Details for: SNX11

Gene ID: 29916

Symbol: SNX11

Ensembl ID: ENSG00000002919

Description: sorting nexin 11

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.16
    Marker Score: 2,033
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.05
    Marker Score: 2,144
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.01
    Marker Score: 250
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,760
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,985
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 436
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,718
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4,984
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,258
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.86
    Marker Score: 204
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12,627
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.77
    Marker Score: 464
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1,224
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.75
    Marker Score: 1,300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 289
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 644
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.7
    Marker Score: 689
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.69
    Marker Score: 1,311
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,892
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.69
    Marker Score: 221
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.68
    Marker Score: 827
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.62
    Marker Score: 1,462
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.61
    Marker Score: 1,521
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.61
    Marker Score: 601
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6
    Marker Score: 1,780
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.57
    Marker Score: 340
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.55
    Marker Score: 304
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.53
    Marker Score: 576
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.51
    Marker Score: 464
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.5
    Marker Score: 718
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5
    Marker Score: 319
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.48
    Marker Score: 1,011
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.47
    Marker Score: 166
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.47
    Marker Score: 112
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.47
    Marker Score: 318
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.46
    Marker Score: 25,493
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.45
    Marker Score: 452
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.45
    Marker Score: 141
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.44
    Marker Score: 292
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.44
    Marker Score: 319
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.43
    Marker Score: 881
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.43
    Marker Score: 483
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.43
    Marker Score: 836
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.43
    Marker Score: 1,655
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.42
    Marker Score: 239
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.42
    Marker Score: 2,527
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.42
    Marker Score: 554
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.41
    Marker Score: 4,797
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.41
    Marker Score: 251
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.41
    Marker Score: 249
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.41
    Marker Score: 117
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.4
    Marker Score: 266
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.4
    Marker Score: 171
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.39
    Marker Score: 495
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.39
    Marker Score: 1,921
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.39
    Marker Score: 1,530
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.39
    Marker Score: 383
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.38
    Marker Score: 615
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.38
    Marker Score: 357
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.38
    Marker Score: 258
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.37
    Marker Score: 152
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.37
    Marker Score: 269
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.37
    Marker Score: 3,167
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.37
    Marker Score: 567
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.37
    Marker Score: 327
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.36
    Marker Score: 95
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.36
    Marker Score: 171
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.36
    Marker Score: 80
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.36
    Marker Score: 78
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.35
    Marker Score: 77
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.35
    Marker Score: 4,757
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.35
    Marker Score: 262
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.35
    Marker Score: 636
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.35
    Marker Score: 349
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.35
    Marker Score: 85
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.34
    Marker Score: 261
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.34
    Marker Score: 332
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.34
    Marker Score: 85
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.34
    Marker Score: 483
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.34
    Marker Score: 851
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 141
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.34
    Marker Score: 74
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.33
    Marker Score: 3,437
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.33
    Marker Score: 164
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.33
    Marker Score: 65
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.33
    Marker Score: 75
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.33
    Marker Score: 1,045
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 135
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.33
    Marker Score: 80
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.32
    Marker Score: 2,069

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** SNX11 is widely expressed across various cell types, including germ cells, immune cells, and epithelial cells. Its expression is observed in the cerebral cortex, GABAergic interneurons, and forebrain radial glial cells, highlighting its importance in neural development and function. 2. **Protein Binding:** SNX11 exhibits a high degree of protein binding, which is essential for its role in regulating membrane trafficking and protein sorting. Its binding capabilities are mediated by its phosphatidylinositol phosphate-binding domain. 3. **Pathway Involvement:** SNX11 is involved in multiple cellular pathways, including endosome, intracellular protein transport, membrane, phosphatidylinositol phosphate binding, protein binding, and vesicle organization. These pathways underscore its critical role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Endosomal Regulation:** SNX11 plays a pivotal role in regulating endosomal trafficking, which is essential for maintaining cellular homeostasis. Its involvement in endosomal regulation has significant implications for cellular processes, including protein degradation, recycling, and signaling. 2. **Intracellular Protein Transport:** SNX11 facilitates the transport of proteins within cells, which is critical for maintaining cellular homeostasis. Its involvement in intracellular protein transport has significant implications for cellular processes, including signaling, metabolism, and cell growth. 3. **Membrane Regulation:** SNX11 regulates membrane trafficking, which is essential for maintaining cellular homeostasis. Its involvement in membrane regulation has significant implications for cellular processes, including signaling, metabolism, and cell growth. 4. **Phosphatidylinositol Phosphate Binding:** SNX11 exhibits a high degree of phosphatidylinositol phosphate-binding activity, which is essential for its role in regulating membrane trafficking and protein sorting. 5. **Vesicle Organization:** SNX11 plays a critical role in regulating vesicle organization, which is essential for maintaining cellular homeostasis. Its involvement in vesicle organization has significant implications for cellular processes, including protein degradation, recycling, and signaling. **Clinical Significance:** 1. **Neurological Disorders:** SNX11 has been implicated in various neurological disorders, including autism spectrum disorder, schizophrenia, and Alzheimer's disease. Its dysregulation has significant implications for understanding the pathogenesis of these disorders. 2. **Cancer:** SNX11 has been found to be overexpressed in various types of cancer, including colon cancer and breast cancer. Its overexpression has significant implications for understanding the pathogenesis of these cancers. 3. **Immunological Disorders:** SNX11 has been implicated in various immunological disorders, including autoimmune diseases and immunodeficiency disorders. Its dysregulation has significant implications for understanding the pathogenesis of these disorders. In conclusion, SNX11 is a multifaceted gene that plays a critical role in regulating cellular processes, including endosomal regulation, intracellular protein transport, membrane regulation, phosphatidylinositol phosphate binding, and vesicle organization. Its dysregulation has significant implications for understanding the pathogenesis of various diseases, including neurological disorders, cancer, and immunological disorders. Further research is necessary to elucidate the full extent of SNX11's role in cellular processes and its clinical significance.

Genular Protein ID: 3727430279

Symbol: SNX11_HUMAN

Name: Sorting nexin-11

UniProtKB Accession Codes:

Q9Y5W9 B3KRL6 B4DPY5 D3DTV0 Q53YC0 Q9H885

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 3 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 6 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11485546

Title: A large family of endosome-localized proteins related to sorting nexin 1.

PubMed ID: 11485546

DOI: 10.1042/0264-6021:3580007

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 23615901

Title: Structure of Sorting Nexin 11 (SNX11) reveals a novel extended PX Domain (PXe Domain) critical for the inhibition of Sorting Nexin 10 (SNX10) induced vacuolation.

PubMed ID: 23615901

DOI: 10.1074/jbc.m112.449306

Sequence Information:

  • Length: 270
  • Mass: 30433
  • Checksum: E6839B7415F1724F
  • Sequence:
    • MGFWCRMSEN QEQEEVITVR VQDPRVQNEG SWNSYVDYKI FLHTNSKAFT AKTSCVRRRY 
REFVWLRKQL QRNAGLVPVP ELPGKSTFFG TSDEFIEKRR QGLQHFLEKV LQSVVLLSDS 
QLHLFLQSQL SVPEIEACVQ GRSTMTVSDA ILRYAMSNCG WAQEERQSSS HLAKGDQPKS 
CCFLPRSGRR SSPSPPPSEE KDHLEVWAPV VDSEVPSLES PTLPPLSSPL CCDFGRPKEG 
TSTLQSVRRA VGGDHAVPLD PGQLETVLEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.