Gene LGALS4 - ENSG00000171747 | NCBI Gene ID: 3960

Details for: LGALS4

Gene ID: 3960

Symbol: LGALS4

Ensembl ID: ENSG00000171747

Description: galectin 4

Associated with

Antibacterial peptide biosynthetic process
(GO:0002780)
Carbohydrate binding
(GO:0030246)
Cell adhesion
(GO:0007155)
Collagen-containing extracellular matrix
(GO:0062023)
Cytosol
(GO:0005829)
Extracellular space
(GO:0005615)
Galactoside binding
(GO:0016936)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon epithelial cell (CL0011108)
Fold Change: 4.27
Marker Score: 13399.5
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 4.06
Marker Score: 3887
Cell Name: enterocyte (CL0000584)
Fold Change: 3.87
Marker Score: 18569
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.23
Marker Score: 20609
Cell Name: stem cell (CL0000034)
Fold Change: 2.94
Marker Score: 6971
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.72
Marker Score: 4193
Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 2.55
Marker Score: 737
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.38
Marker Score: 886
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.14
Marker Score: 4867
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.02
Marker Score: 2012
Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.95
Marker Score: 671
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 1.87
Marker Score: 704
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.7
Marker Score: 2508
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.61
Marker Score: 399
Cell Name: precursor cell (CL0011115)
Fold Change: 1.46
Marker Score: 354
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.34
Marker Score: 354
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.25
Marker Score: 1299
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 1.22
Marker Score: 350
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.1
Marker Score: 317
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 786
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71811
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48036
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.99
Marker Score: 723
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.95
Marker Score: 293
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.95
Marker Score: 492
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.95
Marker Score: 1537
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5342
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2739
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: M cell of gut (CL0000682)
Fold Change: 0.88
Marker Score: 229
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282
Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 689
Cell Name: peptic cell (CL0000155)
Fold Change: 0.75
Marker Score: 316
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 388
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3104
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 466
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7
Marker Score: 282
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.69
Marker Score: 586
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 0.66
Marker Score: 212
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 0.65
Marker Score: 141
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.64
Marker Score: 185.5
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.6
Marker Score: 276
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.55
Marker Score: 670
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 437
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.53
Marker Score: 221
Cell Name: paneth cell (CL0000510)
Fold Change: 0.52
Marker Score: 360
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.51
Marker Score: 1434
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.49
Marker Score: 123
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.48
Marker Score: 152
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.48
Marker Score: 757
Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.47
Marker Score: 129
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.47
Marker Score: 442
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.46
Marker Score: 365
Cell Name: oocyte (CL0000023)
Fold Change: 0.44
Marker Score: 109
Cell Name: goblet cell (CL0000160)
Fold Change: 0.43
Marker Score: 2890
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.4
Marker Score: 119
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.33
Marker Score: 125
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.31
Marker Score: 82
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.3
Marker Score: 1295
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.3
Marker Score: 124
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 0.29
Marker Score: 151
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.29
Marker Score: 213
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.29
Marker Score: 329
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.29
Marker Score: 287.5
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.28
Marker Score: 105
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.27
Marker Score: 60
Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.27
Marker Score: 82
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.25
Marker Score: 87
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.25
Marker Score: 621
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.24
Marker Score: 564
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.24
Marker Score: 236
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.24
Marker Score: 103
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.23
Marker Score: 84
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.23
Marker Score: 226
Cell Name: ionocyte (CL0005006)
Fold Change: 0.22
Marker Score: 67
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.22
Marker Score: 131
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2
Marker Score: 58
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.2
Marker Score: 41
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.2
Marker Score: 1048
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.2
Marker Score: 38.5
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.2
Marker Score: 1052
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.19
Marker Score: 1252
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.19
Marker Score: 87
Cell Name: astrocyte (CL0000127)
Fold Change: 0.19
Marker Score: 165
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.19
Marker Score: 1211
Cell Name: male germ cell (CL0000015)
Fold Change: 0.19
Marker Score: 54
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.19
Marker Score: 144
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.18
Marker Score: 122
Cell Name: GIP cell (CL0002278)
Fold Change: 0.18
Marker Score: 58
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.18
Marker Score: 69
Cell Name: lymphocyte (CL0000542)
Fold Change: 0.18
Marker Score: 89
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.17
Marker Score: 430
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.17
Marker Score: 38
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.17
Marker Score: 39
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.17
Marker Score: 92

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**Key characteristics** * The LGALS4 gene is located on chromosome 17p13.2. * It is a highly conserved protein, with a sequence that is found in mammals, birds, reptiles, and fish. * Gal4 is a secreted protein, and its expression is regulated by a variety of factors, including growth factors, cytokines, and hormones. * Gal4 is a member of the galectin family of proteins, which are a large family of cell adhesion molecules. * Gal4 is a highly versatile protein that can interact with a variety of proteins and molecules. **Pathways and functions** Gal4 is involved in a variety of cellular processes, including: * Cell adhesion: Gal4 is a key component of cell adhesion molecules, which are proteins that help cells stick to each other. * Migration: Gal4 is also involved in cell migration, where cells move from an area of low concentration to an area of high concentration. * Signaling: Gal4 is a signaling molecule that is involved in a variety of cellular processes, including cell growth, differentiation, and migration. **Clinical significance** Mutations in the LGALS4 gene have been linked to a number of human diseases, including: * Galactosemia: Galactosemia is a genetic disorder caused by a deficiency of galectin 4. Galactosemia can cause a number of health problems, including intellectual disability, growth problems, and vision problems. * Cancer: Galectin 4 is a protein that is frequently overexpressed in cancer cells. This overexpression of galectin 4 is thought to contribute to the growth and metastasis of cancer cells. **Additional information** * Galectin 4 is a highly abundant protein in the human body. * It is found in a variety of cell types, including epithelial cells, endothelial cells, and immune cells. * Gal4 is a well-characterized protein that has been extensively studied in both experimental and clinical settings.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Galectin-4

Genular Protein ID: 623807795

Symbol: LEG4_HUMAN

Name: Galectin-4

UniProtKB Accession Codes:

P56470

Database IDs:

Citations:

PubMed ID: 9310382

Title: Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer.

PubMed ID: 9310382

DOI: 10.1111/j.1432-1033.1997.00225.x

PubMed ID: 9162064

Title: Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion.

PubMed ID: 9162064

DOI: 10.1074/jbc.272.22.14294

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 323
Mass: 35941
Checksum: E79EC0A9AB3990EF
Sequence:

MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF VVGQDPGSDV 
AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA FELVFIVLAE HYKVVVNGNP 
FYEYGHRLPL QMVTHLQVDG DLQLQSINFI GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP 
TMEGPPTFNP PVPYFGRLQG GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR 
MGNGTVVRNS LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR 
LSAFQRVDTL EIQGDVTLSY VQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.