Details for: ARRB1
Gene ID: 408
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ARRB1
Ensembl ID: ENSG00000137486
Description: arrestin beta 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 6.86rCSI 15.11%PRS 47.29
-
CSI 6.83rCSI 11.46%PRS 28.49
-
CSI 6.56rCSI 24.78%PRS 29.45
-
CSI 6.23rCSI 36.69%PRS 29.86
-
CSI 6rCSI 6.29%PRS 40.74
-
CSI 5.79rCSI 13.25%PRS 42.75
-
CSI 5.55rCSI 17.34%PRS 29.62
-
CSI 5.51rCSI 21.55%PRS 21.42
-
CSI 5.18rCSI 28.3%PRS 46.83
-
CSI 4.79rCSI 5.97%PRS 54.67
-
CSI 4.61rCSI 3.55%PRS 42.06
-
CSI 4.59rCSI 16.51%PRS 27.43
-
CSI 4.56rCSI 19.78%PRS 59.15
-
CSI 4.52rCSI 13.42%PRS 55.02
-
CSI 4.14rCSI 4.95%PRS 28.48
-
CSI 4.03rCSI 5.13%PRS 48.45
-
CSI 3.99rCSI 6.99%PRS 36.04
-
CSI 3.95rCSI 15.95%PRS 41.97
-
CSI 3.64rCSI 9.48%PRS 42.47
-
CSI 3.61rCSI 8.34%PRS 35.66
-
CSI 3.44rCSI 7.46%PRS 34.04
-
CSI 3.38rCSI 16.2%PRS 41.87
-
CSI 3.18rCSI 2.36%PRS 37.31
-
CSI 3.17rCSI 8.14%PRS 46.28
-
CSI 3.09rCSI 5.09%PRS 48.79
-
CSI 2.97rCSI 6.63%PRS 49.7
-
CSI 2.96rCSI 3.58%PRS 50.88
-
CSI 2.96rCSI 16.7%PRS 30.41
-
CSI 2.94rCSI 5.9%PRS 33.77
-
CSI 2.93rCSI 3.65%PRS 27.05
-
CSI 2.89rCSI 2.39%PRS 41.86
-
CSI 2.8rCSI 2.53%PRS 40.1
-
CSI 2.77rCSI 7.87%PRS 43.41
-
CSI 2.73rCSI 10.24%PRS 36.81
-
CSI 2.68rCSI 4.74%PRS 27.52
-
CSI 2.66rCSI 4.12%PRS 41.33
-
CSI 2.65rCSI 4.27%PRS 30.55
-
CSI 2.65rCSI 6.73%PRS 34.38
-
CSI 2.58rCSI 2%PRS 43.73
-
CSI 2.58rCSI 10.97%PRS 40.97
-
CSI 2.58rCSI 5.79%PRS 63.41
-
CSI 2.55rCSI 3.29%PRS 29.4
-
CSI 2.51rCSI 2.3%PRS 50.54
-
CSI 2.5rCSI 4.32%PRS 34.53
-
CSI 2.5rCSI 2.02%PRS 43.91
-
CSI 2.47rCSI 9.31%PRS 36.96
-
CSI 2.42rCSI 2.34%PRS 34.41
-
CSI 2.4rCSI 2.23%PRS 43.22
-
CSI 2.37rCSI 3.04%PRS 39.2
-
CSI 2.37rCSI 1.87%PRS 31.7
-
CSI 2.29rCSI 7.15%PRS 31.85
-
CSI 2.25rCSI 4.29%PRS 60.08
-
CSI 2.25rCSI 3.26%PRS 59.41
-
CSI 2.24rCSI 5.44%PRS 27.67
-
CSI 2.08rCSI 8.48%PRS 41.14
-
CSI 2.08rCSI 2.78%PRS 44.84
-
CSI 2.08rCSI 4.31%PRS 41.34
-
CSI 1.96rCSI 4.47%PRS 42.04
-
CSI 1.92rCSI 1.78%PRS 44.29
-
CSI 1.92rCSI 2.72%PRS 40.44
-
CSI 1.82rCSI 2.1%PRS 33.92
-
CSI 1.81rCSI 43.72%PRS 28.87
-
CSI 1.81rCSI 2.73%PRS 45.23
-
CSI 1.77rCSI 6.07%PRS 35.57
-
CSI 1.77rCSI 42.43%PRS 27.99
-
CSI 1.77rCSI 2.32%PRS 56.33
-
CSI 1.76rCSI 4.86%PRS 40.27
-
CSI 1.76rCSI 2.39%PRS 56.18
-
CSI 1.72rCSI 8.24%PRS 45.09
-
CSI 1.71rCSI 1.14%PRS 47.22
-
CSI 1.69rCSI 2.48%PRS 39.67
-
CSI 1.67rCSI 5.43%PRS 45.56
-
CSI 1.65rCSI 2.98%PRS 65.67
-
CSI 1.63rCSI 2.05%PRS 56.68
-
CSI 1.55rCSI 9.69%PRS 29.57
-
CSI 1.55rCSI 1.34%PRS 46.98
-
CSI 1.51rCSI 3.05%PRS 26.71
-
CSI 1.5rCSI 1.8%PRS 41.48
-
CSI 1.5rCSI 2.32%PRS 53.33
-
CSI 1.46rCSI 2.08%PRS 45.96
-
CSI 1.45rCSI 6.01%PRS 52.98
-
CSI 1.42rCSI 20.15%PRS 36.32
-
CSI 1.42rCSI 3.67%PRS 39.67
-
CSI 1.28rCSI 3.16%PRS 41.44
-
CSI 1.26rCSI 7.24%PRS 45.58
-
CSI 1.12rCSI 2.48%PRS 32.33
-
CSI 1.07rCSI 3.52%PRS 32.72
-
CSI 1.04rCSI 2.34%PRS 29.13
-
CSI 0.99rCSI 2.38%PRS 33.36
-
CSI 0.97rCSI 1.99%PRS 38.27
-
CSI 0.81rCSI 3.63%PRS 30.66
-
CSI 0.71rCSI 3.15%PRS 42.02
-
CSI 0.7rCSI 2.36%PRS 32.45
-
CSI 0.7rCSI 1.32%PRS 53.41
-
CSI 0.69rCSI 1.1%PRS 53.7
-
CSI 0.66rCSI 1.86%PRS 43.83
-
CSI 0.56rCSI 4.59%PRS 38.24
-
CSI 0.47rCSI 3.47%PRS 31.97
-
CSI 0.35rCSI 7.12%PRS 36.6
-
CSI 0.33rCSI 2.84%PRS 31.51
-
CSI 0.3rCSI 5.4%PRS 37.6%
-
CSI 0.3rCSI 5.7%PRS 68.6%
-
CSI 0.3rCSI 2.8%PRS 31.5%
-
CSI 0.4rCSI 7.1%PRS 36.6%
-
CSI 0.5rCSI 3.5%PRS 32.0%
-
CSI 0.6rCSI 4.6%PRS 38.2%
-
CSI 0.7rCSI 1.9%PRS 43.8%
-
CSI 0.7rCSI 1.1%PRS 53.7%
-
CSI 0.7rCSI 1.3%PRS 53.4%
-
CSI 0.7rCSI 2.4%PRS 32.5%
-
CSI 0.7rCSI 3.2%PRS 42.0%
-
CSI 0.8rCSI 3.6%PRS 30.7%
-
CSI 1.0rCSI 2.0%PRS 38.3%
-
CSI 1.0rCSI 2.4%PRS 33.4%
-
CSI 1.0rCSI 2.3%PRS 29.1%
-
CSI 1.1rCSI 3.5%PRS 32.7%
-
CSI 1.1rCSI 2.5%PRS 32.3%
-
CSI 1.3rCSI 7.2%PRS 45.6%
-
CSI 1.3rCSI 3.2%PRS 41.4%
-
CSI 1.4rCSI 3.7%PRS 39.7%
-
CSI 1.4rCSI 20.2%PRS 36.3%
-
CSI 1.5rCSI 6.0%PRS 53.0%
-
CSI 1.5rCSI 2.1%PRS 46.0%
-
CSI 1.5rCSI 2.3%PRS 53.3%
-
CSI 1.5rCSI 1.8%PRS 41.5%
-
CSI 1.5rCSI 3.1%PRS 26.7%
-
CSI 1.6rCSI 1.3%PRS 47.0%
-
CSI 1.6rCSI 9.7%PRS 29.6%
-
CSI 1.6rCSI 2.1%PRS 56.7%
-
CSI 1.7rCSI 3.0%PRS 65.7%
-
CSI 1.7rCSI 5.4%PRS 45.6%
-
CSI 1.7rCSI 2.5%PRS 39.7%
-
CSI 1.7rCSI 1.1%PRS 47.2%
-
CSI 1.7rCSI 8.2%PRS 45.1%
-
CSI 1.8rCSI 2.4%PRS 56.2%
-
CSI 1.8rCSI 4.9%PRS 40.3%
-
CSI 1.8rCSI 2.3%PRS 56.3%
-
CSI 1.8rCSI 42.4%PRS 28.0%
-
CSI 1.8rCSI 6.1%PRS 35.6%
-
CSI 1.8rCSI 2.7%PRS 45.2%
-
CSI 1.8rCSI 43.7%PRS 28.9%
-
CSI 1.8rCSI 2.1%PRS 33.9%
-
CSI 1.9rCSI 2.7%PRS 40.4%
-
CSI 1.9rCSI 1.8%PRS 44.3%
-
CSI 2.0rCSI 4.5%PRS 42.0%
-
CSI 2.1rCSI 4.3%PRS 41.3%
-
CSI 2.1rCSI 2.8%PRS 44.8%
-
CSI 2.1rCSI 8.5%PRS 41.1%
-
CSI 2.2rCSI 5.4%PRS 27.7%
-
CSI 2.3rCSI 3.3%PRS 59.4%
-
CSI 2.3rCSI 4.3%PRS 60.1%
-
CSI 2.3rCSI 7.2%PRS 31.9%
-
CSI 2.4rCSI 1.9%PRS 31.7%
-
CSI 2.4rCSI 3.0%PRS 39.2%
-
CSI 2.4rCSI 2.2%PRS 43.2%
-
CSI 2.4rCSI 2.3%PRS 34.4%
-
CSI 2.5rCSI 9.3%PRS 37.0%
-
CSI 2.5rCSI 2.0%PRS 43.9%
-
CSI 2.5rCSI 4.3%PRS 34.5%
-
CSI 2.5rCSI 2.3%PRS 50.5%
-
CSI 2.6rCSI 3.3%PRS 29.4%
-
CSI 2.6rCSI 5.8%PRS 63.4%
-
CSI 2.6rCSI 11.0%PRS 41.0%
-
CSI 2.6rCSI 2.0%PRS 43.7%
-
CSI 2.7rCSI 6.7%PRS 34.4%
-
CSI 2.7rCSI 4.3%PRS 30.6%
-
CSI 2.7rCSI 4.1%PRS 41.3%
-
CSI 2.7rCSI 4.7%PRS 27.5%
-
CSI 2.7rCSI 10.2%PRS 36.8%
-
CSI 2.8rCSI 7.9%PRS 43.4%
-
CSI 2.8rCSI 2.5%PRS 40.1%
-
CSI 2.9rCSI 2.4%PRS 41.9%
-
CSI 2.9rCSI 3.7%PRS 27.1%
-
CSI 2.9rCSI 5.9%PRS 33.8%
-
CSI 3.0rCSI 16.7%PRS 30.4%
-
CSI 3.0rCSI 3.6%PRS 50.9%
-
CSI 3.0rCSI 6.6%PRS 49.7%
-
CSI 3.1rCSI 5.1%PRS 48.8%
-
CSI 3.2rCSI 8.1%PRS 46.3%
-
CSI 3.2rCSI 2.4%PRS 37.3%
-
CSI 3.4rCSI 16.2%PRS 41.9%
-
CSI 3.4rCSI 7.5%PRS 34.0%
-
CSI 3.6rCSI 8.3%PRS 35.7%
-
CSI 3.6rCSI 9.5%PRS 42.5%
-
CSI 4.0rCSI 16.0%PRS 42.0%
-
CSI 4.0rCSI 7.0%PRS 36.0%
-
CSI 4.0rCSI 5.1%PRS 48.5%
-
CSI 4.1rCSI 5.0%PRS 28.5%
-
CSI 4.5rCSI 13.4%PRS 55.0%
-
CSI 4.6rCSI 19.8%PRS 59.2%
-
CSI 4.6rCSI 16.5%PRS 27.4%
-
CSI 4.6rCSI 3.6%PRS 42.1%
-
CSI 4.8rCSI 6.0%PRS 54.7%
-
CSI 5.2rCSI 28.3%PRS 46.8%
-
CSI 5.5rCSI 21.6%PRS 21.4%
-
CSI 5.6rCSI 17.3%PRS 29.6%
-
CSI 5.8rCSI 13.3%PRS 42.8%
-
CSI 6.0rCSI 6.3%PRS 40.7%
-
CSI 6.2rCSI 36.7%PRS 29.9%
-
CSI 6.6rCSI 24.8%PRS 29.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3785399271
Symbol: ARRB1_HUMAN
Name: Beta-arrestin-1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8486659
Title: Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.
PubMed ID: 8486659
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9501202
Title: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2.
PubMed ID: 9501202
PubMed ID: 10066734
Title: Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells.
PubMed ID: 10066734
PubMed ID: 9924018
Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
PubMed ID: 9924018
PubMed ID: 10748214
Title: Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.
PubMed ID: 10748214
PubMed ID: 10973280
Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.
PubMed ID: 10973280
DOI: 10.1038/79767
PubMed ID: 12464600
Title: Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.
PubMed ID: 12464600
PubMed ID: 15878855
Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.
PubMed ID: 15878855
PubMed ID: 14711824
Title: Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.
PubMed ID: 14711824
PubMed ID: 16325578
Title: A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.
PubMed ID: 16325578
PubMed ID: 15611106
Title: beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.
PubMed ID: 15611106
PubMed ID: 16144840
Title: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
PubMed ID: 16144840
PubMed ID: 15475570
Title: Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.
PubMed ID: 15475570
PubMed ID: 15671180
Title: Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.
PubMed ID: 15671180
PubMed ID: 16516836
Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.
PubMed ID: 16516836
PubMed ID: 16280323
Title: beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.
PubMed ID: 16280323
PubMed ID: 16492667
Title: Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
PubMed ID: 16492667
PubMed ID: 16709866
Title: Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.
PubMed ID: 16709866
PubMed ID: 16378096
Title: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.
PubMed ID: 16378096
DOI: 10.1038/ni1294
PubMed ID: 16524428
Title: The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.
PubMed ID: 16524428
PubMed ID: 17456551
Title: Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.
PubMed ID: 17456551
DOI: 10.1242/jcs.03444
PubMed ID: 18337459
Title: Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.
PubMed ID: 18337459
DOI: 10.1096/fj.07-102459
PubMed ID: 18419762
Title: Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.
PubMed ID: 18419762
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19643177
Title: Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2.
PubMed ID: 19643177
PubMed ID: 19661922
Title: Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.
PubMed ID: 19661922
PubMed ID: 19782076
Title: A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.
PubMed ID: 19782076
PubMed ID: 19620252
Title: An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.
PubMed ID: 19620252
DOI: 10.1189/jlb.0908551
PubMed ID: 19363159
Title: Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.
PubMed ID: 19363159
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22457824
Title: Ubiquitination of CXCR7 controls receptor trafficking.
PubMed ID: 22457824
PubMed ID: 23341447
Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.
PubMed ID: 23341447
PubMed ID: 23886940
Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.
PubMed ID: 23886940
DOI: 10.1242/jcs.130500
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23633677
Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.
PubMed ID: 23633677
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28827538
Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.
PubMed ID: 28827538
PubMed ID: 16903783
Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.
PubMed ID: 16903783
Sequence Information:
- Length: 418
- Mass: 47066
- Checksum: 0A3C135092338D10
- Sequence:
MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR
Genular Protein ID: 518639045
Symbol: B7Z1Q3_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 169
- Mass: 18632
- Checksum: C156211FA9C86640
- Sequence:
MKCWSNAWQT YALQCLLKPL GLTQDPLVFG MTSFLQTSSP IPNSCMENVC QAGFPSLLHL NITLTLLGLA QCYLANFSSC REGSEHYLFF FFFSWSQDCT RQWPNLVEFS LPSFADDSAL CQVLEPQRWV SPSPCPQEAH GQGNVVGISN RGQLPSGLLV AAGPYGALM