ARRB1 | ENSG00000137486 | NCBI 408

Details for: ARRB1

Gene ID: 408

Symbol: ARRB1

Ensembl ID: ENSG00000137486

Description: arrestin beta 1

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Activation of smo
(R-HSA-5635838)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
G alpha (s) signalling events
(R-HSA-418555)
Golgi associated vesicle biogenesis
(R-HSA-432722)
Gpcr downstream signalling
(R-HSA-388396)
Hedgehog 'on' state
(R-HSA-5632684)
Hemostasis
(R-HSA-109582)
Lysosome vesicle biogenesis
(R-HSA-432720)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Post-translational protein modification
(R-HSA-597592)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by tgfb family members
(R-HSA-9006936)
Signaling by tgfbr3
(R-HSA-9839373)
Signaling downstream of ras mutants
(R-HSA-9649948)
Tgfbr3 regulates tgf-beta signaling
(R-HSA-9839389)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Trans-golgi network vesicle budding
(R-HSA-199992)
Ub-specific processing proteases
(R-HSA-5689880)
Vesicle-mediated transport
(R-HSA-5653656)
Angiotensin receptor binding
(GO:0031701)
Arrestin family protein binding
(GO:1990763)
Chromatin
(GO:0000785)
Clathrin-coated pit
(GO:0005905)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytosol
(GO:0005829)
Endocytic vesicle membrane
(GO:0030666)
Enzyme inhibitor activity
(GO:0004857)
Golgi membrane
(GO:0000139)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor internalization
(GO:0002031)
Gtpase activator activity
(GO:0005096)
Histone acetyltransferase activity
(GO:0004402)
Insulin-like growth factor receptor binding
(GO:0005159)
Lysosomal membrane
(GO:0005765)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of protein ubiquitination
(GO:0031397)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Protein ubiquitination
(GO:0016567)
Pseudopodium
(GO:0031143)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Signal transduction
(GO:0007165)
Stress fiber assembly
(GO:0043149)
Transcription coactivator activity
(GO:0003713)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin protein ligase binding
(GO:0031625)
Visual perception
(GO:0007601)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 185.9266
Cell Significance Index: -28.9200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 103.9057
Cell Significance Index: -26.3600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 64.0406
Cell Significance Index: -30.2400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 61.3035
Cell Significance Index: -24.9100
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 56.4752
Cell Significance Index: -29.0500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 45.1550
Cell Significance Index: -30.3000
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 23.7721
Cell Significance Index: -29.3100
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 10.7994
Cell Significance Index: -28.9300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.2428
Cell Significance Index: -18.0400
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.4733
Cell Significance Index: -29.4900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.6651
Cell Significance Index: 316.8800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.6123
Cell Significance Index: 323.4200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4122
Cell Significance Index: 506.5200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.2438
Cell Significance Index: 33.2100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.0365
Cell Significance Index: 716.8700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9029
Cell Significance Index: 89.3200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8589
Cell Significance Index: 170.4600
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.7905
Cell Significance Index: 17.3100
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7457
Cell Significance Index: 673.3400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.6807
Cell Significance Index: 30.1100
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6474
Cell Significance Index: 38.8700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.6094
Cell Significance Index: 13.0300
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.5791
Cell Significance Index: 21.9300
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5723
Cell Significance Index: 62.2500
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5270
Cell Significance Index: 32.3900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.5014
Cell Significance Index: 13.4400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4742
Cell Significance Index: 77.1200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3972
Cell Significance Index: 747.8300
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.3387
Cell Significance Index: 6.6100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.3373
Cell Significance Index: 49.0300
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.3240
Cell Significance Index: 7.0200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.2722
Cell Significance Index: 2.2200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2525
Cell Significance Index: 17.4600
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2308
Cell Significance Index: 5.7700
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2148
Cell Significance Index: 3.9700
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1767
Cell Significance Index: 9.2000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.1203
Cell Significance Index: 2.8900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1018
Cell Significance Index: 4.6200
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.0894
Cell Significance Index: 6.0100
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0844
Cell Significance Index: 15.2200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.0607
Cell Significance Index: 1.0400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.0417
Cell Significance Index: 3.2000
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0305
Cell Significance Index: 0.8800
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0132
Cell Significance Index: 0.1900
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0119
Cell Significance Index: 6.4800
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0065
Cell Significance Index: 0.2300
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0089
Cell Significance Index: -16.4300
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0153
Cell Significance Index: -23.5700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0189
Cell Significance Index: -3.2300
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0209
Cell Significance Index: -28.4700
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0230
Cell Significance Index: -17.4300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0230
Cell Significance Index: -2.9500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0263
Cell Significance Index: -16.6900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0348
Cell Significance Index: -4.7800
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0352
Cell Significance Index: -25.7800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0417
Cell Significance Index: -30.8900
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0511
Cell Significance Index: -22.5900
Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: -0.0528
Cell Significance Index: -0.2300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0552
Cell Significance Index: -34.5000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0575
Cell Significance Index: -32.4200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0585
Cell Significance Index: -26.5400
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0864
Cell Significance Index: -24.8500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0886
Cell Significance Index: -10.9000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1091
Cell Significance Index: -12.7200
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1315
Cell Significance Index: -9.8000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1487
Cell Significance Index: -3.8000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1645
Cell Significance Index: -34.6500
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.1666
Cell Significance Index: -2.3300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1716
Cell Significance Index: -1.5800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1721
Cell Significance Index: -17.5800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1793
Cell Significance Index: -23.1600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.1829
Cell Significance Index: -5.2200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1852
Cell Significance Index: -9.6200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.1903
Cell Significance Index: -1.1500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1999
Cell Significance Index: -9.3200
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2193
Cell Significance Index: -3.1400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2319
Cell Significance Index: -26.5700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2449
Cell Significance Index: -13.7400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2540
Cell Significance Index: -29.9600
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2601
Cell Significance Index: -16.7800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2648
Cell Significance Index: -27.5800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2719
Cell Significance Index: -5.7700
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.2823
Cell Significance Index: -13.2700
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.2871
Cell Significance Index: -3.8300
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2915
Cell Significance Index: -5.0400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3379
Cell Significance Index: -26.7600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3391
Cell Significance Index: -10.8000
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3393
Cell Significance Index: -6.7100
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3437
Cell Significance Index: -7.3200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3534
Cell Significance Index: -11.5700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3556
Cell Significance Index: -21.8000
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3815
Cell Significance Index: -7.6600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3830
Cell Significance Index: -6.4100
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.4006
Cell Significance Index: -17.4200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4122
Cell Significance Index: -29.1500
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.4563
Cell Significance Index: -7.5200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4638
Cell Significance Index: -24.3500
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.4771
Cell Significance Index: -4.9700
Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4988
Cell Significance Index: -6.2200
Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.5213
Cell Significance Index: -6.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Structure**: ARRB1 is a member of the arrestin family of proteins, which are characterized by their ability to interact with GPCRs and other signaling molecules. 2. **Function**: ARRB1 acts as a scaffold protein to facilitate the interaction between GPCRs and other signaling molecules, thereby modulating the downstream signaling events. 3. **Localization**: ARRB1 is primarily localized to the plasma membrane, where it interacts with GPCRs and other signaling molecules. 4. **Expression**: ARRB1 is highly expressed in the brain, particularly in neurons and astrocytes, and is also found in other tissues, such as the heart and liver. **Pathways and Functions** ARRB1 is involved in various signaling pathways, including: 1. **GPCR signaling**: ARRB1 interacts with GPCRs to modulate the downstream signaling events, including the activation of G-proteins and the regulation of ion channels. 2. **Neurotransmitter release**: ARRB1 is involved in the regulation of neurotransmitter release, particularly in the context of GABAergic neurons. 3. **Neuroplasticity**: ARRB1 has been implicated in the regulation of neuroplasticity, particularly in the context of learning and memory. 4. **Stress signaling**: ARRB1 is involved in the regulation of stress signaling pathways, including the activation of the MAPK/ERK cascade. **Clinical Significance** ARRB1 has been implicated in various neurological and psychiatric disorders, including: 1. **Schizophrenia**: Studies have shown that ARRB1 is associated with schizophrenia, and that alterations in ARRB1 expression and function may contribute to the development of the disorder. 2. **Bipolar disorder**: ARRB1 has been implicated in the regulation of mood disorders, and alterations in ARRB1 expression and function may contribute to the development of bipolar disorder. 3. **Epilepsy**: ARRB1 has been implicated in the regulation of seizure activity, and alterations in ARRB1 expression and function may contribute to the development of epilepsy. 4. **Neurodevelopmental disorders**: ARRB1 has been implicated in the regulation of neurodevelopmental disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder. In conclusion, ARRB1 is a critical protein that plays a key role in regulating various cellular signaling pathways, including those involved in signal transduction by growth factor receptors and second messengers, GPCR signaling, and neurotransmitter release. Alterations in ARRB1 expression and function have been implicated in various neurological and psychiatric disorders, highlighting the importance of this protein in maintaining neural function and plasticity.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Beta-arrestin-1
B7Z1Q3_HUMAN

Genular Protein ID: 3785399271

Symbol: ARRB1_HUMAN

Name: Beta-arrestin-1

UniProtKB Accession Codes:

P49407 B6V9G8 O75625 O75630 Q2PP20 Q9BTK8

Database IDs:

Citations:

PubMed ID: 8486659

Title: Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.

PubMed ID: 8486659

DOI: 10.1016/s0021-9258(18)98412-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9501202

Title: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2.

PubMed ID: 9501202

DOI: 10.1073/pnas.95.6.2985

PubMed ID: 10066734

Title: Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells.

PubMed ID: 10066734

DOI: 10.1074/jbc.274.11.6831

PubMed ID: 9924018

Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

PubMed ID: 9924018

DOI: 10.1126/science.283.5402.655

PubMed ID: 10748214

Title: Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.

PubMed ID: 10748214

DOI: 10.1074/jbc.m910348199

PubMed ID: 10973280

Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

PubMed ID: 10973280

DOI: 10.1038/79767

PubMed ID: 12464600

Title: Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.

PubMed ID: 12464600

DOI: 10.1074/jbc.m210120200

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 14711824

Title: Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

PubMed ID: 14711824

DOI: 10.1074/jbc.c300443200

PubMed ID: 16325578

Title: A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.

PubMed ID: 16325578

DOI: 10.1016/j.cell.2005.09.011

PubMed ID: 15611106

Title: beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.

PubMed ID: 15611106

DOI: 10.1074/jbc.m412924200

PubMed ID: 16144840

Title: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.

PubMed ID: 16144840

DOI: 10.1074/jbc.m500535200

PubMed ID: 15475570

Title: Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.

PubMed ID: 15475570

DOI: 10.1124/mol.104.006072

PubMed ID: 15671180

Title: Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

PubMed ID: 15671180

DOI: 10.1073/pnas.0409534102

PubMed ID: 16516836

Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.

PubMed ID: 16516836

DOI: 10.1016/j.devcel.2006.01.016

PubMed ID: 16280323

Title: beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

PubMed ID: 16280323

DOI: 10.1074/jbc.m506576200

PubMed ID: 16492667

Title: Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

PubMed ID: 16492667

DOI: 10.1074/jbc.m513380200

PubMed ID: 16709866

Title: Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.

PubMed ID: 16709866

DOI: 10.4049/jimmunol.176.11.7039

PubMed ID: 16378096

Title: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.

PubMed ID: 16378096

DOI: 10.1038/ni1294

PubMed ID: 16524428

Title: The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.

PubMed ID: 16524428

DOI: 10.1111/j.1600-0749.2006.00292.x

PubMed ID: 17456551

Title: Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

PubMed ID: 17456551

DOI: 10.1242/jcs.03444

PubMed ID: 18337459

Title: Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.

PubMed ID: 18337459

DOI: 10.1096/fj.07-102459

PubMed ID: 18419762

Title: Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.

PubMed ID: 18419762

DOI: 10.1111/j.1471-4159.2008.05431.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19643177

Title: Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2.

PubMed ID: 19643177

DOI: 10.1016/j.cellsig.2009.07.010

PubMed ID: 19661922

Title: Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

PubMed ID: 19661922

DOI: 10.1038/emboj.2009.215

PubMed ID: 19782076

Title: A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.

PubMed ID: 19782076

DOI: 10.1016/j.febslet.2009.09.035

PubMed ID: 19620252

Title: An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.

PubMed ID: 19620252

DOI: 10.1189/jlb.0908551

PubMed ID: 19363159

Title: Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.

PubMed ID: 19363159

DOI: 10.1073/pnas.0901083106

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22457824

Title: Ubiquitination of CXCR7 controls receptor trafficking.

PubMed ID: 22457824

DOI: 10.1371/journal.pone.0034192

PubMed ID: 23341447

Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

PubMed ID: 23341447

DOI: 10.1074/jbc.m112.406108

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28827538

Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.

PubMed ID: 28827538

DOI: 10.1038/s41598-017-08996-7

PubMed ID: 16903783

Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.

PubMed ID: 16903783

DOI: 10.1371/journal.pbio.0040262

Sequence Information:

Length: 418
Mass: 47066
Checksum: 0A3C135092338D10
Sequence:

MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA 
FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP 
PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP 
QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD 
ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL 
ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP 
PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR

Genular Protein ID: 518639045

Symbol: B7Z1Q3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1Q3

Database IDs:

Sequence Information:

Length: 169
Mass: 18632
Checksum: C156211FA9C86640
Sequence:

MKCWSNAWQT YALQCLLKPL GLTQDPLVFG MTSFLQTSSP IPNSCMENVC QAGFPSLLHL 
NITLTLLGLA QCYLANFSSC REGSEHYLFF FFFSWSQDCT RQWPNLVEFS LPSFADDSAL 
CQVLEPQRWV SPSPCPQEAH GQGNVVGISN RGQLPSGLLV AAGPYGALM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ARRB1

Associated with

Cells (max top 100)

Other Information

Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing. PubMed ID: 8486659

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. PubMed ID: 9501202

Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells. PubMed ID: 10066734

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. PubMed ID: 9924018

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. PubMed ID: 10748214

Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI. PubMed ID: 10973280

Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. PubMed ID: 12464600

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. PubMed ID: 15878855

Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. PubMed ID: 14711824

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. PubMed ID: 16325578

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. PubMed ID: 15611106

G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. PubMed ID: 16144840

Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. PubMed ID: 15475570

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. PubMed ID: 15671180

Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly. PubMed ID: 16516836

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. PubMed ID: 16280323

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. PubMed ID: 16492667

Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. PubMed ID: 16709866

Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. PubMed ID: 16378096

The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor. PubMed ID: 16524428

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex. PubMed ID: 17456551

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. PubMed ID: 18337459

Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms. PubMed ID: 18419762

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2. PubMed ID: 19643177

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. PubMed ID: 19661922

A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. PubMed ID: 19782076

An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages. PubMed ID: 19620252

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. PubMed ID: 19363159

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Ubiquitination of CXCR7 controls receptor trafficking. PubMed ID: 22457824

Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. PubMed ID: 23341447

Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. PubMed ID: 23886940

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. PubMed ID: 23633677

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. PubMed ID: 28827538

Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. PubMed ID: 16903783