Details for: FUS
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 755.4716
Cell Significance Index: -117.5100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 451.0664
Cell Significance Index: -114.4100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 351.0641
Cell Significance Index: -144.6200 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 298.6300
Cell Significance Index: -140.9900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 269.8172
Cell Significance Index: -138.7900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 211.2896
Cell Significance Index: -141.7800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 110.6325
Cell Significance Index: -136.4100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 41.8163
Cell Significance Index: -112.0200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 35.7319
Cell Significance Index: -141.0000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 33.0495
Cell Significance Index: -101.5100 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 28.0501
Cell Significance Index: -61.3900 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 5.1873
Cell Significance Index: 180.2600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.1003
Cell Significance Index: 563.0900 - Cell Name: odontoblast (CL0000060)
Fold Change: 3.9400
Cell Significance Index: 505.0900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.7417
Cell Significance Index: 241.4000 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.3323
Cell Significance Index: 69.7500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.2851
Cell Significance Index: 154.4000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 2.9336
Cell Significance Index: 77.1400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.7300
Cell Significance Index: 335.6800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.5906
Cell Significance Index: 145.3700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4994
Cell Significance Index: 496.0100 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.4813
Cell Significance Index: 112.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.4019
Cell Significance Index: 433.0000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.3048
Cell Significance Index: 64.4100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.2712
Cell Significance Index: 61.8200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.2501
Cell Significance Index: 118.1400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.2340
Cell Significance Index: 64.3700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.1817
Cell Significance Index: 964.5700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.1738
Cell Significance Index: 1187.1600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.9528
Cell Significance Index: 230.3000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.8901
Cell Significance Index: 205.5900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.8618
Cell Significance Index: 373.4800 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.7843
Cell Significance Index: 27.1000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.7317
Cell Significance Index: 49.6400 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.7109
Cell Significance Index: 18.6000 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.6865
Cell Significance Index: 217.8900 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.4684
Cell Significance Index: 103.8500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.3970
Cell Significance Index: 24.6900 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.3579
Cell Significance Index: 101.2000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.2951
Cell Significance Index: 34.5800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.1567
Cell Significance Index: 414.8700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.8970
Cell Significance Index: 10.1900 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8557
Cell Significance Index: 84.6500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6970
Cell Significance Index: 53.4900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4007
Cell Significance Index: 277.1300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2951
Cell Significance Index: 15.3300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2384
Cell Significance Index: 45.3600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2124
Cell Significance Index: 7.4700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2061
Cell Significance Index: 4.4700 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.1880
Cell Significance Index: 3.6700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1268
Cell Significance Index: 238.6800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.1199
Cell Significance Index: 7.3700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1168
Cell Significance Index: 19.9400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0689
Cell Significance Index: 43.7800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0532
Cell Significance Index: 81.8800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0466
Cell Significance Index: 21.1700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0458
Cell Significance Index: 84.3900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0070
Cell Significance Index: 5.1100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0012
Cell Significance Index: -0.0200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: -0.0017
Cell Significance Index: -1.4900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0392
Cell Significance Index: -29.6600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0555
Cell Significance Index: -75.5300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0618
Cell Significance Index: -2.8800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0669
Cell Significance Index: -49.5600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0781
Cell Significance Index: -12.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1176
Cell Significance Index: -12.0200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1202
Cell Significance Index: -17.4700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1409
Cell Significance Index: -87.9600 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.1437
Cell Significance Index: -1.8400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1535
Cell Significance Index: -1.8300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1658
Cell Significance Index: -93.5100 - Cell Name: peg cell (CL4033014)
Fold Change: -0.3558
Cell Significance Index: -8.2200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.4062
Cell Significance Index: -85.5500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4379
Cell Significance Index: -125.9900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4604
Cell Significance Index: -29.0200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.5786
Cell Significance Index: -4.4600 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.8043
Cell Significance Index: -92.1500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8174
Cell Significance Index: -95.2600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8300
Cell Significance Index: -55.8100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.8407
Cell Significance Index: -24.6900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8866
Cell Significance Index: -22.6500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.0767
Cell Significance Index: -122.9000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -1.1227
Cell Significance Index: -20.7500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.2034
Cell Significance Index: -125.3000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.3276
Cell Significance Index: -42.5200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -1.3736
Cell Significance Index: -23.5400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.4665
Cell Significance Index: -116.1500 - Cell Name: kidney cell (CL1000497)
Fold Change: -1.6457
Cell Significance Index: -13.1400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.6638
Cell Significance Index: -22.7000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.6746
Cell Significance Index: -74.0700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.7929
Cell Significance Index: -47.9600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.8764
Cell Significance Index: -46.9100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.9245
Cell Significance Index: -133.0900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -2.0273
Cell Significance Index: -76.7700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.1099
Cell Significance Index: -31.6200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.1139
Cell Significance Index: -129.6000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -2.3644
Cell Significance Index: -123.1600 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -2.5089
Cell Significance Index: -37.0400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.5280
Cell Significance Index: -74.4600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -2.9956
Cell Significance Index: -77.0000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2865356190
Symbol: FUS_HUMAN
Name: RNA-binding protein FUS
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8510758
Title: Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
PubMed ID: 8510758
DOI: 10.1038/363640a0
PubMed ID: 7503811
Title: Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
PubMed ID: 7503811
DOI: 10.1038/ng0693-175
PubMed ID: 9795213
Title: Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
PubMed ID: 9795213
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11063792
Title: Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.
PubMed ID: 11063792
PubMed ID: 10567410
Title: Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation.
PubMed ID: 10567410
PubMed ID: 10442642
Title: Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.
PubMed ID: 10442642
PubMed ID: 8187069
Title: An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
PubMed ID: 8187069
PubMed ID: 9660765
Title: The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.
PubMed ID: 9660765
PubMed ID: 9774382
Title: Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.
PubMed ID: 9774382
PubMed ID: 12964758
Title: Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode.
PubMed ID: 12964758
DOI: 10.1021/ac026283q
PubMed ID: 17196963
Title: Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
PubMed ID: 17196963
PubMed ID: 18632687
Title: TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.
PubMed ID: 18632687
DOI: 10.1093/hmg/ddn203
PubMed ID: 18620545
Title: Identification and characterization of FUS/TLS as a new target of ATM.
PubMed ID: 18620545
DOI: 10.1042/bj20081135
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24204307
Title: ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation.
PubMed ID: 24204307
PubMed ID: 25453086
Title: Self-assembled FUS binds active chromatin and regulates gene transcription.
PubMed ID: 25453086
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27615052
Title: A novel missense mutation of CMT2P alters transcription machinery.
PubMed ID: 27615052
DOI: 10.1002/ana.24776
PubMed ID: 26124092
Title: FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
PubMed ID: 26124092
PubMed ID: 27731383
Title: FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.
PubMed ID: 27731383
DOI: 10.1038/srep35195
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29897835
Title: The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization.
PubMed ID: 29897835
PubMed ID: 30354839
Title: The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.
PubMed ID: 30354839
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 19251627
Title: Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
PubMed ID: 19251627
PubMed ID: 19251628
Title: Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
PubMed ID: 19251628
PubMed ID: 19861302
Title: Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.
PubMed ID: 19861302
PubMed ID: 20124201
Title: Genetic contribution of FUS to frontotemporal lobar degeneration.
PubMed ID: 20124201
PubMed ID: 22863194
Title: Exome sequencing identifies fus mutations as a cause of essential tremor.
PubMed ID: 22863194
PubMed ID: 27604643
Title: Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.
PubMed ID: 27604643
DOI: 10.1038/srep32478
Sequence Information:
- Length: 526
- Mass: 53426
- Checksum: 88C8E263B7905549
- Sequence:
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY GQQPAPSSTS GSYGSSSQSS SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD QSSMSSGGGS GGGYGNQDQS GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE PRGRGGGRGG RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA IDWFDGKEFS GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG GSGGGGRGGF PSGGGGGGGQ QRAGDWKCPN PTCENMNFSW RNECNQCKAP KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD RGGYRGRGGD RGGFRGGRGG GDRGGFGPGK MDSRGEHRQD RRERPY
Genular Protein ID: 3825298007
Symbol: Q13344_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 528
- Mass: 53377
- Checksum: 43CFD6CBDA57A258
- Sequence:
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTGYG QSSYSSYGQS QNTGYGTQSA PQGYGSTGGY GSSQSSQSSY GQQSSYPGYG PQPTPSSTSG SYGSSSQTSS YGQPPSYGQQ PSYGGQQQSY GQQQSYNPSG YGQQNQYNSS SSGSGGGGSY GQDQSSMSGS GGGGGGGGGG GSGGGGGYGN QDQSGGGGGG YGQQDRGGRG RGRSSGGGGG SGGGYNRSSG GYEPRGRGGG RGGRGGMGGS DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR GGFPSGGGGG GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG GPGGSHMGGN YGDDRRGGRG GYDRGGYRGR GGDRGGFRGG RGGGDRGGFG PGKMDSRGEH RQDRRERP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.