Details for: LST1

Gene ID: 7940

Symbol: LST1

Ensembl ID: ENSG00000204482

Description: leukocyte specific transcript 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 91.0989
    Cell Significance Index: -14.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 47.3099
    Cell Significance Index: -19.2200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 38.0065
    Cell Significance Index: -19.5500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.7232
    Cell Significance Index: -17.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 26.4969
    Cell Significance Index: -17.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.9428
    Cell Significance Index: -20.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1521
    Cell Significance Index: -13.7500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 10.5861
    Cell Significance Index: 195.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 10.1025
    Cell Significance Index: 258.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.5980
    Cell Significance Index: -17.6800
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 5.4710
    Cell Significance Index: 22.7700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.1787
    Cell Significance Index: 80.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2245
    Cell Significance Index: -16.6700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5953
    Cell Significance Index: -5.6800
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.6950
    Cell Significance Index: 11.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8342
    Cell Significance Index: 24.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5399
    Cell Significance Index: 15.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4297
    Cell Significance Index: 27.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4184
    Cell Significance Index: 9.0700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3904
    Cell Significance Index: 9.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2188
    Cell Significance Index: 197.5500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1668
    Cell Significance Index: 0.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1488
    Cell Significance Index: 17.5500
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.1260
    Cell Significance Index: 1.2300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1168
    Cell Significance Index: 2.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0754
    Cell Significance Index: 7.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0741
    Cell Significance Index: 12.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0562
    Cell Significance Index: 10.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0261
    Cell Significance Index: 2.6700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0080
    Cell Significance Index: -15.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0128
    Cell Significance Index: -19.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0157
    Cell Significance Index: -0.5500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0185
    Cell Significance Index: -0.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0210
    Cell Significance Index: -11.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0251
    Cell Significance Index: -11.0800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0260
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0267
    Cell Significance Index: -19.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0279
    Cell Significance Index: -15.7200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0304
    Cell Significance Index: -19.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0315
    Cell Significance Index: -1.9300
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0316
    Cell Significance Index: -0.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0345
    Cell Significance Index: -7.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0401
    Cell Significance Index: -6.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0430
    Cell Significance Index: -19.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0435
    Cell Significance Index: -15.6100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0440
    Cell Significance Index: -8.7300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0586
    Cell Significance Index: -2.9600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0752
    Cell Significance Index: -1.4700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0770
    Cell Significance Index: -15.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0848
    Cell Significance Index: -15.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0867
    Cell Significance Index: -11.9000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0881
    Cell Significance Index: -4.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1067
    Cell Significance Index: -4.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1134
    Cell Significance Index: -14.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1269
    Cell Significance Index: -14.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1287
    Cell Significance Index: -15.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1304
    Cell Significance Index: -18.9500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1370
    Cell Significance Index: -17.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1434
    Cell Significance Index: -15.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1438
    Cell Significance Index: -16.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1489
    Cell Significance Index: -7.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1504
    Cell Significance Index: -15.6600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1713
    Cell Significance Index: -2.9100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1930
    Cell Significance Index: -1.9700
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2059
    Cell Significance Index: -1.7400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.2095
    Cell Significance Index: -2.1700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2148
    Cell Significance Index: -3.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2158
    Cell Significance Index: -16.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2346
    Cell Significance Index: -16.2300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2419
    Cell Significance Index: -18.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2494
    Cell Significance Index: -19.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2577
    Cell Significance Index: -16.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2659
    Cell Significance Index: -13.8500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2843
    Cell Significance Index: -4.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3135
    Cell Significance Index: -8.3900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3147
    Cell Significance Index: -2.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3153
    Cell Significance Index: -16.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3197
    Cell Significance Index: -17.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3199
    Cell Significance Index: -13.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3337
    Cell Significance Index: -17.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3453
    Cell Significance Index: -9.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3550
    Cell Significance Index: -16.5500
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3844
    Cell Significance Index: -3.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3973
    Cell Significance Index: -3.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3989
    Cell Significance Index: -8.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4123
    Cell Significance Index: -11.0100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.4196
    Cell Significance Index: -3.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4204
    Cell Significance Index: -18.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4423
    Cell Significance Index: -11.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4484
    Cell Significance Index: -5.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4495
    Cell Significance Index: -16.5000
  • Cell Name: phagocyte (CL0000234)
    Fold Change: -0.4560
    Cell Significance Index: -3.3600
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.4577
    Cell Significance Index: -5.8000
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4622
    Cell Significance Index: -6.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4630
    Cell Significance Index: -16.2200
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: -0.4691
    Cell Significance Index: -4.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding RNA:** LST1 is a non-coding RNA, meaning it does not encode a protein. Instead, it regulates gene expression through various mechanisms, including transcriptional regulation and post-transcriptional modification. 2. **Specific expression in leukocytes:** LST1 is predominantly expressed in leukocytes, particularly in monocytes, dendritic cells, and macrophages, which are key players in the immune system. 3. **Regulation of immune response:** LST1 is involved in the regulation of immune response, including negative regulation of lymphocyte proliferation and immune response. 4. **Cell shape regulation:** LST1 also plays a role in regulating cell shape, which is essential for the proper functioning of immune cells. **Pathways and Functions:** 1. **Immune response regulation:** LST1 regulates immune response by modulating the activity of immune cells, such as monocytes and dendritic cells, which are essential for the initiation and regulation of immune responses. 2. **Negative regulation of lymphocyte proliferation:** LST1 negatively regulates lymphocyte proliferation, which is crucial for preventing excessive immune responses and maintaining immune homeostasis. 3. **Dendrite development:** LST1 is involved in the regulation of dendrite development, which is essential for the formation of functional immune cells, such as dendritic cells. 4. **Golgi apparatus regulation:** LST1 regulates the activity of the Golgi apparatus, which is involved in protein processing and modification, essential for the proper functioning of immune cells. **Clinical Significance:** 1. **Immunodeficiency disorders:** Dysregulation of LST1 has been implicated in various immunodeficiency disorders, including autoimmune diseases and cancer. 2. **Infectious diseases:** LST1 plays a crucial role in regulating immune responses to infectious diseases, and its dysregulation can lead to increased susceptibility to infections. 3. **Cancer:** LST1 has been shown to regulate the activity of immune cells, and its dysregulation can contribute to cancer development and progression. 4. **Therapeutic applications:** Understanding the role of LST1 in immune regulation and development can lead to the development of novel therapeutic strategies for the treatment of immunodeficiency disorders and infectious diseases. In conclusion, LST1 is a critical regulator of immune response and cell shape, and its dysregulation can have significant consequences for human health. Further research is necessary to fully understand the functional significance of LST1 and its potential therapeutic applications.

Genular Protein ID: 3167441065

Symbol: LST1_HUMAN

Name: Leukocyte-specific transcript 1 protein

UniProtKB Accession Codes:

O00453 B0S8E0 B0S8E1 B0S8E5 O00452 O00454 Q13669 Q2HNT3 Q5HYS9 Q5SP24 Q5STA5 Q5STA6 Q5STA7 Q5STA8 Q5STW6 Q9UJR5 Q9UJR6 Q9UJR7 Q9UJR8 Q9UJS1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 24 Ensembl 94 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 RefSeq 10 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7590964

Title: Cloning and genomic characterization of LST1: a new gene in the human TNF region.

PubMed ID: 7590964

DOI: 10.1007/bf00179392

PubMed ID: 9367684

Title: Complex expression pattern of the TNF region gene LST1 through differential regulation, initiation, and alternative splicing.

PubMed ID: 9367684

DOI: 10.1006/geno.1997.4963

PubMed ID: 10706707

Title: LST1: a gene with extensive alternative splicing and immunomodulatory function.

PubMed ID: 10706707

DOI: 10.4049/jimmunol.164.6.3169

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16362817

Title: LST1 and NCR3 expression in autoimmune inflammation and in response to IFN-gamma, LPS and microbial infection.

PubMed ID: 16362817

DOI: 10.1007/s00251-005-0057-2

PubMed ID: 11478849

Title: Functional analysis of B144/LST1: a gene in the tumor necrosis factor cluster that induces formation of long filopodia in eukaryotic cells.

PubMed ID: 11478849

DOI: 10.1006/excr.2001.5290

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 97
  • Mass: 10792
  • Checksum: AA03C77B5787B524
  • Sequence:
    • MLSRNDDICI YGGLGLGGLL LLAVVLLSAC LCWLHRRVKR LERSWAQGSS EQELHYASLQ 
RLPVPSSEGP DLRGRDKRGT KEDPRADYAC IAENKPT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.