Details for: CXCL9

Gene ID: 4283

Symbol: CXCL9

Ensembl ID: ENSG00000138755

Description: C-X-C motif chemokine ligand 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.7474
    Cell Significance Index: -7.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 16.5312
    Cell Significance Index: -6.8100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 6.7525
    Cell Significance Index: 237.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.4437
    Cell Significance Index: 99.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.1237
    Cell Significance Index: 78.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 3.0594
    Cell Significance Index: 63.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.8259
    Cell Significance Index: 173.2600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.3999
    Cell Significance Index: 37.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1245
    Cell Significance Index: 50.9700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.8555
    Cell Significance Index: 10.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7901
    Cell Significance Index: 150.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6164
    Cell Significance Index: 60.9800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.5819
    Cell Significance Index: 5.0000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.5614
    Cell Significance Index: 8.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4792
    Cell Significance Index: 432.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4296
    Cell Significance Index: 13.7600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.3147
    Cell Significance Index: 3.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3070
    Cell Significance Index: 49.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2388
    Cell Significance Index: 25.9700
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2330
    Cell Significance Index: 3.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2275
    Cell Significance Index: 4.8500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.1939
    Cell Significance Index: 2.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1759
    Cell Significance Index: 4.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1067
    Cell Significance Index: 7.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0664
    Cell Significance Index: 3.9900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0225
    Cell Significance Index: 9.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0069
    Cell Significance Index: 0.8800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0058
    Cell Significance Index: 0.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0005
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0028
    Cell Significance Index: -1.5700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0043
    Cell Significance Index: -8.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0059
    Cell Significance Index: -0.3000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0094
    Cell Significance Index: -14.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0096
    Cell Significance Index: -7.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0096
    Cell Significance Index: -0.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0103
    Cell Significance Index: -7.8000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0104
    Cell Significance Index: -6.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0107
    Cell Significance Index: -14.5300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0171
    Cell Significance Index: -9.3200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0183
    Cell Significance Index: -1.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0199
    Cell Significance Index: -9.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0240
    Cell Significance Index: -4.7700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0300
    Cell Significance Index: -8.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0371
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0371
    Cell Significance Index: -6.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0382
    Cell Significance Index: -8.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0405
    Cell Significance Index: -8.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0445
    Cell Significance Index: -6.4700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0457
    Cell Significance Index: -2.3800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0503
    Cell Significance Index: -6.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0545
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0619
    Cell Significance Index: -7.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0697
    Cell Significance Index: -9.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0735
    Cell Significance Index: -8.6700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0775
    Cell Significance Index: -3.6200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0780
    Cell Significance Index: -2.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0788
    Cell Significance Index: -8.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0881
    Cell Significance Index: -2.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0964
    Cell Significance Index: -5.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0990
    Cell Significance Index: -12.7900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1017
    Cell Significance Index: -1.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1184
    Cell Significance Index: -7.9600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1301
    Cell Significance Index: -2.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1364
    Cell Significance Index: -10.4700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1738
    Cell Significance Index: -12.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1872
    Cell Significance Index: -8.8000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1931
    Cell Significance Index: -8.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1937
    Cell Significance Index: -2.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2078
    Cell Significance Index: -12.7700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2292
    Cell Significance Index: -6.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2427
    Cell Significance Index: -9.1900
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.2444
    Cell Significance Index: -2.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2450
    Cell Significance Index: -8.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2568
    Cell Significance Index: -6.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2569
    Cell Significance Index: -9.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2570
    Cell Significance Index: -4.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2575
    Cell Significance Index: -8.2000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2652
    Cell Significance Index: -2.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2665
    Cell Significance Index: -6.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2666
    Cell Significance Index: -3.8700
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2691
    Cell Significance Index: -3.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2796
    Cell Significance Index: -7.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2871
    Cell Significance Index: -7.5500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2885
    Cell Significance Index: -4.2200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.2902
    Cell Significance Index: -4.9600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2981
    Cell Significance Index: -5.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2996
    Cell Significance Index: -8.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3041
    Cell Significance Index: -8.9300
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.3063
    Cell Significance Index: -3.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3072
    Cell Significance Index: -7.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3101
    Cell Significance Index: -11.3900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3210
    Cell Significance Index: -5.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3223
    Cell Significance Index: -8.0400
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.3242
    Cell Significance Index: -4.1500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.3361
    Cell Significance Index: -3.5700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.3367
    Cell Significance Index: -4.6100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3456
    Cell Significance Index: -4.7000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3551
    Cell Significance Index: -3.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3559
    Cell Significance Index: -8.8900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3677
    Cell Significance Index: -10.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CXCL9 shares structural similarities with other C-X-C chemokines, such as CXCL10 and CXCL11. However, its unique sequence and expression profile set it apart from its counterparts. CXCL9 is characterized by its high affinity for the CXCR3 chemokine receptor, which is expressed on various immune cells. This interaction is crucial for the recruitment of CXCL9 to sites of inflammation and infection. **Pathways and Functions** CXCL9 is involved in various signaling pathways that regulate immune responses and chemotaxis. These pathways include: 1. **Adenylate cyclase-activating g protein-coupled receptor signaling pathway**: CXCL9 binds to CXCR3, which activates the adenylate cyclase signaling pathway, leading to increased cAMP levels and subsequent immune cell activation. 2. **Antimicrobial humoral immune response mediated by antimicrobial peptide**: CXCL9 is involved in the recruitment of immune cells that produce antimicrobial peptides, which play a crucial role in combating infections. 3. **Cell-cell signaling**: CXCL9 interacts with CXCR3 to facilitate cell-cell signaling, which is essential for the coordination of immune responses. 4. **Cytokine activity**: CXCL9 is a cytokine that regulates the production of other cytokines and chemokines, which is essential for the modulation of immune responses. **Clinical Significance** CXCL9 plays a significant role in various diseases, including: 1. **Tuberculosis**: CXCL9 is upregulated in tuberculosis, where it recruits immune cells to the site of infection, leading to the activation of macrophages and the release of antimicrobial peptides. 2. **HIV**: CXCL9 is involved in the recruitment of immune cells to the site of HIV infection, where it contributes to the pathogenesis of the disease. 3. **Cancer**: CXCL9 is upregulated in various types of cancer, where it promotes tumor growth and metastasis by recruiting immune suppressive cells. 4. **Autoimmune diseases**: CXCL9 is involved in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, where it contributes to the recruitment of immune cells to sites of inflammation. In conclusion, CXCL9 is a key player in immune response and chemotaxis, and its dysregulation is associated with various diseases. Further research is needed to fully understand the mechanisms by which CXCL9 regulates immune responses and to develop therapeutic strategies to target its activity in disease prevention and treatment.

Genular Protein ID: 43174321

Symbol: CXCL9_HUMAN

Name: C-X-C motif chemokine 9

UniProtKB Accession Codes:

Q07325 Q503B4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 24 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8476424

Title: HuMig: a new human member of the chemokine family of cytokines.

PubMed ID: 8476424

DOI: 10.1006/bbrc.1993.1403

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10233762

Title: Human IP-9: a keratinocyte derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3).

PubMed ID: 10233762

DOI: 10.1046/j.1523-1747.1999.00581.x

Sequence Information:

  • Length: 125
  • Mass: 14019
  • Checksum: 630F8FCFCE125709
  • Sequence:
    • MKKSGVLFLL GIILLVLIGV QGTPVVRKGR CSCISTNQGT IHLQSLKDLK QFAPSPSCEK 
IEIIATLKNG VQTCLNPDSA DVKELIKKWE KQVSQKKKQK NGKKHQKKKV LKVRKSQRSR 
QKKTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.