Details for: FUS
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 90.81rCSI 60.36%PRS 4.96
-
CSI 86.27rCSI 77.91%PRS 3.67
-
CSI 80.28rCSI 77.28%PRS 4.3
-
CSI 79.64rCSI 64.39%PRS 4.09
-
CSI 78.36rCSI 59.28%PRS 5.85
-
CSI 74.89rCSI 64.85%PRS 4.63
-
CSI 72.15rCSI 60.48%PRS 5
-
CSI 70.31rCSI 80.48%PRS 8.67
-
CSI 69.44rCSI 57.5%PRS 4.16
-
CSI 67.08rCSI 84.19%PRS 5.29
-
CSI 61.6rCSI 43.01%PRS 4.39
-
CSI 60.51rCSI 45.37%PRS 12.65
-
CSI 60.3rCSI 52.96%PRS 4.66
-
CSI 60.02rCSI 40%PRS 11.75
-
CSI 58.26rCSI 60.89%PRS 4.42
-
CSI 57.91rCSI 48.01%PRS 3.89
-
CSI 56.87rCSI 43.82%PRS 3.76
-
CSI 55.65rCSI 74.37%PRS 7.99
-
CSI 52.72rCSI 50.83%PRS 2.11
-
CSI 49.4rCSI 67.31%PRS 3.76
-
CSI 48.91rCSI 49.85%PRS 6.04
-
CSI 45.46rCSI 39.52%PRS 5.13
-
CSI 45.18rCSI 30.44%PRS 5.06
-
CSI 43.92rCSI 62.68%PRS 4.74
-
CSI 43.42rCSI 51%PRS 5.04
-
CSI 43.05rCSI 30.23%PRS 12.55
-
CSI 41.52rCSI 59.88%PRS 5.79
-
CSI 40.62rCSI 30.52%PRS 4.29
-
CSI 40.38rCSI 49.95%PRS 3.64
-
CSI 37.9rCSI 45.93%PRS 6.28
-
CSI 37.39rCSI 34.5%PRS 4.21
-
CSI 35.64rCSI 24.78%PRS 4.89
-
CSI 34.31rCSI 20.27%PRS 5.83
-
CSI 34rCSI 33.57%PRS 18.38
-
CSI 33.28rCSI 39.94%PRS 4.16
-
CSI 31.77rCSI 25.11%PRS 2.87
-
CSI 30.74rCSI 32.2%PRS 3.88
-
CSI 30.59rCSI 26.8%PRS 5.63
-
CSI 29.81rCSI 40.76%PRS 7.28
-
CSI 29.24rCSI 80.35%PRS 6.96
-
CSI 29.14rCSI 83.18%PRS 7.39
-
CSI 28.94rCSI 37.12%PRS 4.8
-
CSI 27.88rCSI 50.32%PRS 12.73
-
CSI 27.69rCSI 98.4%PRS 13.63
-
CSI 27.28rCSI 23.99%PRS 3
-
CSI 26.95rCSI 46.18%PRS 5.57
-
CSI 26.4rCSI 20.54%PRS 6
-
CSI 25.87rCSI 32.18%PRS 4.44
-
CSI 25.33rCSI 29.25%PRS 3.77
-
CSI 25.27rCSI 26.47%PRS 4.45
-
CSI 24.64rCSI 71.32%PRS 4.71
-
CSI 24.61rCSI 18.37%PRS 7.07
-
CSI 24.48rCSI 80.13%PRS 13.07
-
CSI 24.47rCSI 37.43%PRS 6.81
-
CSI 24.43rCSI 53.52%PRS 5.77
-
CSI 24.28rCSI 77.9%PRS 6.25
-
CSI 23.76rCSI 64.05%PRS 5.42
-
CSI 23.72rCSI 21.06%PRS 4.17
-
CSI 22.87rCSI 89.02%PRS 6.92
-
CSI 22.61rCSI 38.69%PRS 9.13
-
CSI 22.59rCSI 28.39%PRS 22.39
-
CSI 22.24rCSI 21.88%PRS 4.56
-
CSI 21.49rCSI 17.94%PRS 13.48
-
CSI 21.15rCSI 26.93%PRS 4.85
-
CSI 20.88rCSI 29%PRS 4.36
-
CSI 20.49rCSI 31.66%PRS 3.9
-
CSI 19.71rCSI 16.9%PRS 11.75
-
CSI 19.62rCSI 68.84%PRS 7.57
-
CSI 19.47rCSI 32.69%PRS 2.55
-
CSI 18.93rCSI 97.74%PRS 8.33
-
CSI 18.89rCSI 34.32%PRS 6.37
-
CSI 18.63rCSI 28.62%PRS 6.01
-
CSI 18.4rCSI 19.22%PRS 13.43
-
CSI 18.29rCSI 43.49%PRS 6.34
-
CSI 18.12rCSI 21.28%PRS 39.63
-
CSI 17.96rCSI 17.27%PRS 9.1
-
CSI 17.84rCSI 33.73%PRS 9.39
-
CSI 17.84rCSI 14.16%PRS 7.43
-
CSI 17.82rCSI 45.26%PRS 4.26
-
CSI 17.11rCSI 23.37%PRS 4.6
-
CSI 17.06rCSI 57.66%PRS 7.18
-
CSI 16.96rCSI 14.27%PRS 7.01
-
CSI 16.9rCSI 17.12%PRS 27.22
-
CSI 16.9rCSI 24.35%PRS 6.75
-
CSI 16.57rCSI 22.57%PRS 10.52
-
CSI 16.46rCSI 12.23%PRS 6.23
-
CSI 16.25rCSI 12.36%PRS 5.54
-
CSI 16.2rCSI 12.12%PRS 6.85
-
CSI 16.02rCSI 70.32%PRS 8.14
-
CSI 15.81rCSI 15.78%PRS 3.52
-
CSI 15.77rCSI 30.67%PRS 4.25
-
CSI 15.52rCSI 21.49%PRS 5.99
-
CSI 15.24rCSI 11.81%PRS 3.96
-
CSI 15.13rCSI 39.82%PRS 8.13
-
CSI 15.08rCSI 32.08%PRS 8.04
-
CSI 14.56rCSI 33.92%PRS 10.21
-
CSI 14.17rCSI 39.7%PRS 6.55
-
CSI 14.04rCSI 11.41%PRS 4.37
-
CSI 14.03rCSI 10.39%PRS 3.91
-
CSI 13.97rCSI 14.47%PRS 4.89
-
CSI -17.2rCSI -30.2%PRS 3.3%
-
CSI -12.4rCSI -51.3%PRS 12.5%
-
CSI -9.5rCSI -19.3%PRS 1.4%
-
CSI -7.2rCSI -17.5%PRS 4.3%
-
CSI -6.6rCSI -68.1%PRS 4.1%
-
CSI -6.2rCSI -11.6%PRS 3.3%
-
CSI -5.5rCSI -20.7%PRS 8.9%
-
CSI -4.3rCSI -12.6%PRS 7.1%
-
CSI -4.1rCSI -5.3%PRS 2.7%
-
CSI -3.8rCSI -8.5%PRS 2.7%
-
CSI -3.6rCSI -6.4%PRS 5.5%
-
CSI -3.6rCSI -8.5%PRS 5.6%
-
CSI -3.4rCSI -19.3%PRS 1.3%
-
CSI -3.4rCSI -7.9%PRS 3.8%
-
CSI -3.3rCSI -28.8%PRS 28.6%
-
CSI -3.3rCSI -20.8%PRS 19.9%
-
CSI -3.2rCSI -13.1%PRS 5.2%
-
CSI -3.1rCSI -15.0%PRS 7.1%
-
CSI -3.1rCSI -9.1%PRS 3.3%
-
CSI -2.9rCSI -3.9%PRS 5.7%
-
CSI -2.8rCSI -3.6%PRS 5.2%
-
CSI -2.5rCSI -6.1%PRS 2.4%
-
CSI -2.4rCSI -7.7%PRS 3.2%
-
CSI -2.3rCSI -13.3%PRS 6.3%
-
CSI -2.2rCSI -1.5%PRS 6.1%
-
CSI -1.8rCSI -8.4%PRS 15.7%
-
CSI -1.8rCSI -4.8%PRS 5.0%
-
CSI -1.6rCSI -8.4%PRS 2.7%
-
CSI -1.6rCSI -1.3%PRS 7.8%
-
CSI -1.4rCSI -2.0%PRS 4.8%
-
CSI -1.3rCSI -11.4%PRS 1.2%
-
CSI -1.2rCSI -1.5%PRS 2.5%
-
CSI -1.2rCSI -20.3%PRS 21.7%
-
CSI -1.1rCSI -3.0%PRS 27.4%
-
CSI -1.0rCSI -2.5%PRS 5.0%
-
CSI -0.9rCSI -4.9%PRS 6.5%
-
CSI -0.8rCSI -3.2%PRS 6.9%
-
CSI -0.8rCSI -15.4%PRS 34.8%
-
CSI -0.7rCSI -1.7%PRS 6.0%
-
CSI -0.6rCSI -4.3%PRS 7.2%
-
CSI -0.4rCSI -1.2%PRS 6.1%
-
CSI -0.2rCSI -0.5%PRS 4.0%
-
CSI -0.2rCSI -2.5%PRS 42.9%
-
CSI -0.2rCSI -0.6%PRS 2.3%
-
CSI -0.2rCSI -0.4%PRS 5.6%
-
CSI -0.1rCSI -0.6%PRS 7.2%
-
CSI 0.0rCSI -0.3%PRS 24.0%
-
CSI 0.0rCSI 0.1%PRS 0.6%
-
CSI 0.1rCSI 0.4%PRS 19.1%
-
CSI 0.1rCSI 1.2%PRS 17.1%
-
CSI 0.2rCSI 2.4%PRS 14.9%
-
CSI 0.3rCSI 5.8%PRS 36.0%
-
CSI 0.3rCSI 0.8%PRS 7.5%
-
CSI 0.3rCSI 1.6%PRS 10.5%
-
CSI 0.3rCSI 1.3%PRS 9.0%
-
CSI 0.4rCSI 2.4%PRS 3.5%
-
CSI 0.4rCSI 1.6%PRS 9.6%
-
CSI 0.4rCSI 4.4%PRS 13.9%
-
CSI 0.4rCSI 1.0%PRS 3.9%
-
CSI 0.5rCSI 11.9%PRS 14.9%
-
CSI 0.5rCSI 4.0%PRS 19.0%
-
CSI 0.5rCSI 2.4%PRS 22.6%
-
CSI 0.5rCSI 2.3%PRS 16.8%
-
CSI 0.5rCSI 2.6%PRS 6.7%
-
CSI 0.5rCSI 1.7%PRS 5.0%
-
CSI 0.5rCSI 1.5%PRS 4.8%
-
CSI 0.6rCSI 2.6%PRS 19.4%
-
CSI 0.6rCSI 3.5%PRS 23.4%
-
CSI 0.6rCSI 3.1%PRS 2.4%
-
CSI 0.7rCSI 3.4%PRS 8.6%
-
CSI 0.7rCSI 12.7%PRS 35.7%
-
CSI 0.7rCSI 3.7%PRS 15.7%
-
CSI 0.7rCSI 6.2%PRS 16.2%
-
CSI 0.7rCSI 21.5%PRS 50.7%
-
CSI 0.7rCSI 3.2%PRS 4.2%
-
CSI 0.7rCSI 1.8%PRS 3.3%
-
CSI 0.8rCSI 2.6%PRS 19.1%
-
CSI 0.8rCSI 9.8%PRS 36.8%
-
CSI 0.8rCSI 18.0%PRS 5.6%
-
CSI 0.8rCSI 8.4%PRS 53.1%
-
CSI 0.9rCSI 8.7%PRS 38.0%
-
CSI 0.9rCSI 5.0%PRS 22.9%
-
CSI 0.9rCSI 2.5%PRS 4.5%
-
CSI 1.0rCSI 5.6%PRS 7.2%
-
CSI 1.0rCSI 6.4%PRS 15.9%
-
CSI 1.1rCSI 12.0%PRS 29.0%
-
CSI 1.2rCSI 5.4%PRS 11.7%
-
CSI 1.2rCSI 2.7%PRS 7.3%
-
CSI 1.2rCSI 1.7%PRS 4.3%
-
CSI 1.2rCSI 12.8%PRS 21.0%
-
CSI 1.2rCSI 1.6%PRS 22.5%
-
CSI 1.3rCSI 3.6%PRS 8.1%
-
CSI 1.3rCSI 1.8%PRS 9.0%
-
CSI 1.3rCSI 13.8%PRS 7.1%
-
CSI 1.3rCSI 5.4%PRS 7.2%
-
CSI 1.4rCSI 3.0%PRS 10.6%
-
CSI 1.4rCSI 2.2%PRS 3.2%
-
CSI 1.4rCSI 3.3%PRS 5.4%
-
CSI 1.4rCSI 29.1%PRS 26.9%
-
CSI 1.4rCSI 2.0%PRS 4.4%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2865356190
Symbol: FUS_HUMAN
Name: RNA-binding protein FUS
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8510758
Title: Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma.
PubMed ID: 8510758
DOI: 10.1038/363640a0
PubMed ID: 7503811
Title: Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma.
PubMed ID: 7503811
DOI: 10.1038/ng0693-175
PubMed ID: 9795213
Title: Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes.
PubMed ID: 9795213
PubMed ID: 15616553
Title: The sequence and analysis of duplication-rich human chromosome 16.
PubMed ID: 15616553
DOI: 10.1038/nature03187
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 11063792
Title: Genetic characterization of angiomatoid fibrous histiocytoma identifies fusion of the FUS and ATF-1 genes induced by a chromosomal translocation involving bands 12q13 and 16p11.
PubMed ID: 11063792
PubMed ID: 10567410
Title: Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation.
PubMed ID: 10567410
PubMed ID: 10442642
Title: Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation.
PubMed ID: 10442642
PubMed ID: 8187069
Title: An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation.
PubMed ID: 8187069
PubMed ID: 9660765
Title: The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.
PubMed ID: 9660765
PubMed ID: 9774382
Title: Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.
PubMed ID: 9774382
PubMed ID: 12964758
Title: Detection of arginine dimethylated peptides by parallel precursor ion scanning mass spectrometry in positive ion mode.
PubMed ID: 12964758
DOI: 10.1021/ac026283q
PubMed ID: 17196963
Title: Intracellular characterization of DDX39, a novel growth-associated RNA helicase.
PubMed ID: 17196963
PubMed ID: 18632687
Title: TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules.
PubMed ID: 18632687
DOI: 10.1093/hmg/ddn203
PubMed ID: 18620545
Title: Identification and characterization of FUS/TLS as a new target of ATM.
PubMed ID: 18620545
DOI: 10.1042/bj20081135
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24204307
Title: ALS-associated FUS mutations result in compromised FUS alternative splicing and autoregulation.
PubMed ID: 24204307
PubMed ID: 25453086
Title: Self-assembled FUS binds active chromatin and regulates gene transcription.
PubMed ID: 25453086
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27615052
Title: A novel missense mutation of CMT2P alters transcription machinery.
PubMed ID: 27615052
DOI: 10.1002/ana.24776
PubMed ID: 26124092
Title: FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP.
PubMed ID: 26124092
PubMed ID: 27731383
Title: FUS interacts with nuclear matrix-associated protein SAFB1 as well as Matrin3 to regulate splicing and ligand-mediated transcription.
PubMed ID: 27731383
DOI: 10.1038/srep35195
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 29897835
Title: The prionlike domain of FUS is multiphosphorylated following DNA damage without altering nuclear localization.
PubMed ID: 29897835
PubMed ID: 30354839
Title: The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.
PubMed ID: 30354839
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 19251627
Title: Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
PubMed ID: 19251627
PubMed ID: 19251628
Title: Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6.
PubMed ID: 19251628
PubMed ID: 19861302
Title: Mutations of FUS gene in sporadic amyotrophic lateral sclerosis.
PubMed ID: 19861302
PubMed ID: 20124201
Title: Genetic contribution of FUS to frontotemporal lobar degeneration.
PubMed ID: 20124201
PubMed ID: 22863194
Title: Exome sequencing identifies fus mutations as a cause of essential tremor.
PubMed ID: 22863194
PubMed ID: 27604643
Title: Screening of SOD1, FUS and TARDBP genes in patients with amyotrophic lateral sclerosis in central-southern China.
PubMed ID: 27604643
DOI: 10.1038/srep32478
Sequence Information:
- Length: 526
- Mass: 53426
- Checksum: 88C8E263B7905549
- Sequence:
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTSGY GQSSYSSYGQ SQNTGYGTQS TPQGYGSTGG YGSSQSSQSS YGQQSSYPGY GQQPAPSSTS GSYGSSSQSS SYGQPQSGSY SQQPSYGGQQ QSYGQQQSYN PPQGYGQQNQ YNSSSGGGGG GGGGGNYGQD QSSMSSGGGS GGGYGNQDQS GGGGSGGYGQ QDRGGRGRGG SGGGGGGGGG GYNRSSGGYE PRGRGGGRGG RGGMGGSDRG GFNKFGGPRD QGSRHDSEQD NSDNNTIFVQ GLGENVTIES VADYFKQIGI IKTNKKTGQP MINLYTDRET GKLKGEATVS FDDPPSAKAA IDWFDGKEFS GNPIKVSFAT RRADFNRGGG NGRGGRGRGG PMGRGGYGGG GSGGGGRGGF PSGGGGGGGQ QRAGDWKCPN PTCENMNFSW RNECNQCKAP KPDGPGGGPG GSHMGGNYGD DRRGGRGGYD RGGYRGRGGD RGGFRGGRGG GDRGGFGPGK MDSRGEHRQD RRERPY
Genular Protein ID: 3825298007
Symbol: Q13344_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 528
- Mass: 53377
- Checksum: 43CFD6CBDA57A258
- Sequence:
MASNDYTQQA TQSYGAYPTQ PGQGYSQQSS QPYGQQSYSG YSQSTDTGYG QSSYSSYGQS QNTGYGTQSA PQGYGSTGGY GSSQSSQSSY GQQSSYPGYG PQPTPSSTSG SYGSSSQTSS YGQPPSYGQQ PSYGGQQQSY GQQQSYNPSG YGQQNQYNSS SSGSGGGGSY GQDQSSMSGS GGGGGGGGGG GSGGGGGYGN QDQSGGGGGG YGQQDRGGRG RGRSSGGGGG SGGGYNRSSG GYEPRGRGGG RGGRGGMGGS DRGGFNKFGG PRDQGSRHDS EQDNSDNNTI FVQGLGENVT IESVADYFKQ IGIIKTNKKT GQPMINLYTD RETGKLKGEA TVSFDDPPSA KAAIDWFDGK EFSGNPIKVS FATRRADFNR GGGNGRGGRG RGGPMGRGGY GGGGSGGGGR GGFPSGGGGG GGQQRAGDWK CPNPTCENMN FSWRNECNQC KAPKPDGPGG GPGGSHMGGN YGDDRRGGRG GYDRGGYRGR GGDRGGFRGG RGGGDRGGFG PGKMDSRGEH RQDRRERP