Details for: CCL22

Gene ID: 6367

Symbol: CCL22

Ensembl ID: ENSG00000102962

Description: C-C motif chemokine ligand 22

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 9.0257
    Cell Significance Index: 155.0600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.0752
    Cell Significance Index: 27.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.6023
    Cell Significance Index: 16.1400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.5820
    Cell Significance Index: 8.4500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4137
    Cell Significance Index: 6.4000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3227
    Cell Significance Index: 4.4300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.2837
    Cell Significance Index: 3.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0739
    Cell Significance Index: 1.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0221
    Cell Significance Index: 2.8600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0217
    Cell Significance Index: 1.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0185
    Cell Significance Index: 2.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0035
    Cell Significance Index: 1.5500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.0017
    Cell Significance Index: 0.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0038
    Cell Significance Index: -6.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0046
    Cell Significance Index: -2.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0052
    Cell Significance Index: -1.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0054
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0060
    Cell Significance Index: -4.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0077
    Cell Significance Index: -4.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0095
    Cell Significance Index: -2.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0100
    Cell Significance Index: -5.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0106
    Cell Significance Index: -3.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0107
    Cell Significance Index: -4.8600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0119
    Cell Significance Index: -0.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0135
    Cell Significance Index: -0.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0145
    Cell Significance Index: -1.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0150
    Cell Significance Index: -2.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0157
    Cell Significance Index: -1.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0159
    Cell Significance Index: -3.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0172
    Cell Significance Index: -3.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0194
    Cell Significance Index: -0.5400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0205
    Cell Significance Index: -0.5100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0206
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0213
    Cell Significance Index: -3.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0233
    Cell Significance Index: -2.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0241
    Cell Significance Index: -0.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0242
    Cell Significance Index: -2.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0277
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0350
    Cell Significance Index: -4.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0392
    Cell Significance Index: -0.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0397
    Cell Significance Index: -1.8500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0414
    Cell Significance Index: -1.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0450
    Cell Significance Index: -6.1800
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0465
    Cell Significance Index: -0.5100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0473
    Cell Significance Index: -4.9200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0501
    Cell Significance Index: -1.4700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0529
    Cell Significance Index: -0.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0540
    Cell Significance Index: -3.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0561
    Cell Significance Index: -1.5000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0628
    Cell Significance Index: -3.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0659
    Cell Significance Index: -1.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0714
    Cell Significance Index: -4.8000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0717
    Cell Significance Index: -3.2500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0739
    Cell Significance Index: -0.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0790
    Cell Significance Index: -6.0600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0902
    Cell Significance Index: -0.7800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0950
    Cell Significance Index: -0.9400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0967
    Cell Significance Index: -1.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1033
    Cell Significance Index: -2.5800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.1036
    Cell Significance Index: -1.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1088
    Cell Significance Index: -0.7400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1110
    Cell Significance Index: -1.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1172
    Cell Significance Index: -3.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1190
    Cell Significance Index: -6.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1202
    Cell Significance Index: -4.2100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1207
    Cell Significance Index: -3.2900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1249
    Cell Significance Index: -7.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1255
    Cell Significance Index: -2.4500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1260
    Cell Significance Index: -1.3700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1270
    Cell Significance Index: -2.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1292
    Cell Significance Index: -3.4500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1304
    Cell Significance Index: -1.9000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1304
    Cell Significance Index: -4.2700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1313
    Cell Significance Index: -1.9200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1319
    Cell Significance Index: -2.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1326
    Cell Significance Index: -4.2200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1347
    Cell Significance Index: -2.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1366
    Cell Significance Index: -3.4900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1378
    Cell Significance Index: -4.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1404
    Cell Significance Index: -6.2100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1456
    Cell Significance Index: -3.7100
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: -0.1547
    Cell Significance Index: -0.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1648
    Cell Significance Index: -6.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1703
    Cell Significance Index: -4.8600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.1738
    Cell Significance Index: -1.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1760
    Cell Significance Index: -4.3900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1770
    Cell Significance Index: -3.4600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1863
    Cell Significance Index: -6.8400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1893
    Cell Significance Index: -4.0900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1914
    Cell Significance Index: -4.5900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1947
    Cell Significance Index: -3.4400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2021
    Cell Significance Index: -4.2900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2048
    Cell Significance Index: -3.5000
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: -0.2065
    Cell Significance Index: -1.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2087
    Cell Significance Index: -4.1900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2088
    Cell Significance Index: -3.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL22 is a member of the CC chemokine family, which is characterized by the presence of two conserved cysteine residues at positions 1 and 4 of the protein sequence. This chemokine is known for its ability to bind to the CCR4 receptor, which is a specific chemokine receptor that is expressed on various immune cells, including T cells, dendritic cells, and eosinophils. CCL22 is also unique in that it can bind to the CCR7 receptor, which is expressed on naive T cells, and this interaction is thought to play a role in the migration of these cells to lymphoid organs. **Pathways and Functions** CCL22 is involved in various signaling pathways that regulate immune responses, including: 1. **Chemokine-mediated signaling pathway**: CCL22 binds to its receptors, CCR4 and CCR7, which triggers the activation of downstream signaling pathways, including the ERK/MAPK pathway and the NF-kB pathway. 2. **Cell-cell signaling**: CCL22 interacts with other chemokines and cytokines to regulate the recruitment of immune cells to sites of inflammation and injury. 3. **Cytokine signaling in immune system**: CCL22 is induced by various cytokines, including IL-4, IL-13, and TNF-alpha, and its expression is thought to play a role in the regulation of immune responses, including the differentiation of T cells and the production of cytokines. 4. **Dectin-1 mediated noncanonical NF-kB signaling**: CCL22 is also involved in the activation of the noncanonical NF-kB pathway, which is mediated by the CCR7 receptor and the dectin-1 receptor. CCL22 plays a crucial role in various physiological and pathological processes, including: 1. **Immune response**: CCL22 is involved in the recruitment of immune cells to sites of inflammation and injury, and its expression is thought to play a role in the regulation of immune responses, including the differentiation of T cells and the production of cytokines. 2. **Inflammation**: CCL22 is expressed in inflamed tissues and is thought to play a role in the recruitment of immune cells to these sites. 3. **Tissue repair**: CCL22 is also involved in the regulation of tissue repair, including the recruitment of stem cells to sites of injury. **Clinical Significance** CCL22 has been implicated in various diseases, including: 1. **Allergic diseases**: CCL22 is thought to play a role in the pathogenesis of allergic diseases, including asthma and atopic dermatitis. 2. **Cancer**: CCL22 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer, and its expression is thought to be associated with tumor progression and metastasis. 3. **Inflammatory diseases**: CCL22 is involved in the pathogenesis of inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease. In conclusion, CCL22 is a chemokine that plays a crucial role in the regulation of immune responses, particularly in the context of inflammation and tissue repair. Its expression is induced by various cytokines, and its binding to specific receptors, including CCR4 and CCR7, triggers the activation of downstream signaling pathways that regulate immune responses. CCL22 has been implicated in various diseases, including allergic diseases, cancer, and inflammatory diseases, and its expression is thought to play a role in the pathogenesis of these diseases.

Genular Protein ID: 3395778197

Symbol: CCL22_HUMAN

Name: C-C motif chemokine 22

UniProtKB Accession Codes:

O00626 A0N0Q6 B2R4W2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 3 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9312138

Title: Molecular cloning and functional characterization of a novel CC chemokine, stimulated T cell chemotactic protein (STCP-1) that specifically acts on activated T lymphocytes.

PubMed ID: 9312138

DOI: 10.1074/jbc.272.40.25229

PubMed ID: 9151897

Title: Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells.

PubMed ID: 9151897

DOI: 10.1084/jem.185.9.1595

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9430724

Title: Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4.

PubMed ID: 9430724

DOI: 10.1074/jbc.273.3.1764

PubMed ID: 11241286

Title: Dendritic cells as a major source of macrophage-derived chemokine/CCL22 in vitro and in vivo.

PubMed ID: 11241286

DOI: 10.1002/1521-4141(200103)31:3<812::aid-immu812>3.0.co;2-l

Sequence Information:

  • Length: 93
  • Mass: 10625
  • Checksum: 641FCE999586A7D2
  • Sequence:
    • MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV KHFYWTSDSC 
PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.