Details for: CL4028002

Cell ID: CL4028002

Cell Name: alveolar capillary type 1 endothelial cell

Marker Score Threshold: 2542
(Derived using integrated single-cell and genomic data)

Description: An alveolar capillary endothelial cell that is located distally to alveolar capillary type 2 endothelial cells.

Synonyms: capillary 1 cell, general capillary cell, CAP1, gCAP

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 6.01
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 5.74
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 5.22
    Ensembl ID: ENSG00000105974
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.95
    Ensembl ID: ENSG00000184009
  • Gene Symbol: AQP1 (ENSG00000240583)
    Fold Change: 4.64
    Ensembl ID: ENSG00000240583
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 4.51
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CA4 (ENSG00000167434)
    Fold Change: 4.12
    Ensembl ID: ENSG00000167434
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 3.97
    Ensembl ID: ENSG00000175899
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.87
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: 3.83
    Ensembl ID: ENSG00000139567
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 3.82
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 3.77
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 3.77
    Ensembl ID: ENSG00000155366
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 3.76
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.74
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.73
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.73
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.71
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CAV2 (ENSG00000105971)
    Fold Change: 3.62
    Ensembl ID: ENSG00000105971
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.07
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.99
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.94
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.93
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.92
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.91
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.9
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.85
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 2.8
    Ensembl ID: ENSG00000198898
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.75
    Ensembl ID: ENSG00000204217
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 2.56
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.45
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 2.38
    Ensembl ID: ENSG00000122786
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.33
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 2.29
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 2.27
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.24
    Ensembl ID: ENSG00000110955
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.22
    Ensembl ID: ENSG00000100300
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.18
    Ensembl ID: ENSG00000172270
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 2.18
    Ensembl ID: ENSG00000104964
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 2.15
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.13
    Ensembl ID: ENSG00000141522
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.07
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2
    Ensembl ID: ENSG00000169020
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.99
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.86
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.85
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.84
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.83
    Ensembl ID: ENSG00000177556
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.81
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.8
    Ensembl ID: ENSG00000087274
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.8
    Ensembl ID: ENSG00000169100
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.79
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.76
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ADRB1 (ENSG00000043591)
    Fold Change: 1.73
    Ensembl ID: ENSG00000043591
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.69
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.68
    Ensembl ID: ENSG00000099624
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.67
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.65
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.63
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.55
    Ensembl ID: ENSG00000117410
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.54
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.52
    Ensembl ID: ENSG00000213465
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.49
    Ensembl ID: ENSG00000127022
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.47
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.45
    Ensembl ID: ENSG00000160710
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.42
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.42
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.37
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.36
    Ensembl ID: ENSG00000131100
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.35
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.34
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BCL3 (ENSG00000069399)
    Fold Change: 1.34
    Ensembl ID: ENSG00000069399
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.33
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.32
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.32
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.25
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.25
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.21
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.19
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.18
    Ensembl ID: ENSG00000023445
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.18
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.17
    Ensembl ID: ENSG00000241837
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.15
    Ensembl ID: ENSG00000176171
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.14
    Ensembl ID: ENSG00000126247
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.11
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.11
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.1
    Ensembl ID: ENSG00000165527
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.1
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.09
    Ensembl ID: ENSG00000071553
  • Gene Symbol: CASP4 (ENSG00000196954)
    Fold Change: 1.08
    Ensembl ID: ENSG00000196954
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.05
    Ensembl ID: ENSG00000147872
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.03
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARRB1 (ENSG00000137486)
    Fold Change: 1.02
    Ensembl ID: ENSG00000137486
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.02
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.01
    Ensembl ID: ENSG00000177105
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: 1.01
    Ensembl ID: ENSG00000173369
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.01
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ARHGAP6 (ENSG00000047648)
    Fold Change: 1
    Ensembl ID: ENSG00000047648
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Location**: ACT1ECs are located at the distal end of the alveolar capillary, adjacent to alveolar capillary type 2 endothelial cells. 2. **Gene Expression**: ACT1ECs express specific genes, including B2M, which is involved in antigen processing and presentation. 3. **Function**: ACT1ECs are involved in antigen processing and presentation, iron ion homeostasis, and immune system regulation. 4. **Antigen Processing and Presentation**: ACT1ECs express MHC class I and II molecules, which are involved in the processing and presentation of antigens to T-cells. 5. **Iron Ion Homeostasis**: ACT1ECs play a crucial role in maintaining iron ion homeostasis in the lungs, which is essential for the proper functioning of the immune system. 6. **Immune System Regulation**: ACT1ECs regulate immune responses, including the activation of T-cells and the production of cytokines. 7. **Cellular Processes**: ACT1ECs are involved in various cellular processes, including protein refolding, protein homotetramerization, and protein homodimerization. **Clinical Significance** 1. **Respiratory Diseases**: Understanding the functions of ACT1ECs is essential for understanding the pathophysiology of respiratory diseases, such as asthma, COPD, and idiopathic pulmonary fibrosis. 2. **Antigen Processing and Presentation**: The dysregulation of antigen processing and presentation in ACT1ECs has been implicated in various respiratory diseases. 3. **Iron Ion Homeostasis**: The dysregulation of iron ion homeostasis in ACT1ECs has been implicated in various respiratory diseases, including pulmonary fibrosis. 4. **Immune System Regulation**: The dysregulation of immune system regulation in ACT1ECs has been implicated in various respiratory diseases, including asthma and COPD. 5. **Therapeutic Targeting**: The identification of specific genes and cellular processes involved in ACT1ECs has opened up new avenues for therapeutic targeting of respiratory diseases. In conclusion, alveolar capillary type 1 endothelial cells play a crucial role in the regulation of gas exchange, immune responses, and the maintenance of lung homeostasis. Understanding the functions of ACT1ECs is essential for understanding lung physiology and pathophysiology, particularly in the context of respiratory diseases. The identification of specific genes and cellular processes involved in ACT1ECs has opened up new avenues for therapeutic targeting of respiratory diseases.