Details for: BCL2L14

Gene ID: 79370

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: BCL2L14

Ensembl ID: ENSG00000121380

Description: BCL2 like 14

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • regulatory T cell CL0000815
    CSI 25.5
    rCSI 29.56%
    PRS 94.16
  • basal cell of epidermis CL0002187
    CSI 21
    rCSI 37.22%
    PRS 83.22
  • innate lymphoid cell CL0001065
    CSI 20.27
    rCSI 41.86%
    PRS 94.57
  • helper T cell CL0000912
    CSI 19.2
    rCSI 27.15%
    PRS 95.04
  • melanocyte of skin CL1000458
    CSI 18.74
    rCSI 25.54%
    PRS 84.38
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 18.52
    rCSI 22.45%
    PRS 87.89
  • suprabasal keratinocyte CL4033013
    CSI 14.86
    rCSI 24.26%
    PRS 85.01
  • lung ciliated cell CL1000271
    CSI 14.17
    rCSI 16.39%
    PRS 96.67
  • chondrocyte CL0000138
    CSI 12.97
    rCSI 20.63%
    PRS 97.09
  • mast cell CL0000097
    CSI 11.39
    rCSI 24.6%
    PRS 93.93
  • rod bipolar cell CL0000751
    CSI 11.23
    rCSI 20.18%
    PRS 96.66
  • stem cell CL0000034
    CSI 9.08
    rCSI 8.76%
    PRS 98.13
  • pulmonary alveolar type 2 cell CL0002063
    CSI 8.51
    rCSI 13.2%
    PRS 98.44
  • goblet cell CL0000160
    CSI 8.37
    rCSI 7.91%
    PRS 97.92
  • ependymal cell CL0000065
    CSI 8.02
    rCSI 16.27%
    PRS 91.84
  • bronchus fibroblast of lung CL2000093
    CSI 7.59
    rCSI 6.16%
    PRS 98.74
  • intestine goblet cell CL0019031
    CSI 7.07
    rCSI 6.27%
    PRS 97.86
  • glioblast CL0000030
    CSI 6.5
    rCSI 10.37%
    PRS 96
  • radial glial cell CL0000681
    CSI 6.47
    rCSI 8.99%
    PRS 98.42
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 6.28
    rCSI 8.06%
    PRS 97.6
  • epithelial cell of lower respiratory tract CL0002632
    CSI 6.12
    rCSI 4.74%
    PRS 99.23
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 6.09
    rCSI 7.04%
    PRS 96.11
  • Mueller cell CL0000636
    CSI 5.74
    rCSI 13.09%
    PRS 96.45
  • mesothelial cell CL0000077
    CSI 5.73
    rCSI 22.42%
    PRS 93.88
  • retinal bipolar neuron CL0000748
    CSI 5.6
    rCSI 10.49%
    PRS 95.8
  • neural crest cell CL0011012
    CSI 5.6
    rCSI 4.42%
    PRS 97.54
  • Bergmann glial cell CL0000644
    CSI 5.58
    rCSI 7.63%
    PRS 95.78
  • blood vessel endothelial cell CL0000071
    CSI 5.35
    rCSI 11.11%
    PRS 98.07
  • melanocyte CL0000148
    CSI 5.19
    rCSI 3.84%
    PRS 97.64
  • cardiac neuron CL0010022
    CSI 4.78
    rCSI 15.29%
    PRS 98.15
  • intestinal epithelial cell CL0002563
    CSI 4.74
    rCSI 4.95%
    PRS 97.77
  • hepatic stellate cell CL0000632
    CSI 4.39
    rCSI 16.46%
    PRS 97.72
  • interneuron CL0000099
    CSI 4.21
    rCSI 8.46%
    PRS 97.03
  • brush cell of tracheobronchial tree CL0002075
    CSI 4.14
    rCSI 12.3%
    PRS 99.46
  • fibroblast of cardiac tissue CL0002548
    CSI 3.98
    rCSI 19.06%
    PRS 98.75
  • cytotoxic T cell CL0000910
    CSI 3.95
    rCSI 22.65%
    PRS 96.05
  • paneth cell CL0000510
    CSI 3.9
    rCSI 5.76%
    PRS 99.26
  • dendritic cell, human CL0001056
    CSI 3.89
    rCSI 5.97%
    PRS 99.46
  • adipocyte CL0000136
    CSI 3.88
    rCSI 4.98%
    PRS 95.93
  • alveolar adventitial fibroblast CL4028006
    CSI 3.75
    rCSI 5.92%
    PRS 99.17
  • small intestine goblet cell CL1000495
    CSI 3.68
    rCSI 8.06%
    PRS 98.66
  • retinal ganglion cell CL0000740
    CSI 3.49
    rCSI 7.7%
    PRS 95.13
  • BEST4+ enteroycte CL4030026
    CSI 3.35
    rCSI 4.16%
    PRS 97.92
  • alveolar macrophage CL0000583
    CSI 3.1
    rCSI 5.1%
    PRS 98.67
  • pulmonary alveolar type 1 cell CL0002062
    CSI 3.03
    rCSI 17.49%
    PRS 97.44
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 2.87
    rCSI 5.22%
    PRS 95.96
  • myoepithelial cell CL0000185
    CSI 2.82
    rCSI 7.13%
    PRS 99.05
  • lung secretory cell CL1000272
    CSI 2.8
    rCSI 6.92%
    PRS 99.13
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.61
    rCSI 16.31%
    PRS 95.96
  • retinal pigment epithelial cell CL0002586
    CSI 2.58
    rCSI 5.12%
    PRS 97.11
  • endothelial cell of placenta CL0009092
    CSI 2.54
    rCSI 12.51%
    PRS 98.7
  • GABAergic amacrine cell CL4030027
    CSI 2.52
    rCSI 8.62%
    PRS 93.02
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 2.48
    rCSI 3%
    PRS 99.49
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 2.32
    rCSI 6.24%
    PRS 98.86
  • lung pericyte CL0009089
    CSI 2.09
    rCSI 5.5%
    PRS 99.34
  • OFFx cell CL4033036
    CSI 2.04
    rCSI 9.6%
    PRS 93.17
  • amacrine cell CL0000561
    CSI 2.03
    rCSI 5.89%
    PRS 95.52
  • colon goblet cell CL0009039
    CSI 2.01
    rCSI 4.77%
    PRS 98.68
  • intestinal crypt stem cell of colon CL0009043
    CSI 1.95
    rCSI 14.61%
    PRS 99.32
  • central nervous system neuron CL2000029
    CSI 1.83
    rCSI 13.46%
    PRS 95.85
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.59
    rCSI 38.39%
    PRS 92.93
  • direct pathway medium spiny neuron CL4023026
    CSI 1.15
    rCSI 27.43%
    PRS 93.29
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 1.14
    rCSI 2.59%
    PRS 95.33
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.03
    rCSI 3.69%
    PRS 94.34
  • blood vessel smooth muscle cell CL0019018
    CSI 0.89
    rCSI 7.22%
    PRS 98.35
  • H2 horizontal cell CL0004218
    CSI 0.88
    rCSI 4.36%
    PRS 95.81
  • ON parasol ganglion cell CL4033052
    CSI 0.53
    rCSI 7.55%
    PRS 94.86
  • ON midget ganglion cell CL4033046
    CSI 0.46
    rCSI 9.34%
    PRS 94.76
  • OFF midget ganglion cell CL4033047
    CSI 0.42
    rCSI 8.63%
    PRS 94.8

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [BCL2L14](/details-gene/79370) (B-cell lymphoma 2-like 14), also known as Bcl-G, is a protein-coding gene belonging to the BCL-2 family of apoptosis regulators. Functional annotations and initial research characterize it as a pro-apoptotic protein, playing a role in the positive regulation of the extrinsic apoptotic signaling pathway ([GO:2001238](https://www.ebi.ac.uk/QuickGO/term/GO:2001238)) ([Link](https://doi.org/10.1074/jbc.m005889200)). **Overall**, expression data reveals its significance across a diverse range of cell types, most notably within the immune system, such as in [regulatory T cell](/details-cell/CL0000815) and [innate lymphoid cell](/details-cell/CL0001065), as well as in epithelial tissues like the [basal cell of epidermis](/details-cell/CL0002187). Its regulation as a transcriptional target of TP53 suggests it functions as a critical effector in p53-mediated cell death pathways. ## Cellular Roles and Expression Landscape The expression profile of [BCL2L14](/details-gene/79370) suggests a broad but crucial role in maintaining tissue homeostasis and immune regulation through programmed cell death. The gene shows high significance in several key lymphocyte populations, including [regulatory T cell](/details-cell/CL0000815) (CSI: 25.50), [innate lymphoid cell](/details-cell/CL0001065) (CSI: 20.27), and [helper T cell](/details-cell/CL0000912) (CSI: 19.20). This pattern is consistent with a role in modulating immune responses by controlling the lifespan of specific immune cell subsets. Concurrently, [BCL2L14](/details-gene/79370) is also a highly significant gene in tissues characterized by high cellular turnover. It is prominently expressed in [basal cell of epidermis](/details-cell/CL0002187) (CSI: 21.00), [melanocyte of skin](/details-cell/CL1000458) (CSI: 18.74), and [suprabasal keratinocyte](/details-cell/CL4033013) (CSI: 14.86), indicating a potential function in skin integrity and the elimination of damaged or senescent keratinocytes. Its expression in other specialized epithelial cells, such as [lung ciliated cell](/details-cell/CL1000271) and [pulmonary alveolar type 2 cell](/details-cell/CL0002063), further supports its role in maintaining epithelial barriers. This dual prominence in both immune and epithelial compartments suggests [BCL2L14](/details-gene/79370) is a fundamental component of apoptosis-driven quality control across multiple organ systems. ## Pathways and Molecular Function The functional annotations for [BCL2L14](/details-gene/79370) firmly place it within the cellular machinery of apoptosis. Gene Ontology terms classify it as a participant in the 'apoptotic process' ([GO:0006915](https://www.ebi.ac.uk/QuickGO/term/GO:0006915)) and as a 'positive regulator of the extrinsic apoptotic signaling pathway' ([GO:2001238](https://www.ebi.ac.uk/QuickGO/term/GO:2001238)). It is primarily located in the [cytosol](/details-cell/GO:0005829) and functions through protein-protein interactions, as indicated by its annotation for 'protein binding' ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515)). A critical aspect of its regulation is revealed by Reactome pathway analysis, which links [BCL2L14](/details-gene/79370) directly to the tumor suppressor TP53. It is implicated in pathways such as 'Transcriptional regulation by tp53' ([R-HSA-3700989](https://reactome.org/content/detail/R-HSA-3700989)) and specifically 'Tp53 regulates transcription of cell death genes' ([R-HSA-5633008](https://reactome.org/content/detail/R-HSA-5633008)). This strongly suggests that [BCL2L14](/details-gene/79370) is a downstream transcriptional target of p53, acting as an effector molecule that executes the apoptotic program in response to cellular stress signals like DNA damage. This mechanism is consistent with its proposed role as a candidate tumor suppressor gene ([Link](https://doi.org/10.1038/sj.leu.2403441)). ## Research Directions The widespread yet specific expression pattern of [BCL2L14](/details-gene/79370), coupled with its function as a pro-apoptotic effector of the TP53 pathway, opens several avenues for future investigation. Its potential role as a tumor suppressor warrants further exploration, particularly in the context of specific cell types. Based on the available data, several testable hypotheses can be proposed: 1. Given its high significance in [regulatory T cell](/details-cell/CL0000815), [BCL2L14](/details-gene/79370) may be essential for their peripheral homeostasis, mediating apoptosis to prevent their excessive accumulation and subsequent immunosuppression in contexts like chronic infection or cancer. 2. The high expression in [basal cell of epidermis](/details-cell/CL0002187) suggests that [BCL2L14](/details-gene/79370) is a critical gatekeeper for skin cancer prevention, executing p53-dependent apoptosis in keratinocytes that have sustained significant DNA damage, for instance from UV radiation. To test the second hypothesis regarding its role in skin cancer, a key experiment could involve the development of a conditional knockout mouse model with a keratinocyte-specific deletion of *Bcl2l14*. These mice, alongside wild-type controls, would be subjected to a chronic low-dose UVB irradiation protocol. The primary endpoints would be the incidence and latency of skin tumor formation. Additionally, acute effects could be assessed by analyzing skin biopsies post-irradiation for markers of apoptosis (e.g., cleaved caspase-3 staining) and DNA damage. A reduced apoptotic response and accelerated tumor development in knockout mice would provide strong evidence for its tumor-suppressive function in the skin. As a pro-apoptotic protein, [BCL2L14](/details-gene/79370) is a potential target for therapeutic **activation**, not inhibition. Its downregulation or mutation has been implicated in cancers like acute lymphoblastic leukemia ([Link](https://doi.org/10.1038/sj.leu.2403441)) and breast cancer ([Link](https://doi.org/10.1186/bcr1650)). Therapeutic strategies could involve developing small-molecule mimetics or stabilizers that restore its pro-apoptotic function in cancer cells. However, its broad expression in healthy immune and epithelial tissues presents a significant challenge, necessitating the development of tumor-targeted delivery systems to avoid on-target toxicity in healthy cells.

Genular Protein ID: 1795619593

Symbol: B2L14_HUMAN

Name: Apoptosis facilitator Bcl-2-like protein 14

UniProtKB Accession Codes:

Q9BZR8 A8KAD0 Q96QR5 Q9BZR7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 10 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 7 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11054413

Title: Bcl-G, a novel pro-apoptotic member of the Bcl-2 family.

PubMed ID: 11054413

DOI: 10.1074/jbc.m005889200

PubMed ID: 15284860

Title: Mutational and expression analysis of the chromosome 12p candidate tumor suppressor genes in pre-B acute lymphoblastic leukemia.

PubMed ID: 15284860

DOI: 10.1038/sj.leu.2403441

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17280616

Title: Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.

PubMed ID: 17280616

DOI: 10.1186/bcr1650

Sequence Information:

  • Length: 327
  • Mass: 36598
  • Checksum: 155D43BA91BFB3EA
  • Sequence:
    • MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT RSLSQRGLGN 
CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV EKEDSQSTPA KVSAQGQRTL 
EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV ISIANRVAEI VYSWPPPQAT QAGGFKSKEI 
FVTEGLSFQL QGHVPVASSS KKDEEEQILA KIVELLKYSG DQLERKLKKD KALMGHFQDG 
LSYSVFKTIT DQVLMGVDPR GESEVKAQGF KAALVIDVTA KLTAIDNHPM NRVLGFGTKY 
LKENFSPWIQ QHGGWEKILG ISHEEVD

Genular Protein ID: 1972631624

Symbol: A0A140VJF2_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VJF2

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 3 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 RefSeq 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 252
  • Mass: 28090
  • Checksum: 87D2E5123EFCB9E4
  • Sequence:
    • MCSTSGCDLE EIPLDDDDLN TIEFKILAYY TRHHVFKSTP ALFSPKLLRT RSLSQRGLGN 
CSANESWTEV SWPCRNSQSS EKAINLGKKK SSWKAFFGVV EKEDSQSTPA KVSAQGQRTL 
EYQDSHSQQW SRCLSNVEQC LEHEAVDPKV ISIANRVAEI VYSWPPPQAT QAGGFKSKEI 
FVTEGLSFQL QGHVPVASSS KKDEEEQILA KIVELLKYSG DQLERKDTAF IPIPLVDTSI 
QGFPQDGLMA CI