Details for: HOXC8

Gene ID: 3224

Symbol: HOXC8

Ensembl ID: ENSG00000037965

Description: homeobox C8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.0141
    Cell Significance Index: -5.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0547
    Cell Significance Index: 36.6500
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.8783
    Cell Significance Index: 5.3800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.5634
    Cell Significance Index: 3.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2950
    Cell Significance Index: 14.9100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2581
    Cell Significance Index: 7.4000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.2214
    Cell Significance Index: 6.5200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1790
    Cell Significance Index: 2.0000
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.1360
    Cell Significance Index: 0.7800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1063
    Cell Significance Index: 1.1100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0637
    Cell Significance Index: 0.6300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0439
    Cell Significance Index: 0.2800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0426
    Cell Significance Index: 0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0098
    Cell Significance Index: 7.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0067
    Cell Significance Index: 0.1400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0025
    Cell Significance Index: 0.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0049
    Cell Significance Index: -0.6800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0095
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0125
    Cell Significance Index: -7.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0126
    Cell Significance Index: -6.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0186
    Cell Significance Index: -2.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0217
    Cell Significance Index: -0.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0260
    Cell Significance Index: -1.2200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0269
    Cell Significance Index: -2.7500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0300
    Cell Significance Index: -2.2400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0306
    Cell Significance Index: -0.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0332
    Cell Significance Index: -2.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0402
    Cell Significance Index: -8.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0411
    Cell Significance Index: -4.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0411
    Cell Significance Index: -7.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0497
    Cell Significance Index: -3.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0536
    Cell Significance Index: -0.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0589
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0621
    Cell Significance Index: -7.1200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0649
    Cell Significance Index: -2.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0659
    Cell Significance Index: -1.8000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0672
    Cell Significance Index: -0.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0692
    Cell Significance Index: -1.3500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0837
    Cell Significance Index: -0.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0891
    Cell Significance Index: -4.0400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0892
    Cell Significance Index: -1.3800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0988
    Cell Significance Index: -6.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1038
    Cell Significance Index: -5.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1046
    Cell Significance Index: -2.7500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1060
    Cell Significance Index: -0.8100
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1233
    Cell Significance Index: -0.5900
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1257
    Cell Significance Index: -1.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1392
    Cell Significance Index: -6.4900
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1439
    Cell Significance Index: -1.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1528
    Cell Significance Index: -8.5800
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.1559
    Cell Significance Index: -0.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1580
    Cell Significance Index: -5.0600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1639
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1676
    Cell Significance Index: -1.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1686
    Cell Significance Index: -6.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1790
    Cell Significance Index: -4.6000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1804
    Cell Significance Index: -4.5100
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1888
    Cell Significance Index: -1.5000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1927
    Cell Significance Index: -4.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1966
    Cell Significance Index: -5.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1997
    Cell Significance Index: -5.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2034
    Cell Significance Index: -3.6000
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2172
    Cell Significance Index: -2.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2327
    Cell Significance Index: -4.6400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2329
    Cell Significance Index: -6.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2352
    Cell Significance Index: -8.2700
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.2359
    Cell Significance Index: -2.5100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.2377
    Cell Significance Index: -2.3000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2524
    Cell Significance Index: -3.6700
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: -0.2552
    Cell Significance Index: -2.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2562
    Cell Significance Index: -5.6100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.2644
    Cell Significance Index: -3.3500
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.2670
    Cell Significance Index: -1.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2675
    Cell Significance Index: -6.8200
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2754
    Cell Significance Index: -4.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.2827
    Cell Significance Index: -4.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2828
    Cell Significance Index: -4.0500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2828
    Cell Significance Index: -1.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2849
    Cell Significance Index: -6.8300
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2853
    Cell Significance Index: -3.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2935
    Cell Significance Index: -8.4600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2971
    Cell Significance Index: -6.8700
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2994
    Cell Significance Index: -3.1300
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.3024
    Cell Significance Index: -3.0700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3066
    Cell Significance Index: -7.4800
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.3110
    Cell Significance Index: -3.2600
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3112
    Cell Significance Index: -3.2100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.3143
    Cell Significance Index: -4.1900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3257
    Cell Significance Index: -4.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3292
    Cell Significance Index: -5.5500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.3306
    Cell Significance Index: -4.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3336
    Cell Significance Index: -8.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3350
    Cell Significance Index: -5.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3422
    Cell Significance Index: -8.5600
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.3430
    Cell Significance Index: -3.2200
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.3486
    Cell Significance Index: -4.7800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.3515
    Cell Significance Index: -3.4100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3530
    Cell Significance Index: -4.8000
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.3538
    Cell Significance Index: -2.7500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** HOXC8 is expressed in a variety of cell types, including immune cells, epithelial cells, and neural precursors. 2. **Cell Signaling:** HOXC8 is involved in cell-cell communication, adherens junction interactions, and chromatin regulation through its ability to bind to RNA polymerase II and other transcription factors. 3. **Transcriptional Regulation:** HOXC8 regulates the expression of other genes, including CDH11, a classical cadherin involved in cell adhesion. 4. **Developmental Role:** HOXC8 plays a crucial role in embryonic development, particularly in the specification of anterior-posterior patterns and the organization of cell-cell junctions. **Pathways and Functions:** 1. **Adherens Junction Interactions:** HOXC8 regulates the expression and function of CDH11, a classical cadherin involved in cell adhesion. 2. **Anterior-Posterior Pattern Specification:** HOXC8 is involved in the specification of anterior-posterior patterns during embryonic development. 3. **Cell-Cell Communication:** HOXC8 regulates cell-cell communication through its ability to bind to RNA polymerase II and other transcription factors. 4. **Chromatin Regulation:** HOXC8 regulates chromatin structure and function through its ability to bind to chromatin and RNA polymerase II. 5. **Neuron Differentiation:** HOXC8 is involved in the regulation of neuron differentiation, particularly in the development of GABAergic interneurons in the cerebral cortex. **Clinical Significance:** 1. **Immunological Disorders:** Dysregulation of HOXC8 has been implicated in various immunological disorders, including autoimmune diseases and cancer. 2. **Neurological Disorders:** HOXC8's role in neuron differentiation and development suggests that dysregulation of this gene may contribute to neurological disorders, such as autism spectrum disorder and schizophrenia. 3. **Cancer:** HOXC8's involvement in cell-cell communication and adherens junction interactions suggests that dysregulation of this gene may contribute to cancer progression and metastasis. In conclusion, HOXC8 is a critical regulator of cell adhesion, differentiation, and development, and its dysregulation has been implicated in various diseases. Further research is necessary to fully elucidate the mechanisms by which HOXC8 regulates cell signaling and development, and to explore its therapeutic potential in the treatment of immunological and neurological disorders.

Genular Protein ID: 231081554

Symbol: HXC8_HUMAN

Name: Homeobox protein Hox-C8

UniProtKB Accession Codes:

P31273 A8K4J4 O15221 O15362

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9357979

Title: Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.

PubMed ID: 9357979

DOI: 10.1016/s0014-5793(97)01118-6

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 12925734

Title: Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.

PubMed ID: 12925734

DOI: 10.1073/pnas.1834010100

Sequence Information:

  • Length: 242
  • Mass: 27755
  • Checksum: 30C1FD06228833FC
  • Sequence:
    • MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF 
HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT 
NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI 
EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN 
KD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.