Details for: RDH10 AS1

Gene ID: 101926926

Gene Type:  ncRNA (Non-coding RNA)  - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: RDH10 AS1

Ensembl ID: ENSG00000250295

Description: RDH10 antisense RNA 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • adipocyte CL0000136
    CSI 3.62
    rCSI 4.65%
    PRS 99.45
  • Mueller cell CL0000636
    CSI 3.43
    rCSI 7.83%
    PRS 99.52
  • cardiac endothelial cell CL0010008
    CSI 2.71
    rCSI 10.94%
    PRS 99.9
  • cardiac neuron CL0010022
    CSI 2.12
    rCSI 6.8%
    PRS 99.76
  • mesothelial cell CL0000077
    CSI 1.76
    rCSI 6.88%
    PRS 98.94

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

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  • Node Color (Target Cell CSI, relative to current network):
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    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [RDH10 AS1](/details-gene/101926926) is a non-coding RNA (ncRNA) located on chromosome 8, specifically classified as an antisense RNA. It is transcribed from the opposite strand of the protein-coding gene *RDH10* (Retinol Dehydrogenase 10), which suggests its primary function is likely the regulation of *RDH10* expression. **Overall**, expression analysis indicates that [RDH10 AS1](/details-gene/101926926) is a significant transcript in a diverse set of specialized cell types, including [adipocyte](/details-cell/CL0000136)s, retinal [Mueller cell](/details-cell/CL0000636)s, and [cardiac endothelial cell](/details-cell/CL0010008)s. This expression pattern implies potential roles in metabolic homeostasis, visual cycle regulation, and cardiovascular function. ## Cellular Roles and Expression Landscape The expression profile of [RDH10 AS1](/details-gene/101926926) points to a specialized role in distinct biological systems. **Overall**, its most significant expression is observed in [adipocyte](/details-cell/CL0000136)s (CSI: 3.62) and [Mueller cell](/details-cell/CL0000636)s (CSI: 3.43), indicating a potential involvement in lipid metabolism and retinal biology, respectively. Both of these processes are critically dependent on retinoid metabolism, the pathway in which RDH10 is a key enzyme. Furthermore, [RDH10 AS1](/details-gene/101926926) shows notable significance in several cell types within the cardiovascular system, including [cardiac endothelial cell](/details-cell/CL0010008)s (CSI: 2.71) and [cardiac neuron](/details-cell/CL0010022)s (CSI: 2.12). Its expression is also significant in [mesothelial cell](/details-cell/CL0000077)s, which line various body cavities. This diverse yet specific expression pattern across metabolic, neural, and cardiovascular cell lineages suggests that [RDH10 AS1](/details-gene/101926926) is not a ubiquitously expressed ncRNA but rather a context-specific regulator, likely fine-tuning the activity of its sense-strand counterpart, *RDH10*. ## Pathways and Molecular Function While formal pathway annotations are not provided, the molecular function of [RDH10 AS1](/details-gene/101926926) can be inferred from its nature as an antisense RNA. Its primary role is likely the post-transcriptional regulation of *RDH10* mRNA. This regulation could occur through various mechanisms, such as inducing mRNA degradation via RNA interference pathways, blocking translation, or altering chromatin structure at the *RDH10* gene locus to modulate transcription. By regulating RDH10, an enzyme that catalyzes the conversion of retinol to retinal, [RDH10 AS1](/details-gene/101926926) is indirectly implicated in biological processes dependent on retinoic acid signaling. These include adipogenesis and lipid metabolism in [adipocyte](/details-cell/CL0000136)s, the regeneration of visual pigments in the retina's [Mueller cell](/details-cell/CL0000636)s, and potentially cardiovascular development and homeostasis, all of which are known to be influenced by retinoids. ## Research Directions The specific expression pattern of [RDH10 AS1](/details-gene/101926926) and its predicted regulatory function over a key metabolic enzyme present several avenues for future research. **Proposed Hypotheses:** 1. [RDH10 AS1](/details-gene/101926926) acts as a negative regulator of *RDH10* expression in [adipocyte](/details-cell/CL0000136)s. During adipogenesis, a decrease in [RDH10 AS1](/details-gene/101926926) levels may be required to permit an increase in RDH10 protein, thereby driving the synthesis of retinoic acid needed for cellular differentiation. 2. In retinal [Mueller cell](/details-cell/CL0000636)s, the expression of [RDH10 AS1](/details-gene/101926926) is dynamically regulated in response to light exposure or metabolic stress to provide precise, localized control over the visual cycle, preventing the toxic accumulation of retinoids. **Key Experimental Approach:** To test the hypothesis that [RDH10 AS1](/details-gene/101926926) negatively regulates RDH10 during adipogenesis, one could use a loss-of-function approach in a human pre-adipocyte cell culture model. Specific knockdown of [RDH10 AS1](/details-gene/101926926) using locked nucleic acids (LNAs) or siRNA could be performed prior to inducing differentiation. The effect of the knockdown would be quantified by measuring *RDH10* mRNA and protein levels via RT-qPCR and western blot, respectively. A successful knockdown that results in elevated RDH10 levels and accelerated or enhanced differentiation (assessed by lipid droplet accumulation and expression of adipogenic markers like *PPARG*) would provide strong support for this regulatory role. **Therapeutic Potential:** As a non-coding RNA, [RDH10 AS1](/details-gene/101926926) is a suitable candidate for therapeutic targeting with RNA-based modalities like antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs). In metabolic disorders such as obesity or diabetes where adipocyte retinoid signaling may be dysregulated, modulating [RDH10 AS1](/details-gene/101926926) could offer a novel strategy to restore metabolic balance. For example, if RDH10 is over-expressed due to low levels of this antisense transcript, a synthetic [RDH10 AS1](/details-gene/101926926) mimic could be administered to suppress RDH10 activity. The cell-type-specific expression of [RDH10 AS1](/details-gene/101926926) is advantageous for targeted therapy, although its role in diverse critical tissues like the retina and heart would require careful evaluation of potential off-target effects.