CCL5 | ENSG00000271503 | NCBI 6352

Details for: CCL5

Gene ID: 6352

Symbol: CCL5

Ensembl ID: ENSG00000271503

Description: C-C motif chemokine ligand 5

Associated with

Chemokine receptors bind chemokines
(R-HSA-380108)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Cytokine signaling in immune system
(R-HSA-1280215)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Interleukin-10 signaling
(R-HSA-6783783)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Signal transduction
(R-HSA-162582)
Activation of phospholipase d activity
(GO:0031584)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Calcium ion transport
(GO:0006816)
Ccr1 chemokine receptor binding
(GO:0031726)
Ccr4 chemokine receptor binding
(GO:0031729)
Ccr5 chemokine receptor binding
(GO:0031730)
Ccr chemokine receptor binding
(GO:0048020)
Cell-cell signaling
(GO:0007267)
Cell chemotaxis
(GO:0060326)
Cell surface receptor signaling pathway via stat
(GO:0097696)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Cellular response to virus
(GO:0098586)
Chemoattractant activity
(GO:0042056)
Chemokine (c-c motif) ligand 5 signaling pathway
(GO:0035689)
Chemokine-mediated signaling pathway
(GO:0070098)
Chemokine activity
(GO:0008009)
Chemokine receptor antagonist activity
(GO:0046817)
Chemokine receptor binding
(GO:0042379)
Chemotaxis
(GO:0006935)
Cytoplasm
(GO:0005737)
Dendritic cell chemotaxis
(GO:0002407)
Eosinophil chemotaxis
(GO:0048245)
Epithelial cell proliferation
(GO:0050673)
Exocytosis
(GO:0006887)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
G protein-coupled receptor signaling pathway
(GO:0007186)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Intracellular calcium ion homeostasis
(GO:0006874)
Leukocyte cell-cell adhesion
(GO:0007159)
Macrophage chemotaxis
(GO:0048246)
Monocyte chemotaxis
(GO:0002548)
Negative regulation by host of viral transcription
(GO:0043922)
Negative regulation of chemokine-mediated signaling pathway
(GO:0070100)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Negative regulation of macrophage apoptotic process
(GO:2000110)
Negative regulation of t cell apoptotic process
(GO:0070233)
Negative regulation of viral genome replication
(GO:0045071)
Neutrophil activation
(GO:0042119)
Phosphatidylinositol phospholipase c activity
(GO:0004435)
Phospholipase activator activity
(GO:0016004)
Positive chemotaxis
(GO:0050918)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of cell-cell adhesion mediated by integrin
(GO:0033634)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cellular biosynthetic process
(GO:0031328)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of g protein-coupled receptor signaling pathway
(GO:0045745)
Positive regulation of homotypic cell-cell adhesion
(GO:0034112)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of monocyte chemotaxis
(GO:0090026)
Positive regulation of natural killer cell chemotaxis
(GO:2000503)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of receptor signaling pathway via stat
(GO:1904894)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Positive regulation of t cell apoptotic process
(GO:0070234)
Positive regulation of t cell chemotaxis
(GO:0010820)
Positive regulation of t cell migration
(GO:2000406)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of translational initiation
(GO:0045948)
Positive regulation of viral genome replication
(GO:0045070)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Receptor signaling protein tyrosine kinase activator activity
(GO:0030298)
Regulation of chronic inflammatory response
(GO:0002676)
Regulation of insulin secretion
(GO:0050796)
Regulation of t cell activation
(GO:0050863)
Response to toxic substance
(GO:0009636)
Response to virus
(GO:0009615)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 62.2296
Cell Significance Index: -32.0100
Cell Name: hepatic pit cell (CL2000054)
Fold Change: 56.6281
Cell Significance Index: 151.7000
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 47.6359
Cell Significance Index: -22.4900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.0864
Cell Significance Index: -30.9800
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 4.3237
Cell Significance Index: 66.9000
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.0599
Cell Significance Index: 17.7500
Cell Name: activated type II NK T cell (CL0000931)
Fold Change: 1.6366
Cell Significance Index: 4.1900
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2608
Cell Significance Index: 239.9400
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.2399
Cell Significance Index: 10.1100
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 1.1511
Cell Significance Index: 8.9600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9999
Cell Significance Index: 98.9200
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.9365
Cell Significance Index: 9.9500
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 0.8227
Cell Significance Index: 8.5300
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 0.8196
Cell Significance Index: 6.5500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8162
Cell Significance Index: 736.9500
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 0.6991
Cell Significance Index: 6.4700
Cell Name: mature T cell (CL0002419)
Fold Change: 0.6990
Cell Significance Index: 5.0300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.4681
Cell Significance Index: 292.3200
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4602
Cell Significance Index: 74.8500
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 0.4314
Cell Significance Index: 4.5900
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3892
Cell Significance Index: 10.4100
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.2714
Cell Significance Index: 1.4800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2623
Cell Significance Index: 28.5300
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 0.2298
Cell Significance Index: 1.7100
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 0.1991
Cell Significance Index: 1.6800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.1268
Cell Significance Index: 4.0600
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 0.1129
Cell Significance Index: 1.0700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0615
Cell Significance Index: 4.2500
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0019
Cell Significance Index: -0.1300
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0025
Cell Significance Index: -1.8200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0034
Cell Significance Index: -2.6000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0038
Cell Significance Index: -2.1600
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0067
Cell Significance Index: -0.3200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0074
Cell Significance Index: -0.2600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0087
Cell Significance Index: -0.4400
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0099
Cell Significance Index: -18.6700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0131
Cell Significance Index: -2.7500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0151
Cell Significance Index: -27.8800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0164
Cell Significance Index: -0.4100
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0176
Cell Significance Index: -27.0900
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0187
Cell Significance Index: -0.5400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0202
Cell Significance Index: -27.4500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0227
Cell Significance Index: -1.0300
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0331
Cell Significance Index: -0.5700
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0373
Cell Significance Index: -20.3600
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0433
Cell Significance Index: -19.1300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0444
Cell Significance Index: -32.5400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0510
Cell Significance Index: -32.3600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0540
Cell Significance Index: -19.3600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0591
Cell Significance Index: -10.0900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0597
Cell Significance Index: -11.9900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0614
Cell Significance Index: -1.3300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0675
Cell Significance Index: -30.6500
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: -0.0679
Cell Significance Index: -0.5500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0698
Cell Significance Index: -2.8600
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0795
Cell Significance Index: -15.7700
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0795
Cell Significance Index: -22.8700
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: -0.0961
Cell Significance Index: -0.9800
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0969
Cell Significance Index: -9.9000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1081
Cell Significance Index: -14.8400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.1113
Cell Significance Index: -20.0600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1176
Cell Significance Index: -13.4200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1327
Cell Significance Index: -15.2000
Cell Name: hematopoietic cell (CL0000988)
Fold Change: -0.1367
Cell Significance Index: -2.0000
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1508
Cell Significance Index: -1.2900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1665
Cell Significance Index: -19.4100
Cell Name: lymphocyte (CL0000542)
Fold Change: -0.1676
Cell Significance Index: -2.2800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1690
Cell Significance Index: -19.9300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1693
Cell Significance Index: -4.5200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.1728
Cell Significance Index: -21.2500
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1760
Cell Significance Index: -2.9900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1822
Cell Significance Index: -23.5400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2058
Cell Significance Index: -8.9500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2091
Cell Significance Index: -21.7700
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.2110
Cell Significance Index: -12.6700
Cell Name: odontoblast (CL0000060)
Fold Change: -0.2123
Cell Significance Index: -27.2100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2150
Cell Significance Index: -31.2500
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2156
Cell Significance Index: -13.2200
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: -0.2280
Cell Significance Index: -2.0300
Cell Name: T cell (CL0000084)
Fold Change: -0.2422
Cell Significance Index: -2.8600
Cell Name: type I NK T cell (CL0000921)
Fold Change: -0.2678
Cell Significance Index: -2.6100
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: -0.2685
Cell Significance Index: -2.6800
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: -0.3087
Cell Significance Index: -2.5800
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3092
Cell Significance Index: -23.7300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3265
Cell Significance Index: -23.0900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3447
Cell Significance Index: -25.6900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3515
Cell Significance Index: -7.4900
Cell Name: natural killer cell (CL0000623)
Fold Change: -0.3720
Cell Significance Index: -4.1200
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: -0.3973
Cell Significance Index: -3.2600
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4046
Cell Significance Index: -25.5000
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4052
Cell Significance Index: -22.7400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4170
Cell Significance Index: -33.0300
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.4194
Cell Significance Index: -6.3200
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.4204
Cell Significance Index: -4.3600
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4238
Cell Significance Index: -22.2500
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.4528
Cell Significance Index: -11.6400
Cell Name: blood cell (CL0000081)
Fold Change: -0.4634
Cell Significance Index: -3.9500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.4739
Cell Significance Index: -24.6200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4798
Cell Significance Index: -13.4100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4983
Cell Significance Index: -22.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CCL5 is a member of the CC chemokine family, which consists of four subfamilies: C (C-C), C1 (C-C1), C2 (C-C2), and C3 (C-C3). CCL5 is the only member of the C-C subfamily that is induced by interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha), making it a key regulator of inflammatory responses. CCL5 is also known for its ability to bind to multiple chemokine receptors, including CCR1, CCR4, CCR5, and CCR6, which allows it to exert its effects on different cell types. **Pathways and Functions** CCL5 is involved in various signaling pathways, including: 1. **Phospholipase D Activity**: CCL5 activates phospholipase D, an enzyme that regulates cell signaling and membrane trafficking. 2. **Calcium Ion Transport**: CCL5 regulates calcium ion transport, which is essential for cellular signaling and immune responses. 3. **Chemokine Receptor Binding**: CCL5 binds to multiple chemokine receptors, including CCR1, CCR4, CCR5, and CCR6, which allows it to exert its effects on different cell types. 4. **Cellular Response to Fibroblast Growth Factor Stimulus**: CCL5 is involved in the regulation of cellular responses to fibroblast growth factor (FGF) stimuli. 5. **Inflammation and Immune Response**: CCL5 plays a key role in the regulation of inflammatory responses and immune responses, including the recruitment of immune cells to sites of inflammation. **Clinical Significance** CCL5 is involved in various diseases, including: 1. **Asthma**: CCL5 is a key player in the pathogenesis of asthma, where it promotes the recruitment of eosinophils and other immune cells to the airways. 2. **Rheumatoid Arthritis**: CCL5 is involved in the regulation of inflammatory responses in rheumatoid arthritis, where it promotes the recruitment of immune cells to the joints. 3. **HIV Infection**: CCL5 is a key chemokine involved in the replication of HIV, where it promotes the recruitment of immune cells to the site of infection. 4. **Cancer**: CCL5 is involved in the regulation of tumor growth and metastasis, where it promotes the recruitment of immune cells to the tumor microenvironment. In conclusion, CCL5 is a critical chemokine that plays a key role in the regulation of immune responses and inflammation. Its dysregulation has been implicated in various diseases, including asthma, rheumatoid arthritis, HIV infection, and cancer. Further research is needed to fully understand the mechanisms by which CCL5 regulates immune responses and to develop effective therapeutic strategies to modulate its activity.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C-C motif chemokine 5
A0A494C1Q1_HUMAN

Genular Protein ID: 817885315

Symbol: CCL5_HUMAN

Name: C-C motif chemokine 5

UniProtKB Accession Codes:

P13501 O43646 Q0QVW8 Q4ZGJ1 Q9NYA2 Q9UBG2 Q9UC99

Database IDs:

Citations:

PubMed ID: 2456327

Title: A human T cell-specific molecule is a member of a new gene family.

PubMed ID: 2456327

PubMed ID: 10213461

Title: Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES.

PubMed ID: 10213461

DOI: 10.1089/107999099314153

PubMed ID: 16791620

Title: A natural CCL5/RANTES variant antagonist for CCR1 and CCR3.

PubMed ID: 16791620

DOI: 10.1007/s00251-006-0133-2

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1380064

Title: Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils.

PubMed ID: 1380064

DOI: 10.1084/jem.176.2.587

PubMed ID: 7524281

Title: Platelets secrete an eosinophil-chemotactic cytokine which is a member of the C-C-chemokine family.

PubMed ID: 7524281

DOI: 10.1007/978-1-4615-2952-1_13

PubMed ID: 8525373

Title: Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells.

PubMed ID: 8525373

DOI: 10.1126/science.270.5243.1811

PubMed ID: 9516414

Title: Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection.

PubMed ID: 9516414

DOI: 10.1074/jbc.273.13.7222

PubMed ID: 15923218

Title: Multiple pathways of amino terminal processing produce two truncated variants of RANTES/CCL5.

PubMed ID: 15923218

DOI: 10.1189/jlb.0305161

PubMed ID: 17001303

Title: RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75.

PubMed ID: 17001303

DOI: 10.1038/sj.bjp.0706909

PubMed ID: 16963625

Title: N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant.

PubMed ID: 16963625

DOI: 10.1189/jlb.0406290

PubMed ID: 23979485

Title: The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis.

PubMed ID: 23979485

DOI: 10.1007/s00125-013-3022-x

PubMed ID: 25266725

Title: Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and -4 using phage display.

PubMed ID: 25266725

DOI: 10.1074/jbc.m114.599233

PubMed ID: 23765988

Title: A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis.

PubMed ID: 23765988

DOI: 10.1002/jcp.24418

PubMed ID: 32817341

Title: Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4.

PubMed ID: 32817341

DOI: 10.1074/jbc.ra120.013891

PubMed ID: 7537088

Title: Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type.

PubMed ID: 7537088

DOI: 10.1021/bi00016a004

PubMed ID: 7542919

Title: The three-dimensional solution structure of RANTES.

PubMed ID: 7542919

DOI: 10.1021/bi00029a005

PubMed ID: 9889151

Title: Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES.

PubMed ID: 9889151

DOI: 10.1016/s1074-5521(99)80019-2

Sequence Information:

Length: 91
Mass: 9990
Checksum: FB0BFAF9A87C620F
Sequence:

MKVSAAALAV ILIATALCAP ASASPYSSDT TPCCFAYIAR PLPRAHIKEY FYTSGKCSNP 
AVVFVTRKNR QVCANPEKKW VREYINSLEM S

Genular Protein ID: 2349448257

Symbol: A0A494C1Q1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A494C1Q1

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

Length: 154
Mass: 17038
Checksum: E2CF6CBBF7B5F206
Sequence:

MKVSAAALAV ILIATALCAP ASASPYSSDT TPCCFAYIAR PLPRAHIKEY FYTSGKCSNP 
AVVHRSRMPK REGQQVWQDF LYDSRLNKGK LCHPKEPPSV CQPREEMGSG VHQLFGDELG 
WRVLEPELTQ ICLFLLALVL AWEASPHYPT PPAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CCL5

Associated with

Cells (max top 100)

Other Information

A human T cell-specific molecule is a member of a new gene family. PubMed ID: 2456327

Organization of the chemokine gene cluster on human chromosome 17q11.2 containing the genes for CC chemokine MPIF-1, HCC-2, LEC, and RANTES. PubMed ID: 10213461

A natural CCL5/RANTES variant antagonist for CCR1 and CCR3. PubMed ID: 16791620

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. PubMed ID: 1380064

Platelets secrete an eosinophil-chemotactic cytokine which is a member of the C-C-chemokine family. PubMed ID: 7524281

Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. PubMed ID: 8525373

Amino-terminal truncation of chemokines by CD26/dipeptidyl-peptidase IV. Conversion of RANTES into a potent inhibitor of monocyte chemotaxis and HIV-1-infection. PubMed ID: 9516414

Multiple pathways of amino terminal processing produce two truncated variants of RANTES/CCL5. PubMed ID: 15923218

RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75. PubMed ID: 17001303

N-terminal proteolytic processing by cathepsin G converts RANTES/CCL5 and related analogs into a truncated 4-68 variant. PubMed ID: 16963625

The novel chemokine receptor, G-protein-coupled receptor 75, is expressed by islets and is coupled to stimulation of insulin secretion and improved glucose homeostasis. PubMed ID: 23979485

Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and -4 using phage display. PubMed ID: 25266725

A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis. PubMed ID: 23765988

Structural characterization of anti-CCL5 activity of the tick salivary protein evasin-4. PubMed ID: 32817341

Proton NMR assignments and solution conformation of RANTES, a chemokine of the C-C type. PubMed ID: 7537088

The three-dimensional solution structure of RANTES. PubMed ID: 7542919

Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES. PubMed ID: 9889151

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196