Details for: P2RY6

Gene ID: 5031

Symbol: P2RY6

Ensembl ID: ENSG00000171631

Description: pyrimidinergic receptor P2Y6

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-HSA-373076)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Nucleotide-like (purinergic) receptors
    (R-HSA-418038)
  • P2y receptors
    (R-HSA-417957)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • Apical plasma membrane
    (GO:0016324)
  • Basolateral plasma membrane
    (GO:0016323)
  • Cellular response to prostaglandin e stimulus
    (GO:0071380)
  • Cellular response to purine-containing compound
    (GO:0071415)
  • Cellular response to pyrimidine ribonucleotide
    (GO:1905835)
  • G protein-coupled adp receptor activity
    (GO:0001621)
  • G protein-coupled purinergic nucleotide receptor signaling pathway
    (GO:0035589)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • G protein-coupled udp receptor activity
    (GO:0045029)
  • G protein-coupled utp receptor activity
    (GO:0045030)
  • Phagocytosis
    (GO:0006909)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
    (GO:0031587)
  • Positive regulation of inositol trisphosphate biosynthetic process
    (GO:0032962)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of vascular associated smooth muscle cell proliferation
    (GO:1904707)
  • Protein binding
    (GO:0005515)
  • Transepithelial chloride transport
    (GO:0030321)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 58.2789
    Cell Significance Index: -9.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.8771
    Cell Significance Index: -9.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 18.6089
    Cell Significance Index: -7.5600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.3441
    Cell Significance Index: -9.0600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.3792
    Cell Significance Index: 90.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.3155
    Cell Significance Index: 191.2300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7042
    Cell Significance Index: 22.5600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.5344
    Cell Significance Index: 6.6100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.5313
    Cell Significance Index: 5.5000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3823
    Cell Significance Index: 72.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2412
    Cell Significance Index: 6.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1513
    Cell Significance Index: 136.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1466
    Cell Significance Index: 29.0900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1363
    Cell Significance Index: 13.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0938
    Cell Significance Index: 5.6300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0883
    Cell Significance Index: 0.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0869
    Cell Significance Index: 9.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0742
    Cell Significance Index: 12.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0621
    Cell Significance Index: 33.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0482
    Cell Significance Index: 1.3900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0459
    Cell Significance Index: 1.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0424
    Cell Significance Index: 3.2500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0347
    Cell Significance Index: 6.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0131
    Cell Significance Index: 0.9000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0126
    Cell Significance Index: 19.4100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0028
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.4600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0046
    Cell Significance Index: -1.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0065
    Cell Significance Index: -0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0072
    Cell Significance Index: -9.7300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0129
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0152
    Cell Significance Index: -5.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0172
    Cell Significance Index: -7.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -10.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0183
    Cell Significance Index: -0.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0220
    Cell Significance Index: -0.5500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0222
    Cell Significance Index: -0.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0235
    Cell Significance Index: -0.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0322
    Cell Significance Index: -4.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0360
    Cell Significance Index: -0.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0385
    Cell Significance Index: -3.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0416
    Cell Significance Index: -5.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0424
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0454
    Cell Significance Index: -9.5700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0524
    Cell Significance Index: -8.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0617
    Cell Significance Index: -3.1200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0646
    Cell Significance Index: -1.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0656
    Cell Significance Index: -9.0100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0677
    Cell Significance Index: -8.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0707
    Cell Significance Index: -8.2400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0711
    Cell Significance Index: -1.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0718
    Cell Significance Index: -1.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0803
    Cell Significance Index: -1.2100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0813
    Cell Significance Index: -9.5900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0820
    Cell Significance Index: -9.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0885
    Cell Significance Index: -9.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0951
    Cell Significance Index: -7.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0970
    Cell Significance Index: -2.7100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1038
    Cell Significance Index: -4.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1062
    Cell Significance Index: -6.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1092
    Cell Significance Index: -8.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1159
    Cell Significance Index: -7.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1292
    Cell Significance Index: -6.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1355
    Cell Significance Index: -6.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1401
    Cell Significance Index: -7.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1434
    Cell Significance Index: -9.2500
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1448
    Cell Significance Index: -0.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1466
    Cell Significance Index: -4.6700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1477
    Cell Significance Index: -9.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1480
    Cell Significance Index: -3.9600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1589
    Cell Significance Index: -6.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1634
    Cell Significance Index: -7.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1790
    Cell Significance Index: -10.0400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1799
    Cell Significance Index: -1.7800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1823
    Cell Significance Index: -2.5900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1916
    Cell Significance Index: -4.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1988
    Cell Significance Index: -10.4400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2140
    Cell Significance Index: -3.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2286
    Cell Significance Index: -8.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2286
    Cell Significance Index: -8.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2395
    Cell Significance Index: -10.6000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2402
    Cell Significance Index: -3.8100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.2409
    Cell Significance Index: -1.7300
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.2415
    Cell Significance Index: -1.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2465
    Cell Significance Index: -6.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2565
    Cell Significance Index: -4.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2599
    Cell Significance Index: -8.5100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2615
    Cell Significance Index: -3.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2752
    Cell Significance Index: -10.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2755
    Cell Significance Index: -3.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2813
    Cell Significance Index: -8.2900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2841
    Cell Significance Index: -4.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2885
    Cell Significance Index: -7.7300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2988
    Cell Significance Index: -3.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** P2Y6 is a GPCR that belongs to the Class A/1 (rhodopsin-like receptors) subfamily. It is a heterotrimeric receptor composed of three subunits: α, β, and γ. The receptor is activated by binding of pyrimidine-containing compounds, such as adenosine and uridine, which triggers a conformational change in the receptor, leading to activation of G proteins and downstream signaling pathways. P2Y6 is widely expressed in various tissues, including the nervous system, placenta, colon, and immune cells, and has been implicated in various physiological and pathological processes, including inflammation, immune responses, and cardiovascular diseases. **Pathways and Functions:** P2Y6 activation leads to the activation of phospholipase C (PLC) activity, which in turn triggers the production of inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 mediates the release of calcium from intracellular stores, while DAG activates protein kinase C (PKC), leading to various downstream signaling events. P2Y6 has also been implicated in the regulation of smooth muscle cell migration, vascular associated smooth muscle cell proliferation, and transepithelial chloride transport. Furthermore, P2Y6 has been shown to modulate immune responses, including the activation of innate lymphoid cells and the regulation of inflammatory responses. **Clinical Significance:** P2Y6 has been implicated in various diseases, including inflammatory bowel disease, cardiovascular disease, and cancer. In inflammatory bowel disease, P2Y6 has been shown to play a role in the regulation of inflammation and immune responses. In cardiovascular disease, P2Y6 has been implicated in the regulation of vascular smooth muscle cell proliferation and migration. In cancer, P2Y6 has been shown to promote tumor growth and metastasis. Therefore, P2Y6 represents a promising target for the development of novel therapeutic strategies for these diseases. **Significantly Expressed Cells:** P2Y6 is widely expressed in various tissues, including: * Neural progenitor cells * Placental villous trophoblast * Colon goblet cells * Immature innate lymphoid cells * Enterocytes of the epithelium of large intestine * Cardiac endothelial cells * Enterocytes of the colon * Enterocytes of the epithelium of small intestine * Cardiac muscle myoblasts * Myeloid leukocytes In conclusion, P2Y6 is a complex GPCR that plays a crucial role in various physiological and pathological processes. Its involvement in inflammation, immune responses, and cardiovascular disease makes it a promising target for the development of novel therapeutic strategies. Further research is needed to fully elucidate the mechanisms of P2Y6 and its clinical significance.

Genular Protein ID: 3594485101

Symbol: P2RY6_HUMAN

Name: P2Y purinoceptor 6

UniProtKB Accession Codes:

Q15077 Q15754

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 9 Ensembl 13 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 12 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8670200

Title: Cloning, functional expression and tissue distribution of the human P2Y6 receptor.

PubMed ID: 8670200

DOI: 10.1006/bbrc.1996.0739

PubMed ID: 9286708

Title: Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family.

PubMed ID: 9286708

DOI: 10.1006/geno.1997.4841

PubMed ID: 9268704

Title: Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.

PubMed ID: 9268704

DOI: 10.1006/bbrc.1997.7135

PubMed ID: 9412455

Title:

PubMed ID: 9412455

DOI: 10.1006/bbrc.1997.7653

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 328
  • Mass: 36429
  • Checksum: AAD6C55A43818107
  • Sequence:
    • MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ ICTSRRALTR 
TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR LVRFLFYANL HGSILFLTCI 
SFQRYLGICH PLAPWHKRGG RRAAWLVCVA VWLAVTTQCL PTAIFAATGI QRNRTVCYDL 
SPPALATHYM PYGMALTVIG FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM 
AVVVAAAFAI SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL 
FYFTQKKFRR RPHELLQKLT AKWQRQGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.