Details for: SRPX

Gene ID: 8406

Symbol: SRPX

Ensembl ID: ENSG00000101955

Description: sushi repeat containing protein X-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 76.6430
    Cell Significance Index: -19.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.8516
    Cell Significance Index: -16.1900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 36.0711
    Cell Significance Index: -17.0300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 8.0924
    Cell Significance Index: 54.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8403
    Cell Significance Index: -19.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.1349
    Cell Significance Index: 118.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.1275
    Cell Significance Index: 78.1800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.3374
    Cell Significance Index: 45.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.0653
    Cell Significance Index: 26.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0159
    Cell Significance Index: 43.6800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.6039
    Cell Significance Index: 5.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.4716
    Cell Significance Index: 38.7000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.3154
    Cell Significance Index: 18.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.0619
    Cell Significance Index: 8.9200
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.0340
    Cell Significance Index: 6.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.8576
    Cell Significance Index: 17.9500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8572
    Cell Significance Index: 7.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8381
    Cell Significance Index: 37.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7848
    Cell Significance Index: 149.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.7767
    Cell Significance Index: 39.2500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.7121
    Cell Significance Index: 4.1800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.6656
    Cell Significance Index: 8.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4608
    Cell Significance Index: 45.5800
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.3896
    Cell Significance Index: 2.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3745
    Cell Significance Index: 338.1400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2980
    Cell Significance Index: 4.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2776
    Cell Significance Index: 21.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2439
    Cell Significance Index: 33.4900
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2435
    Cell Significance Index: 1.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2296
    Cell Significance Index: 37.3500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2162
    Cell Significance Index: 3.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1857
    Cell Significance Index: 20.2000
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.1578
    Cell Significance Index: 0.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1021
    Cell Significance Index: 2.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0891
    Cell Significance Index: 5.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0623
    Cell Significance Index: 4.3100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0581
    Cell Significance Index: 0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0396
    Cell Significance Index: 7.9500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0103
    Cell Significance Index: 0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0017
    Cell Significance Index: 0.7300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0024
    Cell Significance Index: -0.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0062
    Cell Significance Index: -2.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0095
    Cell Significance Index: -17.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0105
    Cell Significance Index: -7.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0110
    Cell Significance Index: -20.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0133
    Cell Significance Index: -20.4100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0148
    Cell Significance Index: -0.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0155
    Cell Significance Index: -21.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0212
    Cell Significance Index: -1.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0230
    Cell Significance Index: -17.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0237
    Cell Significance Index: -10.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0254
    Cell Significance Index: -18.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0260
    Cell Significance Index: -19.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0274
    Cell Significance Index: -17.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0299
    Cell Significance Index: -18.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0304
    Cell Significance Index: -16.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0340
    Cell Significance Index: -19.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0466
    Cell Significance Index: -5.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0512
    Cell Significance Index: -3.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0561
    Cell Significance Index: -16.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0633
    Cell Significance Index: -1.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0732
    Cell Significance Index: -14.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0739
    Cell Significance Index: -8.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0880
    Cell Significance Index: -10.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0940
    Cell Significance Index: -19.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1129
    Cell Significance Index: -19.2800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1187
    Cell Significance Index: -17.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1201
    Cell Significance Index: -15.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1242
    Cell Significance Index: -5.8400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1258
    Cell Significance Index: -12.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1369
    Cell Significance Index: -2.8400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.1536
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1798
    Cell Significance Index: -20.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1838
    Cell Significance Index: -19.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1951
    Cell Significance Index: -14.5400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2020
    Cell Significance Index: -3.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2276
    Cell Significance Index: -7.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2329
    Cell Significance Index: -6.5100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2360
    Cell Significance Index: -18.6900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2672
    Cell Significance Index: -7.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2762
    Cell Significance Index: -18.5700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2912
    Cell Significance Index: -15.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2932
    Cell Significance Index: -16.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2966
    Cell Significance Index: -18.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3038
    Cell Significance Index: -19.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.3081
    Cell Significance Index: -3.3500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3257
    Cell Significance Index: -8.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3565
    Cell Significance Index: -18.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3598
    Cell Significance Index: -18.8900
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.3627
    Cell Significance Index: -2.6300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3783
    Cell Significance Index: -17.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3945
    Cell Significance Index: -10.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4008
    Cell Significance Index: -17.7300
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4073
    Cell Significance Index: -2.5500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4215
    Cell Significance Index: -5.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4234
    Cell Significance Index: -6.3800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.4306
    Cell Significance Index: -10.4300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4338
    Cell Significance Index: -15.9300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.4527
    Cell Significance Index: -5.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SRPX is predominantly expressed in cells of the connective tissue, including skeletal muscle fibroblasts, fibroblasts from mammary glands, pulmonary artery endothelial cells, and decidual cells. 2. **Protein Structure:** The SRPX protein contains sushi repeat domains, which are conserved motifs that facilitate protein-protein interactions. 3. **Cellular Localization:** The protein is primarily localized to the cell surface, where it can interact with extracellular ligands and influence cell signaling pathways. **Pathways and Functions:** 1. **Autophagy and Cell Death:** SRPX has been implicated in the regulation of autophagic processes, including autophagosome formation and phagolysosome assembly. It also modulates the positive regulation of extrinsic apoptotic signaling pathways in the absence of ligand. 2. **Cell Adhesion and Migration:** SRPX interacts with various ligands, influencing cell adhesion and migration. This interaction is crucial for tissue repair, wound healing, and immune responses. 3. **Collagen Production and Extracellular Matrix Formation:** SRPX plays a role in the regulation of collagen production and extracellular matrix formation, which is essential for maintaining tissue integrity. 4. **Endoplasmic Reticulum Stress Response:** SRPX has been shown to interact with proteins involved in the endoplasmic reticulum stress response, modulating this process to prevent cellular damage. **Clinical Significance:** 1. **Wound Healing and Tissue Repair:** SRPX plays a critical role in wound healing and tissue repair. Dysregulation of SRPX expression has been linked to impaired wound healing and fibrosis. 2. **Fibrosis and Cancer:** SRPX has been implicated in the development of fibrosis and cancer. Its dysregulation can lead to the formation of aberrant extracellular matrices, promoting tumor growth and metastasis. 3. **Immune Response and Autoimmunity:** SRPX modulates immune responses and has been linked to autoimmune diseases. Its dysregulation can lead to impaired immune function and increased susceptibility to infections. 4. **Cardiovascular Disease:** SRPX has been shown to play a role in cardiovascular disease, including atherosclerosis and cardiac fibrosis. Its dysregulation can contribute to the development of these diseases. In conclusion, the SRPX gene is a crucial regulator of various cellular processes, including autophagy, cell adhesion, and immune responses. Its dysregulation has been linked to several diseases, including fibrosis, cancer, autoimmune disorders, and cardiovascular disease. Further studies are needed to fully elucidate the role of SRPX in human health and disease.

Genular Protein ID: 3518033791

Symbol: SRPX_HUMAN

Name: Sushi repeat-containing protein SRPX

UniProtKB Accession Codes:

P78539 A8K065 B3KWP8 B4DDB8 B4DQH5 F5H4D7 G3V1L0 Q4VX66 Q99652 Q99913

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 4 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8634708

Title: A gene (SRPX) encoding a sushi-repeat-containing protein is deleted in patients with X-linked retinitis pigmentosa.

PubMed ID: 8634708

DOI: 10.1093/hmg/4.12.2339

PubMed ID: 8634709

Title: Identification of a novel gene, ETX1 from Xp21.1, a candidate gene for X-linked retinitis pigmentosa (RP3).

PubMed ID: 8634709

DOI: 10.1093/hmg/4.12.2347

PubMed ID: 9162095

Title: Cloning of a new human gene with short consensus repeats using the EST database.

PubMed ID: 9162095

DOI: 10.1007/s002510050247

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

Sequence Information:

  • Length: 464
  • Mass: 51572
  • Checksum: 9CD5E57BC2848680
  • Sequence:
    • MGSPAHRPAL LLLLPPLLLL LLLRVPPSRS FPGSGDSPLE DDEVGYSHPR YKDTPWCSPI 
KVKYGDVYCR APQGGYYKTA LGTRCDIRCQ KGYELHGSSL LICQSNKRWS DKVICKQKRC 
PTLAMPANGG FKCVDGAYFN SRCEYYCSPG YTLKGERTVT CMDNKAWSGR PASCVDMEPP 
RIKCPSVKER IAEPNKLTVR VSWETPEGRD TADGILTDVI LKGLPPGSNF PEGDHKIQYT 
VYDRAENKGT CKFRVKVRVK RCGKLNAPEN GYMKCSSDGD NYGATCEFSC IGGYELQGSP 
ARVCQSNLAW SGTEPTCAAM NVNVGVRTAA ALLDQFYEKR RLLIVSTPTA RNLLYRLQLG 
MLQQAQCGLD LRHITVVELV GVFPTLIGRI GAKIMPPALA LQLRLLLRIP LYSFSMVLVD 
KHGMDKERYV SLVMPVALFN LIDTFPLRKE EMVLQAEMSQ TCNT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.