Details for: TMBIM6

Gene ID: 7009

Symbol: TMBIM6

Ensembl ID: ENSG00000139644

Description: transmembrane BAX inhibitor motif containing 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 802.7569
    Cell Significance Index: -124.8700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 505.8677
    Cell Significance Index: -128.3100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 362.9102
    Cell Significance Index: -149.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 324.8435
    Cell Significance Index: -131.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 309.4747
    Cell Significance Index: -146.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 283.4840
    Cell Significance Index: -145.8200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 219.0017
    Cell Significance Index: -146.9600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 139.1893
    Cell Significance Index: -132.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 113.5686
    Cell Significance Index: -140.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 39.2973
    Cell Significance Index: -120.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 37.3614
    Cell Significance Index: -147.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 31.9240
    Cell Significance Index: -85.5200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.6225
    Cell Significance Index: -51.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 8.0137
    Cell Significance Index: 373.6400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 6.0237
    Cell Significance Index: 55.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8617
    Cell Significance Index: 159.5500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.8233
    Cell Significance Index: 273.6900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.6449
    Cell Significance Index: 34.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.9866
    Cell Significance Index: 898.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.5726
    Cell Significance Index: 340.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.5200
    Cell Significance Index: 129.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.5013
    Cell Significance Index: 553.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.0988
    Cell Significance Index: 2238.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.2646
    Cell Significance Index: 170.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.2214
    Cell Significance Index: 442.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8550
    Cell Significance Index: 368.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.7683
    Cell Significance Index: 354.8800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4423
    Cell Significance Index: 126.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.0459
    Cell Significance Index: 202.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9543
    Cell Significance Index: 864.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.8785
    Cell Significance Index: 34.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.8523
    Cell Significance Index: 49.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.8036
    Cell Significance Index: 307.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7489
    Cell Significance Index: 347.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6559
    Cell Significance Index: 117.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6374
    Cell Significance Index: 37.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.6347
    Cell Significance Index: 42.9900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6048
    Cell Significance Index: 47.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5528
    Cell Significance Index: 53.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4009
    Cell Significance Index: 165.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3591
    Cell Significance Index: 87.6800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2335
    Cell Significance Index: 247.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.9811
    Cell Significance Index: 111.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8797
    Cell Significance Index: 167.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8251
    Cell Significance Index: 295.9500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7542
    Cell Significance Index: 39.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7009
    Cell Significance Index: 20.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6983
    Cell Significance Index: 31.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5054
    Cell Significance Index: 382.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3746
    Cell Significance Index: 6.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3255
    Cell Significance Index: 238.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2687
    Cell Significance Index: 43.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1110
    Cell Significance Index: 2.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0340
    Cell Significance Index: 64.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0254
    Cell Significance Index: -0.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0558
    Cell Significance Index: -41.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0645
    Cell Significance Index: -3.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0825
    Cell Significance Index: -152.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0920
    Cell Significance Index: -141.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1173
    Cell Significance Index: -74.5100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1206
    Cell Significance Index: -1.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1207
    Cell Significance Index: -164.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1223
    Cell Significance Index: -76.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1655
    Cell Significance Index: -2.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1705
    Cell Significance Index: -96.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2208
    Cell Significance Index: -100.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2844
    Cell Significance Index: -59.9000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3980
    Cell Significance Index: -8.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4241
    Cell Significance Index: -122.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4644
    Cell Significance Index: -16.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5425
    Cell Significance Index: -34.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5581
    Cell Significance Index: -63.9400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5946
    Cell Significance Index: -8.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6851
    Cell Significance Index: -99.5900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.8053
    Cell Significance Index: -6.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8296
    Cell Significance Index: -55.7800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8363
    Cell Significance Index: -97.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8712
    Cell Significance Index: -53.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0210
    Cell Significance Index: -13.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -1.0307
    Cell Significance Index: -112.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2498
    Cell Significance Index: -40.0300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3651
    Cell Significance Index: -104.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.3719
    Cell Significance Index: -23.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3851
    Cell Significance Index: -144.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4497
    Cell Significance Index: -114.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.7050
    Cell Significance Index: -25.1700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.7130
    Cell Significance Index: -20.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7171
    Cell Significance Index: -36.5700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.7396
    Cell Significance Index: -36.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.7443
    Cell Significance Index: -37.7900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.7822
    Cell Significance Index: -44.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8873
    Cell Significance Index: -48.2200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.0255
    Cell Significance Index: -25.9400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.3518
    Cell Significance Index: -62.9100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.3887
    Cell Significance Index: -146.4500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -2.6782
    Cell Significance Index: -52.2700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.9305
    Cell Significance Index: -148.1000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.9357
    Cell Significance Index: -50.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.0400
    Cell Significance Index: -89.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein:** TMBIM6 is a transmembrane protein, suggesting its involvement in cell-cell interactions and signaling. 2. **BAX inhibitor motif:** The protein contains a BAX inhibitor motif, which is a conserved sequence that inhibits the pro-apoptotic activity of BAX. 3. **Negative regulation of apoptosis:** TMBIM6 is a negative regulator of apoptosis, suggesting its role in promoting cell survival. 4. **Expression in various cell types:** The gene is expressed in a wide range of cell types, including thyroid follicular cells, hepatoblasts, and T cells. **Pathways and Functions:** 1. **Autophagy:** TMBIM6 has been shown to regulate autophagy, a cellular process that involves the degradation and recycling of cellular components. 2. **Cellular response to unfolded protein:** The protein is involved in the response to unfolded protein, a process that is critical for maintaining protein homeostasis. 3. **Endoplasmic reticulum calcium ion homeostasis:** TMBIM6 regulates the transport of calcium ions into the cytosol, which is essential for maintaining cellular calcium homeostasis. 4. **Negative regulation of apoptotic signaling pathway:** The protein is a negative regulator of the apoptotic signaling pathway, which is critical for promoting cell survival. 5. **Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway:** TMBIM6 has been shown to regulate the response to endoplasmic reticulum stress, a process that is critical for maintaining cellular homeostasis. **Clinical Significance:** 1. **Cancer:** Dysregulation of TMBIM6 has been implicated in various cancers, including breast cancer and lung cancer. 2. **Neurodegenerative disorders:** The protein has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Autoimmune diseases:** TMBIM6 has been shown to regulate the production of immunoglobulins, which is critical for maintaining immune homeostasis. 4. **Thyroid disorders:** The protein is expressed in thyroid follicular cells, suggesting its potential role in thyroid disorders, including hypothyroidism and hyperthyroidism. In conclusion, TMBIM6 is a critical regulator of cellular processes, including autophagy, endoplasmic reticulum stress, and apoptosis. Its dysregulation has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. Further research is needed to fully understand the role of TMBIM6 in maintaining cellular homeostasis and regulating apoptosis.

Genular Protein ID: 1132490018

Symbol: BI1_HUMAN

Name: Bax inhibitor 1

UniProtKB Accession Codes:

P55061 B2R5M4 F8W034 O14938 Q643A7 Q96J50

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 6 ExpressionAtlas 1 GO 24 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530040

Title: Identification of a novel conserved human gene, TEGT.

PubMed ID: 8530040

DOI: 10.1006/geno.1995.1145

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9660918

Title: Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast.

PubMed ID: 9660918

DOI: 10.1016/s1097-2765(00)80034-9

PubMed ID: 21075086

Title: Endoplasmic reticulum protein BI-1 modulates unfolded protein response signaling and protects against stroke and traumatic brain injury.

PubMed ID: 21075086

DOI: 10.1016/j.brainres.2010.11.015

PubMed ID: 22128171

Title: The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

PubMed ID: 22128171

DOI: 10.1074/jbc.m111.275354

PubMed ID: 22418439

Title: Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family.

PubMed ID: 22418439

DOI: 10.1074/jbc.m111.336149

Sequence Information:

  • Length: 237
  • Mass: 26538
  • Checksum: 6567E73A1AD6238E
  • Sequence:
    • MNIFDRKINF DALLKFSHIT PSTQQHLKKV YASFALCMFV AAAGAYVHMV THFIQAGLLS 
ALGSLILMIW LMATPHSHET EQKRLGLLAG FAFLTGVGLG PALEFCIAVN PSILPTAFMG 
TAMIFTCFTL SALYARRRSY LFLGGILMSA LSLLLLSSLG NVFFGSIWLF QANLYVGLVV 
MCGFVLFDTQ LIIEKAEHGD QDYIWHCIDL FLDFITVFRK LMMILAMNEK DKKKEKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.