Details for: SEMA7A

Gene ID: 8482

Symbol: SEMA7A

Ensembl ID: ENSG00000138623

Description: semaphorin 7A (JohnMiltonHagen blood group)

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.8
    Marker Score: 2592
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1155
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.45
    Marker Score: 5623
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.35
    Marker Score: 8014
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.24
    Marker Score: 842
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.15
    Marker Score: 475
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.02
    Marker Score: 1099
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.97
    Marker Score: 314
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 497
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5339
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.93
    Marker Score: 1372
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.92
    Marker Score: 275
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.92
    Marker Score: 1422
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.91
    Marker Score: 16136
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.91
    Marker Score: 1881
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 316
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.82
    Marker Score: 676
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.82
    Marker Score: 3420
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.79
    Marker Score: 7528
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1251
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.75
    Marker Score: 6402
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.74
    Marker Score: 2119
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.74
    Marker Score: 461
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 564
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.73
    Marker Score: 207
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 644
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 281
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2938
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.69
    Marker Score: 6972
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.66
    Marker Score: 157
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.65
    Marker Score: 1101
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.64
    Marker Score: 229
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.64
    Marker Score: 2501
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.61
    Marker Score: 37469
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.54
    Marker Score: 570
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.53
    Marker Score: 19724
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.53
    Marker Score: 338
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.5
    Marker Score: 269.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.47
    Marker Score: 1157
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.46
    Marker Score: 794
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.45
    Marker Score: 225
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.45
    Marker Score: 236
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.42
    Marker Score: 235
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.41
    Marker Score: 1116
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.39
    Marker Score: 298
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.39
    Marker Score: 403
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.38
    Marker Score: 1559
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.36
    Marker Score: 285
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.35
    Marker Score: 1467
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.35
    Marker Score: 574
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.35
    Marker Score: 159
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.34
    Marker Score: 81
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.33
    Marker Score: 201
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.33
    Marker Score: 790
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.32
    Marker Score: 949
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.32
    Marker Score: 192
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.32
    Marker Score: 151
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.3
    Marker Score: 159
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.3
    Marker Score: 107
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.29
    Marker Score: 4382
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.28
    Marker Score: 118
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.28
    Marker Score: 407
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.28
    Marker Score: 484
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.27
    Marker Score: 205
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.27
    Marker Score: 2564
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.26
    Marker Score: 179
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.26
    Marker Score: 8825
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.26
    Marker Score: 2698
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.26
    Marker Score: 106
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 247
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.26
    Marker Score: 1972
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.25
    Marker Score: 226
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.25
    Marker Score: 223
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.25
    Marker Score: 588
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 64
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.24
    Marker Score: 58
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.24
    Marker Score: 247.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.23
    Marker Score: 133
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.23
    Marker Score: 231
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.22
    Marker Score: 235.5
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.22
    Marker Score: 108
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.22
    Marker Score: 161
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62

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Other Information

**Key Characteristics:** 1. **Semaphorin Receptor:** SEMA7A belongs to the semaphorin family, a group of proteins that interact with plexins to regulate cell migration, axon guidance, and immune responses. 2. **Chemorepellent Activity:** SEMA7A exhibits chemorepellent properties, which enable it to repel cells and influence their migration patterns. 3. **Regulation of Axon Extension:** SEMA7A negatively regulates axon extension involved in axon guidance, suggesting its role in fine-tuning neural development. 4. **Immune Regulation:** SEMA7A is involved in the positive regulation of macrophage cytokine production, macrophage activation, and the regulation of inflammatory responses. 5. **Cell Migration:** SEMA7A promotes cell migration by regulating the positive regulation of erk1 and erk2 cascade, which is essential for cell migration and differentiation. **Pathways and Functions:** SEMA7A is involved in various signaling pathways, including: 1. **Semaphorin-Plexin Signaling Pathway:** SEMA7A interacts with plexins to regulate cell migration, axon guidance, and immune responses. 2. **Integrin-Mediated Signaling Pathway:** SEMA7A regulates integrin signaling, which is crucial for cell adhesion, migration, and differentiation. 3. **Erk1 and Erk2 Cascade:** SEMA7A positively regulates the Erk1 and Erk2 cascade, which is essential for cell migration, differentiation, and survival. **Clinical Significance:** 1. **Immune System Disorders:** Alterations in SEMA7A expression have been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, highlighting its potential as a therapeutic target. 2. **Cancer:** SEMA7A has been implicated in cancer development and progression, suggesting its role as a tumor suppressor or oncogene. 3. **Neurological Disorders:** SEMA7A's involvement in axon guidance and neural development makes it a potential candidate for the treatment of neurological disorders, such as autism and schizophrenia. 4. **Regenerative Medicine:** SEMA7A's role in cell migration and differentiation makes it an attractive target for regenerative medicine applications, such as tissue engineering and organ transplantation. In conclusion, SEMA7A is a complex protein involved in various cellular processes, including immune regulation, axon guidance, and development. Its multifaceted role highlights its potential as a therapeutic target for various diseases and disorders, and further research is needed to fully elucidate its functions and mechanisms of action.

Genular Protein ID: 179999846

Symbol: SEM7A_HUMAN

Name: Semaphorin-7A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9721204

Title: New eukaryotic semaphorins with close homology to semaphorins of DNA viruses.

PubMed ID: 9721204

DOI: 10.1006/geno.1998.5256

PubMed ID: 10201933

Title: Molecular cloning of a glycosylphosphatidylinositol-anchored molecule CDw108.

PubMed ID: 10201933

PubMed ID: 9712866

Title: Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins.

PubMed ID: 9712866

DOI: 10.1074/jbc.273.35.22428

PubMed ID: 17207242

Title: The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens.

PubMed ID: 17207242

DOI: 10.1111/j.1537-2995.2007.01076.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10416131

Title: Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules.

PubMed ID: 10416131

DOI: 10.1016/s0171-2985(99)80073-4

PubMed ID: 12879062

Title: Semaphorin 7A promotes axon outgrowth through integrins and MAPKs.

PubMed ID: 12879062

DOI: 10.1038/nature01790

PubMed ID: 17377534

Title: Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin.

PubMed ID: 17377534

DOI: 10.1038/nature05652

PubMed ID: 17671519

Title: Semaphorin 7a promotes spreading and dendricity in human melanocytes through beta1-integrins.

PubMed ID: 17671519

DOI: 10.1038/sj.jid.5700974

PubMed ID: 20727575

Title: Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1.

PubMed ID: 20727575

DOI: 10.1016/j.cell.2010.07.040

PubMed ID: 20854351

Title: A new SEMA7A variant found in Native Americans with alloantibody.

PubMed ID: 20854351

DOI: 10.1111/j.1423-0410.2010.01413.x

PubMed ID: 34585848

Title: A homozygous R148W mutation in Semaphorin 7A causes progressive familial intrahepatic cholestasis.

PubMed ID: 34585848

DOI: 10.15252/emmm.202114563

Sequence Information:

  • Length: 666
  • Mass: 74824
  • Checksum: AD3ABE56B5EBE194
  • Sequence:
  • MTPPPPGRAA PSAPRARVPG PPARLGLPLR LRLLLLLWAA AASAQGHLRS GPRIFAVWKG 
    HVGQDRVDFG QTEPHTVLFH EPGSSSVWVG GRGKVYLFDF PEGKNASVRT VNIGSTKGSC 
    LDKRDCENYI TLLERRSEGL LACGTNARHP SCWNLVNGTV VPLGEMRGYA PFSPDENSLV 
    LFEGDEVYST IRKQEYNGKI PRFRRIRGES ELYTSDTVMQ NPQFIKATIV HQDQAYDDKI 
    YYFFREDNPD KNPEAPLNVS RVAQLCRGDQ GGESSLSVSK WNTFLKAMLV CSDAATNKNF 
    NRLQDVFLLP DPSGQWRDTR VYGVFSNPWN YSAVCVYSLG DIDKVFRTSS LKGYHSSLPN 
    PRPGKCLPDQ QPIPTETFQV ADRHPEVAQR VEPMGPLKTP LFHSKYHYQK VAVHRMQASH 
    GETFHVLYLT TDRGTIHKVV EPGEQEHSFA FNIMEIQPFR RAAAIQTMSL DAERRKLYVS 
    SQWEVSQVPL DLCEVYGGGC HGCLMSRDPY CGWDQGRCIS IYSSERSVLQ SINPAEPHKE 
    CPNPKPDKAP LQKVSLAPNS RYYLSCPMES RHATYSWRHK ENVEQSCEPG HQSPNCILFI 
    ENLTAQQYGH YFCEAQEGSY FREAQHWQLL PEDGIMAEHL LGHACALAAS LWLGVLPTLT 
    LGLLVH

Genular Protein ID: 975830014

Symbol: F5GYX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 501
  • Mass: 57077
  • Checksum: 5EFC380AAB241E70
  • Sequence:
  • MRGYAPFSPD ENSLVLFEGD EVYSTIRKQE YNGKIPRFRR IRGESELYTS DTVMQNPQFI 
    KATIVHQDQA YDDKIYYFFR EDNPDKNPEA PLNVSRVAQL CRGDQGGESS LSVSKWNTFL 
    KAMLVCSDAA TNKNFNRLQD VFLLPDPSGQ WRDTRVYGVF SNPWNYSAVC VYSLGDIDKV 
    FRTSSLKGYH SSLPNPRPGK CLPDQQPIPT ETFQVADRHP EVAQRVEPMG PLKTPLFHSK 
    YHYQKVAVHR MQASHGETFH VLYLTTDRGT IHKVVEPGEQ EHSFAFNIME IQPFRRAAAI 
    QTMSLDAERR KLYVSSQWEV SQVPLDLCEV YGGGCHGCLM SRDPYCGWDQ GRCISIYSSE 
    RSVLQSINPA EPHKECPNPK PDKAPLQKVS LAPNSRYYLS CPMESRHATY SWRHKENVEQ 
    SCEPGHQSPN CILFIENLTA QQYGHYFCEA QEGSYFREAQ HWQLLPEDGI MAEHLLGHAC 
    ALAASLWLGV LPTLTLGLLV H

Genular Protein ID: 3355678140

Symbol: B3KMH6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 379
  • Mass: 42973
  • Checksum: D8042EDD79F88C8F
  • Sequence:
  • MLVCSDAATN KNFNRLQDVF LLPDPSGQWR DTRVYGVFSN PWNYSAVCVY SLGDIDKVFR 
    TSSLKGYHSS LPNPRPGKCL PDQQPIPTET FQVADRHPEV AQRVEPMGPL KTPLFHSKYH 
    YQKVAVHRMQ ASHGETFHVL YLTTDRGTIH KVVEPGEQEH SFAFNIMEIQ PFRRAAAIQT 
    MSLDAERRKL YVSSQWEVSQ VPLDLCEVYG GGCHGCLMSR DPYCGWDQGR CISIYSSERS 
    VLQSINPAEP HKECPNPKPD KAPLQKVSLA PNSRYYLSCP MESRHATYSW RHKENVEQSC 
    EPGHQSPNCI LFIENLTAQQ YGHYFCEAQE GSYFREAQHW QLLPEDGIMA EHLLGHACAL 
    AASLWLGVLP TLTLGLLVH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.