Details for: B3GALT4

Gene ID: 8705

Symbol: B3GALT4

Ensembl ID: ENSG00000235863

Description: beta-1,3-galactosyltransferase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.9048
    Cell Significance Index: -11.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.3286
    Cell Significance Index: -10.9900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 27.9588
    Cell Significance Index: -13.2000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 24.4953
    Cell Significance Index: -12.6000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 19.7385
    Cell Significance Index: -13.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.3353
    Cell Significance Index: -11.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5873
    Cell Significance Index: -9.6100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.9320
    Cell Significance Index: -11.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.6763
    Cell Significance Index: -8.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1922
    Cell Significance Index: 29.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1454
    Cell Significance Index: 59.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9435
    Cell Significance Index: 102.6300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7577
    Cell Significance Index: 123.2300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.7091
    Cell Significance Index: 6.5300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6834
    Cell Significance Index: 10.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.6633
    Cell Significance Index: 10.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5449
    Cell Significance Index: 24.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4530
    Cell Significance Index: 21.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4310
    Cell Significance Index: 77.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4145
    Cell Significance Index: 28.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3913
    Cell Significance Index: 45.6000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3743
    Cell Significance Index: 8.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2861
    Cell Significance Index: 54.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2806
    Cell Significance Index: 8.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2804
    Cell Significance Index: 34.4800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2691
    Cell Significance Index: 2.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2639
    Cell Significance Index: 16.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2278
    Cell Significance Index: 6.5600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1812
    Cell Significance Index: 17.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1366
    Cell Significance Index: 8.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1362
    Cell Significance Index: 74.3600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1260
    Cell Significance Index: 3.3700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1138
    Cell Significance Index: 4.0000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1075
    Cell Significance Index: 1.5300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0898
    Cell Significance Index: 11.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0862
    Cell Significance Index: 4.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0784
    Cell Significance Index: 9.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0761
    Cell Significance Index: 33.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0687
    Cell Significance Index: 7.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0597
    Cell Significance Index: 11.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0473
    Cell Significance Index: 32.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0453
    Cell Significance Index: 1.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0402
    Cell Significance Index: 5.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0369
    Cell Significance Index: 13.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0344
    Cell Significance Index: 0.9400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0203
    Cell Significance Index: 0.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0192
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0184
    Cell Significance Index: 3.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0020
    Cell Significance Index: -3.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0046
    Cell Significance Index: -6.3000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0071
    Cell Significance Index: -0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0074
    Cell Significance Index: -5.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0080
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0093
    Cell Significance Index: -5.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0127
    Cell Significance Index: -9.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0130
    Cell Significance Index: -1.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0158
    Cell Significance Index: -8.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0200
    Cell Significance Index: -9.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0247
    Cell Significance Index: -1.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0253
    Cell Significance Index: -15.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0426
    Cell Significance Index: -12.2500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0462
    Cell Significance Index: -6.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0514
    Cell Significance Index: -6.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0569
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0582
    Cell Significance Index: -9.9400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0598
    Cell Significance Index: -12.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0635
    Cell Significance Index: -2.9900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0715
    Cell Significance Index: -5.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0800
    Cell Significance Index: -1.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0815
    Cell Significance Index: -6.2600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1008
    Cell Significance Index: -3.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1027
    Cell Significance Index: -2.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1042
    Cell Significance Index: -0.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1087
    Cell Significance Index: -11.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1260
    Cell Significance Index: -7.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1359
    Cell Significance Index: -1.6200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1393
    Cell Significance Index: -2.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1419
    Cell Significance Index: -11.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1468
    Cell Significance Index: -6.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1478
    Cell Significance Index: -1.5300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1818
    Cell Significance Index: -8.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1875
    Cell Significance Index: -3.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1937
    Cell Significance Index: -3.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2060
    Cell Significance Index: -12.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2077
    Cell Significance Index: -2.3600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2187
    Cell Significance Index: -8.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2458
    Cell Significance Index: -8.6100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.2469
    Cell Significance Index: -1.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2517
    Cell Significance Index: -6.4300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.2588
    Cell Significance Index: -2.6700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2694
    Cell Significance Index: -9.8900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2703
    Cell Significance Index: -4.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2712
    Cell Significance Index: -6.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2868
    Cell Significance Index: -9.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2906
    Cell Significance Index: -8.5600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3010
    Cell Significance Index: -9.5900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3020
    Cell Significance Index: -7.9400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** B3GALT4 is a member of the beta-1,3-galactosyltransferase family, which catalyzes the transfer of galactose residues from UDP-galactose to various acceptor molecules. The enzyme exhibits a high degree of specificity, with a preference for transferring galactose residues to N-acetylglucosamine, resulting in the formation of galactosylglycerophospholipids and glycosphingolipids. B3GALT4 is also involved in the biosynthesis of Lewis blood group antigens, gangliosides, and glycoproteins, highlighting its crucial role in maintaining the integrity of the cellular membrane. **Pathways and Functions:** B3GALT4 is integral to several critical biological pathways, including: 1. **Glycosphingolipid biosynthesis**: B3GALT4 catalyzes the formation of galactosylglycerophospholipids, which are essential components of the cellular membrane. 2. **Ganglioside biosynthesis**: The enzyme plays a key role in the synthesis of gangliosides, which are complex lipids that regulate various cellular processes, including cell adhesion, signaling, and neurotransmission. 3. **Glycosphingolipid metabolism**: B3GALT4 is involved in the degradation of glycosphingolipids, which is essential for maintaining cellular homeostasis. 4. **Oligosaccharide biosynthesis**: The enzyme contributes to the formation of oligosaccharides, which are crucial for protein glycosylation and cell-cell interactions. **Clinical Significance:** B3GALT4 has significant implications in various diseases, including: 1. **Blood disorders**: Abnormalities in B3GALT4 expression have been linked to blood group disorders, such as hemolytic disease of the newborn. 2. **Cancer**: The enzyme's dysregulation has been associated with various types of cancer, including colorectal, breast, and lung cancer. 3. **Neurological disorders**: B3GALT4 has been implicated in the pathogenesis of neurological diseases, such as Alzheimer's and Parkinson's disease. 4. **Immune system dysfunction**: The enzyme's role in immune cell function has been explored in the context of autoimmune diseases, such as rheumatoid arthritis. In conclusion, B3GALT4 is a multifaceted enzyme that plays a critical role in various biological pathways, including glycosphingolipid biosynthesis, ganglioside biosynthesis, and oligosaccharide biosynthesis. Its dysregulation has significant implications in various diseases, highlighting the need for further research into the molecular mechanisms underlying B3GALT4's functions.

Genular Protein ID: 799074835

Symbol: B3GT4_HUMAN

Name: Gal-T2

UniProtKB Accession Codes:

O96024

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 8 SMR 1 STRING 1 SignaLink 1 SwissLipids 1 TreeFam 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9582303

Title: A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-N-acetyl-galactosamine beta-1,3-galactosyltransferase family.

PubMed ID: 9582303

DOI: 10.1074/jbc.273.21.12770

PubMed ID: 10663566

Title: The beta 1,3-galactosyltransferase-4 (b3Gal-T4) gene is located in the centromeric segment of the human MHC class II region.

PubMed ID: 10663566

DOI: 10.1007/s002510050012

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 378
  • Mass: 41537
  • Checksum: 4E55DFC72AE96213
  • Sequence:
    • MQLRLFRRLL LAALLLVIVW TLFGPSGLGE ELLSLSLASL LPAPASPGPP LALPRLLIPN 
QEACSGPGAP PFLLILVCTA PENLNQRNAI RASWGGLREA RGLRVQTLFL LGEPNAQHPV 
WGSQGSDLAS ESAAQGDILQ AAFQDSYRNL TLKTLSGLNW AEKHCPMARY VLKTDDDVYV 
NVPELVSELV LRGGRWGQWE RSTEPQREAE QEGGQVLHSE EVPLLYLGRV HWRVNPSRTP 
GGRHRVSEEQ WPHTWGPFPP YASGTGYVLS ASAVQLILKV ASRAPLLPLE DVFVGVSARR 
GGLAPTQCVK LAGATHYPLD RCCYGKFLLT SHRLDPWKMQ EAWKLVGGSD GERTAPFCSW 
FQGVLGILRC RAIAWLQS

Genular Protein ID: 3182632353

Symbol: B3KQP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KQP5

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 PharmGKB 1 RefSeq 1 RuleBase 1

Citations:

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 378
  • Mass: 41438
  • Checksum: BB5A6FC8954C78B9
  • Sequence:
    • MQLRLFRRLL LAALLLVIVW TLFGPSGLGE ELLSLSLASL LPAPASPGPP LALPRLLIPN 
QEACSGPGAP PFLLILVCTA PENLNQRNAI RASWGGLREA RGLRVQTLFL LGEPNAQHPV 
WGSQGSDLAS ESAAQGDILQ AAFQDSYRNL TLKTLSGLNW AEKHCPMARY VLKTDDDVYV 
NVPELVSELV LRGGRWGQWE GSTEPQREAE QEGGQVLHSE EVPLLYLGRV HWRVNPSRTP 
GGRHRVSEEQ WPHTWGPFPP YASGTGYVLS ASAVQLILKV ASRAPLLPLE DVFVGVSARR 
GGLAPTQCVK LAGATHYPLD RCCYGKFLLT SHRLDPWKMQ EAWKLVGGSD GERTAPFCSW 
FQGVLGILRC RAIAWLQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.