Details for: DNASE1L1

Gene ID: 1774

Symbol: DNASE1L1

Ensembl ID: ENSG00000013563

Description: deoxyribonuclease 1 like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 64.0971
    Cell Significance Index: -9.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.3252
    Cell Significance Index: -8.9600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.3933
    Cell Significance Index: -10.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 16.7804
    Cell Significance Index: -11.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6134
    Cell Significance Index: -10.6200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5052
    Cell Significance Index: -9.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7217
    Cell Significance Index: -10.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.1932
    Cell Significance Index: -4.8000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4849
    Cell Significance Index: 20.2600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.4027
    Cell Significance Index: 23.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1155
    Cell Significance Index: 110.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.0703
    Cell Significance Index: 124.7300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9640
    Cell Significance Index: 870.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7537
    Cell Significance Index: 45.2500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7200
    Cell Significance Index: 78.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6117
    Cell Significance Index: 99.4800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4451
    Cell Significance Index: 23.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4304
    Cell Significance Index: 4.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4026
    Cell Significance Index: 27.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3586
    Cell Significance Index: 7.7700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3150
    Cell Significance Index: 7.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2584
    Cell Significance Index: 7.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2513
    Cell Significance Index: 11.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1967
    Cell Significance Index: 35.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1937
    Cell Significance Index: 23.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1842
    Cell Significance Index: 8.5900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1813
    Cell Significance Index: 11.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1796
    Cell Significance Index: 3.3200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1589
    Cell Significance Index: 4.4400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1251
    Cell Significance Index: 9.6000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1247
    Cell Significance Index: 25.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.1171
    Cell Significance Index: 2.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1121
    Cell Significance Index: 21.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0959
    Cell Significance Index: 52.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0904
    Cell Significance Index: 17.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0858
    Cell Significance Index: 11.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0776
    Cell Significance Index: 1.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0439
    Cell Significance Index: 1.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0368
    Cell Significance Index: 16.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0258
    Cell Significance Index: 9.2700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0231
    Cell Significance Index: 0.5900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0223
    Cell Significance Index: 2.6300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0209
    Cell Significance Index: 14.4300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.0180
    Cell Significance Index: 0.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0169
    Cell Significance Index: 31.7500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0077
    Cell Significance Index: 11.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0065
    Cell Significance Index: 4.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0056
    Cell Significance Index: 0.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0055
    Cell Significance Index: 7.4600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0039
    Cell Significance Index: 7.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0019
    Cell Significance Index: -0.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0038
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0042
    Cell Significance Index: -3.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0051
    Cell Significance Index: -3.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0072
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0085
    Cell Significance Index: -1.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0112
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0113
    Cell Significance Index: -8.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0130
    Cell Significance Index: -1.8900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0151
    Cell Significance Index: -6.8700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0152
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0161
    Cell Significance Index: -1.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0167
    Cell Significance Index: -9.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0189
    Cell Significance Index: -11.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0208
    Cell Significance Index: -0.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0240
    Cell Significance Index: -1.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0244
    Cell Significance Index: -3.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0342
    Cell Significance Index: -4.3900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0358
    Cell Significance Index: -2.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0373
    Cell Significance Index: -10.7400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0374
    Cell Significance Index: -0.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0462
    Cell Significance Index: -1.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0563
    Cell Significance Index: -11.8600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0574
    Cell Significance Index: -0.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0689
    Cell Significance Index: -1.8400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0825
    Cell Significance Index: -2.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0884
    Cell Significance Index: -4.1600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0889
    Cell Significance Index: -2.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0892
    Cell Significance Index: -4.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0936
    Cell Significance Index: -9.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0964
    Cell Significance Index: -3.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0993
    Cell Significance Index: -6.0900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1105
    Cell Significance Index: -7.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1164
    Cell Significance Index: -9.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1165
    Cell Significance Index: -1.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1208
    Cell Significance Index: -2.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1226
    Cell Significance Index: -7.7300
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1433
    Cell Significance Index: -1.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1436
    Cell Significance Index: -8.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1532
    Cell Significance Index: -6.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1562
    Cell Significance Index: -9.6000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1746
    Cell Significance Index: -2.4900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1833
    Cell Significance Index: -4.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1840
    Cell Significance Index: -6.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1908
    Cell Significance Index: -1.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1975
    Cell Significance Index: -10.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1985
    Cell Significance Index: -2.8500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1989
    Cell Significance Index: -8.1500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.2062
    Cell Significance Index: -2.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2144
    Cell Significance Index: -5.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA Degradation:** DNASE1L1 is a deoxyribonuclease enzyme that cleaves and degrades DNA, a process that is essential for maintaining genomic stability and preventing DNA damage. 2. **Immune Regulation:** DNASE1L1 is highly expressed in immune cells, such as monocytes and dendritic cells, where it plays a crucial role in regulating immune responses and inflammation. 3. **Cellular Homeostasis:** DNASE1L1 is also involved in maintaining cellular homeostasis by regulating the degradation of DNA in various cell types, including epithelial and neural cells. 4. **Cellular Localization:** DNASE1L1 is localized to the extracellular region, where it can interact with other molecules and regulate cellular processes. **Pathways and Functions:** 1. **Deoxyribonuclease Activity:** DNASE1L1 is involved in the degradation of DNA, which is essential for maintaining genomic stability and preventing DNA damage. 2. **Immune System Regulation:** DNASE1L1 regulates immune responses and inflammation by modulating the activity of immune cells, such as monocytes and dendritic cells. 3. **Cellular Homeostasis:** DNASE1L1 maintains cellular homeostasis by regulating the degradation of DNA in various cell types, including epithelial and neural cells. 4. **Endoplasmic Reticulum and Nucleus:** DNASE1L1 is localized to the endoplasmic reticulum and nucleus, where it can interact with other molecules and regulate cellular processes. **Clinical Significance:** 1. **Autoimmune Diseases:** DNASE1L1 has been implicated in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus, where it plays a crucial role in regulating immune responses and inflammation. 2. **Cancer:** DNASE1L1 has been found to be overexpressed in various types of cancer, including breast and lung cancer, where it contributes to tumorigenesis and metastasis. 3. **Neurological Disorders:** DNASE1L1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it plays a crucial role in regulating cellular homeostasis and immune responses. 4. **Diagnostic and Therapeutic Applications:** DNASE1L1 has potential diagnostic and therapeutic applications, particularly in the development of novel treatments for autoimmune diseases and cancer. In conclusion, DNASE1L1 is a complex gene that plays a critical role in the regulation of the immune system and maintenance of cellular homeostasis. Further research is necessary to fully elucidate the functional roles of DNASE1L1 and its potential applications in the treatment of various diseases.

Genular Protein ID: 400159477

Symbol: DNSL1_HUMAN

Name: Deoxyribonuclease-1-like 1

UniProtKB Accession Codes:

P49184 D3DWW7 Q5HY41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 13 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 8 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 17180083

Title: Isolation, differential splicing and protein expression of a DNase on the human X chromosome.

PubMed ID: 17180083

PubMed ID: 8541839

Title: A muscle-specific DNase I-like gene in human Xq28.

PubMed ID: 8541839

DOI: 10.1093/hmg/4.9.1557

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 8654957

Title: Cloning of a gene encoding a DNase I-like endonuclease in the human Xq28 region.

PubMed ID: 8654957

DOI: 10.1016/0378-1119(95)00741-5

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16107205

Title: Physical and biochemical properties of mammalian DNase X proteins: non-AUG translation initiation of porcine and bovine mRNAs for DNase X.

PubMed ID: 16107205

DOI: 10.1042/bj20051114

Sequence Information:

  • Length: 302
  • Mass: 33893
  • Checksum: D10CE8B470173727
  • Sequence:
    • MHYPTALLFL ILANGAQAFR ICAFNAQRLT LAKVAREQVM DTLVRILARC DIMVLQEVVD 
SSGSAIPLLL RELNRFDGSG PYSTLSSPQL GRSTYMETYV YFYRSHKTQV LSSYVYNDED 
DVFAREPFVA QFSLPSNVLP SLVLVPLHTT PKAVEKELNA LYDVFLEVSQ HWQSKDVILL 
GDFNADCASL TKKRLDKLEL RTEPGFHWVI ADGEDTTVRA STHCTYDRVV LHGERCRSLL 
HTAAAFDFPT SFQLTEEEAL NISDHYPVEV ELKLSQAHSV QPLSLTVLLL LSLLSPQLCP 
AA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.