Details for: CL0001056

Cell ID: CL0001056

Cell Name: dendritic cell, human

Marker Score Threshold: 1018
(Derived using integrated single-cell and genomic data)

Description: A dendritic cell with the phenotype HLA-DRA-positive.

Synonyms: dendritic cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.45
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.38
    Ensembl ID: ENSG00000166710
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.28
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.26
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.26
    Ensembl ID: ENSG00000135390
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.25
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 2.25
    Ensembl ID: ENSG00000185883
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.2
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.2
    Ensembl ID: ENSG00000124172
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.19
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.13
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.03
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.03
    Ensembl ID: ENSG00000099624
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.02
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.02
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.01
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.98
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.97
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.95
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.95
    Ensembl ID: ENSG00000164111
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 1.95
    Ensembl ID: ENSG00000136250
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.92
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.92
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.91
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.91
    Ensembl ID: ENSG00000154723
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.89
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.87
    Ensembl ID: ENSG00000165629
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.85
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.85
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.84
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.84
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.82
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.75
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.72
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.71
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.71
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.7
    Ensembl ID: ENSG00000127022
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.68
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.65
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.65
    Ensembl ID: ENSG00000241837
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.64
    Ensembl ID: ENSG00000177105
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.64
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.59
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.57
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.55
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.54
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.54
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.53
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.53
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.53
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.51
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.5
    Ensembl ID: ENSG00000165527
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.5
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.48
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.44
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.44
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.42
    Ensembl ID: ENSG00000177556
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.4
    Ensembl ID: ENSG00000104765
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.39
    Ensembl ID: ENSG00000183255
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.39
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.38
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.38
    Ensembl ID: ENSG00000128272
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.36
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 1.36
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.34
    Ensembl ID: ENSG00000012779
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.33
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.32
    Ensembl ID: ENSG00000060971
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.31
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.29
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.29
    Ensembl ID: ENSG00000197043
  • Gene Symbol: ADAM8 (ENSG00000151651)
    Fold Change: 1.29
    Ensembl ID: ENSG00000151651
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.28
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.26
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.26
    Ensembl ID: ENSG00000089820
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.25
    Ensembl ID: ENSG00000148700
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.23
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130402
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.16
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.14
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.13
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.13
    Ensembl ID: ENSG00000163399
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ASGR2 (ENSG00000161944)
    Fold Change: 1.1
    Ensembl ID: ENSG00000161944
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.1
    Ensembl ID: ENSG00000004455
  • Gene Symbol: BCKDHA (ENSG00000248098)
    Fold Change: 1.1
    Ensembl ID: ENSG00000248098
  • Gene Symbol: FMNL1 (ENSG00000184922)
    Fold Change: 1.09
    Ensembl ID: ENSG00000184922
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.08
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.08
    Ensembl ID: ENSG00000162772
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.08
    Ensembl ID: ENSG00000143878
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.07
    Ensembl ID: ENSG00000142192
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.06
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.06
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.04
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ASGR1 (ENSG00000141505)
    Fold Change: 1.04
    Ensembl ID: ENSG00000141505
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.03
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.03
    Ensembl ID: ENSG00000132965
  • Gene Symbol: BTK (ENSG00000010671)
    Fold Change: 1.02
    Ensembl ID: ENSG00000010671
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.02
    Ensembl ID: ENSG00000197894
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Phenotype**: Dendritic cells can be identified by their HLA-DRA-positive phenotype, which is a marker of their ability to present antigens to T-cells. 2. **Morphology**: Dendritic cells have a unique morphology, characterized by long, thin extensions called dendrites that allow them to survey their environment and capture antigens. 3. **Antigen presentation**: Dendritic cells are responsible for the processing and presentation of antigens to T-cells, which leads to the activation of the immune system. 4. **Cell surface molecules**: Dendritic cells express a range of cell surface molecules, including MHC class I and II molecules, co-receptors, and adhesion molecules, which facilitate antigen presentation and T-cell activation. 5. **Cytoskeleton**: The cytoskeleton of dendritic cells is composed of actin filaments, which provide structural support and facilitate cell migration and antigen uptake. **Clinical Significance** 1. **Vaccine development**: Dendritic cells have been used as a model system to develop vaccines against a range of diseases, including cancer and infectious diseases. 2. **Immunotherapy**: Dendritic cells have been used as a form of immunotherapy to treat cancer and autoimmune diseases. 3. **Innate immunity**: Dendritic cells play a key role in the innate immune response, particularly in the recognition and elimination of pathogens. 4. **Autoimmune diseases**: Dendritic cells have been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 5. **Cancer immunotherapy**: Dendritic cells have been used to enhance the immune response against cancer, particularly in the context of checkpoint inhibitors. **Functions** 1. **Antigen capture**: Dendritic cells capture antigens from their environment and process them for presentation to T-cells. 2. **Antigen presentation**: Dendritic cells present antigens to T-cells, which leads to the activation of the immune system. 3. **T-cell activation**: Dendritic cells activate T-cells, which leads to the production of cytokines and the initiation of an immune response. 4. **Immune tolerance**: Dendritic cells can also promote immune tolerance by presenting antigens to regulatory T-cells. 5. **Immune modulation**: Dendritic cells can modulate the immune response by presenting antigens to T-cells in a way that promotes tolerance or activation, depending on the context.