Gene HOXC8 - ENSG00000037965 | NCBI Gene ID: 3224

Details for: HOXC8

Gene ID: 3224

Symbol: HOXC8

Ensembl ID: ENSG00000037965

Description: homeobox C8

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 gene transcription
(R-HSA-9762293)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Anterior/posterior pattern specification
(GO:0009952)
Chromatin
(GO:0000785)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Microtubule cytoskeleton
(GO:0015630)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal system morphogenesis
(GO:0048705)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.19
Marker Score: 1508
Cell Name: mesangial cell (CL0000650)
Fold Change: 1.67
Marker Score: 2019.5
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 868
Cell Name: goblet cell (CL0000160)
Fold Change: 1.15
Marker Score: 7656
Cell Name: T cell (CL0000084)
Fold Change: 1.05
Marker Score: 1811
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 794
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71815
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48040
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5345
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5292
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.81
Marker Score: 1688
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 708
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.76
Marker Score: 1286
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.75
Marker Score: 499
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179.5
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.69
Marker Score: 1633
Cell Name: plasma cell (CL0000786)
Fold Change: 0.67
Marker Score: 748
Cell Name: stromal cell (CL0000499)
Fold Change: 0.67
Marker Score: 780
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.61
Marker Score: 138
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 446
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 233
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.52
Marker Score: 807
Cell Name: B cell (CL0000236)
Fold Change: 0.51
Marker Score: 482
Cell Name: mast cell (CL0000097)
Fold Change: 0.51
Marker Score: 293
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 474
Cell Name: fibroblast (CL0000057)
Fold Change: 0.47
Marker Score: 451
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.46
Marker Score: 277
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.46
Marker Score: 569
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.43
Marker Score: 174
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.43
Marker Score: 246
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.42
Marker Score: 239
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.41
Marker Score: 439
Cell Name: smooth muscle cell of small intestine (CL1000275)
Fold Change: 0.37
Marker Score: 97
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 370
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.36
Marker Score: 382
Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.36
Marker Score: 4735
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.35
Marker Score: 12023
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.34
Marker Score: 422
Cell Name: male germ cell (CL0000015)
Fold Change: 0.33
Marker Score: 95
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.33
Marker Score: 151
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.33
Marker Score: 333
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.32
Marker Score: 323
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.32
Marker Score: 96
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.31
Marker Score: 109
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.3
Marker Score: 213
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.27
Marker Score: 639
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.27
Marker Score: 4210
Cell Name: inflammatory cell (CL0009002)
Fold Change: 0.27
Marker Score: 115
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.26
Marker Score: 173
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.26
Marker Score: 68
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.26
Marker Score: 492
Cell Name: kidney cell (CL1000497)
Fold Change: 0.25
Marker Score: 167
Cell Name: neural cell (CL0002319)
Fold Change: 0.24
Marker Score: 118
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 0.24
Marker Score: 57
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.24
Marker Score: 387
Cell Name: reticular cell (CL0000432)
Fold Change: 0.24
Marker Score: 87.5
Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.24
Marker Score: 69
Cell Name: pericyte (CL0000669)
Fold Change: 0.24
Marker Score: 138
Cell Name: osteoblast (CL0000062)
Fold Change: 0.23
Marker Score: 126
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.23
Marker Score: 153
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.23
Marker Score: 72
Cell Name: preosteoblast (CL0007010)
Fold Change: 0.23
Marker Score: 64
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.23
Marker Score: 459
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.22
Marker Score: 1438
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.21
Marker Score: 1041.5
Cell Name: germ cell (CL0000586)
Fold Change: 0.19
Marker Score: 334
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.19
Marker Score: 84
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.19
Marker Score: 178
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.18
Marker Score: 492
Cell Name: Unknown (CL0002371)
Fold Change: 0.18
Marker Score: 195
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.18
Marker Score: 150.5
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.18
Marker Score: 35
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.18
Marker Score: 254
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.18
Marker Score: 45
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.18
Marker Score: 81
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.17
Marker Score: 44.5
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.17
Marker Score: 1030.5
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.16
Marker Score: 232
Cell Name: malignant cell (CL0001064)
Fold Change: 0.16
Marker Score: 2164
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 0.16
Marker Score: 42
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.16
Marker Score: 323
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.15
Marker Score: 93
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.15
Marker Score: 420
Cell Name: mesenchymal lymphangioblast (CL0005021)
Fold Change: 0.15
Marker Score: 34
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.15
Marker Score: 133
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.15
Marker Score: 516
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.14
Marker Score: 60
Cell Name: adventitial cell (CL0002503)
Fold Change: 0.14
Marker Score: 35
Cell Name: oocyte (CL0000023)
Fold Change: 0.14
Marker Score: 35
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.13
Marker Score: 64
Cell Name: chondrocyte (CL0000138)
Fold Change: 0.13
Marker Score: 59
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 0.12
Marker Score: 31
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.11
Marker Score: 1150
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.11
Marker Score: 88

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**Key characteristics:** - HOXC8 is a homeobox gene, which are a family of transcription factors that play a crucial role in development and tissue maintenance. - It is involved in the specification of the anterior-posterior (A/P) axis in mammals. - It is also involved in cell-cell adhesion, tissue morphogenesis, and neuronal differentiation. **Pathways and functions:** - HOXC8 is involved in cell-cell adhesion through its interaction with cadherins, a family of cell adhesion molecules. - It is also involved in tissue morphogenesis and neural tube closure. - In neurons, HOXC8 is required for the development of the cerebral cortex and the specification of the A/P axis. - It is also involved in the regulation of neuronal differentiation and survival. **Clinical significance:** - Mutations in HOXC8 have been linked to several human diseases, including autism, schizophrenia, and cancer. - Understanding the role of HOXC8 in human health and disease is important for the development of new therapeutic strategies. **Additional information:** - The HOXC8 gene is located on chromosome 19p13.2. - It is a highly conserved gene, with a similar gene found in other mammals. - HOXC8 is a key transcription factor in the development and function of various cell types.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Homeobox protein Hox-C8

Genular Protein ID: 231081554

Symbol: HXC8_HUMAN

Name: Homeobox protein Hox-C8

UniProtKB Accession Codes:

P31273 A8K4J4 O15221 O15362

Database IDs:

Citations:

PubMed ID: 11857506

Title: Complete mutation analysis panel of the 39 human HOX genes.

PubMed ID: 11857506

DOI: 10.1002/tera.10009

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9357979

Title: Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.

PubMed ID: 9357979

DOI: 10.1016/s0014-5793(97)01118-6

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 7791786

Title: Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.

PubMed ID: 7791786

DOI: 10.1128/mcb.15.7.3786

PubMed ID: 12925734

Title: Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.

PubMed ID: 12925734

DOI: 10.1073/pnas.1834010100

Sequence Information:

Length: 242
Mass: 27755
Checksum: 30C1FD06228833FC
Sequence:

MSSYFVNPLF SKYKAGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF 
HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT 
NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI 
EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN 
KD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HOXC8

Associated with

Cells (max top 100)

Other Information

Complete mutation analysis panel of the 39 human HOX genes. PubMed ID: 11857506

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines. PubMed ID: 9357979

Organization of human class I homeobox genes. PubMed ID: 2576652

Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. PubMed ID: 7791786

Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. PubMed ID: 12925734