Details for: CL0000186

Cell ID: CL0000186

Cell Name: myofibroblast cell

Marker Score Threshold: 1234
(Derived using integrated single-cell and genomic data)

Description: An animal cell that has characteristics of both a fibroblast cell and a smooth muscle cell.

Synonyms: MFB

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 4.76
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.55
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 4.03
    Ensembl ID: ENSG00000122786
  • Gene Symbol: FOXL2 (ENSG00000183770)
    Fold Change: 3.9
    Ensembl ID: ENSG00000183770
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.6
    Ensembl ID: ENSG00000185650
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.24
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.89
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.81
    Ensembl ID: ENSG00000164111
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.81
    Ensembl ID: ENSG00000067560
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.63
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.62
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.55
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.44
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.41
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: 2.26
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.26
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 2.18
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.17
    Ensembl ID: ENSG00000184009
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.16
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.07
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.07
    Ensembl ID: ENSG00000124172
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.07
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.06
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.04
    Ensembl ID: ENSG00000104765
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.93
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.84
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.81
    Ensembl ID: ENSG00000154723
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.8
    Ensembl ID: ENSG00000151914
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.8
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.8
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.78
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154518
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.77
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.74
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.72
    Ensembl ID: ENSG00000169020
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.65
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.63
    Ensembl ID: ENSG00000177556
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.59
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.59
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.58
    Ensembl ID: ENSG00000162772
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.58
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.56
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.56
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.54
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.54
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.5
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.48
    Ensembl ID: ENSG00000100823
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.46
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.45
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.44
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.44
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.42
    Ensembl ID: ENSG00000090013
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.42
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.41
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.41
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 1.39
    Ensembl ID: ENSG00000165092
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.39
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.37
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.34
    Ensembl ID: ENSG00000087274
  • Gene Symbol: AEBP1 (ENSG00000106624)
    Fold Change: 1.34
    Ensembl ID: ENSG00000106624
  • Gene Symbol: C1S (ENSG00000182326)
    Fold Change: 1.33
    Ensembl ID: ENSG00000182326
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.33
    Ensembl ID: ENSG00000104763
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.31
    Ensembl ID: ENSG00000119138
  • Gene Symbol: C1R (ENSG00000159403)
    Fold Change: 1.31
    Ensembl ID: ENSG00000159403
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.31
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.31
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.3
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.28
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.28
    Ensembl ID: ENSG00000198363
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.28
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.27
    Ensembl ID: ENSG00000141522
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.27
    Ensembl ID: ENSG00000142599
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.25
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.24
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.23
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.23
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.22
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.19
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.18
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ARL3 (ENSG00000138175)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138175
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.15
    Ensembl ID: ENSG00000159199
  • Gene Symbol: CACNA1D (ENSG00000157388)
    Fold Change: 1.11
    Ensembl ID: ENSG00000157388
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.11
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 1.09
    Ensembl ID: ENSG00000058668
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.09
    Ensembl ID: ENSG00000108561
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.07
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ALDH9A1 (ENSG00000143149)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143149
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.07
    Ensembl ID: ENSG00000087088
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.07
    Ensembl ID: ENSG00000123505
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.06
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160710
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.04
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.03
    Ensembl ID: ENSG00000137845
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.03
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.02
    Ensembl ID: ENSG00000196975
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.01
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.01
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.01
    Ensembl ID: ENSG00000131100
Hovered Details

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Hovered Details

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**Key characteristics** 1. **Bipolar morphology**: MFB cells have a bipolar morphology, with a prominent nucleus and a long, thin cytoplasm. 2. **Actin cytoskeleton**: MFB cells have a well-developed actin cytoskeleton, which is essential for their contractile and motility functions. 3. **Smooth muscle-like properties**: MFB cells exhibit smooth muscle-like properties, including contractility and the ability to produce contractile forces. 4. **Fibroblast-like properties**: MFB cells also exhibit fibroblast-like properties, including the ability to produce collagen and other extracellular matrix components. 5. **Immune cell-like properties**: MFB cells have immune cell-like properties, including the ability to present antigens and regulate immune responses. **Clinical significance** 1. **Wound healing**: MFB cells play a crucial role in wound healing, where they contribute to the production of collagen and other extracellular matrix components. 2. **Fibrosis**: MFB cells are involved in the development of fibrosis, a condition characterized by the excessive accumulation of extracellular matrix components. 3. **Inflammation**: MFB cells are implicated in inflammatory responses, where they contribute to the production of pro-inflammatory cytokines and chemokines. 4. **Cancer**: MFB cells have been implicated in cancer, where they contribute to the development and progression of tumors. 5. **Neurodegenerative disorders**: MFB cells have been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where they contribute to the formation of amyloid fibers. 6. **Cardiovascular disease**: MFB cells are involved in cardiovascular disease, where they contribute to the development of atherosclerosis and cardiac fibrosis. 7. **Immunological disorders**: MFB cells are implicated in immunological disorders, such as rheumatoid arthritis and lupus, where they contribute to the production of autoantibodies and the development of autoimmune responses. In conclusion, the myofibroblast cell is a unique cell type that plays a crucial role in various physiological and pathological processes. Its characteristics, including its bipolar morphology, actin cytoskeleton, smooth muscle-like properties, fibroblast-like properties, and immune cell-like properties, make it an essential component of the immune system and a key player in various diseases.