Details for: PGK1

Gene ID: 5230

Symbol: PGK1

Ensembl ID: ENSG00000102144

Description: phosphoglycerate kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 625.5415
    Cell Significance Index: -97.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 315.0486
    Cell Significance Index: -79.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 261.7687
    Cell Significance Index: -107.8400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 234.2612
    Cell Significance Index: -110.6000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 207.8987
    Cell Significance Index: -106.9400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 165.2106
    Cell Significance Index: -110.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 84.9828
    Cell Significance Index: -104.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.5658
    Cell Significance Index: -90.8100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.4452
    Cell Significance Index: -108.3000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.4299
    Cell Significance Index: -52.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.8687
    Cell Significance Index: -34.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.7415
    Cell Significance Index: 301.4500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.1085
    Cell Significance Index: 150.0300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.1944
    Cell Significance Index: 32.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9463
    Cell Significance Index: 1609.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6282
    Cell Significance Index: 169.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5153
    Cell Significance Index: 46.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1695
    Cell Significance Index: 266.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1634
    Cell Significance Index: 389.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0364
    Cell Significance Index: 240.1600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.7927
    Cell Significance Index: 21.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.6914
    Cell Significance Index: 79.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6086
    Cell Significance Index: 113.7700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.5588
    Cell Significance Index: 689.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5427
    Cell Significance Index: 41.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.4818
    Cell Significance Index: 203.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3261
    Cell Significance Index: 61.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3136
    Cell Significance Index: 34.5400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0616
    Cell Significance Index: 136.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0541
    Cell Significance Index: 211.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0122
    Cell Significance Index: 75.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8937
    Cell Significance Index: 170.0800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8699
    Cell Significance Index: 45.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8182
    Cell Significance Index: 133.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.7007
    Cell Significance Index: 90.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6967
    Cell Significance Index: 24.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6905
    Cell Significance Index: 43.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5936
    Cell Significance Index: 117.8000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5717
    Cell Significance Index: 6.5000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.4791
    Cell Significance Index: 737.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4437
    Cell Significance Index: 159.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3235
    Cell Significance Index: 439.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3065
    Cell Significance Index: 565.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2851
    Cell Significance Index: 536.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2668
    Cell Significance Index: 121.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2194
    Cell Significance Index: 21.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1203
    Cell Significance Index: 88.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1035
    Cell Significance Index: 78.3300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0896
    Cell Significance Index: 0.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0724
    Cell Significance Index: 12.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0575
    Cell Significance Index: 36.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0491
    Cell Significance Index: 1.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0386
    Cell Significance Index: -3.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0462
    Cell Significance Index: -34.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0822
    Cell Significance Index: -51.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0955
    Cell Significance Index: -2.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1082
    Cell Significance Index: -2.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1317
    Cell Significance Index: -74.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1622
    Cell Significance Index: -18.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1656
    Cell Significance Index: -3.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1856
    Cell Significance Index: -6.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2088
    Cell Significance Index: -43.9800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2189
    Cell Significance Index: -5.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3226
    Cell Significance Index: -5.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3269
    Cell Significance Index: -47.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3793
    Cell Significance Index: -29.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6591
    Cell Significance Index: -68.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6697
    Cell Significance Index: -76.4500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6897
    Cell Significance Index: -17.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7458
    Cell Significance Index: -59.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7511
    Cell Significance Index: -87.5300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.8203
    Cell Significance Index: -89.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8746
    Cell Significance Index: -49.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8904
    Cell Significance Index: -54.7300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9066
    Cell Significance Index: -11.2500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.9100
    Cell Significance Index: -7.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9389
    Cell Significance Index: -20.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.0049
    Cell Significance Index: -67.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.0256
    Cell Significance Index: -11.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.1072
    Cell Significance Index: -8.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.2273
    Cell Significance Index: -20.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.4249
    Cell Significance Index: -14.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.5125
    Cell Significance Index: -104.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5348
    Cell Significance Index: -20.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5842
    Cell Significance Index: -50.7400
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -1.6143
    Cell Significance Index: -14.2200
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: -1.7215
    Cell Significance Index: -7.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.7576
    Cell Significance Index: -50.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7850
    Cell Significance Index: -109.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.7894
    Cell Significance Index: -38.1100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.8215
    Cell Significance Index: -31.4000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.9426
    Cell Significance Index: -12.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9602
    Cell Significance Index: -49.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9685
    Cell Significance Index: -57.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9913
    Cell Significance Index: -88.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.0365
    Cell Significance Index: -92.3100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.0512
    Cell Significance Index: -58.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.1346
    Cell Significance Index: -54.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.1497
    Cell Significance Index: -36.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.3261
    Cell Significance Index: -73.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Mitochondrial localization**: PGK1 is predominantly found in the mitochondrial matrix, where it plays a crucial role in energy production. 2. **ATP-generating activity**: PGK1 is responsible for producing ATP through the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. 3. **Regulation of energy metabolism**: PGK1 is involved in the regulation of energy metabolism, particularly under hypoxic conditions, where it helps maintain ATP production. 4. **Immune cell expression**: PGK1 is highly expressed in immune cells, such as monocytes, dendritic cells, and T cells, highlighting its role in immune function. **Pathways and Functions** PGK1 is involved in various metabolic pathways, including: 1. **Glycolysis**: PGK1 is a key enzyme in the glycolytic pathway, where it generates ATP by converting 1,3-bisphosphoglycerate to 3-phosphoglycerate. 2. **Gluconeogenesis**: PGK1 is also involved in gluconeogenesis, where it helps generate glucose from non-carbohydrate sources. 3. **Canonical glycolysis**: PGK1 is a critical component of the canonical glycolytic pathway, where it plays a central role in energy production. 4. **Cellular response to hypoxia**: PGK1 is induced under hypoxic conditions, where it helps maintain ATP production and support cellular survival. 5. **Infection with mycobacterium tuberculosis**: PGK1 is involved in the regulation of energy metabolism during M. tuberculosis infection, highlighting its importance in immune response. **Clinical Significance** The dysregulation of PGK1 has been implicated in various diseases, including: 1. **Cancer**: Altered PGK1 expression has been observed in various types of cancer, where it contributes to tumor progression and metastasis. 2. **Neurodegenerative diseases**: PGK1 dysfunction has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's, where it contributes to energy metabolism and neuronal survival. 3. **Immune disorders**: PGK1 is involved in the regulation of immune function, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, PGK1 is a multifaceted enzyme that plays a critical role in metabolic regulation and immune function. Its dysregulation has been implicated in various diseases, highlighting the importance of PGK1 in maintaining energy homeostasis and immune function. Further research is needed to fully elucidate the role of PGK1 in human disease and to develop therapeutic strategies targeting this enzyme.

Genular Protein ID: 2630504915

Symbol: PGK1_HUMAN

Name: Phosphoglycerate kinase 1

UniProtKB Accession Codes:

P00558 A8K4W6 B7Z7A9 Q5J7W1 Q6IBT6 Q8NI87

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 EC 1 EMBL 26 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 26 PDBsum 26 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6188151

Title: Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.

PubMed ID: 6188151

DOI: 10.1073/pnas.80.2.472

PubMed ID: 2995995

Title: Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.

PubMed ID: 2995995

DOI: 10.1073/pnas.82.20.6965

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6099325

Title: Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase].

PubMed ID: 6099325

DOI: 10.1016/0378-1119(84)90016-7

PubMed ID: 2814502

Title: Genomic sequencing and methylation analysis by ligation mediated PCR.

PubMed ID: 2814502

DOI: 10.1126/science.2814502

PubMed ID: 7391027

Title: Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence.

PubMed ID: 7391027

DOI: 10.1016/s0021-9258(18)43754-4

PubMed ID: 2324090

Title: Functional identity of a primer recognition protein as phosphoglycerate kinase.

PubMed ID: 2324090

DOI: 10.1016/s0021-9258(19)39179-3

PubMed ID: 9075577

Title: Hematologically important mutations: molecular abnormalities of phosphoglycerate kinase.

PubMed ID: 9075577

DOI: 10.1006/bcmd.1996.0108

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26677959

Title: Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm quality.

PubMed ID: 26677959

DOI: 10.1093/humrep/dev301

PubMed ID: 29192674

Title: Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway.

PubMed ID: 29192674

DOI: 10.1038/cr.2017.149

PubMed ID: 30323285

Title: A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.

PubMed ID: 30323285

DOI: 10.1038/s41586-018-0622-0

PubMed ID: 29775581

Title: p300-mediated lysine 2-hydroxyisobutyrylation regulates glycolysis.

PubMed ID: 29775581

DOI: 10.1016/j.molcel.2018.04.011

PubMed ID: 18463139

Title: Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase.

PubMed ID: 18463139

DOI: 10.1093/nar/gkn212

PubMed ID: 8673469

Title: Molecular abnormality of a phosphoglycerate kinase variant (PGK-Alabama).

PubMed ID: 8673469

DOI: 10.1006/bcmd.1995.0020

PubMed ID: 8043870

Title: Identification of new mutations in two phosphoglycerate kinase (PGK) variants expressing different clinical syndromes: PGK Creteil and PGK Amiens.

PubMed ID: 8043870

PubMed ID: 8615693

Title: Retarded and aberrant splicings caused by single exon mutation in a phosphoglycerate kinase variant.

PubMed ID: 8615693

DOI: 10.1006/abbi.1996.0089

PubMed ID: 9744480

Title: A phosphoglycerate kinase mutant (PGK Herlev; D285V) in a Danish patient with isolated chronic hemolytic anemia: mechanism of mutation and structure-function relationships.

PubMed ID: 9744480

DOI: 10.1002/(sici)1098-1004(1998)12:4<280::aid-humu10>3.0.co;2-v

PubMed ID: 2001457

Title: Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu-->Pro substitution caused by T/A-->C/G transition in exon 3.

PubMed ID: 2001457

PubMed ID: 1586722

Title: Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation.

PubMed ID: 1586722

PubMed ID: 7391028

Title: A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK Munchen) associated with enzyme deficiency.

PubMed ID: 7391028

DOI: 10.1016/s0021-9258(18)43755-6

PubMed ID: 7440217

Title: Structure and function of normal and variant human phosphoglycerate kinase.

PubMed ID: 7440217

DOI: 10.3109/03630268008997730

PubMed ID: 1547346

Title: A single amino acid substitution (157 Gly-->Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria.

PubMed ID: 1547346

PubMed ID: 6941312

Title: Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia.

PubMed ID: 6941312

DOI: 10.1073/pnas.78.4.2587

PubMed ID: 6933565

Title: Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia.

PubMed ID: 6933565

DOI: 10.1073/pnas.77.9.5461

Sequence Information:

  • Length: 417
  • Mass: 44615
  • Checksum: B5DFC7B5FA01767C
  • Sequence:
    • MSLSNKLTLD KLDVKGKRVV MRVDFNVPMK NNQITNNQRI KAAVPSIKFC LDNGAKSVVL 
MSHLGRPDGV PMPDKYSLEP VAVELKSLLG KDVLFLKDCV GPEVEKACAN PAAGSVILLE 
NLRFHVEEEG KGKDASGNKV KAEPAKIEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN 
LPQKAGGFLM KKELNYFAKA LESPERPFLA ILGGAKVADK IQLINNMLDK VNEMIIGGGM 
AFTFLKVLNN MEIGTSLFDE EGAKIVKDLM SKAEKNGVKI TLPVDFVTAD KFDENAKTGQ 
ATVASGIPAG WMGLDCGPES SKKYAEAVTR AKQIVWNGPV GVFEWEAFAR GTKALMDEVV 
KATSRGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VDALSNI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.