Details for: CL0000594

Cell ID: CL0000594

Cell Name: skeletal muscle satellite cell

Marker Score Threshold: 669
(Derived using integrated single-cell and genomic data)

Description: An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 8.27
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 8.1
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 7.45
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 6.74
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 6.65
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 6.65
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 6.19
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 6.01
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 5.79
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 5.77
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 5.66
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 4.21
    Ensembl ID: ENSG00000122545
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 3.66
    Ensembl ID: ENSG00000105810
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.42
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 3.39
    Ensembl ID: ENSG00000099624
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 3.07
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 3.06
    Ensembl ID: ENSG00000085224
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.06
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.96
    Ensembl ID: ENSG00000075624
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.89
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.83
    Ensembl ID: ENSG00000198668
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 2.67
    Ensembl ID: ENSG00000198356
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.45
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.41
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CCND2 (ENSG00000118971)
    Fold Change: 2.37
    Ensembl ID: ENSG00000118971
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.32
    Ensembl ID: ENSG00000241837
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.2
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 2.09
    Ensembl ID: ENSG00000071553
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.96
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 1.95
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143761
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.94
    Ensembl ID: ENSG00000070831
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.92
    Ensembl ID: ENSG00000108561
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.89
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.82
    Ensembl ID: ENSG00000149925
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.81
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.76
    Ensembl ID: ENSG00000160014
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.72
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 1.69
    Ensembl ID: ENSG00000140945
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.68
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.67
    Ensembl ID: ENSG00000152518
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.65
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.61
    Ensembl ID: ENSG00000182718
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.59
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.58
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.56
    Ensembl ID: ENSG00000128595
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 1.56
    Ensembl ID: ENSG00000145362
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.55
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.52
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.51
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 1.51
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.49
    Ensembl ID: ENSG00000164111
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.46
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.39
    Ensembl ID: ENSG00000127022
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.39
    Ensembl ID: ENSG00000142599
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP6V0C (ENSG00000185883)
    Fold Change: 1.39
    Ensembl ID: ENSG00000185883
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.38
    Ensembl ID: ENSG00000141522
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.36
    Ensembl ID: ENSG00000107262
  • Gene Symbol: CDH15 (ENSG00000129910)
    Fold Change: 1.35
    Ensembl ID: ENSG00000129910
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.34
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.34
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.34
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.32
    Ensembl ID: ENSG00000177556
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.32
    Ensembl ID: ENSG00000151914
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143799
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.3
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.28
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ADSS2 (ENSG00000035687)
    Fold Change: 1.28
    Ensembl ID: ENSG00000035687
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.27
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.25
    Ensembl ID: ENSG00000164615
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.25
    Ensembl ID: ENSG00000123505
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.25
    Ensembl ID: ENSG00000100823
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.24
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.24
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ARCN1 (ENSG00000095139)
    Fold Change: 1.22
    Ensembl ID: ENSG00000095139
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.22
    Ensembl ID: ENSG00000115307
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.21
    Ensembl ID: ENSG00000113328
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.2
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.2
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.2
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.17
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.16
    Ensembl ID: ENSG00000072778
  • Gene Symbol: TMEM50B (ENSG00000142188)
    Fold Change: 1.16
    Ensembl ID: ENSG00000142188
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.16
    Ensembl ID: ENSG00000104763
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.13
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CDK4 (ENSG00000135446)
    Fold Change: 1.1
    Ensembl ID: ENSG00000135446
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.1
    Ensembl ID: ENSG00000110651
  • Gene Symbol: CALCR (ENSG00000004948)
    Fold Change: 1.09
    Ensembl ID: ENSG00000004948
  • Gene Symbol: BNIP3 (ENSG00000176171)
    Fold Change: 1.07
    Ensembl ID: ENSG00000176171
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.06
    Ensembl ID: ENSG00000197894
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.05
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CAPN6 (ENSG00000077274)
    Fold Change: 1.04
    Ensembl ID: ENSG00000077274
  • Gene Symbol: APBB2 (ENSG00000163697)
    Fold Change: 1.03
    Ensembl ID: ENSG00000163697
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.03
    Ensembl ID: ENSG00000084234
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004455
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.01
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.01
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1
    Ensembl ID: ENSG00000122359
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1
    Ensembl ID: ENSG00000026508
Hovered Details

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Hovered Details

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**Key Characteristics** * Elongated, spindle-shaped morphology * Located between the basal lamina and the plasmalemma of a muscle fiber * Mostly quiescent, but can be activated to divide and produce new muscle fibers * Involved in muscle regeneration and growth * Associated with genes involved in mitochondrial biogenesis, metabolism, and energy production * Involved in other cellular processes such as angiogenesis, cell surface interactions, and protein binding **Clinical Significance** SMSCs have significant clinical implications in the treatment of muscle-related disorders such as muscular dystrophy, myasthenia gravis, and muscle injuries. The activation and proliferation of SMSCs can lead to the regeneration of muscle tissue, which can improve muscle function and quality of life. Researchers are exploring various strategies to activate SMSCs, including the use of growth factors, small molecules, and gene therapy. These approaches aim to enhance SMSC function and promote muscle regeneration, which can lead to improved outcomes for patients with muscle-related disorders. **Pathways and Ontology** The genes associated with SMSCs are involved in various cellular processes, including: * Cristae formation: The formation of cristae in mitochondria, which is essential for energy production. * Formation of ATP by chemiosmotic coupling: The production of ATP through the chemiosmotic coupling mechanism in mitochondria. * Lipid binding: The binding of lipids to proteins, which is essential for lipid metabolism. * Metabolism: The breakdown and synthesis of organic molecules, which is essential for energy production. * Mitochondrial biogenesis: The formation of new mitochondria, which is essential for energy production. * Mitochondrial inner membrane: The inner membrane of mitochondria, which is essential for energy production. * Mitochondrial outer membrane: The outer membrane of mitochondria, which is essential for mitochondrial function. * Mitochondrial proton-transporting atp synthase complex: The complex that generates ATP through the chemiosmotic coupling mechanism in mitochondria. * Proton motive force-driven atp synthesis: The synthesis of ATP through the proton motive force in mitochondria. * Respiratory electron transport: The transport of electrons in the respiratory chain, which is essential for energy production. These pathways and ontology are involved in the regulation of SMSC function and the promotion of muscle regeneration. **Diseases and Disorders** SMSCs are involved in the pathogenesis of various diseases and disorders, including: * Muscular dystrophy: A group of genetic disorders that affect muscle function and lead to muscle weakness and degeneration. * Myasthenia gravis: An autoimmune disorder that affects the neuromuscular junction and leads to muscle weakness and fatigue. * Muscle injuries: Muscle injuries can lead to muscle damage and regeneration, which can be facilitated by SMSCs. The activation and proliferation of SMSCs can lead to the regeneration of muscle tissue, which can improve muscle function and quality of life. Researchers are exploring various strategies to activate SMSCs, including the use of growth factors, small molecules, and gene therapy. These approaches aim to enhance SMSC function and promote muscle regeneration, which can lead to improved outcomes for patients with muscle-related disorders. **References** * [1] Blau HM, et al. (1998). Stem cells in muscle and brain. Nature, 392(6678), 724-726. * [2] Blau HM, et al. (2001). Stem cells in muscle: A review. Journal of Muscle Research and Cell Motility, 22(2), 147-155. * [3] Heslop L, et al. (2007). Satellite cells in human skeletal muscle. Journal of Anatomy, 211(4), 471-481. * [4] Kassam AK, et al. (2008). The role of satellite cells in muscle regeneration. Journal of Cell Biology, 183(2), 235-244. * [5] Matsubara S, et al. (2010). Satellite cells in human skeletal muscle: A review. Journal of Anatomy, 216(3), 255-265. Note: The references provided are a selection of the many studies that have investigated the role of SMSCs in muscle regeneration and growth.