Details for: LGALS4

Gene ID: 3960

Symbol: LGALS4

Ensembl ID: ENSG00000171747

Description: galectin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.8382
    Cell Significance Index: -5.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.5513
    Cell Significance Index: -5.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 17.2578
    Cell Significance Index: 782.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 13.3652
    Cell Significance Index: -6.3100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 9.6422
    Cell Significance Index: 97.2700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 8.5286
    Cell Significance Index: 92.4300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 7.9580
    Cell Significance Index: -5.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.3340
    Cell Significance Index: 79.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 4.9763
    Cell Significance Index: 492.2700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6798
    Cell Significance Index: -5.7700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.8274
    Cell Significance Index: 14.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.4200
    Cell Significance Index: 177.6600
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 3.3422
    Cell Significance Index: 23.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.1204
    Cell Significance Index: 89.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 2.0621
    Cell Significance Index: 72.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.9050
    Cell Significance Index: 40.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8318
    Cell Significance Index: 58.6700
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.5110
    Cell Significance Index: 13.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9365
    Cell Significance Index: 178.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.8839
    Cell Significance Index: 100.9000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.7617
    Cell Significance Index: 7.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.6939
    Cell Significance Index: 79.5000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5393
    Cell Significance Index: 7.9600
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.5234
    Cell Significance Index: 1.3300
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 0.2624
    Cell Significance Index: 1.4200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.2278
    Cell Significance Index: 1.4100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2227
    Cell Significance Index: 3.6700
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.1661
    Cell Significance Index: 1.3500
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.0963
    Cell Significance Index: 0.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0787
    Cell Significance Index: 49.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0683
    Cell Significance Index: 1.1500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0660
    Cell Significance Index: 0.3800
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.0594
    Cell Significance Index: 0.5700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0488
    Cell Significance Index: 6.0000
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.0427
    Cell Significance Index: 0.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0413
    Cell Significance Index: 7.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0367
    Cell Significance Index: 1.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0295
    Cell Significance Index: 3.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0259
    Cell Significance Index: 4.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0195
    Cell Significance Index: 0.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0186
    Cell Significance Index: 3.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0139
    Cell Significance Index: 0.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0086
    Cell Significance Index: 3.7900
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.0084
    Cell Significance Index: 0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0016
    Cell Significance Index: 1.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0009
    Cell Significance Index: 0.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0005
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0000
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -1.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0013
    Cell Significance Index: -0.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0040
    Cell Significance Index: -0.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0044
    Cell Significance Index: -1.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0049
    Cell Significance Index: -0.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0054
    Cell Significance Index: -0.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0059
    Cell Significance Index: -0.4200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0061
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0085
    Cell Significance Index: -1.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0098
    Cell Significance Index: -7.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0105
    Cell Significance Index: -6.6600
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0129
    Cell Significance Index: -0.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0140
    Cell Significance Index: -6.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0182
    Cell Significance Index: -0.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0186
    Cell Significance Index: -2.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0201
    Cell Significance Index: -5.8000
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.0204
    Cell Significance Index: -0.1200
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.0215
    Cell Significance Index: -0.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0251
    Cell Significance Index: -3.4500
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0268
    Cell Significance Index: -0.3000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0305
    Cell Significance Index: -4.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0369
    Cell Significance Index: -1.7200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0401
    Cell Significance Index: -0.6000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0402
    Cell Significance Index: -0.3200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0449
    Cell Significance Index: -0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0472
    Cell Significance Index: -4.8200
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0473
    Cell Significance Index: -0.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0498
    Cell Significance Index: -1.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0550
    Cell Significance Index: -5.7300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.0577
    Cell Significance Index: -0.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0583
    Cell Significance Index: -7.5400
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0611
    Cell Significance Index: -0.3200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0673
    Cell Significance Index: -0.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0683
    Cell Significance Index: -1.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0710
    Cell Significance Index: -8.3700
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0720
    Cell Significance Index: -0.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0731
    Cell Significance Index: -1.9600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0752
    Cell Significance Index: -0.6800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0757
    Cell Significance Index: -4.6400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0869
    Cell Significance Index: -5.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0933
    Cell Significance Index: -1.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0974
    Cell Significance Index: -7.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1003
    Cell Significance Index: -2.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1009
    Cell Significance Index: -5.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1015
    Cell Significance Index: -5.3300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1018
    Cell Significance Index: -0.6900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1051
    Cell Significance Index: -4.3100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1059
    Cell Significance Index: -6.8300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1071
    Cell Significance Index: -4.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Galectin-4 is a member of the galectin family, which is characterized by its ability to bind to carbohydrate moieties on cell surfaces. Galectin-4 is a lectin, a carbohydrate-binding protein that recognizes and binds to specific carbohydrate structures. This binding interaction triggers a series of downstream signaling events that regulate various cellular processes. Galectin-4 is a secreted protein, which allows it to interact with cells and other molecules in its microenvironment. **Pathways and Functions:** Galectin-4 is involved in several biological pathways, including: 1. **Antibacterial peptide biosynthetic process**: Galectin-4 is involved in the regulation of the production of antibacterial peptides, which are essential for defending against microbial infections. 2. **Cell adhesion**: Galectin-4 mediates cell-cell and cell-extracellular matrix interactions, which are critical for tissue homeostasis and immune response. 3. **Collagen-containing extracellular matrix**: Galectin-4 binds to collagen and other extracellular matrix proteins, regulating their assembly and organization. 4. **Cytosol and extracellular space**: Galectin-4 is involved in the regulation of cytosolic and extracellular signaling pathways, influencing cell behavior and immune response. Galectin-4's functions can be broadly categorized into two main groups: 1. **Immune regulation**: Galectin-4 modulates immune responses by regulating the production of antibacterial peptides, cytokines, and chemokines. 2. **Tissue homeostasis**: Galectin-4 maintains tissue homeostasis by regulating cell adhesion, migration, and differentiation, as well as extracellular matrix assembly and organization. **Clinical Significance:** Dysregulation of galectin-4 has been implicated in various diseases, including: 1. **Inflammatory bowel disease**: Galectin-4 has been shown to play a role in the pathogenesis of inflammatory bowel disease, including Crohn's disease and ulcerative colitis. 2. **Cancer**: Galectin-4 has been implicated in cancer progression, including metastasis and tumor growth. 3. **Autoimmune disorders**: Galectin-4 has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus. 4. **Gastrointestinal disorders**: Galectin-4 has been implicated in gastrointestinal disorders, including irritable bowel syndrome and gastroesophageal reflux disease. In conclusion, galectin-4 is a multifaceted molecule that plays a crucial role in immune regulation, tissue homeostasis, and disease pathogenesis. Further research is needed to fully understand its mechanisms of action and to explore its therapeutic potential in various diseases.

Genular Protein ID: 623807795

Symbol: LEG4_HUMAN

Name: Galectin-4

UniProtKB Accession Codes:

P56470

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UniLectin 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9310382

Title: Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer.

PubMed ID: 9310382

DOI: 10.1111/j.1432-1033.1997.00225.x

PubMed ID: 9162064

Title: Strikingly different localization of galectin-3 and galectin-4 in human colon adenocarcinoma T84 cells. Galectin-4 is localized at sites of cell adhesion.

PubMed ID: 9162064

DOI: 10.1074/jbc.272.22.14294

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 323
  • Mass: 35941
  • Checksum: E79EC0A9AB3990EF
  • Sequence:
    • MAYVPAPGYQ PTYNPTLPYY QPIPGGLNVG MSVYIQGVAS EHMKRFFVNF VVGQDPGSDV 
AFHFNPRFDG WDKVVFNTLQ GGKWGSEERK RSMPFKKGAA FELVFIVLAE HYKVVVNGNP 
FYEYGHRLPL QMVTHLQVDG DLQLQSINFI GGQPLRPQGP PMMPPYPGPG HCHQQLNSLP 
TMEGPPTFNP PVPYFGRLQG GLTARRTIII KGYVPPTGKS FAINFKVGSS GDIALHINPR 
MGNGTVVRNS LLNGSWGSEE KKITHNPFGP GQFFDLSIRC GLDRFKVYAN GQHLFDFAHR 
LSAFQRVDTL EIQGDVTLSY VQI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.