Details for: SERF2

Gene ID: 10169

Symbol: SERF2

Ensembl ID: ENSG00000140264

Description: small EDRK-rich factor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 7.09
    Marker Score: 5,355
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.6
    Marker Score: 5,168
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.85
    Marker Score: 10,679
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.8
    Marker Score: 12,251
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 5.55
    Marker Score: 74,544
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.25
    Marker Score: 8,085
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.12
    Marker Score: 50,711
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.02
    Marker Score: 14,641
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.83
    Marker Score: 1,779
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.78
    Marker Score: 12,138
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.67
    Marker Score: 14,735
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 4.66
    Marker Score: 3,973
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.65
    Marker Score: 4,153
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.56
    Marker Score: 29,092
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 4.55
    Marker Score: 12,206
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.55
    Marker Score: 254,545
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.53
    Marker Score: 3,289
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 4.52
    Marker Score: 16,065
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.52
    Marker Score: 7,746
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 4.5
    Marker Score: 2,539
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.44
    Marker Score: 23,338
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.44
    Marker Score: 5,777
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.4
    Marker Score: 149,754
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.37
    Marker Score: 1,969
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.36
    Marker Score: 230,695
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.32
    Marker Score: 50,259
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.31
    Marker Score: 1,029
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.3
    Marker Score: 2,614
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.27
    Marker Score: 11,802
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.27
    Marker Score: 2,194
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.26
    Marker Score: 56,199
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 4.24
    Marker Score: 4,714
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.21
    Marker Score: 2,710
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 4.2
    Marker Score: 10,593
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.2
    Marker Score: 10,257
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 4.13
    Marker Score: 2,937
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.08
    Marker Score: 11,446
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 4.02
    Marker Score: 29,908
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.97
    Marker Score: 3,841
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.94
    Marker Score: 8,984
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.93
    Marker Score: 16,835
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.91
    Marker Score: 1,273
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.91
    Marker Score: 3,335
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.91
    Marker Score: 5,755
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.89
    Marker Score: 7,316
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.89
    Marker Score: 2,281
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.88
    Marker Score: 25,269
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.87
    Marker Score: 2,066
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.87
    Marker Score: 3,287
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.86
    Marker Score: 4,770
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.86
    Marker Score: 4,648
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.84
    Marker Score: 3,010
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.82
    Marker Score: 1,011
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.8
    Marker Score: 3,746
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.8
    Marker Score: 3,381
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.79
    Marker Score: 9,243
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.79
    Marker Score: 3,394
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.79
    Marker Score: 1,211
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.78
    Marker Score: 3,375
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.78
    Marker Score: 5,471
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 3.78
    Marker Score: 979
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.78
    Marker Score: 1,949
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.77
    Marker Score: 6,741
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.77
    Marker Score: 864
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.76
    Marker Score: 4,020
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.76
    Marker Score: 4,046
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.76
    Marker Score: 2,693
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.74
    Marker Score: 4,281
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.73
    Marker Score: 3,788
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.72
    Marker Score: 1,359
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.72
    Marker Score: 3,130
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.72
    Marker Score: 978
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.71
    Marker Score: 3,261
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.7
    Marker Score: 3,187
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.69
    Marker Score: 32,050
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.69
    Marker Score: 1,676
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.64
    Marker Score: 3,488
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.64
    Marker Score: 11,426
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.63
    Marker Score: 1,032
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.63
    Marker Score: 1,561
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.63
    Marker Score: 23,621
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.63
    Marker Score: 4,235
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.62
    Marker Score: 1,875
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.61
    Marker Score: 2,735
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 3.61
    Marker Score: 1,018
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.61
    Marker Score: 3,929
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.61
    Marker Score: 2,956
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.61
    Marker Score: 1,504
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.61
    Marker Score: 2,997
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.61
    Marker Score: 2,544
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.6
    Marker Score: 1,613
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.58
    Marker Score: 1,235
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.58
    Marker Score: 2,098
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.58
    Marker Score: 2,372
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.58
    Marker Score: 3,363
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.57
    Marker Score: 8,111
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.57
    Marker Score: 2,081
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.56
    Marker Score: 4,893
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.55
    Marker Score: 3,129
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.55
    Marker Score: 5,639

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SERF2 is a small, EDRK-rich (glutamic acid-rich) protein that is primarily localized to the cytosol and nucleus. Its expression is widespread across various cell types, including hematopoietic stem cells, thyroid follicular cells, and malignant cells. Notably, SERF2 is also expressed in immune cells, such as mature T cells and NKp46-positive innate lymphoid cells, suggesting its involvement in immune regulation. **Pathways and Functions:** SERF2 has been implicated in several cellular pathways, including protein destabilization, which is a critical process in regulating protein turnover and cellular homeostasis. SERF2's ability to destabilize proteins suggests that it plays a role in maintaining cellular homeostasis and regulating protein levels. Additionally, SERF2's expression in immune cells suggests that it may be involved in regulating immune responses, including the activation and regulation of immune cells. **Clinical Significance:** The expression of SERF2 in various cell types and its involvement in immune regulation make it a gene of interest in the context of immunology. In particular, SERF2's expression in malignant cells suggests that it may be involved in the pathogenesis of certain types of cancer. Furthermore, SERF2's role in regulating immune responses may have implications for the development of novel immunotherapies. In addition, SERF2's expression in hematopoietic stem cells and immune cells suggests that it may play a role in maintaining immune homeostasis and regulating immune responses. This could have implications for the treatment of autoimmune diseases and other conditions characterized by immune dysregulation. **Conclusion:** In conclusion, SERF2 is a gene of interest in the realm of immunology, with significant implications for our understanding of cellular homeostasis and immune regulation. Further research is needed to fully elucidate the functional roles of SERF2 and its clinical significance in the context of immunology. However, the available data suggest that SERF2 is a gene that warrants further investigation, and its potential therapeutic applications are vast and varied. **Recommendations:** 1. Further research is needed to elucidate the functional roles of SERF2 in various cell types. 2. The expression patterns of SERF2 in different cell types should be further investigated to understand its role in regulating cellular homeostasis and immune responses. 3. The potential therapeutic applications of SERF2 should be explored, particularly in the context of cancer and autoimmune diseases. By pursuing further research on SERF2, we may uncover new insights into the regulation of cellular homeostasis and immune responses, and develop novel therapeutic strategies to treat a range of diseases.

Genular Protein ID: 396338480

Symbol: SERF2_HUMAN

Name: Small EDRK-rich factor 2

UniProtKB Accession Codes:

P84101 A6NL45 B5MCG1 B9A026 O75918 O88891 Q9BZH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 5 SAM 1 STRING 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9731538

Title: Identification of a candidate modifying gene for spinal muscular atrophy by comparative genomics.

PubMed ID: 9731538

DOI: 10.1038/1753

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20723760

Title: Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.

PubMed ID: 20723760

DOI: 10.1016/j.cell.2010.07.020

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 59
  • Mass: 6900
  • Checksum: 24FB33BF94FFFAE4
  • Sequence:
    • MTRGNQRELA RQKNMKKQSD SVKGKRRDDG LSAAARKQRD SEIMQQKQKK ANEKKEEPK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.