Details for: CCL17

Gene ID: 6361

Symbol: CCL17

Ensembl ID: ENSG00000102970

Description: C-C motif chemokine ligand 17

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.1738
    Cell Significance Index: 14.4300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.7113
    Cell Significance Index: 24.8500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.6440
    Cell Significance Index: 22.5500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.4839
    Cell Significance Index: 13.4200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.6694
    Cell Significance Index: 11.5000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4841
    Cell Significance Index: 7.4900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1314
    Cell Significance Index: 3.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0411
    Cell Significance Index: 1.0600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0048
    Cell Significance Index: 0.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0041
    Cell Significance Index: 0.5100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0001
    Cell Significance Index: 0.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0006
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0014
    Cell Significance Index: -2.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0019
    Cell Significance Index: -1.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0047
    Cell Significance Index: -3.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0050
    Cell Significance Index: -6.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0056
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0060
    Cell Significance Index: -3.2500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0062
    Cell Significance Index: -1.7700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0094
    Cell Significance Index: -5.2800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0098
    Cell Significance Index: -1.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0099
    Cell Significance Index: -4.4900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0108
    Cell Significance Index: -1.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0116
    Cell Significance Index: -4.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0133
    Cell Significance Index: -2.6400
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: -0.0146
    Cell Significance Index: -0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0184
    Cell Significance Index: -2.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0203
    Cell Significance Index: -4.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0204
    Cell Significance Index: -2.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0212
    Cell Significance Index: -3.6200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0238
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0255
    Cell Significance Index: -0.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0295
    Cell Significance Index: -1.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0310
    Cell Significance Index: -4.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0389
    Cell Significance Index: -1.0900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0394
    Cell Significance Index: -0.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0413
    Cell Significance Index: -4.3000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0421
    Cell Significance Index: -1.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0423
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0468
    Cell Significance Index: -5.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0513
    Cell Significance Index: -3.3100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0538
    Cell Significance Index: -2.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0599
    Cell Significance Index: -3.1100
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0608
    Cell Significance Index: -0.6300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0610
    Cell Significance Index: -3.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0614
    Cell Significance Index: -4.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0633
    Cell Significance Index: -2.5900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0637
    Cell Significance Index: -4.8900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0688
    Cell Significance Index: -1.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0836
    Cell Significance Index: -1.7500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0848
    Cell Significance Index: -0.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0868
    Cell Significance Index: -3.0400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0889
    Cell Significance Index: -1.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0896
    Cell Significance Index: -5.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0904
    Cell Significance Index: -3.3200
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0917
    Cell Significance Index: -2.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0933
    Cell Significance Index: -2.9700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0939
    Cell Significance Index: -3.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0969
    Cell Significance Index: -2.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0974
    Cell Significance Index: -2.6500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1064
    Cell Significance Index: -2.8400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1075
    Cell Significance Index: -0.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1123
    Cell Significance Index: -3.2200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1127
    Cell Significance Index: -1.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1149
    Cell Significance Index: -3.0800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1160
    Cell Significance Index: -5.1300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1239
    Cell Significance Index: -1.5700
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1253
    Cell Significance Index: -2.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1259
    Cell Significance Index: -2.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1260
    Cell Significance Index: -3.2200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1271
    Cell Significance Index: -3.1700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1293
    Cell Significance Index: -0.8800
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.1314
    Cell Significance Index: -0.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1344
    Cell Significance Index: -5.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1366
    Cell Significance Index: -2.9900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1400
    Cell Significance Index: -2.4000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1413
    Cell Significance Index: -3.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1435
    Cell Significance Index: -2.0600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1443
    Cell Significance Index: -2.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1470
    Cell Significance Index: -3.1200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1477
    Cell Significance Index: -4.6700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.1481
    Cell Significance Index: -1.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1500
    Cell Significance Index: -4.2800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1511
    Cell Significance Index: -2.9500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1520
    Cell Significance Index: -3.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1524
    Cell Significance Index: -3.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1527
    Cell Significance Index: -3.3000
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1559
    Cell Significance Index: -1.5200
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1564
    Cell Significance Index: -1.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1603
    Cell Significance Index: -1.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1610
    Cell Significance Index: -1.7500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1623
    Cell Significance Index: -1.9100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1635
    Cell Significance Index: -3.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1643
    Cell Significance Index: -3.4300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1651
    Cell Significance Index: -3.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1654
    Cell Significance Index: -3.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1679
    Cell Significance Index: -5.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL17 exhibits several key characteristics that distinguish it from other chemokines: 1. **Chemokine structure**: CCL17 is a small, secreted protein composed of 8 amino acids, with a characteristic C-C motif at its N-terminus. 2. **Receptor specificity**: CCL17 binds to specific receptors, including CCR6, which is expressed on the surface of T helper 2 (Th2) cells, dendritic cells, and other immune cells. 3. **Chemotactic activity**: CCL17 exhibits chemotactic activity, attracting immune cells to sites of inflammation and promoting their recruitment to lymphoid organs. 4. **Immunomodulatory effects**: CCL17 can modulate immune responses by promoting the activation and proliferation of Th2 cells, which are involved in the regulation of allergic responses and inflammation. **Pathways and Functions** CCL17 is involved in several signaling pathways that regulate immune responses: 1. **Chemokine receptor signaling**: CCL17 binds to CCR6, triggering a signaling cascade that activates downstream pathways, including the MAPK/ERK and PI3K/AKT signaling pathways. 2. **JAK/STAT signaling**: CCL17 also activates the JAK/STAT signaling pathway, which regulates the expression of genes involved in immune responses. 3. **NF-κB signaling**: CCL17 can activate the NF-κB transcription factor, which regulates the expression of genes involved in inflammation and immune responses. 4. **Cell-cell signaling**: CCL17 can interact with other chemokines and cytokines to regulate cell-cell signaling, promoting the recruitment of immune cells to sites of inflammation. **Clinical Significance** CCL17 has significant implications for various diseases, including: 1. **Allergic disorders**: CCL17 is involved in the regulation of Th2 responses, making it a potential target for the treatment of allergic disorders, such as asthma and atopic dermatitis. 2. **Inflammatory diseases**: CCL17 can contribute to the development of inflammatory diseases, such as rheumatoid arthritis and multiple sclerosis, by promoting the recruitment of immune cells to sites of inflammation. 3. **Cancer**: CCL17 is expressed in various types of cancer, including leukemia and lymphoma, where it may contribute to tumor progression and metastasis. 4. **Immunomodulatory therapies**: CCL17 may be used as a target for immunomodulatory therapies, such as vaccines and immunotherapies, to regulate immune responses and prevent disease. In conclusion, CCL17 is a chemokine that plays a critical role in regulating immune responses, particularly in the recruitment of immune cells to sites of inflammation. Its involvement in various diseases, including allergic disorders, inflammatory diseases, and cancer, highlights its potential as a therapeutic target for the treatment of these conditions.

Genular Protein ID: 2981132841

Symbol: CCL17_HUMAN

Name: C-C motif chemokine 17

UniProtKB Accession Codes:

Q92583 A0N0Q9 Q2M287

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8702936

Title: Molecular cloning of a novel T cell-directed CC chemokine expressed in thymus by signal sequence trap using Epstein-Barr virus vector.

PubMed ID: 8702936

DOI: 10.1074/jbc.271.35.21514

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9169480

Title: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4.

PubMed ID: 9169480

DOI: 10.1074/jbc.272.23.15036

PubMed ID: 9521068

Title: Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor.

PubMed ID: 9521068

DOI: 10.1002/(sici)1521-4141(199802)28:02<582::aid-immu582>3.0.co;2-a

PubMed ID: 10540332

Title: The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8.

PubMed ID: 10540332

DOI: 10.1002/(sici)1521-4141(199910)29:10<3210::aid-immu3210>3.0.co;2-w

PubMed ID: 27525438

Title: Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation.

PubMed ID: 27525438

DOI: 10.1172/jci87828

PubMed ID: 29871928

Title: Epigenetic and transcriptional regulation of IL4-induced CCL17 production in human monocytes and murine macrophages.

PubMed ID: 29871928

DOI: 10.1074/jbc.ra118.002416

PubMed ID: 12832759

Title: Structures of thymus and activation-regulated chemokine (TARC).

PubMed ID: 12832759

DOI: 10.1107/s0907444903009454

Sequence Information:

  • Length: 94
  • Mass: 10507
  • Checksum: 7959C56BA8FDAF08
  • Sequence:
    • MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD 
AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.