Details for: CAPN6

Gene ID: 827

Symbol: CAPN6

Ensembl ID: ENSG00000077274

Description: calpain 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 5.1311
    Cell Significance Index: 180.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.5461
    Cell Significance Index: 102.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.2901
    Cell Significance Index: 87.8500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.5985
    Cell Significance Index: 64.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.2738
    Cell Significance Index: 56.8400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.2030
    Cell Significance Index: 23.9500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 1.4473
    Cell Significance Index: 21.8100
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.4310
    Cell Significance Index: 8.4000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.3541
    Cell Significance Index: 32.8000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7323
    Cell Significance Index: 4.5500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.7028
    Cell Significance Index: 11.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6245
    Cell Significance Index: 118.8600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5019
    Cell Significance Index: 10.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4840
    Cell Significance Index: 56.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4829
    Cell Significance Index: 101.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4785
    Cell Significance Index: 47.3300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4644
    Cell Significance Index: 9.7200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.3379
    Cell Significance Index: 2.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2737
    Cell Significance Index: 247.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2632
    Cell Significance Index: 15.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2508
    Cell Significance Index: 7.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2463
    Cell Significance Index: 40.0600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.2205
    Cell Significance Index: 3.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1341
    Cell Significance Index: 3.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0919
    Cell Significance Index: 6.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0789
    Cell Significance Index: 1.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0615
    Cell Significance Index: 38.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0390
    Cell Significance Index: 1.2500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0010
    Cell Significance Index: 0.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0032
    Cell Significance Index: -1.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0042
    Cell Significance Index: -7.9300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0066
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0092
    Cell Significance Index: -1.5700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0095
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0104
    Cell Significance Index: -7.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0119
    Cell Significance Index: -0.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0126
    Cell Significance Index: -0.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0129
    Cell Significance Index: -8.2200
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0153
    Cell Significance Index: -0.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0157
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0165
    Cell Significance Index: -1.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0166
    Cell Significance Index: -4.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0169
    Cell Significance Index: -6.0600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0175
    Cell Significance Index: -0.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0190
    Cell Significance Index: -8.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0227
    Cell Significance Index: -2.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0277
    Cell Significance Index: -3.8100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0336
    Cell Significance Index: -3.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0365
    Cell Significance Index: -7.2400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0367
    Cell Significance Index: -1.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0405
    Cell Significance Index: -8.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0430
    Cell Significance Index: -1.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0431
    Cell Significance Index: -7.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0501
    Cell Significance Index: -1.0400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0595
    Cell Significance Index: -0.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0597
    Cell Significance Index: -6.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0642
    Cell Significance Index: -7.8900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0644
    Cell Significance Index: -8.3200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0774
    Cell Significance Index: -9.1300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0801
    Cell Significance Index: -1.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0991
    Cell Significance Index: -7.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1031
    Cell Significance Index: -2.7100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1115
    Cell Significance Index: -5.2400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1190
    Cell Significance Index: -8.8700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1199
    Cell Significance Index: -1.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1282
    Cell Significance Index: -9.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1293
    Cell Significance Index: -7.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1295
    Cell Significance Index: -8.7100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1421
    Cell Significance Index: -7.4000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1461
    Cell Significance Index: -2.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1479
    Cell Significance Index: -5.1400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1693
    Cell Significance Index: -2.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1811
    Cell Significance Index: -1.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1827
    Cell Significance Index: -10.2500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1838
    Cell Significance Index: -13.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1977
    Cell Significance Index: -10.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2081
    Cell Significance Index: -2.9800
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.2212
    Cell Significance Index: -2.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2238
    Cell Significance Index: -9.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2257
    Cell Significance Index: -2.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2264
    Cell Significance Index: -2.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2281
    Cell Significance Index: -7.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2394
    Cell Significance Index: -6.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2460
    Cell Significance Index: -11.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2508
    Cell Significance Index: -6.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2549
    Cell Significance Index: -8.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2612
    Cell Significance Index: -9.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2618
    Cell Significance Index: -9.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2685
    Cell Significance Index: -8.5500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2695
    Cell Significance Index: -7.2100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2971
    Cell Significance Index: -7.4200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3098
    Cell Significance Index: -8.8400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3307
    Cell Significance Index: -8.2500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3536
    Cell Significance Index: -9.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3727
    Cell Significance Index: -7.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3770
    Cell Significance Index: -8.7100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3771
    Cell Significance Index: -9.2000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3809
    Cell Significance Index: -7.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Calcium-dependent cysteine-type endopeptidase activity:** CAPN6 is a calcium-dependent protease, which means its activity is regulated by the presence of calcium ions. 2. **Regulation of cytoskeleton organization:** CAPN6 is involved in the regulation of cytoskeleton organization, including microtubule bundle formation and microtubule binding. 3. **Protein degradation:** CAPN6 is a protease that degrades proteins, which is essential for cellular processes such as cell signaling and protein turnover. 4. **Widespread expression:** CAPN6 is expressed in various cell types, including skeletal muscle, granulocyte monocyte progenitor cells, enterocytes, goblet cells, and trophoblast giant cells. **Pathways and Functions:** 1. **Calcium-dependent cysteine-type endopeptidase activity:** CAPN6's activity is regulated by the presence of calcium ions, which is essential for its function as a protease. 2. **Regulation of cytoskeleton organization:** CAPN6 is involved in the regulation of cytoskeleton organization, including microtubule bundle formation and microtubule binding. This is essential for maintaining cellular structure and function. 3. **Protein degradation:** CAPN6 is a protease that degrades proteins, which is essential for cellular processes such as cell signaling and protein turnover. 4. **Microtubule binding:** CAPN6 binds to microtubules, which is essential for regulating microtubule organization and function. **Clinical Significance:** 1. **Muscle disorders:** CAPN6 has been associated with muscle disorders, such as muscular dystrophy and myopathy. 2. **Neurological disorders:** CAPN6 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** CAPN6 has been associated with cancer, including colon cancer and breast cancer. 4. **Inflammatory disorders:** CAPN6 has been implicated in inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, CAPN6 is a multifunctional protein that plays critical roles in various cellular processes, including cytoskeleton organization, protein degradation, and cell signaling. Its widespread expression and involvement in various diseases make it an important target for therapeutic interventions. Further research is needed to fully understand the role of CAPN6 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 4292562886

Symbol: CAN6_HUMAN

Name: Calpain-6

UniProtKB Accession Codes:

Q9Y6Q1 D3DUY7 Q9UEQ1 Q9UJA8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 7 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9339374

Title: A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.

PubMed ID: 9339374

DOI: 10.1006/geno.1997.4870

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17210638

Title: Calpain 6 is involved in microtubule stabilization and cytoskeletal organization.

PubMed ID: 17210638

DOI: 10.1128/mcb.00992-06

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 641
  • Mass: 74576
  • Checksum: A48E5291169B1028
  • Sequence:
    • MGPPLKLFKN QKYQELKQEC IKDSRLFCDP TFLPENDSLF YNRLLPGKVV WKRPQDICDD 
PHLIVGNISN HQLTQGRLGH KPMVSAFSCL AVQESHWTKT IPNHKEQEWD PQKTEKYAGI 
FHFRFWHFGE WTEVVIDDLL PTINGDLVFS FSTSMNEFWN ALLEKAYAKL LGCYEALDGL 
TITDIIVDFT GTLAETVDMQ KGRYTELVEE KYKLFGELYK TFTKGGLICC SIESPNQEEQ 
EVETDWGLLK GHTYTMTDIR KIRLGERLVE VFSAEKVYMV RLRNPLGRQE WSGPWSEISE 
EWQQLTASDR KNLGLVMSDD GEFWMSLEDF CRNFHKLNVC RNVNNPIFGR KELESVLGCW 
TVDDDPLMNR SGGCYNNRDT FLQNPQYIFT VPEDGHKVIM SLQQKDLRTY RRMGRPDNYI 
IGFELFKVEM NRKFRLHHLY IQERAGTSTY IDTRTVFLSK YLKKGNYVLV PTMFQHGRTS 
EFLLRIFSEV PVQLRELTLD MPKMSCWNLA RGYPKVVTQI TVHSAEDLEK KYANETVNPY 
LVIKCGKEEV RSPVQKNTVH AIFDTQAIFY RRTTDIPIIV QVWNSRKFCD QFLGQVTLDA 
DPSDCRDLKS LYLRKKGGPT AKVKQGHISF KVISSDDLTE L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.