Details for: CL0010022

Cell ID: CL0010022

Cell Name: cardiac neuron

Marker Score Threshold: 1246
(Derived using integrated single-cell and genomic data)

Description: A neuron that has its soma in the heart.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 6.91
    Ensembl ID: ENSG00000151150
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 6.61
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 6.41
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 6.07
    Ensembl ID: ENSG00000145362
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 5.66
    Ensembl ID: ENSG00000171791
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 4.37
    Ensembl ID: ENSG00000156110
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 3.8
    Ensembl ID: ENSG00000122786
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.71
    Ensembl ID: ENSG00000142599
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 3.64
    Ensembl ID: ENSG00000163697
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 3.47
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 3.38
    Ensembl ID: ENSG00000010278
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.18
    Ensembl ID: ENSG00000198363
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 3
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.8
    Ensembl ID: ENSG00000140836
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.72
    Ensembl ID: ENSG00000198589
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.71
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.55
    Ensembl ID: ENSG00000151746
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.48
    Ensembl ID: ENSG00000157764
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 2.42
    Ensembl ID: ENSG00000058668
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 2.41
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.4
    Ensembl ID: ENSG00000140945
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.38
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.38
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.34
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.33
    Ensembl ID: ENSG00000170558
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 2.32
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 2.32
    Ensembl ID: ENSG00000165092
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 2.28
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.21
    Ensembl ID: ENSG00000087274
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 2.2
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CBFB (ENSG00000067955)
    Fold Change: 2.19
    Ensembl ID: ENSG00000067955
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 2.14
    Ensembl ID: ENSG00000153113
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 2.13
    Ensembl ID: ENSG00000119138
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 2.13
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.13
    Ensembl ID: ENSG00000170634
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.11
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ASPA (ENSG00000108381)
    Fold Change: 2.09
    Ensembl ID: ENSG00000108381
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.02
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 2.01
    Ensembl ID: ENSG00000143322
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2
    Ensembl ID: ENSG00000107779
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 2
    Ensembl ID: ENSG00000083123
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 2
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.97
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: 1.97
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.94
    Ensembl ID: ENSG00000171094
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 1.92
    Ensembl ID: ENSG00000076555
  • Gene Symbol: BBS2 (ENSG00000125124)
    Fold Change: 1.89
    Ensembl ID: ENSG00000125124
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.87
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: 1.86
    Ensembl ID: ENSG00000097007
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 1.84
    Ensembl ID: ENSG00000114423
  • Gene Symbol: AUH (ENSG00000148090)
    Fold Change: 1.83
    Ensembl ID: ENSG00000148090
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.81
    Ensembl ID: ENSG00000122545
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.74
    Ensembl ID: ENSG00000138696
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.7
    Ensembl ID: ENSG00000100852
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.68
    Ensembl ID: ENSG00000175899
  • Gene Symbol: BCR (ENSG00000186716)
    Fold Change: 1.67
    Ensembl ID: ENSG00000186716
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.65
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ALDH7A1 (ENSG00000164904)
    Fold Change: 1.58
    Ensembl ID: ENSG00000164904
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.58
    Ensembl ID: ENSG00000167601
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.55
    Ensembl ID: ENSG00000113916
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 1.54
    Ensembl ID: ENSG00000151067
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.54
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.53
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.51
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: 1.5
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.48
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.47
    Ensembl ID: ENSG00000221869
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.45
    Ensembl ID: ENSG00000196975
  • Gene Symbol: CDC27 (ENSG00000004897)
    Fold Change: 1.44
    Ensembl ID: ENSG00000004897
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.43
    Ensembl ID: ENSG00000184009
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.37
    Ensembl ID: ENSG00000134982
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: 1.36
    Ensembl ID: ENSG00000165029
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 1.32
    Ensembl ID: ENSG00000151729
  • Gene Symbol: CDK8 (ENSG00000132964)
    Fold Change: 1.32
    Ensembl ID: ENSG00000132964
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.31
    Ensembl ID: ENSG00000112576
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.31
    Ensembl ID: ENSG00000077549
  • Gene Symbol: AP2B1 (ENSG00000006125)
    Fold Change: 1.29
    Ensembl ID: ENSG00000006125
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 1.29
    Ensembl ID: ENSG00000018625
  • Gene Symbol: KRIT1 (ENSG00000001631)
    Fold Change: 1.26
    Ensembl ID: ENSG00000001631
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.23
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.23
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATR (ENSG00000175054)
    Fold Change: 1.22
    Ensembl ID: ENSG00000175054
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.21
    Ensembl ID: ENSG00000116489
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.2
    Ensembl ID: ENSG00000079102
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.19
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: 1.17
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.15
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ARNT (ENSG00000143437)
    Fold Change: 1.14
    Ensembl ID: ENSG00000143437
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: 1.14
    Ensembl ID: ENSG00000162104
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.13
    Ensembl ID: ENSG00000196776
  • Gene Symbol: CDR2 (ENSG00000140743)
    Fold Change: 1.12
    Ensembl ID: ENSG00000140743
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: 1.1
    Ensembl ID: ENSG00000075239
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.06
    Ensembl ID: ENSG00000115963
  • Gene Symbol: CA1 (ENSG00000133742)
    Fold Change: 1.05
    Ensembl ID: ENSG00000133742
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.03
    Ensembl ID: ENSG00000121691
  • Gene Symbol: CCNT2 (ENSG00000082258)
    Fold Change: 1.02
    Ensembl ID: ENSG00000082258
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.02
    Ensembl ID: ENSG00000138760
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.02
    Ensembl ID: ENSG00000067560
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.02
    Ensembl ID: ENSG00000171552
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 1.01
    Ensembl ID: ENSG00000165995
Hovered Details

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Hovered Details

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**Key Characteristics** * **Soma location**: Located in the heart * **Gene expression**: ANK3, DST, ADGRB3 * **Morphology**: Specialized to function within the heart * **Function**: Regulates cardiac muscle cell contraction and electrical activity * **Interaction**: Interacts with other cells and structures within the heart, including the intercalated disc and the sarcoplasmic reticulum **Clinical Significance** Cardiac neurons play a critical role in maintaining cardiac function and regulating heart rate. Abnormalities in cardiac neuron function or expression can lead to various cardiac disorders, including arrhythmias and heart failure. Understanding the role of cardiac neurons in cardiac function and disease can provide valuable insights into the development of novel therapeutic strategies for cardiac disorders. **Regulation of Cardiac Muscle Cell Contraction** Cardiac neurons regulate cardiac muscle cell contraction through the expression of specific genes, including ANK3. ANK3 is involved in the regulation of calcium ion transmembrane transporter activity, which is critical for cardiac muscle cell contraction. Abnormalities in ANK3 expression or function can lead to impaired cardiac muscle cell contraction and contribute to various cardiac disorders. **Interactions with Other Cells and Structures** Cardiac neurons interact with other cells and structures within the heart, including the intercalated disc and the sarcoplasmic reticulum. These interactions are critical for maintaining cardiac function and regulating heart rate. For example, cardiac neurons interact with the intercalated disc to regulate cardiac muscle cell contraction and electrical activity. **Diseases Associated with Cardiac Neurons** Abnormalities in cardiac neuron function or expression can lead to various cardiac disorders, including: * Arrhythmias * Heart failure * Cardiac conduction disorders Understanding the role of cardiac neurons in cardiac function and disease can provide valuable insights into the development of novel therapeutic strategies for cardiac disorders. **Future Research Directions** Further research is needed to fully understand the role of cardiac neurons in cardiac function and disease. This includes the development of novel therapeutic strategies for cardiac disorders and the exploration of new targets for the treatment of cardiac disease.