Details for: CL0000136

Cell ID: CL0000136

Cell Name: fat cell

Marker Score Threshold: 559
(Derived using integrated single-cell and genomic data)

Description: A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.

Synonyms: adipose cell, fat cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: EBF1 (ENSG00000164330)
    Fold Change: 3.96
    Ensembl ID: ENSG00000164330
  • Gene Symbol: GHR (ENSG00000112964)
    Fold Change: 3.83
    Ensembl ID: ENSG00000112964
  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 3.74
    Ensembl ID: ENSG00000165269
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 3.66
    Ensembl ID: ENSG00000198947
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 3.64
    Ensembl ID: ENSG00000134871
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 3.59
    Ensembl ID: ENSG00000187498
  • Gene Symbol: FOXO1 (ENSG00000150907)
    Fold Change: 3.57
    Ensembl ID: ENSG00000150907
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: 3.41
    Ensembl ID: ENSG00000196616
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.24
    Ensembl ID: ENSG00000108654
  • Gene Symbol: MGST1 (ENSG00000008394)
    Fold Change: 3.19
    Ensembl ID: ENSG00000008394
  • Gene Symbol: FABP4 (ENSG00000170323)
    Fold Change: 3.17
    Ensembl ID: ENSG00000170323
  • Gene Symbol: LAMA2 (ENSG00000196569)
    Fold Change: 3.15
    Ensembl ID: ENSG00000196569
  • Gene Symbol: CPM (ENSG00000135678)
    Fold Change: 3.13
    Ensembl ID: ENSG00000135678
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 3.12
    Ensembl ID: ENSG00000135218
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 3.01
    Ensembl ID: ENSG00000152601
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 2.96
    Ensembl ID: ENSG00000162599
  • Gene Symbol: ACSL1 (ENSG00000151726)
    Fold Change: 2.95
    Ensembl ID: ENSG00000151726
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.93
    Ensembl ID: ENSG00000076555
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 2.88
    Ensembl ID: ENSG00000145012
  • Gene Symbol: NFIB (ENSG00000147862)
    Fold Change: 2.87
    Ensembl ID: ENSG00000147862
  • Gene Symbol: COL5A2 (ENSG00000204262)
    Fold Change: 2.83
    Ensembl ID: ENSG00000204262
  • Gene Symbol: MECOM (ENSG00000085276)
    Fold Change: 2.79
    Ensembl ID: ENSG00000085276
  • Gene Symbol: GBE1 (ENSG00000114480)
    Fold Change: 2.73
    Ensembl ID: ENSG00000114480
  • Gene Symbol: MEIS2 (ENSG00000134138)
    Fold Change: 2.73
    Ensembl ID: ENSG00000134138
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 2.7
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 2.69
    Ensembl ID: ENSG00000198363
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 2.68
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 2.65
    Ensembl ID: ENSG00000163697
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 2.65
    Ensembl ID: ENSG00000096060
  • Gene Symbol: ITPR2 (ENSG00000123104)
    Fold Change: 2.64
    Ensembl ID: ENSG00000123104
  • Gene Symbol: IGF1 (ENSG00000017427)
    Fold Change: 2.63
    Ensembl ID: ENSG00000017427
  • Gene Symbol: GPD1 (ENSG00000167588)
    Fold Change: 2.57
    Ensembl ID: ENSG00000167588
  • Gene Symbol: FOXO3 (ENSG00000118689)
    Fold Change: 2.55
    Ensembl ID: ENSG00000118689
  • Gene Symbol: GSN (ENSG00000148180)
    Fold Change: 2.53
    Ensembl ID: ENSG00000148180
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 2.52
    Ensembl ID: ENSG00000144674
  • Gene Symbol: CIDEA (ENSG00000176194)
    Fold Change: 2.52
    Ensembl ID: ENSG00000176194
  • Gene Symbol: LPL (ENSG00000175445)
    Fold Change: 2.51
    Ensembl ID: ENSG00000175445
  • Gene Symbol: ADRA1A (ENSG00000120907)
    Fold Change: 2.49
    Ensembl ID: ENSG00000120907
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 2.49
    Ensembl ID: ENSG00000128585
  • Gene Symbol: EPS8 (ENSG00000151491)
    Fold Change: 2.46
    Ensembl ID: ENSG00000151491
  • Gene Symbol: INSR (ENSG00000171105)
    Fold Change: 2.46
    Ensembl ID: ENSG00000171105
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 2.44
    Ensembl ID: ENSG00000135821
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.44
    Ensembl ID: ENSG00000122566
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.44
    Ensembl ID: ENSG00000153956
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.44
    Ensembl ID: ENSG00000189403
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.44
    Ensembl ID: ENSG00000092199
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.42
    Ensembl ID: ENSG00000053254
  • Gene Symbol: DIAPH2 (ENSG00000147202)
    Fold Change: 2.42
    Ensembl ID: ENSG00000147202
  • Gene Symbol: HNRNPH1 (ENSG00000169045)
    Fold Change: 2.35
    Ensembl ID: ENSG00000169045
  • Gene Symbol: LAMB1 (ENSG00000091136)
    Fold Change: 2.35
    Ensembl ID: ENSG00000091136
  • Gene Symbol: PPP1R12B (ENSG00000077157)
    Fold Change: 2.35
    Ensembl ID: ENSG00000077157
  • Gene Symbol: EPB41L2 (ENSG00000079819)
    Fold Change: 2.35
    Ensembl ID: ENSG00000079819
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.34
    Ensembl ID: ENSG00000104765
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.34
    Ensembl ID: ENSG00000263001
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.32
    Ensembl ID: ENSG00000113712
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.29
    Ensembl ID: ENSG00000167996
  • Gene Symbol: MAN1A1 (ENSG00000111885)
    Fold Change: 2.29
    Ensembl ID: ENSG00000111885
  • Gene Symbol: LIPE (ENSG00000079435)
    Fold Change: 2.28
    Ensembl ID: ENSG00000079435
  • Gene Symbol: LAMC1 (ENSG00000135862)
    Fold Change: 2.28
    Ensembl ID: ENSG00000135862
  • Gene Symbol: MAP4 (ENSG00000047849)
    Fold Change: 2.28
    Ensembl ID: ENSG00000047849
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 2.27
    Ensembl ID: ENSG00000189283
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 2.27
    Ensembl ID: ENSG00000188641
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 2.25
    Ensembl ID: ENSG00000150672
  • Gene Symbol: EYA2 (ENSG00000064655)
    Fold Change: 2.25
    Ensembl ID: ENSG00000064655
  • Gene Symbol: LIMS1 (ENSG00000169756)
    Fold Change: 2.25
    Ensembl ID: ENSG00000169756
  • Gene Symbol: EGFR (ENSG00000146648)
    Fold Change: 2.23
    Ensembl ID: ENSG00000146648
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.23
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 2.22
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.21
    Ensembl ID: ENSG00000099622
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 2.21
    Ensembl ID: ENSG00000257923
  • Gene Symbol: LRP1 (ENSG00000123384)
    Fold Change: 2.2
    Ensembl ID: ENSG00000123384
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.19
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.18
    Ensembl ID: ENSG00000145349
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 2.18
    Ensembl ID: ENSG00000184349
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 2.18
    Ensembl ID: ENSG00000075711
  • Gene Symbol: AFF1 (ENSG00000172493)
    Fold Change: 2.18
    Ensembl ID: ENSG00000172493
  • Gene Symbol: LAMA4 (ENSG00000112769)
    Fold Change: 2.16
    Ensembl ID: ENSG00000112769
  • Gene Symbol: ELF1 (ENSG00000120690)
    Fold Change: 2.16
    Ensembl ID: ENSG00000120690
  • Gene Symbol: NID1 (ENSG00000116962)
    Fold Change: 2.14
    Ensembl ID: ENSG00000116962
  • Gene Symbol: DECR1 (ENSG00000104325)
    Fold Change: 2.14
    Ensembl ID: ENSG00000104325
  • Gene Symbol: EMP1 (ENSG00000134531)
    Fold Change: 2.11
    Ensembl ID: ENSG00000134531
  • Gene Symbol: EXT1 (ENSG00000182197)
    Fold Change: 2.1
    Ensembl ID: ENSG00000182197
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 2.1
    Ensembl ID: ENSG00000083123
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.1
    Ensembl ID: ENSG00000113916
  • Gene Symbol: NHS (ENSG00000188158)
    Fold Change: 2.09
    Ensembl ID: ENSG00000188158
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.08
    Ensembl ID: ENSG00000204217
  • Gene Symbol: MARK3 (ENSG00000075413)
    Fold Change: 2.08
    Ensembl ID: ENSG00000075413
  • Gene Symbol: C7 (ENSG00000112936)
    Fold Change: 2.07
    Ensembl ID: ENSG00000112936
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 2.06
    Ensembl ID: ENSG00000044115
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.05
    Ensembl ID: ENSG00000085224
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 2.04
    Ensembl ID: ENSG00000156052
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 2.04
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.03
    Ensembl ID: ENSG00000140836
  • Gene Symbol: NFE2L2 (ENSG00000116044)
    Fold Change: 2.03
    Ensembl ID: ENSG00000116044
  • Gene Symbol: AGFG1 (ENSG00000173744)
    Fold Change: 2.03
    Ensembl ID: ENSG00000173744
  • Gene Symbol: SLC26A3 (ENSG00000091138)
    Fold Change: 2.02
    Ensembl ID: ENSG00000091138
  • Gene Symbol: MNAT1 (ENSG00000020426)
    Fold Change: 2.02
    Ensembl ID: ENSG00000020426
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ITGB1 (ENSG00000150093)
    Fold Change: 2
    Ensembl ID: ENSG00000150093
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: 2
    Ensembl ID: ENSG00000122729

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in fat cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in fat cell cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Cell Type**: Adipocyte (Fat-Storing Cell) * **Location**: Abdominal cavity and subcutaneous tissue * **Function**: Stores energy in the form of triglycerides * **Gene Symbol**: EBF1 * **Pathways/Ontology**: Chromatin, Developmental biology, Dna-binding transcription factor activity, rna polymerase ii-specific, Expression and translocation of olfactory receptors, Metal ion binding, Nucleus, Olfactory signaling pathway, Protein binding, Regulation of transcription by rna polymerase ii, Rna polymerase ii cis-regulatory region sequence-specific dna binding, Sensory perception, Transcriptional regulation of white adipocyte differentiation **Clinical Significance** Adipocytes play a critical role in various physiological processes, including energy storage and metabolism. Abnormalities in adipocyte function or number can lead to various diseases, including obesity, insulin resistance, and type 2 diabetes. The regulation of adipocyte function is complex and involves multiple signaling pathways, including those mediated by growth factors, hormones, and cytokines. Understanding the biology of adipocytes is essential for the development of novel therapeutic strategies for the treatment of metabolic disorders. In addition, adipocytes are also involved in the regulation of various other physiological processes, including cardiovascular health, immune function, and inflammation. For example, adipocytes produce various cytokines and chemokines that can influence immune responses and inflammation. Abnormalities in adipocyte function or number can also contribute to cardiovascular disease, including hypertension and atherosclerosis. Furthermore, adipocytes have been implicated in the regulation of various other physiological processes, including bone metabolism, muscle function, and reproductive health. For example, adipocytes produce various hormones and growth factors that can influence bone metabolism and muscle function. Abnormalities in adipocyte function or number can also contribute to reproductive disorders, including polycystic ovary syndrome (PCOS). In summary, adipocytes play a critical role in various physiological processes, and their dysregulation can contribute to various diseases, including metabolic disorders, cardiovascular disease, and reproductive disorders. Understanding the biology of adipocytes is essential for the development of novel therapeutic strategies for the treatment of these diseases.