SNAI1 | ENSG00000124216 | NCBI 6615

Details for: SNAI1

Gene ID: 6615

Symbol: SNAI1

Ensembl ID: ENSG00000124216

Description: snail family transcriptional repressor 1

Associated with

Adherens junctions interactions
(R-HSA-418990)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell junction organization
(R-HSA-446728)
Developmental biology
(R-HSA-1266738)
Epithelial-mesenchymal transition (emt) during gastrulation
(R-HSA-9758919)
Gastrulation
(R-HSA-9758941)
Intracellular signaling by second messengers
(R-HSA-9006925)
Pip3 activates akt signaling
(R-HSA-1257604)
Pten regulation
(R-HSA-6807070)
Regulation of cdh11 expression and function
(R-HSA-9759475)
Regulation of cdh11 gene transcription
(R-HSA-9762293)
Regulation of expression and function of type ii classical cadherins
(R-HSA-9764260)
Regulation of homotypic cell-cell adhesion
(R-HSA-9759476)
Regulation of pten gene transcription
(R-HSA-8943724)
Signal transduction
(R-HSA-162582)
Aortic valve morphogenesis
(GO:0003180)
Canonical wnt signaling pathway
(GO:0060070)
Cartilage morphogenesis
(GO:0060536)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
E-box binding
(GO:0070888)
Epithelial cell migration
(GO:0010631)
Epithelial to mesenchymal transition
(GO:0001837)
Epithelial to mesenchymal transition involved in endocardial cushion formation
(GO:0003198)
Fibrillar center
(GO:0001650)
Hair follicle morphogenesis
(GO:0031069)
Heterochromatin organization
(GO:0070828)
Intracellular membrane-bounded organelle
(GO:0043231)
Kinase binding
(GO:0019900)
Left/right pattern formation
(GO:0060972)
Mesoderm formation
(GO:0001707)
Metal ion binding
(GO:0046872)
Negative regulation of cell differentiation involved in embryonic placenta development
(GO:0060806)
Negative regulation of dna damage response, signal transduction by p53 class mediator
(GO:0043518)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of vitamin d biosynthetic process
(GO:0010957)
Notch signaling pathway
(GO:0007219)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Pericentric heterochromatin
(GO:0005721)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Protein binding
(GO:0005515)
Regulation of bicellular tight junction assembly
(GO:2000810)
Regulation of dna-templated transcription
(GO:0006355)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Roof of mouth development
(GO:0060021)
Sequence-specific double-stranded dna binding
(GO:1990837)
Trophoblast giant cell differentiation
(GO:0060707)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 60.1754
Cell Significance Index: -9.3600
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 36.6262
Cell Significance Index: -9.2900
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 23.4981
Cell Significance Index: -9.6800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 7.6321
Cell Significance Index: -9.4100
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.0410
Cell Significance Index: 32.3100
Cell Name: glomerular capillary endothelial cell (CL1001005)
Fold Change: 2.5718
Cell Significance Index: 9.5900
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.3923
Cell Significance Index: -9.4400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.9079
Cell Significance Index: -5.8600
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.7758
Cell Significance Index: 31.3800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 1.6815
Cell Significance Index: 18.2800
Cell Name: odontoblast (CL0000060)
Fold Change: 1.5966
Cell Significance Index: 204.6800
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 1.3281
Cell Significance Index: 27.8000
Cell Name: myometrial cell (CL0002366)
Fold Change: 1.0541
Cell Significance Index: 12.1400
Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 1.0468
Cell Significance Index: 17.2500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.8393
Cell Significance Index: 24.0600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.6317
Cell Significance Index: 18.2000
Cell Name: theca cell (CL0000503)
Fold Change: 0.5277
Cell Significance Index: 3.1000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.3356
Cell Significance Index: 15.2100
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.2881
Cell Significance Index: 1.7900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2163
Cell Significance Index: 7.6000
Cell Name: decidual cell (CL2000002)
Fold Change: 0.2138
Cell Significance Index: 3.4300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2000
Cell Significance Index: 9.4000
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1744
Cell Significance Index: 157.4900
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1315
Cell Significance Index: 13.0100
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1043
Cell Significance Index: 19.8500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0918
Cell Significance Index: 14.9300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.0813
Cell Significance Index: 5.2500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0690
Cell Significance Index: 8.9200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0588
Cell Significance Index: 36.7300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0434
Cell Significance Index: 23.6900
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0414
Cell Significance Index: 0.6200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0173
Cell Significance Index: 7.6300
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 0.0167
Cell Significance Index: 0.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0115
Cell Significance Index: 1.5800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0100
Cell Significance Index: 0.2500
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0081
Cell Significance Index: 0.2800
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0028
Cell Significance Index: 0.1300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0019
Cell Significance Index: 0.0200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0018
Cell Significance Index: 0.0300
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0013
Cell Significance Index: 0.0200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0038
Cell Significance Index: -2.7900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0045
Cell Significance Index: -0.1200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0046
Cell Significance Index: -8.5900
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0079
Cell Significance Index: -10.7700
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0095
Cell Significance Index: -5.3800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0100
Cell Significance Index: -1.8100
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0114
Cell Significance Index: -8.6000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0123
Cell Significance Index: -2.4600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0124
Cell Significance Index: -9.1200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0138
Cell Significance Index: -8.7600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0148
Cell Significance Index: -5.3000
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.0172
Cell Significance Index: -0.2200
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0180
Cell Significance Index: -3.7900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0192
Cell Significance Index: -3.2800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0198
Cell Significance Index: -1.0000
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0208
Cell Significance Index: -5.9800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0209
Cell Significance Index: -9.5000
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0215
Cell Significance Index: -4.2600
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0241
Cell Significance Index: -0.9900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0334
Cell Significance Index: -3.8900
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0371
Cell Significance Index: -0.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0382
Cell Significance Index: -4.7000
Cell Name: keratocyte (CL0002363)
Fold Change: -0.0403
Cell Significance Index: -0.6400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.0407
Cell Significance Index: -4.4300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0443
Cell Significance Index: -4.5300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0448
Cell Significance Index: -5.1400
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.0494
Cell Significance Index: -5.6400
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0530
Cell Significance Index: -0.4500
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0550
Cell Significance Index: -1.4700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0588
Cell Significance Index: -8.5500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0615
Cell Significance Index: -3.7700
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.0627
Cell Significance Index: -0.4500
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0629
Cell Significance Index: -0.3800
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0630
Cell Significance Index: -1.6200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0688
Cell Significance Index: -4.8700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0723
Cell Significance Index: -8.5300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0820
Cell Significance Index: -2.1600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0869
Cell Significance Index: -6.4800
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0904
Cell Significance Index: -9.4100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0925
Cell Significance Index: -2.0100
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.1093
Cell Significance Index: -2.0200
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.1197
Cell Significance Index: -8.2800
Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.1341
Cell Significance Index: -1.4700
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1357
Cell Significance Index: -10.4100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1369
Cell Significance Index: -8.6300
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1386
Cell Significance Index: -9.3200
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1482
Cell Significance Index: -7.7000
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1509
Cell Significance Index: -6.5600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1577
Cell Significance Index: -9.6900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1594
Cell Significance Index: -8.3700
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1746
Cell Significance Index: -9.8000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2010
Cell Significance Index: -7.3800
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: -0.2011
Cell Significance Index: -2.1800
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.2071
Cell Significance Index: -1.7600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2080
Cell Significance Index: -9.2000
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2161
Cell Significance Index: -7.5700
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2334
Cell Significance Index: -7.6400
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.2364
Cell Significance Index: -3.4000
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.2431
Cell Significance Index: -7.1600
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2435
Cell Significance Index: -9.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Transcriptional Repressor**: SNAI1 acts as a transcriptional repressor, binding to specific DNA sequences and inhibiting the transcription of target genes. 2. **Zinc Finger Protein**: SNAI1 contains a zinc finger protein domain, which enables it to recognize and bind to specific DNA sequences. 3. **Cell-Cycle Regulation**: SNAI1 is involved in regulating the cell cycle, particularly during epithelial-to-mesenchymal transition (EMT), a process crucial for tissue development and cancer metastasis. 4. **Cell-Migration and Differentiation**: SNAI1 modulates cell migration and differentiation by regulating the expression of genes involved in these processes. **Pathways and Functions:** 1. **Canonical Wnt Signaling Pathway**: SNAI1 is involved in regulating the canonical Wnt signaling pathway, which plays a critical role in developmental processes, including cell proliferation, differentiation, and migration. 2. **Epithelial-Mesenchymal Transition (EMT)**: SNAI1 is a key regulator of EMT, a process essential for tissue development, wound healing, and cancer metastasis. 3. **Cell-Cell Communication**: SNAI1 modulates cell-cell communication by regulating the expression of adhesion molecules and signaling proteins. 4. **Intracellular Signaling**: SNAI1 is involved in regulating intracellular signaling pathways, including those mediated by p53 and PI3K/AKT. **Clinical Significance:** 1. **Cancer**: SNAI1 is overexpressed in various cancers, including breast, lung, and colon cancer, and its dysregulation contributes to tumor progression and metastasis. 2. **Cardiovascular Disorders**: SNAI1 is implicated in cardiovascular disorders, including aortic valve morphogenesis and left/right pattern formation. 3. **Neurological Conditions**: SNAI1 has been linked to neurological conditions, including cerebral cortex development and GABAergic interneuron function. 4. **Developmental Biology**: SNAI1 plays a crucial role in regulating developmental processes, including gastrulation, hair follicle morphogenesis, and osteoblast differentiation. In conclusion, SNAI1 is a complex gene that plays a multifaceted role in regulating cellular processes, including cell-cell communication, cell migration, and differentiation. Its dysregulation has significant implications for various diseases, including cancer, cardiovascular disorders, and neurological conditions. Further research is necessary to fully elucidate the mechanisms by which SNAI1 regulates cellular processes and to explore its therapeutic potential.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Zinc finger protein SNAI1

Genular Protein ID: 2215023936

Symbol: SNAI1_HUMAN

Name: Zinc finger protein SNAI1

UniProtKB Accession Codes:

O95863 B2R842 Q9P113 Q9UBP7 Q9UHH7

Database IDs:

Citations:

PubMed ID: 11245431

Title: Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH).

PubMed ID: 11245431

PubMed ID: 10543399

Title: Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis.

PubMed ID: 10543399

DOI: 10.1007/s004399900143

PubMed ID: 10585766

Title: Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P).

PubMed ID: 10585766

DOI: 10.1006/geno.1999.6010

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10655587

Title: The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells.

PubMed ID: 10655587

DOI: 10.1038/35000034

PubMed ID: 15448698

Title: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.

PubMed ID: 15448698

DOI: 10.1038/ncb1173

PubMed ID: 15833848

Title: Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions.

PubMed ID: 15833848

DOI: 10.1158/0008-5472.can-04-3480

PubMed ID: 16096638

Title: A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.

PubMed ID: 16096638

DOI: 10.1038/sj.emboj.7600781

PubMed ID: 15836774

Title: Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway.

PubMed ID: 15836774

DOI: 10.1111/j.1365-2443.2005.00850.x

PubMed ID: 15647282

Title: Wnt-dependent regulation of the E-cadherin repressor snail.

PubMed ID: 15647282

DOI: 10.1074/jbc.m413878200

PubMed ID: 18331720

Title: Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

PubMed ID: 18331720

DOI: 10.1016/j.devcel.2008.01.005

PubMed ID: 19386897

Title: Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors.

PubMed ID: 19386897

DOI: 10.1242/jcs.041749

PubMed ID: 20389281

Title: The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1.

PubMed ID: 20389281

DOI: 10.1038/emboj.2010.63

PubMed ID: 20959806

Title: Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition.

PubMed ID: 20959806

DOI: 10.1038/emboj.2010.254

PubMed ID: 20121949

Title: Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b.

PubMed ID: 20121949

DOI: 10.1111/j.1742-4658.2009.07553.x

PubMed ID: 20385133

Title: p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.

PubMed ID: 20385133

DOI: 10.1016/j.febslet.2010.04.006

PubMed ID: 19955572

Title: The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation.

PubMed ID: 19955572

DOI: 10.1074/jbc.m109.065995

PubMed ID: 19923321

Title: Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.

PubMed ID: 19923321

DOI: 10.1091/mbc.e09-06-0504

PubMed ID: 20305697

Title: Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail.

PubMed ID: 20305697

DOI: 10.1038/onc.2010.77

PubMed ID: 20562920

Title: Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition.

PubMed ID: 20562920

DOI: 10.1038/onc.2010.234

PubMed ID: 22128911

Title: Notch1 binds and induces degradation of Snail in hepatocellular carcinoma.

PubMed ID: 22128911

DOI: 10.1186/1741-7007-9-83

PubMed ID: 21454664

Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.

PubMed ID: 21454664

DOI: 10.1074/jbc.m110.213579

PubMed ID: 21577210

Title: Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.

PubMed ID: 21577210

DOI: 10.1038/onc.2011.153

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 21952048

Title: Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.

PubMed ID: 21952048

DOI: 10.1038/emboj.2011.357

PubMed ID: 24157836

Title: Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability.

PubMed ID: 24157836

DOI: 10.1093/nar/gkt935

PubMed ID: 25893292

Title: Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization.

PubMed ID: 25893292

DOI: 10.1038/onc.2015.100

PubMed ID: 25827072

Title: FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development.

PubMed ID: 25827072

DOI: 10.1016/j.canlet.2015.03.037

PubMed ID: 29059170

Title: SPSB3 targets SNAIL for degradation in GSK-3beta phosphorylation-dependent manner and regulates metastasis.

PubMed ID: 29059170

DOI: 10.1038/onc.2017.370

PubMed ID: 31911859

Title: USP37 is a SNAI1 deubiquitinase.

PubMed ID: 31911859

PubMed ID: 21300290

Title: Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex.

PubMed ID: 21300290

DOI: 10.1016/j.str.2011.01.001

PubMed ID: 24699649

Title: Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta.

PubMed ID: 24699649

DOI: 10.1107/s1399004714000972

PubMed ID: 23721412

Title: Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase.

PubMed ID: 23721412

DOI: 10.1021/cb4001926

Sequence Information:

Length: 264
Mass: 29083
Checksum: 70E298C9BB154115
Sequence:

MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI 
WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSVSS 
LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC 
VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA 
CARTFSRMSL LHKHQESGCS GCPR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SNAI1

Associated with

Cells (max top 100)

Other Information

Down-regulation of promoter 1.3 activity of the human aromatase gene in breast tissue by zinc-finger protein, snail (SnaH). PubMed ID: 11245431

Characterisation of the human snail (SNAI1) gene and exclusion as a major disease gene in craniosynostosis. PubMed ID: 10543399

Genomic organization, expression, and chromosome location of the human SNAIL gene (SNAI1) and a related processed pseudogene (SNAI1P). PubMed ID: 10585766

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcription factor Snail is a repressor of E-cadherin gene expression in epithelial tumour cells. PubMed ID: 10655587

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. PubMed ID: 15448698

Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. PubMed ID: 15833848

A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. PubMed ID: 16096638

Zinc finger domain of Snail functions as a nuclear localization signal for importin beta-mediated nuclear import pathway. PubMed ID: 15836774

Wnt-dependent regulation of the E-cadherin repressor snail. PubMed ID: 15647282

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus. PubMed ID: 18331720

Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors. PubMed ID: 19386897

The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. PubMed ID: 20389281

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition. PubMed ID: 20959806

Snail associates with EGR-1 and SP-1 to upregulate transcriptional activation of p15INK4b. PubMed ID: 20121949

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. PubMed ID: 20385133

The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation. PubMed ID: 19955572

Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. PubMed ID: 19923321

Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. PubMed ID: 20305697

Requirement of the histone demethylase LSD1 in Snai1-mediated transcriptional repression during epithelial-mesenchymal transition. PubMed ID: 20562920

Notch1 binds and induces degradation of Snail in hepatocellular carcinoma. PubMed ID: 22128911

Importin alpha protein acts as a negative regulator for Snail protein nuclear import. PubMed ID: 21454664

Poly(ADP-ribose)-dependent regulation of Snail1 protein stability. PubMed ID: 21577210

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. PubMed ID: 21952048

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. PubMed ID: 24157836

Syntenin regulates TGF-beta1-induced Smad activation and the epithelial-to-mesenchymal transition by inhibiting caveolin-mediated TGF-beta type I receptor internalization. PubMed ID: 25893292

FBXO11 promotes ubiquitination of the Snail family of transcription factors in cancer progression and epidermal development. PubMed ID: 25827072

SPSB3 targets SNAIL for degradation in GSK-3beta phosphorylation-dependent manner and regulates metastasis. PubMed ID: 29059170

USP37 is a SNAI1 deubiquitinase. PubMed ID: 31911859

Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. PubMed ID: 21300290

Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta. PubMed ID: 24699649

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. PubMed ID: 23721412