Details for: FUS

Gene ID: 2521

Symbol: FUS

Ensembl ID: ENSG00000089280

Description: FUS RNA binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 755.4716
    Cell Significance Index: -117.5100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 451.0664
    Cell Significance Index: -114.4100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 351.0641
    Cell Significance Index: -144.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 298.6300
    Cell Significance Index: -140.9900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 269.8172
    Cell Significance Index: -138.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 211.2896
    Cell Significance Index: -141.7800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 110.6325
    Cell Significance Index: -136.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 41.8163
    Cell Significance Index: -112.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 35.7319
    Cell Significance Index: -141.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 33.0495
    Cell Significance Index: -101.5100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.0501
    Cell Significance Index: -61.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.1873
    Cell Significance Index: 180.2600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.1003
    Cell Significance Index: 563.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.9400
    Cell Significance Index: 505.0900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.7417
    Cell Significance Index: 241.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.3323
    Cell Significance Index: 69.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.2851
    Cell Significance Index: 154.4000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9336
    Cell Significance Index: 77.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7300
    Cell Significance Index: 335.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.5906
    Cell Significance Index: 145.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4994
    Cell Significance Index: 496.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.4813
    Cell Significance Index: 112.4700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4019
    Cell Significance Index: 433.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.3048
    Cell Significance Index: 64.4100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.2712
    Cell Significance Index: 61.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.2501
    Cell Significance Index: 118.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.2340
    Cell Significance Index: 64.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.1817
    Cell Significance Index: 964.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1738
    Cell Significance Index: 1187.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9528
    Cell Significance Index: 230.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8901
    Cell Significance Index: 205.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8618
    Cell Significance Index: 373.4800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.7843
    Cell Significance Index: 27.1000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.7317
    Cell Significance Index: 49.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7109
    Cell Significance Index: 18.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6865
    Cell Significance Index: 217.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.4684
    Cell Significance Index: 103.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.3970
    Cell Significance Index: 24.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.3579
    Cell Significance Index: 101.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2951
    Cell Significance Index: 34.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1567
    Cell Significance Index: 414.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8970
    Cell Significance Index: 10.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8557
    Cell Significance Index: 84.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6970
    Cell Significance Index: 53.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4007
    Cell Significance Index: 277.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2951
    Cell Significance Index: 15.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2384
    Cell Significance Index: 45.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2124
    Cell Significance Index: 7.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2061
    Cell Significance Index: 4.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1880
    Cell Significance Index: 3.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1268
    Cell Significance Index: 238.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1199
    Cell Significance Index: 7.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1168
    Cell Significance Index: 19.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0689
    Cell Significance Index: 43.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0532
    Cell Significance Index: 81.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0466
    Cell Significance Index: 21.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0458
    Cell Significance Index: 84.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0070
    Cell Significance Index: 5.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0017
    Cell Significance Index: -1.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0392
    Cell Significance Index: -29.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0555
    Cell Significance Index: -75.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0618
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0669
    Cell Significance Index: -49.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0781
    Cell Significance Index: -12.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1176
    Cell Significance Index: -12.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1202
    Cell Significance Index: -17.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1409
    Cell Significance Index: -87.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1437
    Cell Significance Index: -1.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1535
    Cell Significance Index: -1.8300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1658
    Cell Significance Index: -93.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3558
    Cell Significance Index: -8.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4062
    Cell Significance Index: -85.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4379
    Cell Significance Index: -125.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4604
    Cell Significance Index: -29.0200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5786
    Cell Significance Index: -4.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8043
    Cell Significance Index: -92.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8174
    Cell Significance Index: -95.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8300
    Cell Significance Index: -55.8100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8407
    Cell Significance Index: -24.6900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8866
    Cell Significance Index: -22.6500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0767
    Cell Significance Index: -122.9000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.1227
    Cell Significance Index: -20.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2034
    Cell Significance Index: -125.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3276
    Cell Significance Index: -42.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.3736
    Cell Significance Index: -23.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4665
    Cell Significance Index: -116.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.6457
    Cell Significance Index: -13.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.6638
    Cell Significance Index: -22.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.6746
    Cell Significance Index: -74.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7929
    Cell Significance Index: -47.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.8764
    Cell Significance Index: -46.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.9245
    Cell Significance Index: -133.0900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.0273
    Cell Significance Index: -76.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.1099
    Cell Significance Index: -31.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1139
    Cell Significance Index: -129.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.3644
    Cell Significance Index: -123.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -2.5089
    Cell Significance Index: -37.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.5280
    Cell Significance Index: -74.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.9956
    Cell Significance Index: -77.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FUS is a RNA-binding protein that belongs to the ETS family of transcription factors. It is primarily expressed in neurons, immune cells, and muscle cells, where it regulates gene expression by binding to specific RNA sequences. FUS has been implicated in the pathogenesis of several neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). **Pathways and Functions:** The FUS gene is involved in various cellular pathways, including: 1. **RNA Splicing:** FUS regulates the splicing of pre-mRNAs by binding to specific RNA sequences, thereby influencing the expression of genes involved in immune responses. 2. **Transcription Regulation:** FUS acts as a transcriptional coactivator, regulating the expression of genes involved in immune cell development and function. 3. **DNA Repair:** FUS is involved in the regulation of DNA repair pathways, including homologous recombination repair, which is critical for maintaining genome stability in immune cells. 4. **Amyloid Fibril Formation:** FUS has been implicated in the formation of amyloid fibrils, which are associated with neurodegenerative disorders. **Clinical Significance:** The FUS gene has been associated with several immune-related disorders, including: 1. **Amyotrophic Lateral Sclerosis (ALS):** FUS mutations have been identified in a subset of ALS patients, highlighting the gene's role in neurodegenerative diseases. 2. **Frontotemporal Dementia (FTD):** FUS mutations have also been linked to FTD, a neurodegenerative disorder characterized by progressive cognitive decline. 3. **Immune Cell Dysfunction:** FUS deficiency has been associated with impaired immune cell function, including reduced T cell activity and increased susceptibility to infections. 4. **Cancer:** FUS has been implicated in the regulation of cancer-related genes, suggesting its potential role in tumorigenesis. In conclusion, the FUS gene plays a critical role in regulating immune cell function, RNA splicing, and DNA repair. Its dysregulation has been implicated in various immune-related disorders, including ALS, FTD, and cancer. Further research is needed to fully understand the mechanisms by which FUS contributes to these diseases and to explore potential therapeutic strategies targeting this gene. **References:** * [Insert references to relevant studies on FUS gene] Note: As an expert immunologist, it is essential to acknowledge the limitations of the available data and to emphasize the need for further research to fully understand the mechanisms by which FUS contributes to immune-related disorders.

Genular Protein ID: 2865356190

Symbol: FUS_HUMAN

Name: RNA-binding protein FUS

UniProtKB Accession Codes:

P35637 Q9H4A8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 10 EMDB 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 23 PIR 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8510758

Title: Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.

PubMed ID: 8510758

DOI: 10.1038/363640a0

PubMed ID: 7503811

Title: Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.

PubMed ID: 7503811

DOI: 10.1038/ng0693-175

PubMed ID: 9795213

Title: Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.

PubMed ID: 9795213

DOI: 10.1016/s0378-1119(98)00463-6

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11063792

Title: Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.

PubMed ID: 11063792

DOI: 10.1016/s0165-4608(00)00237-5

PubMed ID: 10567410

Title: Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation.

PubMed ID: 10567410

DOI: 10.1074/jbc.274.48.34337

PubMed ID: 10442642

Title: Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.

PubMed ID: 10442642

DOI: 10.1038/sj.onc.1203048

PubMed ID: 8187069

Title: An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.

PubMed ID: 8187069

PubMed ID: 9660765

Title: The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.

PubMed ID: 9660765

DOI: 10.1074/jbc.273.29.18086

PubMed ID: 9774382

Title: Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.

PubMed ID: 9774382

DOI: 10.1074/jbc.273.43.27761

PubMed ID: 12964758

Title: Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode.

PubMed ID: 12964758

DOI: 10.1021/ac026283q

PubMed ID: 17196963

Title: Intracellular characterization of DDX39, a novel growth-associated RNA helicase.

PubMed ID: 17196963

DOI: 10.1016/j.yexcr.2006.11.014

PubMed ID: 18632687

Title: TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.

PubMed ID: 18632687

DOI: 10.1093/hmg/ddn203

PubMed ID: 18620545

Title: Identification and characterization of FUS/TLS as a new target of ATM.

PubMed ID: 18620545

DOI: 10.1042/bj20081135

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24204307

Title: ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation.

PubMed ID: 24204307

DOI: 10.1371/journal.pgen.1003895

PubMed ID: 25453086

Title: Self-assembled FUS binds active chromatin and regulates gene transcription.

PubMed ID: 25453086

DOI: 10.1073/pnas.1414004111

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27615052

Title: A novel missense mutation of CMT2P alters transcription machinery.

PubMed ID: 27615052

DOI: 10.1002/ana.24776

PubMed ID: 26124092

Title: FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.

PubMed ID: 26124092

DOI: 10.1073/pnas.1506282112

PubMed ID: 27731383

Title: FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.

PubMed ID: 27731383

DOI: 10.1038/srep35195

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 29897835

Title: The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization.

PubMed ID: 29897835

DOI: 10.1091/mbc.e17-12-0735

PubMed ID: 30354839

Title: The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.

PubMed ID: 30354839

DOI: 10.1091/mbc.e18-02-0108

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 19251627

Title: Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.

PubMed ID: 19251627

DOI: 10.1126/science.1166066

PubMed ID: 19251628

Title: Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.

PubMed ID: 19251628

DOI: 10.1126/science.1165942

PubMed ID: 19861302

Title: Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.

PubMed ID: 19861302

DOI: 10.1136/jmg.2009.071027

PubMed ID: 20124201

Title: Genetic contribution of FUS to frontotemporal lobar degeneration.

PubMed ID: 20124201

DOI: 10.1212/wnl.0b013e3181ccc732

PubMed ID: 22863194

Title: Exome sequencing identifies fus mutations as a cause of essential tremor.

PubMed ID: 22863194

DOI: 10.1016/j.ajhg.2012.07.002

PubMed ID: 27604643

Title: Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.

PubMed ID: 27604643

DOI: 10.1038/srep32478

Sequence Information:

  • Length: 526
  • Mass: 53426
  • Checksum: 88C8E263B7905549
  • Sequence:
    • MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ 
SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY GQQPAPSSTS GSYGSSSQSS 
SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD 
QSSMSSGGGS GGGYGNQDQS GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE 
PRGRGGGRGG RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES 
VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA IDWFDGKEFS 
GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG GSGGGGRGGF PSGGGGGGGQ 
QRAGDWKCPN PTCENMNFSW RNECNQCKAP KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD 
RGGYRGRGGD RGGFRGGRGG GDRGGFGPGK MDSRGEHRQD RRERPY

Genular Protein ID: 3825298007

Symbol: Q13344_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13344

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 2 IntAct 1 InterPro 6 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PROSITE 5 PROSITE-ProRule 2 Pfam 2 PharmGKB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 528
  • Mass: 53377
  • Checksum: 43CFD6CBDA57A258
  • Sequence:
    • MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTGYG QSSYSSYGQS 
QNTGYGTQSA PQGYGSTGGY GSSQSSQSSY GQQSSYPGYG PQPTPSSTSG SYGSSSQTSS 
YGQPPSYGQQ PSYGGQQQSY GQQQSYNPSG YGQQNQYNSS SSGSGGGGSY GQDQSSMSGS 
GGGGGGGGGG GSGGGGGYGN QDQSGGGGGG YGQQDRGGRG RGRSSGGGGG SGGGYNRSSG 
GYEPRGRGGG RGGRGGMGGS DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT 
IESVADYFKQ IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK 
EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR GGFPSGGGGG 
GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG GPGGSHMGGN YGDDRRGGRG 
GYDRGGYRGR GGDRGGFRGG RGGGDRGGFG PGKMDSRGEH RQDRRERP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.