Gene ARRB1 - ENSG00000137486 | NCBI Gene ID: 408

Details for: ARRB1

Gene ID: 408

Symbol: ARRB1

Ensembl ID: ENSG00000137486

Description: arrestin beta 1

Associated with

Activated notch1 transmits signal to the nucleus
(R-HSA-2122948)
Activation of smo
(R-HSA-5635838)
Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Deubiquitination
(R-HSA-5688426)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
G alpha (s) signalling events
(R-HSA-418555)
Golgi associated vesicle biogenesis
(R-HSA-432722)
Gpcr downstream signalling
(R-HSA-388396)
Hedgehog 'on' state
(R-HSA-5632684)
Hemostasis
(R-HSA-109582)
Lysosome vesicle biogenesis
(R-HSA-432720)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Post-translational protein modification
(R-HSA-597592)
Raf/map kinase cascade
(R-HSA-5673001)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by gpcr
(R-HSA-372790)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by notch
(R-HSA-157118)
Signaling by notch1
(R-HSA-1980143)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling downstream of ras mutants
(R-HSA-9649948)
Thrombin signalling through proteinase activated receptors (pars)
(R-HSA-456926)
Trans-golgi network vesicle budding
(R-HSA-199992)
Ub-specific processing proteases
(R-HSA-5689880)
Vesicle-mediated transport
(R-HSA-5653656)
Angiotensin receptor binding
(GO:0031701)
Arrestin family protein binding
(GO:1990763)
Chromatin
(GO:0000785)
Clathrin-coated pit
(GO:0005905)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Cytosol
(GO:0005829)
Enzyme inhibitor activity
(GO:0004857)
Golgi membrane
(GO:0000139)
G protein-coupled receptor binding
(GO:0001664)
G protein-coupled receptor internalization
(GO:0002031)
Gtpase activator activity
(GO:0005096)
Histone acetyltransferase activity
(GO:0004402)
Insulin-like growth factor receptor binding
(GO:0005159)
Lysosomal membrane
(GO:0005765)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of notch signaling pathway
(GO:0045746)
Negative regulation of protein ubiquitination
(GO:0031397)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein transport
(GO:0015031)
Protein ubiquitination
(GO:0016567)
Pseudopodium
(GO:0031143)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Signal transduction
(GO:0007165)
Stress fiber assembly
(GO:0043149)
Transcription coactivator activity
(GO:0003713)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin protein ligase binding
(GO:0031625)
Visual perception
(GO:0007601)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.04
Marker Score: 43465.5
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.85
Marker Score: 36855.5
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.84
Marker Score: 27497
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.84
Marker Score: 69695
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.8
Marker Score: 6972
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.8
Marker Score: 66488
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8
Marker Score: 110575
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.79
Marker Score: 16820
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.77
Marker Score: 7342
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 1.77
Marker Score: 13552
Cell Name: neuron (CL0000540)
Fold Change: 1.76
Marker Score: 7153
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.73
Marker Score: 16420
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.72
Marker Score: 1984
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.7
Marker Score: 17515
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.67
Marker Score: 6982
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.66
Marker Score: 14230
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.57
Marker Score: 3200
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.54
Marker Score: 562
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.49
Marker Score: 2162
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.44
Marker Score: 715
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.41
Marker Score: 7587
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.4
Marker Score: 2154
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.4
Marker Score: 437
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.31
Marker Score: 2529
Cell Name: astrocyte (CL0000127)
Fold Change: 1.3
Marker Score: 1128
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.24
Marker Score: 41719
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.21
Marker Score: 703
Cell Name: lactocyte (CL0002325)
Fold Change: 1.2
Marker Score: 19343
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.2
Marker Score: 986
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.19
Marker Score: 383
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 1.16
Marker Score: 1684
Cell Name: podocyte (CL0000653)
Fold Change: 1.13
Marker Score: 416
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.06
Marker Score: 409
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.06
Marker Score: 846
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.05
Marker Score: 1054
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.05
Marker Score: 441
Cell Name: granule cell (CL0000120)
Fold Change: 1.03
Marker Score: 7801
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.03
Marker Score: 2005
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.02
Marker Score: 2602
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.02
Marker Score: 1226
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.02
Marker Score: 3996
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.01
Marker Score: 15871
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.01
Marker Score: 4660
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71744
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47970
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.99
Marker Score: 17526
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.98
Marker Score: 1053
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30399
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.98
Marker Score: 54719
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.97
Marker Score: 582
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.97
Marker Score: 469
Cell Name: hepatoblast (CL0005026)
Fold Change: 0.96
Marker Score: 3151
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.96
Marker Score: 2207
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.96
Marker Score: 1157
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.96
Marker Score: 630
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 491
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2406
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 446
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.94
Marker Score: 257
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.94
Marker Score: 546
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.93
Marker Score: 5589
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.91
Marker Score: 1477
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2722
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 0.89
Marker Score: 2155
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.89
Marker Score: 765
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 314
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.87
Marker Score: 4958
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.87
Marker Score: 22217
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.87
Marker Score: 313
Cell Name: fat cell (CL0000136)
Fold Change: 0.85
Marker Score: 473
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.83
Marker Score: 456
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.81
Marker Score: 619
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 321
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.79
Marker Score: 5180
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.77
Marker Score: 4023
Cell Name: osteoclast (CL0000092)
Fold Change: 0.76
Marker Score: 381
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.74
Marker Score: 214
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.74
Marker Score: 3107
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.74
Marker Score: 414
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.74
Marker Score: 382
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.72
Marker Score: 301
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.71
Marker Score: 860.5
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.7
Marker Score: 335
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.7
Marker Score: 541
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.7
Marker Score: 178
Cell Name: brush cell (CL0002204)
Fold Change: 0.7
Marker Score: 637
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.7
Marker Score: 1117
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.69
Marker Score: 343
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.69
Marker Score: 3644
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: blood cell (CL0000081)
Fold Change: 0.68
Marker Score: 7881
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.68
Marker Score: 1150
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.66
Marker Score: 675
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.66
Marker Score: 476
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 0.66
Marker Score: 1101
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.65
Marker Score: 1612
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.64
Marker Score: 402
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 0.64
Marker Score: 2679.5
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.64
Marker Score: 690

Hover over a box to see details here...

**Key characteristics:** * ARRB1 is a transmembrane protein that is expressed in a variety of cell types, including astrocytes, neurons, and endothelial cells. * It is a ubiquitination-dependent protein that is degraded by the proteasome. * It is a key regulator of the Hippocampus-specific interneuron (HIC) network, which is responsible for the development and function of the cerebral cortex. * It is involved in the regulation of synaptic plasticity, learning, and memory. * It is a key regulator of the development of the cerebral cortex. **Pathways and functions:** * ARRB1 is involved in the regulation of cell growth, migration, and differentiation. * It is a key regulator of the HIC network, which is responsible for the development and function of the cerebral cortex. * It is involved in the regulation of synaptic plasticity, learning, and memory. * It is a key regulator of the development of the cerebral cortex. **Clinical significance:** * Mutations in ARRB1 have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * ARRB1 is a potential target for the treatment of these disorders. **Additional information:** * ARRB1 is a member of the arrestin family of proteins, which are involved in the regulation of cell signaling. * It is a highly conserved protein, with a similar sequence in mammals and humans. * It is a well-established target for cancer immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Beta-arrestin-1
B7Z1Q3_HUMAN

Genular Protein ID: 3785399271

Symbol: ARRB1_HUMAN

Name: Beta-arrestin-1

UniProtKB Accession Codes:

P49407 B6V9G8 O75625 O75630 Q2PP20 Q9BTK8

Database IDs:

Citations:

PubMed ID: 8486659

Title: Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing.

PubMed ID: 8486659

DOI: 10.1016/s0021-9258(18)98412-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9501202

Title: Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2.

PubMed ID: 9501202

DOI: 10.1073/pnas.95.6.2985

PubMed ID: 10066734

Title: Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells.

PubMed ID: 10066734

DOI: 10.1074/jbc.274.11.6831

PubMed ID: 9924018

Title: Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

PubMed ID: 9924018

DOI: 10.1126/science.283.5402.655

PubMed ID: 10748214

Title: Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.

PubMed ID: 10748214

DOI: 10.1074/jbc.m910348199

PubMed ID: 10973280

Title: Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.

PubMed ID: 10973280

DOI: 10.1038/79767

PubMed ID: 12464600

Title: Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.

PubMed ID: 12464600

DOI: 10.1074/jbc.m210120200

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 14711824

Title: Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2.

PubMed ID: 14711824

DOI: 10.1074/jbc.c300443200

PubMed ID: 16325578

Title: A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.

PubMed ID: 16325578

DOI: 10.1016/j.cell.2005.09.011

PubMed ID: 15611106

Title: beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation.

PubMed ID: 15611106

DOI: 10.1074/jbc.m412924200

PubMed ID: 16144840

Title: G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.

PubMed ID: 16144840

DOI: 10.1074/jbc.m500535200

PubMed ID: 15475570

Title: Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking.

PubMed ID: 15475570

DOI: 10.1124/mol.104.006072

PubMed ID: 15671180

Title: Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

PubMed ID: 15671180

DOI: 10.1073/pnas.0409534102

PubMed ID: 16516836

Title: Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly.

PubMed ID: 16516836

DOI: 10.1016/j.devcel.2006.01.016

PubMed ID: 16280323

Title: beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

PubMed ID: 16280323

DOI: 10.1074/jbc.m506576200

PubMed ID: 16492667

Title: Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

PubMed ID: 16492667

DOI: 10.1074/jbc.m513380200

PubMed ID: 16709866

Title: Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation.

PubMed ID: 16709866

DOI: 10.4049/jimmunol.176.11.7039

PubMed ID: 16378096

Title: Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.

PubMed ID: 16378096

DOI: 10.1038/ni1294

PubMed ID: 16524428

Title: The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor.

PubMed ID: 16524428

DOI: 10.1111/j.1600-0749.2006.00292.x

PubMed ID: 17456551

Title: Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex.

PubMed ID: 17456551

DOI: 10.1242/jcs.03444

PubMed ID: 18337459

Title: Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle.

PubMed ID: 18337459

DOI: 10.1096/fj.07-102459

PubMed ID: 18419762

Title: Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms.

PubMed ID: 18419762

DOI: 10.1111/j.1471-4159.2008.05431.x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19643177

Title: Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2.

PubMed ID: 19643177

DOI: 10.1016/j.cellsig.2009.07.010

PubMed ID: 19661922

Title: Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling.

PubMed ID: 19661922

DOI: 10.1038/emboj.2009.215

PubMed ID: 19782076

Title: A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex.

PubMed ID: 19782076

DOI: 10.1016/j.febslet.2009.09.035

PubMed ID: 19620252

Title: An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages.

PubMed ID: 19620252

DOI: 10.1189/jlb.0908551

PubMed ID: 19363159

Title: Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2.

PubMed ID: 19363159

DOI: 10.1073/pnas.0901083106

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22457824

Title: Ubiquitination of CXCR7 controls receptor trafficking.

PubMed ID: 22457824

DOI: 10.1371/journal.pone.0034192

PubMed ID: 23341447

Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

PubMed ID: 23341447

DOI: 10.1074/jbc.m112.406108

PubMed ID: 23886940

Title: Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals.

PubMed ID: 23886940

DOI: 10.1242/jcs.130500

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23633677

Title: Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6.

PubMed ID: 23633677

DOI: 10.1126/scisignal.2003627

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28827538

Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions.

PubMed ID: 28827538

DOI: 10.1038/s41598-017-08996-7

PubMed ID: 16903783

Title: Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly.

PubMed ID: 16903783

DOI: 10.1371/journal.pbio.0040262

Sequence Information:

Length: 418
Mass: 47066
Checksum: 0A3C135092338D10
Sequence:

MGDKGTRVFK KASPNGKLTV YLGKRDFVDH IDLVDPVDGV VLVDPEYLKE RRVYVTLTCA 
FRYGREDLDV LGLTFRKDLF VANVQSFPPA PEDKKPLTRL QERLIKKLGE HAYPFTFEIP 
PNLPCSVTLQ PGPEDTGKAC GVDYEVKAFC AENLEEKIHK RNSVRLVIRK VQYAPERPGP 
QPTAETTRQF LMSDKPLHLE ASLDKEIYYH GEPISVNVHV TNNTNKTVKK IKISVRQYAD 
ICLFNTAQYK CPVAMEEADD TVAPSSTFCK VYTLTPFLAN NREKRGLALD GKLKHEDTNL 
ASSTLLREGA NREILGIIVS YKVKVKLVVS RGGLLGDLAS SDVAVELPFT LMHPKPKEEP 
PHREVPENET PVDTNLIELD TNDDDIVFED FARQRLKGMK DDKEEEEDGT GSPQLNNR

Genular Protein ID: 518639045

Symbol: B7Z1Q3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z1Q3

Database IDs:

Sequence Information:

Length: 169
Mass: 18632
Checksum: C156211FA9C86640
Sequence:

MKCWSNAWQT YALQCLLKPL GLTQDPLVFG MTSFLQTSSP IPNSCMENVC QAGFPSLLHL 
NITLTLLGLA QCYLANFSSC REGSEHYLFF FFFSWSQDCT RQWPNLVEFS LPSFADDSAL 
CQVLEPQRWV SPSPCPQEAH GQGNVVGISN RGQLPSGLLV AAGPYGALM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ARRB1

Associated with

Cells (max top 100)

Other Information

Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing. PubMed ID: 8486659

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2. PubMed ID: 9501202

Targeted construction of phosphorylation-independent beta-arrestin mutants with constitutive activity in cells. PubMed ID: 10066734

Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. PubMed ID: 9924018

Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors. PubMed ID: 10748214

Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI. PubMed ID: 10973280

Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. PubMed ID: 12464600

{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. PubMed ID: 15878855

Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. PubMed ID: 14711824

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. PubMed ID: 16325578

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. PubMed ID: 15611106

G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. PubMed ID: 16144840

Multiple independent functions of arrestins in the regulation of protease-activated receptor-2 signaling and trafficking. PubMed ID: 15475570

Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. PubMed ID: 15671180

Molecular switches involving the AP-2 beta2 appendage regulate endocytic cargo selection and clathrin coat assembly. PubMed ID: 16516836

beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. PubMed ID: 16280323

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. PubMed ID: 16492667

Platelet-activating factor-induced clathrin-mediated endocytosis requires beta-arrestin-1 recruitment and activation of the p38 MAPK signalosome at the plasma membrane for actin bundle formation. PubMed ID: 16709866

Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling. PubMed ID: 16378096

The melanosomal/lysosomal protein OA1 has properties of a G protein-coupled receptor. PubMed ID: 16524428

Src-dependent phosphorylation of beta2-adaptin dissociates the beta-arrestin-AP-2 complex. PubMed ID: 17456551

Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. PubMed ID: 18337459

Post-endocytic fates of delta-opioid receptor are regulated by GRK2-mediated receptor phosphorylation and distinct beta-arrestin isoforms. PubMed ID: 18419762

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Inhibition of dynamin prevents CCL2-mediated endocytosis of CCR2 and activation of ERK1/2. PubMed ID: 19643177

Beta-arrestin1 phosphorylation by GRK5 regulates G protein-independent 5-HT4 receptor signalling. PubMed ID: 19661922

A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex. PubMed ID: 19782076

An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta/CCL4 signaling and chemotaxis of primary human macrophages. PubMed ID: 19620252

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. PubMed ID: 19363159

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Ubiquitination of CXCR7 controls receptor trafficking. PubMed ID: 22457824

Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. PubMed ID: 23341447

Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals. PubMed ID: 23886940

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6. PubMed ID: 23633677

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT2 receptor reciprocally modulate their signaling functions. PubMed ID: 28827538

Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. PubMed ID: 16903783