238E
- Sequence:
MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHMV THFIQAGLLS ALGSLILMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG PALEFCIAVN PSILPTAFMG TAMIFTCFTL SALYARRRSY LFLGGILMSA LSLLLLSSLG NVFFGSIWLF QANLYVGLVV MCGFVLFDTQ LIIEKAEHGD QDYIWHCIDL FLDFITVFRK LMMILAMNEK DKKKEKK