Details for: CL0002496

Cell ID: CL0002496

Cell Name: intraepithelial lymphocyte

Marker Score Threshold: 1111
(Derived using integrated single-cell and genomic data)

Description: A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response.

Synonyms: IEL, intraepithelial T cell, intraepithelial T-cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CD7 (ENSG00000173762)
    Fold Change: 4.8
    Ensembl ID: ENSG00000173762
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.66
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.63
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 4.4
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.29
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD247 (ENSG00000198821)
    Fold Change: 4.29
    Ensembl ID: ENSG00000198821
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 4.24
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 3.98
    Ensembl ID: ENSG00000169442
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.89
    Ensembl ID: ENSG00000111348
  • Gene Symbol: CD3E (ENSG00000198851)
    Fold Change: 3.84
    Ensembl ID: ENSG00000198851
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.84
    Ensembl ID: ENSG00000198668
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.83
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 3.7
    Ensembl ID: ENSG00000213719
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 3.52
    Ensembl ID: ENSG00000131143
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 3.48
    Ensembl ID: ENSG00000122545
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.48
    Ensembl ID: ENSG00000133639
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.48
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CD69 (ENSG00000110848)
    Fold Change: 3.25
    Ensembl ID: ENSG00000110848
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 3.23
    Ensembl ID: ENSG00000164919
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 3.23
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.19
    Ensembl ID: ENSG00000135390
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.95
    Ensembl ID: ENSG00000126267
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.92
    Ensembl ID: ENSG00000149925
  • Gene Symbol: RUNX3 (ENSG00000020633)
    Fold Change: 2.89
    Ensembl ID: ENSG00000020633
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.81
    Ensembl ID: ENSG00000152518
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.79
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.79
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.76
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.74
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.73
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 2.68
    Ensembl ID: ENSG00000117091
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.64
    Ensembl ID: ENSG00000135940
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.62
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 2.59
    Ensembl ID: ENSG00000155366
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 2.56
    Ensembl ID: ENSG00000143119
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.55
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.53
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.45
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 2.41
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 2.4
    Ensembl ID: ENSG00000118971
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 2.39
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.37
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.36
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 2.33
    Ensembl ID: ENSG00000104894
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.32
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ENTPD1 (ENSG00000138185)
    Fold Change: 2.29
    Ensembl ID: ENSG00000138185
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.28
    Ensembl ID: ENSG00000104964
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.25
    Ensembl ID: ENSG00000005022
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2.23
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 2.23
    Ensembl ID: ENSG00000109861
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.15
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.09
    Ensembl ID: ENSG00000179218
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.05
    Ensembl ID: ENSG00000019582
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.04
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 2.01
    Ensembl ID: ENSG00000196954
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.96
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.87
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.85
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD3D (ENSG00000167286)
    Fold Change: 1.84
    Ensembl ID: ENSG00000167286
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.82
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.8
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.78
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.71
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.69
    Ensembl ID: ENSG00000221869
  • Gene Symbol: FASLG (ENSG00000117560)
    Fold Change: 1.66
    Ensembl ID: ENSG00000117560
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.54
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.52
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 1.5
    Ensembl ID: ENSG00000102575
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.5
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.45
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.44
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.43
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CLTA (ENSG00000122705)
    Fold Change: 1.42
    Ensembl ID: ENSG00000122705
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.4
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CD3G (ENSG00000160654)
    Fold Change: 1.4
    Ensembl ID: ENSG00000160654
  • Gene Symbol: RHOH (ENSG00000168421)
    Fold Change: 1.37
    Ensembl ID: ENSG00000168421
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.35
    Ensembl ID: ENSG00000161203
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.35
    Ensembl ID: ENSG00000105254
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 1.29
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.28
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.26
    Ensembl ID: ENSG00000085224
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.24
    Ensembl ID: ENSG00000146731
  • Gene Symbol: CD38 (ENSG00000004468)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004468
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.2
    Ensembl ID: ENSG00000042753
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.2
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.19
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CLTB (ENSG00000175416)
    Fold Change: 1.18
    Ensembl ID: ENSG00000175416
  • Gene Symbol: CD2 (ENSG00000116824)
    Fold Change: 1.18
    Ensembl ID: ENSG00000116824
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.17
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.15
    Ensembl ID: ENSG00000173575
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.11
    Ensembl ID: ENSG00000127022
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.08
    Ensembl ID: ENSG00000177105
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.08
    Ensembl ID: ENSG00000184922
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.05
    Ensembl ID: ENSG00000006125
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.05
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.03
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1
    Ensembl ID: ENSG00000197894
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: IELs are primarily found in the epithelial layer of the small intestine, where they are in close proximity to the intestinal lumen. 2. **Function**: IELs are involved in regulating the immune response against commensal microbes and pathogens, and they play a key role in maintaining intestinal homeostasis. 3. **Antigen presentation**: IELs recognize and respond to antigens presented by the epithelial cells, which are derived from the gut microbiota or pathogens. 4. **T cell activation**: IELs are capable of activating T cells through the presentation of antigens, which is essential for initiating an immune response. 5. **Adaptive immune response**: IELs are part of the adaptive immune response, which is characterized by specific and targeted responses to pathogens and antigens. **Clinical Significance** 1. **Inflammatory bowel disease (IBD)**: IELs have been implicated in the pathogenesis of IBD, including Crohn's disease and ulcerative colitis. 2. **Immunodeficiency**: Abnormalities in IEL function or number have been linked to immunodeficiency syndromes, such as DiGeorge syndrome. 3. **Cancer**: IELs have been found to be involved in the development of certain cancers, including colorectal cancer. 4. **Infectious diseases**: IELs play a key role in regulating the immune response against pathogens, such as Salmonella and Shigella. 5. **Gastrointestinal disorders**: IELs have been implicated in various gastrointestinal disorders, including irritable bowel syndrome (IBS) and functional dyspepsia. **Pathways and Ontology** 1. **Adaptive immune response**: IELs are part of the adaptive immune response, which is characterized by specific and targeted responses to pathogens and antigens. 2. **Immune response**: IELs are involved in regulating the immune response against commensal microbes and pathogens. 3. **Membrane**: IELs are characterized by their ability to recognize and respond to antigens presented by the epithelial cells. 4. **Protein binding**: IELs have been found to bind to various proteins, including those involved in the immune response. 5. **Signaling receptor activity**: IELs are capable of activating T cells through the presentation of antigens, which is essential for initiating an immune response. **Gene Symbol and Ensembl ID** 1. **Gene Symbol**: CD7 2. **Ensembl ID**: ENSG00000173762 **Other relevant information** 1. **Synonyms**: IEL, Intraepithelial T cell, Intraepithelial T-cell 2. **Pathways/Ontology**: Adaptive immune response, Immune response, Membrane, Plasma membrane, Protein binding, Signaling receptor activity, T cell activation, Transmembrane receptor protein tyrosine kinase signaling pathway 3. **Gene Symbol**: B2M 4. **Ensembl ID**: ENSG00000166710