Details for: CL0010022

Cell ID: CL0010022

Cell Name: cardiac neuron

Marker Score Threshold: 1,246
(Derived using integrated single-cell and genomic data)

Description: A neuron that has its soma in the heart.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 6.91
    Ensembl ID: ENSG00000151150
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 6.61
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 6.41
    Ensembl ID: ENSG00000135298
  • Gene Symbol: FOXO1 (ENSG00000150907)
    Fold Change: 6.13
    Ensembl ID: ENSG00000150907
  • Gene Symbol: NCAM2 (ENSG00000154654)
    Fold Change: 6.09
    Ensembl ID: ENSG00000154654
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 6.07
    Ensembl ID: ENSG00000145362
  • Gene Symbol: NCAM1 (ENSG00000149294)
    Fold Change: 5.88
    Ensembl ID: ENSG00000149294
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 5.66
    Ensembl ID: ENSG00000171791
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 5.59
    Ensembl ID: ENSG00000145012
  • Gene Symbol: MAP4 (ENSG00000047849)
    Fold Change: 5.54
    Ensembl ID: ENSG00000047849
  • Gene Symbol: EPB41L2 (ENSG00000079819)
    Fold Change: 5.47
    Ensembl ID: ENSG00000079819
  • Gene Symbol: PRKCA (ENSG00000154229)
    Fold Change: 5.44
    Ensembl ID: ENSG00000154229
  • Gene Symbol: LAMA2 (ENSG00000196569)
    Fold Change: 5.37
    Ensembl ID: ENSG00000196569
  • Gene Symbol: LPAR1 (ENSG00000198121)
    Fold Change: 5.17
    Ensembl ID: ENSG00000198121
  • Gene Symbol: GPM6B (ENSG00000046653)
    Fold Change: 5.06
    Ensembl ID: ENSG00000046653
  • Gene Symbol: PTK2 (ENSG00000169398)
    Fold Change: 4.95
    Ensembl ID: ENSG00000169398
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 4.62
    Ensembl ID: ENSG00000096060
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 4.55
    Ensembl ID: ENSG00000198947
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 4.54
    Ensembl ID: ENSG00000128585
  • Gene Symbol: IGFBP7 (ENSG00000163453)
    Fold Change: 4.53
    Ensembl ID: ENSG00000163453
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 4.37
    Ensembl ID: ENSG00000156110
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 4.36
    Ensembl ID: ENSG00000152601
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 4.34
    Ensembl ID: ENSG00000162599
  • Gene Symbol: GSN (ENSG00000148180)
    Fold Change: 4.29
    Ensembl ID: ENSG00000148180
  • Gene Symbol: COL4A2 (ENSG00000134871)
    Fold Change: 4.16
    Ensembl ID: ENSG00000134871
  • Gene Symbol: PTEN (ENSG00000171862)
    Fold Change: 4.07
    Ensembl ID: ENSG00000171862
  • Gene Symbol: GAB1 (ENSG00000109458)
    Fold Change: 3.98
    Ensembl ID: ENSG00000109458
  • Gene Symbol: PCDH9 (ENSG00000184226)
    Fold Change: 3.91
    Ensembl ID: ENSG00000184226
  • Gene Symbol: GRIK2 (ENSG00000164418)
    Fold Change: 3.88
    Ensembl ID: ENSG00000164418
  • Gene Symbol: MYL2 (ENSG00000111245)
    Fold Change: 3.88
    Ensembl ID: ENSG00000111245
  • Gene Symbol: ITGB8 (ENSG00000105855)
    Fold Change: 3.84
    Ensembl ID: ENSG00000105855
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.8
    Ensembl ID: ENSG00000122786
  • Gene Symbol: MYO1E (ENSG00000157483)
    Fold Change: 3.8
    Ensembl ID: ENSG00000157483
  • Gene Symbol: PDK4 (ENSG00000004799)
    Fold Change: 3.73
    Ensembl ID: ENSG00000004799
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.71
    Ensembl ID: ENSG00000142599
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.69
    Ensembl ID: ENSG00000108654
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 3.64
    Ensembl ID: ENSG00000163697
  • Gene Symbol: FOXO3 (ENSG00000118689)
    Fold Change: 3.62
    Ensembl ID: ENSG00000118689
  • Gene Symbol: PIP4K2A (ENSG00000150867)
    Fold Change: 3.6
    Ensembl ID: ENSG00000150867
  • Gene Symbol: PMP22 (ENSG00000109099)
    Fold Change: 3.6
    Ensembl ID: ENSG00000109099
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 3.57
    Ensembl ID: ENSG00000044115
  • Gene Symbol: PDE8A (ENSG00000073417)
    Fold Change: 3.51
    Ensembl ID: ENSG00000073417
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 3.47
    Ensembl ID: ENSG00000148700
  • Gene Symbol: PIK3R1 (ENSG00000145675)
    Fold Change: 3.46
    Ensembl ID: ENSG00000145675
  • Gene Symbol: ABLIM1 (ENSG00000099204)
    Fold Change: 3.39
    Ensembl ID: ENSG00000099204
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 3.38
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ITGA1 (ENSG00000213949)
    Fold Change: 3.38
    Ensembl ID: ENSG00000213949
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 3.34
    Ensembl ID: ENSG00000151422
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 3.34
    Ensembl ID: ENSG00000140443
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 3.24
    Ensembl ID: ENSG00000058866
  • Gene Symbol: ROR1 (ENSG00000185483)
    Fold Change: 3.22
    Ensembl ID: ENSG00000185483
  • Gene Symbol: NFIB (ENSG00000147862)
    Fold Change: 3.2
    Ensembl ID: ENSG00000147862
  • Gene Symbol: OPHN1 (ENSG00000079482)
    Fold Change: 3.2
    Ensembl ID: ENSG00000079482
  • Gene Symbol: DPYD (ENSG00000188641)
    Fold Change: 3.19
    Ensembl ID: ENSG00000188641
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.18
    Ensembl ID: ENSG00000198363
  • Gene Symbol: LAMC1 (ENSG00000135862)
    Fold Change: 3.18
    Ensembl ID: ENSG00000135862
  • Gene Symbol: PRKN (ENSG00000185345)
    Fold Change: 3.14
    Ensembl ID: ENSG00000185345
  • Gene Symbol: COL4A1 (ENSG00000187498)
    Fold Change: 3.09
    Ensembl ID: ENSG00000187498
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 3.05
    Ensembl ID: ENSG00000171634
  • Gene Symbol: PAPPA (ENSG00000182752)
    Fold Change: 3.05
    Ensembl ID: ENSG00000182752
  • Gene Symbol: EXT1 (ENSG00000182197)
    Fold Change: 3.02
    Ensembl ID: ENSG00000182197
  • Gene Symbol: PDE1C (ENSG00000154678)
    Fold Change: 3.01
    Ensembl ID: ENSG00000154678
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 3
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 3
    Ensembl ID: ENSG00000134480
  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 2.97
    Ensembl ID: ENSG00000109846
  • Gene Symbol: HIP1 (ENSG00000127946)
    Fold Change: 2.96
    Ensembl ID: ENSG00000127946
  • Gene Symbol: PDE4D (ENSG00000113448)
    Fold Change: 2.96
    Ensembl ID: ENSG00000113448
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 2.94
    Ensembl ID: ENSG00000150672
  • Gene Symbol: NF1 (ENSG00000196712)
    Fold Change: 2.94
    Ensembl ID: ENSG00000196712
  • Gene Symbol: HSPG2 (ENSG00000142798)
    Fold Change: 2.93
    Ensembl ID: ENSG00000142798
  • Gene Symbol: COL5A2 (ENSG00000204262)
    Fold Change: 2.93
    Ensembl ID: ENSG00000204262
  • Gene Symbol: IFNGR2 (ENSG00000159128)
    Fold Change: 2.92
    Ensembl ID: ENSG00000159128
  • Gene Symbol: MYO5A (ENSG00000197535)
    Fold Change: 2.89
    Ensembl ID: ENSG00000197535
  • Gene Symbol: ELF2 (ENSG00000109381)
    Fold Change: 2.83
    Ensembl ID: ENSG00000109381
  • Gene Symbol: LAMB1 (ENSG00000091136)
    Fold Change: 2.82
    Ensembl ID: ENSG00000091136
  • Gene Symbol: FYN (ENSG00000010810)
    Fold Change: 2.81
    Ensembl ID: ENSG00000010810
  • Gene Symbol: ELN (ENSG00000049540)
    Fold Change: 2.8
    Ensembl ID: ENSG00000049540
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.8
    Ensembl ID: ENSG00000140836
  • Gene Symbol: PKN2 (ENSG00000065243)
    Fold Change: 2.79
    Ensembl ID: ENSG00000065243
  • Gene Symbol: GLI3 (ENSG00000106571)
    Fold Change: 2.78
    Ensembl ID: ENSG00000106571
  • Gene Symbol: DOCK1 (ENSG00000150760)
    Fold Change: 2.74
    Ensembl ID: ENSG00000150760
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.72
    Ensembl ID: ENSG00000198589
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 2.71
    Ensembl ID: ENSG00000092964
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.71
    Ensembl ID: ENSG00000142192
  • Gene Symbol: PAFAH1B1 (ENSG00000007168)
    Fold Change: 2.66
    Ensembl ID: ENSG00000007168
  • Gene Symbol: GSK3B (ENSG00000082701)
    Fold Change: 2.66
    Ensembl ID: ENSG00000082701
  • Gene Symbol: MEF2A (ENSG00000068305)
    Fold Change: 2.66
    Ensembl ID: ENSG00000068305
  • Gene Symbol: PBX1 (ENSG00000185630)
    Fold Change: 2.64
    Ensembl ID: ENSG00000185630
  • Gene Symbol: MYO9A (ENSG00000066933)
    Fold Change: 2.64
    Ensembl ID: ENSG00000066933
  • Gene Symbol: GRB10 (ENSG00000106070)
    Fold Change: 2.64
    Ensembl ID: ENSG00000106070
  • Gene Symbol: PKD2 (ENSG00000118762)
    Fold Change: 2.61
    Ensembl ID: ENSG00000118762
  • Gene Symbol: PPP1R12A (ENSG00000058272)
    Fold Change: 2.58
    Ensembl ID: ENSG00000058272
  • Gene Symbol: DLG1 (ENSG00000075711)
    Fold Change: 2.57
    Ensembl ID: ENSG00000075711
  • Gene Symbol: MEF2C (ENSG00000081189)
    Fold Change: 2.56
    Ensembl ID: ENSG00000081189
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 2.56
    Ensembl ID: ENSG00000198938
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.55
    Ensembl ID: ENSG00000151746
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.52
    Ensembl ID: ENSG00000198804
  • Gene Symbol: PCM1 (ENSG00000078674)
    Fold Change: 2.52
    Ensembl ID: ENSG00000078674
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.5
    Ensembl ID: ENSG00000263001
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.49
    Ensembl ID: ENSG00000122566

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in cardiac neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in cardiac neuron cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** The cardiac neuron (CL0010022) exhibits the following key characteristics: 1. **Location**: The neuron has its soma located in the heart, indicating its role in cardiac function. 2. **Gene Symbol**: The gene symbol ANK3 (ANK3 Ensembl ID: ENSG00000151150) is associated with the neuron's function and regulation. 3. **Cellular Processes**: The neuron is involved in various cellular processes, including asparagine n-linked glycosylation, axon guidance, and regulation of potassium ion transport. 4. **Interactions**: The neuron interacts with other cellular components, such as the Golgi apparatus, plasma membrane, and cytoskeleton, to maintain its structure and function. 5. **Developmental Biology**: The neuron is linked to the development and maintenance of the heart, particularly in the context of cardiac muscle cell action potential and intercalated disc formation. **Clinical Significance** The cardiac neuron (CL0010022) has significant clinical implications, particularly in the context of cardiac function and disease. Some potential clinical significance of this cell includes: 1. **Cardiac Function**: The neuron plays a crucial role in maintaining cardiac function, particularly in the context of cardiac muscle cell action potential and intercalated disc formation. 2. **Cardiac Disease**: Abnormalities in the cardiac neuron could contribute to various cardiac diseases, such as arrhythmias, cardiac hypertrophy, and heart failure. 3. **Neurological Disorders**: The neuron's interaction with other cellular components may also be relevant to neurological disorders, such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis (ALS). 4. **Therapeutic Targets**: Understanding the mechanisms of the cardiac neuron could lead to the development of new therapeutic targets for treating cardiac and neurological disorders. In conclusion, the cardiac neuron (CL0010022) is a critical component of the heart, playing a key role in maintaining cardiac function and interacting with other cellular components to regulate various cellular processes. Further research on this cell could lead to a better understanding of cardiac and neurological disorders, as well as the development of new therapeutic targets.