Details for: TEP1

Gene ID: 7011

Symbol: TEP1

Ensembl ID: ENSG00000129566

Description: telomerase associated protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 74.3835
    Cell Significance Index: -11.5700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.4325
    Cell Significance Index: -11.2700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.2642
    Cell Significance Index: -10.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 23.1539
    Cell Significance Index: -11.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.1444
    Cell Significance Index: -10.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.4002
    Cell Significance Index: -11.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.5355
    Cell Significance Index: -12.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 3.0613
    Cell Significance Index: -6.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.8435
    Cell Significance Index: 127.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0859
    Cell Significance Index: 107.4200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.0578
    Cell Significance Index: 10.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7243
    Cell Significance Index: 78.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6437
    Cell Significance Index: 18.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5795
    Cell Significance Index: 94.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5767
    Cell Significance Index: 26.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4952
    Cell Significance Index: 7.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4515
    Cell Significance Index: 23.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4039
    Cell Significance Index: 10.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.3146
    Cell Significance Index: 6.7300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2929
    Cell Significance Index: 7.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2909
    Cell Significance Index: 22.3200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2873
    Cell Significance Index: 198.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.2791
    Cell Significance Index: 4.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2735
    Cell Significance Index: 54.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2191
    Cell Significance Index: 4.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2190
    Cell Significance Index: 7.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1960
    Cell Significance Index: 4.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1660
    Cell Significance Index: 4.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1637
    Cell Significance Index: 29.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1433
    Cell Significance Index: 9.2500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1296
    Cell Significance Index: 24.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1170
    Cell Significance Index: 5.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1061
    Cell Significance Index: 5.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0889
    Cell Significance Index: 31.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0876
    Cell Significance Index: 1.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0791
    Cell Significance Index: 9.7200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0712
    Cell Significance Index: 14.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0695
    Cell Significance Index: 1.4800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0560
    Cell Significance Index: 0.3700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0485
    Cell Significance Index: 0.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0420
    Cell Significance Index: 4.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0398
    Cell Significance Index: 21.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0397
    Cell Significance Index: 1.0800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0396
    Cell Significance Index: 0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0369
    Cell Significance Index: 50.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0341
    Cell Significance Index: 30.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0286
    Cell Significance Index: 12.6300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0257
    Cell Significance Index: 0.4400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0244
    Cell Significance Index: 45.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0164
    Cell Significance Index: 10.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0144
    Cell Significance Index: 26.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0123
    Cell Significance Index: 18.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0118
    Cell Significance Index: 0.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0085
    Cell Significance Index: 3.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0035
    Cell Significance Index: 0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0011
    Cell Significance Index: 0.1900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0005
    Cell Significance Index: 0.0600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0028
    Cell Significance Index: -2.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0030
    Cell Significance Index: -0.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0043
    Cell Significance Index: -2.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0085
    Cell Significance Index: -4.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0103
    Cell Significance Index: -1.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0121
    Cell Significance Index: -9.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0130
    Cell Significance Index: -9.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0172
    Cell Significance Index: -0.8100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0313
    Cell Significance Index: -3.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0329
    Cell Significance Index: -6.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0348
    Cell Significance Index: -10.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0418
    Cell Significance Index: -4.8800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0434
    Cell Significance Index: -5.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0446
    Cell Significance Index: -2.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0595
    Cell Significance Index: -1.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0623
    Cell Significance Index: -7.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0694
    Cell Significance Index: -5.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0756
    Cell Significance Index: -1.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0784
    Cell Significance Index: -1.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0871
    Cell Significance Index: -5.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0889
    Cell Significance Index: -6.2900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0933
    Cell Significance Index: -1.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0945
    Cell Significance Index: -1.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0953
    Cell Significance Index: -9.9200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0961
    Cell Significance Index: -0.8900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1108
    Cell Significance Index: -1.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1121
    Cell Significance Index: -4.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1253
    Cell Significance Index: -2.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1411
    Cell Significance Index: -4.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1417
    Cell Significance Index: -8.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1433
    Cell Significance Index: -11.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1555
    Cell Significance Index: -5.8900
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1974
    Cell Significance Index: -2.7700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2059
    Cell Significance Index: -3.0800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2072
    Cell Significance Index: -1.6900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2133
    Cell Significance Index: -11.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2244
    Cell Significance Index: -6.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2371
    Cell Significance Index: -3.4000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2373
    Cell Significance Index: -5.7900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2681
    Cell Significance Index: -4.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Telomerase binding:** TEP1 is a non-catalytic component of the telomerase holoenzyme complex, interacting with telomerase RNA (TR) and the telomerase enzyme. 2. **Telomere maintenance:** TEP1 plays a role in maintaining telomere length by facilitating telomerase activity and protecting telomeres from degradation. 3. **DNA replication:** TEP1 is involved in DNA replication, specifically in the recruitment of telomerase to telomeres during DNA synthesis. 4. **Immune regulation:** TEP1 has been shown to regulate immune responses, particularly in the context of innate lymphoid cells and intestinal epithelial cells. 5. **Expression pattern:** TEP1 is expressed in a wide range of tissues, including the cerebral cortex, forebrain radial glial cells, and intestinal epithelial cells. **Pathways and Functions:** 1. **Telomerase activity:** TEP1 facilitates telomerase activity, enabling the elongation of telomeres and maintaining genomic stability. 2. **DNA replication:** TEP1 recruits telomerase to telomeres during DNA synthesis, ensuring proper telomere length and chromosomal stability. 3. **Immune regulation:** TEP1 modulates immune responses in innate lymphoid cells and intestinal epithelial cells, influencing the development and function of the immune system. 4. **Chromatin remodeling:** TEP1 interacts with chromatin remodeling complexes, influencing chromatin structure and gene expression. 5. **Stem cell maintenance:** TEP1 is expressed in stem cells, including intestinal crypt stem cells and absorptive cells, suggesting a role in maintaining stem cell identity and function. **Clinical Significance:** 1. **Cancer:** Dysregulation of telomerase activity and TEP1 expression has been implicated in various cancers, including breast, lung, and colon cancer. 2. **Aging:** Telomere shortening and TEP1 expression have been linked to aging and age-related diseases, such as atherosclerosis and Alzheimer's disease. 3. **Immune disorders:** TEP1 has been shown to play a role in immune disorders, including autoimmune diseases and allergies. 4. **Stem cell disorders:** TEP1 expression has been linked to stem cell disorders, including aplastic anemia and leukemia. 5. **Gene therapy:** TEP1 has been explored as a potential target for gene therapy in cancer and immune disorders, given its role in telomerase activity and immune regulation. In conclusion, TEP1 is a multifunctional protein with a complex role in telomere maintenance, DNA replication, and immune regulation. Its dysregulation has been implicated in various human diseases, including cancer, aging, and immune disorders. Further research is needed to fully elucidate the mechanisms by which TEP1 regulates telomere length and immune responses, and to explore its potential as a therapeutic target in human diseases.

Genular Protein ID: 1521962098

Symbol: TEP1_HUMAN

Name: Telomerase protein component 1

UniProtKB Accession Codes:

Q99973 A0AUV9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9020079

Title: A mammalian telomerase-associated protein.

PubMed ID: 9020079

DOI: 10.1126/science.275.5302.973

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 9389643

Title: Human telomerase contains evolutionarily conserved catalytic and structural subunits.

PubMed ID: 9389643

DOI: 10.1101/gad.11.23.3109

PubMed ID: 10551828

Title: Vaults and telomerase share a common subunit, TEP1.

PubMed ID: 10551828

DOI: 10.1074/jbc.274.46.32712

PubMed ID: 11029039

Title: Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding.

PubMed ID: 11029039

DOI: 10.1091/mbc.11.10.3329

PubMed ID: 19179534

Title: A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis.

PubMed ID: 19179534

DOI: 10.1126/science.1165357

Sequence Information:

  • Length: 2627
  • Mass: 290490
  • Checksum: 32628238704A8860
  • Sequence:
    • MEKLHGHVSA HPDILSLENR CLAMLPDLQP LEKLHQHVST HSDILSLKNQ CLATLPDLKT 
MEKPHGYVSA HPDILSLENQ CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLSSLKS 
TVSASPLFQS LQISHMTQAD LYRVNNSNCL LSEPPSWRAQ HFSKGLDLST CPIALKSISA 
TETAQEATLG RWFDSEEKKG AETQMPSYSL SLGEEEEVED LAVKLTSGDS ESHPEPTDHV 
LQEKKMALLS LLCSTLVSEV NMNNTSDPTL AAIFEICREL ALLEPEFILK ASLYARQQLN 
VRNVANNILA IAAFLPACRP HLRRYFCAIV QLPSDWIQVA ELYQSLAEGD KNKLVPLPAC 
LRTAMTDKFA QFDEYQLAKY NPRKHRAKRH PRRPPRSPGM EPPFSHRCFP RYIGFLREEQ 
RKFEKAGDTV SEKKNPPRFT LKKLVQRLHI HKPAQHVQAL LGYRYPSNLQ LFSRSRLPGP 
WDSSRAGKRM KLSRPETWER ELSLRGNKAS VWEELIENGK LPFMAMLRNL CNLLRVGISS 
RHHELILQRL QHAKSVIHSR QFPFRFLNAH DAIDALEAQL RNQALPFPSN ITLMRRILTR 
NEKNRPRRRF LCHLSRQQLR MAMRIPVLYE QLKREKLRVH KARQWKYDGE MLNRYRQALE 
TAVNLSVKHS LPLLPGRTVL VYLTDANADR LCPKSNPQGP PLNYALLLIG MMITRAEQVD 
VVLCGGDTLK TAVLKAEEGI LKTAIKLQAQ VQEFDENDGW SLNTFGKYLL SLAGQRVPVD 
RVILLGQSMD DGMINVAKQL YWQRVNSKCL FVGILLRRVQ YLSTDLNPND VTLSGCTDAI 
LKFIAEHGAS HLLEHVGQMD KIFKIPPPPG KTGVQSLRPL EEDTPSPLAP VSQQGWRSIR 
LFISSTFRDM HGERDLLLRS VLPALQARAA PHRISLHGID LRWGVTEEET RRNRQLEVCL 
GEVENAQLFV GILGSRYGYI PPSYNLPDHP HFHWAQQYPS GRSVTEMEVM QFLNRNQRLQ 
PSAQALIYFR DSSFLSSVPD AWKSDFVSES EEAARRISEL KSYLSRQKGI TCRRYPCEWG 
GVAAGRPYVG GLEEFGQLVL QDVWNMIQKL YLQPGALLEQ PVSIPDDDLV QATFQQLQKP 
PSPARPRLLQ DTVQRLMLPH GRLSLVTGQS GQGKTAFLAS LVSALQAPDG AKVASLVFFH 
FSGARPDQGL ALTLLRRLCT YLRGQLKEPG ALPSTYRSLV WELQQRLLPK SAESLHPGQT 
QVLIIDGADR LVDQNGQLIS DWIPKKLPRC VHLVLSVSSD AGLGETLEQS QGAHVLALGP 
LEASARARLV REELALYGKR LEESPFNNQM RLLLVKRESG RPLYLRLVTD HLRLFTLYEQ 
VSERLRTLPA TVPLLLQHIL STLEKEHGPD VLPQALTALE VTRSGLTVDQ LHGVLSVWRT 
LPKGTKSWEE AVAAGNSGDP YPMGPFACLV QSLRSLLGEG PLERPGARLC LPDGPLRTAA 
KRCYGKRPGL EDTAHILIAA QLWKTCDADA SGTFRSCPPE ALGDLPYHLL QSGNRGLLSK 
FLTNLHVVAA HLELGLVSRL LEAHALYASS VPKEEQKLPE ADVAVFRTFL RQQASILSQY 
PRLLPQQAAN QPLDSPLCHQ ASLLSRRWHL QHTLRWLNKP RTMKNQQSSS LSLAVSSSPT 
AVAFSTNGQR AAVGTANGTV YLLDLRTWQE EKSVVSGCDG ISACLFLSDD TLFLTAFDGL 
LELWDLQHGC RVLQTKAHQY QITGCCLSPD CRLLATVCLG GCLKLWDTVR GQLAFQHTYP 
KSLNCVAFHP EGQVIATGSW AGSISFFQVD GLKVTKDLGA PGASIRTLAF NVPGGVVAVG 
RLDSMVELWA WREGARLAAF PAHHGFVAAA LFLHAGCQLL TAGEDGKVQV WSGSLGRPRG 
HLGSLSLSPA LSVALSPDGD RVAVGYRADG IRIYKISSGS QGAQGQALDV AVSALAWLSP 
KVLVSGAEDG SLQGWALKEC SLQSLWLLSR FQKPVLGLAT SQELLASASE DFTVQLWPRQ 
LLTRPHKAED FPCGTELRGH EGPVSCCSFS TDGGSLATGG RDRSLLCWDV RTPKTPVLIH 
SFPACHRDWV TGCAWTKDNL LISCSSDGSV GLWDPESGQR LGQFLGHQSA VSAVAAVEEH 
VVSVSRDGTL KVWDHQGVEL TSIPAHSGPI SHCAAAMEPR AAGQPGSELL VVTVGLDGAT 
RLWHPLLVCQ THTLLGHSGP VRAAAVSETS GLMLTASEDG SVRLWQVPKE ADDTCIPRSS 
AAVTAVAWAP DGSMAVSGNQ AGELILWQEA KAVATAQAPG HIGALIWSSA HTFFVLSADE 
KISEWQVKLR KGSAPGNLSL HLNRILQEDL GVLTSLDWAP DGHFLILAKA DLKLLCMKPG 
DAPSEIWSSY TENPMILSTH KEYGIFVLQP KDPGVLSFLR QKESGEFEER LNFDINLENP 
SRTLISITQA KPESESSFLC ASSDGILWNL AKCSPEGEWT TGNMWQKKAN TPETQTPGTD 
PSTCRESDAS MDSDASMDSE PTPHLKTRQR RKIHSGSVTA LHVLPELLVT ASKDRDVKLW 
ERPSMQLLGL FRCEGSVSCL EPWLGANSTL QLAVGDVQGN VYFLNWE

Genular Protein ID: 2360903201

Symbol: G3V5X7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V5X7

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 1 Gene3D 3 GeneTree 1 HGNC 1 InterPro 11 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 6 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 2519
  • Mass: 278023
  • Checksum: B0D4EEE6A55B1A9A
  • Sequence:
    • MEKLHGHVSA HPDILSLENR CLAMLPDLQP LEKLHQHVST HSDILSLKNQ CLATLPDLKT 
MEKPHGYVSA HPDILSLENQ CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLSSLKS 
TVSASPLFQS LQISHMTQAD LYRVNNSNCL LSEPPSWRAQ HFSKGLDLST CPIALKSISA 
TETAQEATLG RWFDSEEKKG AETQMPSYSL SLGEEEEVED LAVKLTSGDS ESHPEPTDHV 
LQEKKMALLS LLCSTLVSEV NMNNTSDPTL AAIFEICREL ALLEPEFILK GMEPPFSHRC 
FPRYIGFLRE EQRKFEKAGD TVSEKKNPPR FTLKKLVQRL HIHKPAQHVQ ALLGYRYPSN 
LQLFSRSRLP GPWDSSRAGK RMKLSRPETW ERELSLRGNK ASVWEELIEN GKLPFMAMLR 
NLCNLLRVGI SSRHHELILQ RLQHAKSVIH SRQFPFRFLN AHDAIDALEA QLRNQALPFP 
SNITLMRRIL TRNEKNRPRR RFLCHLSRQQ LRMAMRIPVL YEQLKREKLR VHKARQWKYD 
GEMLNRYRQA LETAVNLSVK HSLPLLPGRT VLVYLTDANA DRLCPKSNPQ GPPLNYALLL 
IGMMITRAEQ VDVVLCGGDT LKTAVLKAEE GILKTAIKLQ AQVQEFDEND GWSLNTFGKY 
LLSLAGQRVP VDRVILLGQS MDDGMINVAK QLYWQRVNSK CLFVGILLRR VQYLSTDLNP 
NDVTLSGCTD AILKFIAEHG ASHLLEHVGQ MDKIFKIPPP PGKTGVQSLR PLEEDTPSPL 
APVSQQGWRS IRLFISSTFR DMHGERDLLL RSVLPALQAR AAPHRISLHG IDLRWGVTEE 
ETRRNRQLEV CLGEVENAQL FVGILGSRYG YIPPSYNLPD HPHFHWAQQY PSGRSVTEME 
VMQFLNRNQR LQPSAQALIY FRDSSFLSSV PDAWKSDFVS ESEEAARRIS ELKSYLSRQK 
GITCRRYPCE WGGVAAGRPY VGGLEEFGQL VLQDVWNMIQ KLYLQPGALL EQPVSIPDDD 
LVQATFQQLQ KPPSPARPRL LQDTVQRLML PHGRLSLVTG QSGQGKTAFL ASLVSALQAP 
DGAKVASLVF FHFSGARPDQ GLALTLLRRL CTYLRGQLKE PGALPSTYRS LVWELQQRLL 
PKSAESLHPG QTQVLIIDGA DRLVDQNGQL ISDWIPKKLP RCVHLVLSVS SDAGLGETLE 
QSQGAHVLAL GPLEASARAR LVREELALYG KRLEESPFNN QMRLLLVKRE SGRPLYLRLV 
TDHLRLFTLY EQVSERLRTL PATVPLLLQH ILSTLEKEHG PDVLPQALTA LEVTRSGLTV 
DQLHGVLSVW RTLPKGTKSW EEAVAAGNSG DPYPMGPFAC LVQSLRSLLG EGPLERPGAR 
LCLPDGPLRT AAKRCYGKRP GLEDTAHILI AAQLWKTCDA DASGTFRSCP PEALGDLPYH 
LLQSGNRGLL SKFLTNLHVV AAHLELGLVS RLLEAHALYA SSVPKEEQKL PEADVAVFRT 
FLRQQASILS QYPRLLPQQA ANQPLDSPLC HQASLLSRRW HLQHTLRWLN KPRTMKNQQS 
SSLSLAVSSS PTAVAFSTNG QRAAVGTANG TVYLLDLRTW QEEKSVVSGC DGISACLFLS 
DDTLFLTAFD GLLELWDLQH GCRVLQTKAH QYQITGCCLS PDCRLLATVC LGGCLKLWDT 
VRGQLAFQHT YPKSLNCVAF HPEGQVIATG SWAGSISFFQ VDGLKVTKDL GAPGASIRTL 
AFNVPGGVVA VGRLDSMVEL WAWREGARLA AFPAHHGFVA AALFLHAGCQ LLTAGEDGKV 
QVWSGSLGRP RGHLGSLSLS PALSVALSPD GDRVAVGYRA DGIRIYKISS GSQGAQGQAL 
DVAVSALAWL SPKVLVSGAE DGSLQGWALK ECSLQSLWLL SRFQKPVLGL ATSQELLASA 
SEDFTVQLWP RQLLTRPHKA EDFPCGTELR GHEGPVSCCS FSTDGGSLAT GGRDRSLLCW 
DVRTPKTPVL IHSFPACHRD WVTGCAWTKD NLLISCSSDG SVGLWDPESG QRLGQFLGHQ 
SAVSAVAAVE EHVVSVSRDG TLKVWDHQGV ELTSIPAHSG PISHCAAAME PRAAGQPGSE 
LLVVTVGLDG ATRLWHPLLV CQTHTLLGHS GPVRAAAVSE TSGLMLTASE DGSVRLWQVP 
KEADDTCIPR SSAAVTAVAW APDGSMAVSG NQAGELILWQ EAKAVATAQA PGHIGALIWS 
SAHTFFVLSA DEKISEWQVK LRKGSAPGNL SLHLNRILQE DLGVLTSLDW APDGHFLILA 
KADLKLLCMK PGDAPSEIWS SYTENPMILS THKEYGIFVL QPKDPGVLSF LRQKESGEFE 
ERLNFDINLE NPSRTLISIT QAKPESESSF LCASSDGILW NLAKCSPEGE WTTGNMWQKK 
ANTPETQTPG TDPSTCRESD ASMDSDASMD SEPTPHLKTR QRRKIHSGSV TALHVLPELL 
VTASKDRDVK LWERPSMQLL GLFRCEGSVS CLEPWLGANS TLQLAVGDVQ GNVYFLNWE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.