Details for: CAPN6

Gene ID: 827

Symbol: CAPN6

Ensembl ID: ENSG00000077274

Description: calpain 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 2.76
    Marker Score: 2102
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 869
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7498
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.12
    Marker Score: 813
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 1.1
    Marker Score: 356
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.04
    Marker Score: 698
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.97
    Marker Score: 403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.93
    Marker Score: 626.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.83
    Marker Score: 483
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.76
    Marker Score: 500
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.72
    Marker Score: 806
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.7
    Marker Score: 387
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.67
    Marker Score: 2620
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.62
    Marker Score: 1405.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.6
    Marker Score: 1477
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.58
    Marker Score: 476
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.57
    Marker Score: 670
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.52
    Marker Score: 834
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.52
    Marker Score: 2169
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 132.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.49
    Marker Score: 204
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.49
    Marker Score: 1142
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.48
    Marker Score: 113
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.44
    Marker Score: 132
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.39
    Marker Score: 13289
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.38
    Marker Score: 398
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.37
    Marker Score: 159
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.36
    Marker Score: 161
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.33
    Marker Score: 164
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.32
    Marker Score: 608
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.32
    Marker Score: 318
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.31
    Marker Score: 327
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.3
    Marker Score: 208
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.29
    Marker Score: 133
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.29
    Marker Score: 203
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.28
    Marker Score: 289
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.26
    Marker Score: 526.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.25
    Marker Score: 158
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.24
    Marker Score: 233
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.24
    Marker Score: 241
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.24
    Marker Score: 643
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.24
    Marker Score: 206
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.23
    Marker Score: 89.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.22
    Marker Score: 224
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.22
    Marker Score: 289
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.22
    Marker Score: 341
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.22
    Marker Score: 601
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.22
    Marker Score: 3415
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.2
    Marker Score: 194.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.19
    Marker Score: 2559
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.19
    Marker Score: 193
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.19
    Marker Score: 70
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.18
    Marker Score: 111
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.18
    Marker Score: 72
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.18
    Marker Score: 35
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.18
    Marker Score: 190
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.18
    Marker Score: 1119
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.17
    Marker Score: 200.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.16
    Marker Score: 1069
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.16
    Marker Score: 567
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.16
    Marker Score: 91
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.15
    Marker Score: 128
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.15
    Marker Score: 136
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.15
    Marker Score: 81
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.15
    Marker Score: 73
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.15
    Marker Score: 100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.15
    Marker Score: 205
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.14
    Marker Score: 76
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.14
    Marker Score: 236
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 90
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.13
    Marker Score: 38
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.13
    Marker Score: 55

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Other Information

**Key characteristics:** * The CAPN6 gene is located on chromosome 1q21. * It is a member of the CAPN family of endopeptidases, which are involved in the regulation of cell signaling and cytoskeletal dynamics. * CAPN6 is a ubiquitin-dependent protein, which means that it is regulated by the proteasome. * It is a key regulator of the organization and dynamics of the extracellular matrix (ECM). **Pathways and functions:** * CAPN6 is involved in the regulation of cell migration, proliferation, and differentiation. * It is also involved in the degradation of the extracellular matrix, which is essential for the migration of cells and the formation of new tissues. * CAPN6 is a key regulator of microtubule dynamics, which are essential for many cellular processes, including cell migration, organelle transport, and cell division. **Clinical significance:** * Mutations in the CAPN6 gene have been linked to a number of human diseases, including cerebral palsy, muscular dystrophy, and cancer. * CAPN6 inhibitors are being investigated as potential treatments for these diseases. **Other relevant information:** * CAPN6 is a highly conserved protein, with similar genes found in mammals, birds, and fish. * The CAPN6 protein is a multi-domain protein, with a cytoplasmic domain that is responsible for the endoplasmic reticulum-resident activity of the protein, and a nuclear domain that is responsible for the nuclear localization of the protein. * CAPN6 is a ubiquitin-dependent protein, which means that it is regulated by the proteasome. * It is a key regulator of the organization and dynamics of the extracellular matrix.

Genular Protein ID: 4292562886

Symbol: CAN6_HUMAN

Name: Calpain-6

UniProtKB Accession Codes:

Q9Y6Q1 D3DUY7 Q9UEQ1 Q9UJA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339374

Title: A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.

PubMed ID: 9339374

DOI: 10.1006/geno.1997.4870

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17210638

Title: Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.

PubMed ID: 17210638

DOI: 10.1128/mcb.00992-06

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 641
  • Mass: 74576
  • Checksum: A48E5291169B1028
  • Sequence:
    • MGPPLKLFKN QKYQELKQEC IKDSRLFCDP TFLPENDSLF YNRLLPGKVV WKRPQDICDD 
PHLIVGNISN HQLTQGRLGH KPMVSAFSCL AVQESHWTKT IPNHKEQEWD PQKTEKYAGI 
FHFRFWHFGE WTEVVIDDLL PTINGDLVFS FSTSMNEFWN ALLEKAYAKL LGCYEALDGL 
TITDIIVDFT GTLAETVDMQ KGRYTELVEE KYKLFGELYK TFTKGGLICC SIESPNQEEQ 
EVETDWGLLK GHTYTMTDIR KIRLGERLVE VFSAEKVYMV RLRNPLGRQE WSGPWSEISE 
EWQQLTASDR KNLGLVMSDD GEFWMSLEDF CRNFHKLNVC RNVNNPIFGR KELESVLGCW 
TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM SLQQKDLRTY RRMGRPDNYI 
IGFELFKVEM NRKFRLHHLY IQERAGTSTY IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS 
EFLLRIFSEV PVQLRELTLD MPKMSCWNLA RGYPKVVTQI TVHSAEDLEK KYANETVNPY 
LVIKCGKEEV RSPVQKNTVH AIFDTQAIFY RRTTDIPIIV QVWNSRKFCD QFLGQVTLDA 
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.