Details for: SNX11

Gene ID: 29916

Symbol: SNX11

Ensembl ID: ENSG00000002919

Description: sorting nexin 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.9691
    Cell Significance Index: -11.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.7980
    Cell Significance Index: -11.8700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 29.1056
    Cell Significance Index: -11.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.2395
    Cell Significance Index: -10.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.0287
    Cell Significance Index: -12.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 11.3015
    Cell Significance Index: -10.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9598
    Cell Significance Index: -12.2800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.1622
    Cell Significance Index: -11.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.8586
    Cell Significance Index: -8.7800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0048
    Cell Significance Index: 99.4000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8784
    Cell Significance Index: 142.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8693
    Cell Significance Index: 784.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5761
    Cell Significance Index: 62.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4673
    Cell Significance Index: 28.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3929
    Cell Significance Index: 46.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3741
    Cell Significance Index: 43.6000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3186
    Cell Significance Index: 22.0300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3088
    Cell Significance Index: 19.4700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2609
    Cell Significance Index: 4.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1899
    Cell Significance Index: 9.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1893
    Cell Significance Index: 37.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1532
    Cell Significance Index: 3.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1519
    Cell Significance Index: 7.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1288
    Cell Significance Index: 5.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1278
    Cell Significance Index: 6.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1119
    Cell Significance Index: 49.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1118
    Cell Significance Index: 21.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1086
    Cell Significance Index: 13.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1086
    Cell Significance Index: 59.3300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1083
    Cell Significance Index: 74.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1038
    Cell Significance Index: 2.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0985
    Cell Significance Index: 19.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0876
    Cell Significance Index: 1.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0862
    Cell Significance Index: 15.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0834
    Cell Significance Index: 29.9100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0776
    Cell Significance Index: 3.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0713
    Cell Significance Index: 1.9400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0570
    Cell Significance Index: 3.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0489
    Cell Significance Index: 6.7200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0411
    Cell Significance Index: 1.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0215
    Cell Significance Index: 1.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0211
    Cell Significance Index: 2.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0100
    Cell Significance Index: 0.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0023
    Cell Significance Index: 0.0500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0026
    Cell Significance Index: -0.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0028
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0048
    Cell Significance Index: -7.4000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0068
    Cell Significance Index: -9.1900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0105
    Cell Significance Index: -7.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0129
    Cell Significance Index: -0.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0136
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0156
    Cell Significance Index: -7.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0173
    Cell Significance Index: -1.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0178
    Cell Significance Index: -1.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0192
    Cell Significance Index: -10.8500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0201
    Cell Significance Index: -0.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0237
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0240
    Cell Significance Index: -14.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0317
    Cell Significance Index: -9.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0331
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0457
    Cell Significance Index: -6.6500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0548
    Cell Significance Index: -4.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0559
    Cell Significance Index: -1.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0580
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0627
    Cell Significance Index: -7.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0698
    Cell Significance Index: -14.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0948
    Cell Significance Index: -6.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1036
    Cell Significance Index: -6.3700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1083
    Cell Significance Index: -1.5200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1144
    Cell Significance Index: -11.9100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1171
    Cell Significance Index: -5.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1177
    Cell Significance Index: -3.3800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1231
    Cell Significance Index: -1.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1268
    Cell Significance Index: -10.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1297
    Cell Significance Index: -4.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1332
    Cell Significance Index: -3.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1350
    Cell Significance Index: -3.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1509
    Cell Significance Index: -9.2500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1569
    Cell Significance Index: -8.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1674
    Cell Significance Index: -5.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1914
    Cell Significance Index: -4.9200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2051
    Cell Significance Index: -5.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2081
    Cell Significance Index: -10.5200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2265
    Cell Significance Index: -2.7000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2296
    Cell Significance Index: -3.4600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2388
    Cell Significance Index: -6.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2503
    Cell Significance Index: -4.2900
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2508
    Cell Significance Index: -1.6400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2584
    Cell Significance Index: -7.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2729
    Cell Significance Index: -9.5600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2799
    Cell Significance Index: -10.2800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2818
    Cell Significance Index: -3.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2831
    Cell Significance Index: -9.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2835
    Cell Significance Index: -9.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SNX11 is widely expressed across various cell types, including germ cells, immune cells, and epithelial cells. Its expression is observed in the cerebral cortex, GABAergic interneurons, and forebrain radial glial cells, highlighting its importance in neural development and function. 2. **Protein Binding:** SNX11 exhibits a high degree of protein binding, which is essential for its role in regulating membrane trafficking and protein sorting. Its binding capabilities are mediated by its phosphatidylinositol phosphate-binding domain. 3. **Pathway Involvement:** SNX11 is involved in multiple cellular pathways, including endosome, intracellular protein transport, membrane, phosphatidylinositol phosphate binding, protein binding, and vesicle organization. These pathways underscore its critical role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Endosomal Regulation:** SNX11 plays a pivotal role in regulating endosomal trafficking, which is essential for maintaining cellular homeostasis. Its involvement in endosomal regulation has significant implications for cellular processes, including protein degradation, recycling, and signaling. 2. **Intracellular Protein Transport:** SNX11 facilitates the transport of proteins within cells, which is critical for maintaining cellular homeostasis. Its involvement in intracellular protein transport has significant implications for cellular processes, including signaling, metabolism, and cell growth. 3. **Membrane Regulation:** SNX11 regulates membrane trafficking, which is essential for maintaining cellular homeostasis. Its involvement in membrane regulation has significant implications for cellular processes, including signaling, metabolism, and cell growth. 4. **Phosphatidylinositol Phosphate Binding:** SNX11 exhibits a high degree of phosphatidylinositol phosphate-binding activity, which is essential for its role in regulating membrane trafficking and protein sorting. 5. **Vesicle Organization:** SNX11 plays a critical role in regulating vesicle organization, which is essential for maintaining cellular homeostasis. Its involvement in vesicle organization has significant implications for cellular processes, including protein degradation, recycling, and signaling. **Clinical Significance:** 1. **Neurological Disorders:** SNX11 has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. Its dysregulation has significant implications for understanding the pathogenesis of these disorders. 2. **Cancer:** SNX11 has been found to be overexpressed in various types of cancer, including colon cancer and breast cancer. Its overexpression has significant implications for understanding the pathogenesis of these cancers. 3. **Immunological Disorders:** SNX11 has been implicated in various immunological disorders, including autoimmune diseases and immunodeficiency disorders. Its dysregulation has significant implications for understanding the pathogenesis of these disorders. In conclusion, SNX11 is a multifaceted gene that plays a critical role in regulating cellular processes, including endosomal regulation, intracellular protein transport, membrane regulation, phosphatidylinositol phosphate binding, and vesicle organization. Its dysregulation has significant implications for understanding the pathogenesis of various diseases, including neurological disorders, cancer, and immunological disorders. Further research is necessary to elucidate the full extent of SNX11's role in cellular processes and its clinical significance.

Genular Protein ID: 3727430279

Symbol: SNX11_HUMAN

Name: Sorting nexin-11

UniProtKB Accession Codes:

Q9Y5W9 B3KRL6 B4DPY5 D3DTV0 Q53YC0 Q9H885

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26818531

Title: Sorting Nexin 11 Regulates Lysosomal Degradation of Plasma Membrane TRPV3.

PubMed ID: 26818531

DOI: 10.1111/tra.12379

PubMed ID: 23615901

Title: Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation.

PubMed ID: 23615901

DOI: 10.1074/jbc.m112.449306

Sequence Information:

  • Length: 270
  • Mass: 30433
  • Checksum: E6839B7415F1724F
  • Sequence:
    • MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT AKTSCVRRRY 
REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR QGLQHFLEKV LQSVVLLSDS 
QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA ILRYAMSNCG WAQEERQSSS HLAKGDQPKS 
CCFLPRSGRR SSPSPPPSEE KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG 
TSTLQSVRRA VGGDHAVPLD PGQLETVLEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.