DLL1 | ENSG00000198719 | NCBI 28514

Details for: DLL1

Gene ID: 28514

Symbol: DLL1

Ensembl ID: ENSG00000198719

Description: delta like canonical Notch ligand 1

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Constitutive signaling by notch1 hd+pest domain mutants
(R-HSA-2894862)
Constitutive signaling by notch1 hd domain mutants
(R-HSA-2691232)
Constitutive signaling by notch1 pest domain mutants
(R-HSA-2644606)
Constitutive signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660826)
Developmental biology
(R-HSA-1266738)
Developmental cell lineages
(R-HSA-9734767)
Differentiation of keratinocytes in interfollicular epidermis in mammalian skin
(R-HSA-9725554)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Formation of paraxial mesoderm
(R-HSA-9793380)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Kidney development
(R-HSA-9830369)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Notch2 activation and transmission of signal to the nucleus
(R-HSA-2979096)
Notch3 activation and transmission of signal to the nucleus
(R-HSA-9013507)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by notch1 hd+pest domain mutants in cancer
(R-HSA-2894858)
Signaling by notch1 hd domain mutants in cancer
(R-HSA-2691230)
Signaling by notch1 in cancer
(R-HSA-2644603)
Signaling by notch1 pest domain mutants in cancer
(R-HSA-2644602)
Signaling by notch1 t(7;9)(notch1:m1580_k2555) translocation mutant
(R-HSA-2660825)
Signaling by notch2
(R-HSA-1980145)
Signaling by notch3
(R-HSA-9012852)
Signal transduction
(R-HSA-162582)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Astrocyte development
(GO:0014002)
Calcium ion binding
(GO:0005509)
Cell differentiation
(GO:0030154)
Cell fate determination
(GO:0001709)
Cerebellar molecular layer formation
(GO:0021688)
Cerebellar purkinje cell layer structural organization
(GO:0021693)
Clathrin-dependent endocytosis
(GO:0072583)
Compartment pattern specification
(GO:0007386)
Determination of left/right symmetry
(GO:0007368)
Heart looping
(GO:0001947)
Hemopoiesis
(GO:0030097)
Inhibition of neuroepithelial cell differentiation
(GO:0002085)
Inner ear auditory receptor cell differentiation
(GO:0042491)
Lateral inhibition
(GO:0046331)
Left/right axis specification
(GO:0070986)
Loop of henle development
(GO:0072070)
Marginal zone b cell differentiation
(GO:0002315)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cell differentiation
(GO:0045596)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epidermal cell differentiation
(GO:0045605)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Negative regulation of hemocyte differentiation
(GO:0045611)
Negative regulation of inner ear auditory receptor cell differentiation
(GO:0045608)
Negative regulation of interleukin-10 production
(GO:0032693)
Negative regulation of myeloid cell differentiation
(GO:0045638)
Negative regulation of myoblast differentiation
(GO:0045662)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of notch signaling pathway
(GO:0045746)
Nephron development
(GO:0072006)
Neuroepithelial cell differentiation
(GO:0060563)
Neuron fate specification
(GO:0048665)
Notch binding
(GO:0005112)
Notch signaling pathway
(GO:0007219)
Notch signaling pathway involved in arterial endothelial cell fate commitment
(GO:0060853)
Organ growth
(GO:0035265)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of notch signaling pathway
(GO:0045747)
Positive regulation of skeletal muscle tissue growth
(GO:0048633)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Proximal/distal pattern formation
(GO:0009954)
Proximal tubule development
(GO:0072014)
Receptor ligand activity
(GO:0048018)
Regulation of blood pressure
(GO:0008217)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell division
(GO:0051302)
Regulation of growth
(GO:0040008)
Regulation of neurogenesis
(GO:0050767)
Regulation of skeletal muscle tissue growth
(GO:0048631)
Regulation of somitogenesis
(GO:0014807)
Regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030947)
Retina development in camera-type eye
(GO:0060041)
Retina morphogenesis in camera-type eye
(GO:0060042)
Scaffold protein binding
(GO:0097110)
Skeletal muscle tissue growth
(GO:0048630)
Somite specification
(GO:0001757)
Somitogenesis
(GO:0001756)
Spinal cord development
(GO:0021510)
Tat protein binding
(GO:0030957)
Type b pancreatic cell development
(GO:0003323)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 101.3853
Cell Significance Index: -15.7700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 61.8979
Cell Significance Index: -15.7000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 31.6794
Cell Significance Index: -12.8700
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 23.7250
Cell Significance Index: -15.9200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 13.4696
Cell Significance Index: -12.8600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 12.7904
Cell Significance Index: -15.7700
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 5.7674
Cell Significance Index: -15.4500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.9964
Cell Significance Index: -15.7700
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 3.2121
Cell Significance Index: -7.0300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.3630
Cell Significance Index: 32.2400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.3382
Cell Significance Index: 1208.2800
Cell Name: sensory neuron (CL0000101)
Fold Change: 0.9166
Cell Significance Index: 5.2100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8961
Cell Significance Index: 97.4700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8398
Cell Significance Index: 136.5900
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.7460
Cell Significance Index: 11.3300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7414
Cell Significance Index: 44.5100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6605
Cell Significance Index: 18.4600
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6149
Cell Significance Index: 32.0300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5107
Cell Significance Index: 35.3200
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4925
Cell Significance Index: 12.3100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.4220
Cell Significance Index: 23.6800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3982
Cell Significance Index: 252.8800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3868
Cell Significance Index: 38.2600
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3498
Cell Significance Index: 9.5200
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.3340
Cell Significance Index: 3.6200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3046
Cell Significance Index: 21.5400
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.2490
Cell Significance Index: 2.2100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2332
Cell Significance Index: 8.2000
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2100
Cell Significance Index: 39.9700
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1867
Cell Significance Index: 37.4600
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.1400
Cell Significance Index: 1.5900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1302
Cell Significance Index: 71.1100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.1141
Cell Significance Index: 40.9400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0971
Cell Significance Index: 4.4000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0964
Cell Significance Index: 42.6300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0615
Cell Significance Index: 4.7200
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0535
Cell Significance Index: 0.7700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0344
Cell Significance Index: 6.2000
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: 0.0341
Cell Significance Index: 0.3100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0314
Cell Significance Index: 59.1500
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0216
Cell Significance Index: 1.0900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0169
Cell Significance Index: 2.8800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0139
Cell Significance Index: 1.6200
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0111
Cell Significance Index: 0.3200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0048
Cell Significance Index: 0.5900
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0045
Cell Significance Index: -0.9000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0049
Cell Significance Index: -3.6600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0050
Cell Significance Index: -9.2000
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0083
Cell Significance Index: -1.0700
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0086
Cell Significance Index: -13.2300
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0104
Cell Significance Index: -0.4600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0112
Cell Significance Index: -7.0200
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0113
Cell Significance Index: -7.8400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0130
Cell Significance Index: -17.6100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0182
Cell Significance Index: -10.2600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0198
Cell Significance Index: -14.5200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0201
Cell Significance Index: -15.2400
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.0202
Cell Significance Index: -0.1200
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0221
Cell Significance Index: -3.0400
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0251
Cell Significance Index: -0.4200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0258
Cell Significance Index: -11.6900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0268
Cell Significance Index: -0.5700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0329
Cell Significance Index: -9.4600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0329
Cell Significance Index: -6.9200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0460
Cell Significance Index: -6.6900
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.0502
Cell Significance Index: -1.4400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0538
Cell Significance Index: -2.5100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0549
Cell Significance Index: -2.0800
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0641
Cell Significance Index: -1.3300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0878
Cell Significance Index: -8.9700
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1033
Cell Significance Index: -13.3500
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.1152
Cell Significance Index: -3.6900
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1195
Cell Significance Index: -13.6400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1264
Cell Significance Index: -14.9100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1351
Cell Significance Index: -15.4800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1394
Cell Significance Index: -9.3700
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1503
Cell Significance Index: -15.6500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1560
Cell Significance Index: -7.3300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1634
Cell Significance Index: -10.0200
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1824
Cell Significance Index: -11.7700
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1840
Cell Significance Index: -13.7100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1850
Cell Significance Index: -14.6500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2025
Cell Significance Index: -8.3000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2279
Cell Significance Index: -3.9400
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2515
Cell Significance Index: -3.7900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.2516
Cell Significance Index: -13.0700
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.2551
Cell Significance Index: -2.7100
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2586
Cell Significance Index: -4.5700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2632
Cell Significance Index: -9.2200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2716
Cell Significance Index: -3.8900
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2739
Cell Significance Index: -17.2700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2760
Cell Significance Index: -9.5900
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2783
Cell Significance Index: -9.1100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2892
Cell Significance Index: -9.2100
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.3007
Cell Significance Index: -8.5800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3154
Cell Significance Index: -16.5600
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.3420
Cell Significance Index: -8.7900
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.3421
Cell Significance Index: -7.2600
Cell Name: epidermal cell (CL0000362)
Fold Change: -0.3903
Cell Significance Index: -0.8800
Cell Name: glioblast (CL0000030)
Fold Change: -0.4109
Cell Significance Index: -2.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** DLL1 is a member of the Notch ligand family and is characterized by its ability to interact with Notch receptors to transmit signals that regulate cell fate and differentiation. The gene is composed of 7 exons and spans approximately 13 kilobases of genomic DNA. DLL1 is highly conserved across species, with a high degree of sequence similarity to its Drosophila homolog. The gene's expression is tightly regulated, with specific patterns of expression observed in various tissues and cell types. **Pathways and Functions** The Notch signaling pathway, in which DLL1 plays a key role, is a complex signaling cascade that regulates cell fate and differentiation. The pathway involves the binding of DLL1 to Notch receptors, which triggers a series of intracellular events that ultimately lead to the transcription of target genes. DLL1's involvement in the Notch pathway has been implicated in various biological processes, including: 1. **Cell differentiation**: DLL1's role in promoting cell differentiation has been observed in various tissues, including the nervous system, heart, and skeletal muscle. 2. **Fate determination**: DLL1's involvement in determining cell fate has been demonstrated in the development of various tissues, including the nervous system and the heart. 3. **Developmental biology**: DLL1's role in developmental processes, including gastrulation, organogenesis, and tissue patterning, has been highlighted in the literature. 4. **Gene expression**: DLL1's ability to regulate gene expression has been observed in various tissues, including the nervous system and the heart. **Clinical Significance** DLL1's involvement in disease has been a subject of increasing interest in recent years. Research has identified DLL1's role in various diseases, including: 1. **Neurological disorders**: DLL1's involvement in neurological disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis, has been highlighted in the literature. 2. **Cancer**: DLL1's role in cancer, including its involvement in tumor progression and metastasis, has been observed in various studies. 3. **Cardiovascular disease**: DLL1's involvement in cardiovascular disease, including its role in atherosclerosis and cardiac hypertrophy, has been demonstrated in the literature. Overall, DLL1's role in the Notch signaling pathway and its involvement in various biological processes highlight its significance in development, disease, and therapeutic strategy. Further research is needed to fully understand the mechanisms by which DLL1 regulates cell fate and differentiation, as well as its involvement in disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Drosophila Delta homolog 1

Genular Protein ID: 3738030338

Symbol: DLL1_HUMAN

Name: Drosophila Delta homolog 1

UniProtKB Accession Codes:

O00548 B2RAK7 B5M0B3 Q9NU41 Q9UJV2

Database IDs:

Citations:

PubMed ID: 10079256

Title: Human ligands of the Notch receptor.

PubMed ID: 10079256

DOI: 10.1016/s0002-9440(10)65325-4

PubMed ID: 10688816

Title: A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells.

PubMed ID: 10688816

PubMed ID: 19906316

Title: Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site.

PubMed ID: 19906316

DOI: 10.1186/1471-2164-10-518

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 11006133

Title: Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.

PubMed ID: 11006133

DOI: 10.1006/bbrc.2000.3469

PubMed ID: 11581320

Title: Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation.

PubMed ID: 11581320

DOI: 10.1084/jem.194.7.991

PubMed ID: 15509766

Title: Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.

PubMed ID: 15509766

DOI: 10.1242/dev.01417

PubMed ID: 24025447

Title: Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.

PubMed ID: 24025447

DOI: 10.1161/circresaha.113.301686

PubMed ID: 29856955

Title: Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation.

PubMed ID: 29856955

DOI: 10.1016/j.cell.2018.03.067

PubMed ID: 31353024

Title: Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders.

PubMed ID: 31353024

DOI: 10.1016/j.ajhg.2019.07.002

Sequence Information:

Length: 723
Mass: 78056
Checksum: 094B8F235DFD899D
Sequence:

MGSRCALALA VLSALLCQVW SSGVFELKLQ EFVNKKGLLG NRNCCRGGAG PPPCACRTFF 
RVCLKHYQAS VSPEPPCTYG SAVTPVLGVD SFSLPDGGGA DSAFSNPIRF PFGFTWPGTF 
SLIIEALHTD SPDDLATENP ERLISRLATQ RHLTVGEEWS QDLHSSGRTD LKYSYRFVCD 
EHYYGEGCSV FCRPRDDAFG HFTCGERGEK VCNPGWKGPY CTEPICLPGC DEQHGFCDKP 
GECKCRVGWQ GRYCDECIRY PGCLHGTCQQ PWQCNCQEGW GGLFCNQDLN YCTHHKPCKN 
GATCTNTGQG SYTCSCRPGY TGATCELGID ECDPSPCKNG GSCTDLENSY SCTCPPGFYG 
KICELSAMTC ADGPCFNGGR CSDSPDGGYS CRCPVGYSGF NCEKKIDYCS SSPCSNGAKC 
VDLGDAYLCR CQAGFSGRHC DDNVDDCASS PCANGGTCRD GVNDFSCTCP PGYTGRNCSA 
PVSRCEHAPC HNGATCHERG HRYVCECARG YGGPNCQFLL PELPPGPAVV DLTEKLEGQG 
GPFPWVAVCA GVILVLMLLL GCAAVVVCVR LRLQKHRPPA DPCRGETETM NNLANCQREK 
DISVSIIGAT QIKNTNKKAD FHGDHSADKN GFKARYPAVD YNLVQDLKGD DTAVRDAHSK 
RDTKCQPQGS SGEEKGTPTT LRGGEASERK RPDSGCSTSK DTKYQSVYVI SEEKDECVIA 
TEV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: DLL1

Associated with

Cells (max top 100)

Other Information

Human ligands of the Notch receptor. PubMed ID: 10079256

A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells. PubMed ID: 10688816

Discovery of novel human transcript variants by analysis of intronic single-block EST with polyadenylation site. PubMed ID: 19906316

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. PubMed ID: 12975309

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors. PubMed ID: 11006133

Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation. PubMed ID: 11581320

Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. PubMed ID: 15509766

Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis. PubMed ID: 24025447

Human-specific NOTCH2NL genes expand cortical neurogenesis through Delta/Notch regulation. PubMed ID: 29856955

Haploinsufficiency of the Notch Ligand DLL1 Causes Variable Neurodevelopmental Disorders. PubMed ID: 31353024