Details for: CD274

Gene ID: 29126

Symbol: CD274

Ensembl ID: ENSG00000120217

Description: CD274 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 28.8662
    Cell Significance Index: -4.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 17.8597
    Cell Significance Index: -4.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.6583
    Cell Significance Index: -4.3300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6822
    Cell Significance Index: -4.5400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 2.4944
    Cell Significance Index: 36.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.3894
    Cell Significance Index: 76.5300
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.8427
    Cell Significance Index: 15.2400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.3213
    Cell Significance Index: 8.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.0484
    Cell Significance Index: -3.2200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9963
    Cell Significance Index: 45.1600
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.8961
    Cell Significance Index: 6.8900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.8341
    Cell Significance Index: 14.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7936
    Cell Significance Index: 151.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5769
    Cell Significance Index: 15.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5236
    Cell Significance Index: 51.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4601
    Cell Significance Index: 415.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4275
    Cell Significance Index: 11.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4057
    Cell Significance Index: 8.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2899
    Cell Significance Index: 47.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2821
    Cell Significance Index: 30.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2595
    Cell Significance Index: 19.9200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: 0.1862
    Cell Significance Index: 2.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1850
    Cell Significance Index: 11.1100
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.1751
    Cell Significance Index: 1.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1560
    Cell Significance Index: 10.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1371
    Cell Significance Index: 7.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0865
    Cell Significance Index: 1.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0595
    Cell Significance Index: 1.6200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0461
    Cell Significance Index: 0.4900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0451
    Cell Significance Index: 2.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0380
    Cell Significance Index: 7.6200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0329
    Cell Significance Index: 0.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0231
    Cell Significance Index: 8.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0215
    Cell Significance Index: 0.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0196
    Cell Significance Index: 0.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0175
    Cell Significance Index: 32.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0152
    Cell Significance Index: 9.6700
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.0143
    Cell Significance Index: 0.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0132
    Cell Significance Index: 0.3300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0089
    Cell Significance Index: 0.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0079
    Cell Significance Index: 0.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0052
    Cell Significance Index: 0.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0021
    Cell Significance Index: 1.4200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0018
    Cell Significance Index: 0.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0013
    Cell Significance Index: 0.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0005
    Cell Significance Index: -0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0028
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0035
    Cell Significance Index: -4.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0039
    Cell Significance Index: -0.5000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0041
    Cell Significance Index: -0.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0047
    Cell Significance Index: -0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0061
    Cell Significance Index: -4.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0061
    Cell Significance Index: -4.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0063
    Cell Significance Index: -1.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0064
    Cell Significance Index: -0.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0083
    Cell Significance Index: -2.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0089
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0093
    Cell Significance Index: -5.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0096
    Cell Significance Index: -1.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0161
    Cell Significance Index: -0.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0162
    Cell Significance Index: -1.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0180
    Cell Significance Index: -0.8400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0181
    Cell Significance Index: -2.1100
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0194
    Cell Significance Index: -0.1400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0255
    Cell Significance Index: -5.3800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0258
    Cell Significance Index: -2.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0262
    Cell Significance Index: -3.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0278
    Cell Significance Index: -1.2300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0281
    Cell Significance Index: -0.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0302
    Cell Significance Index: -1.4200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0313
    Cell Significance Index: -4.0500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0337
    Cell Significance Index: -0.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0344
    Cell Significance Index: -2.1100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0388
    Cell Significance Index: -2.6100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0407
    Cell Significance Index: -4.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0416
    Cell Significance Index: -4.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0444
    Cell Significance Index: -2.8000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0510
    Cell Significance Index: -0.7300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0512
    Cell Significance Index: -1.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0632
    Cell Significance Index: -1.2500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0654
    Cell Significance Index: -0.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0678
    Cell Significance Index: -4.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0702
    Cell Significance Index: -4.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0707
    Cell Significance Index: -3.9700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0750
    Cell Significance Index: -1.3300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0769
    Cell Significance Index: -3.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0809
    Cell Significance Index: -4.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0860
    Cell Significance Index: -2.2100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0913
    Cell Significance Index: -1.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0914
    Cell Significance Index: -1.9400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0922
    Cell Significance Index: -4.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0948
    Cell Significance Index: -3.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0956
    Cell Significance Index: -3.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0971
    Cell Significance Index: -3.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein:** CD274 is a transmembrane protein, meaning it spans the cell membrane and is exposed to both the extracellular and intracellular environments. 2. **Ligand for PD-1:** CD274 interacts with its receptor, PD-1, on activated T cells, leading to their downregulation and apoptosis. 3. **Costimulatory molecule:** CD274 is a costimulatory molecule, meaning it provides a second signal necessary for T cell activation and proliferation. 4. **Regulator of immune response:** CD274 plays a critical role in regulating the adaptive immune response, particularly in the context of tumor immunosurveillance. 5. **Tumor-associated antigen:** CD274 is overexpressed in various types of cancer, making it a potential target for cancer immunotherapy. **Pathways and Functions:** 1. **Immune response:** CD274 regulates the adaptive immune response by interacting with PD-1 on activated T cells, leading to their downregulation and apoptosis. 2. **Tumor immunosurveillance:** CD274 plays a critical role in tumor immunosurveillance, as its expression is often downregulated in cancer cells, allowing them to evade immune detection. 3. **Costimulation:** CD274 provides a second signal necessary for T cell activation and proliferation, enhancing the immune response against antigens. 4. **Apoptosis:** CD274 induces apoptosis in activated T cells, regulating the immune response and preventing excessive inflammation. 5. **Stem cell maintenance:** CD274 is expressed in stem cells, including intestinal crypt stem cells, suggesting its role in maintaining stem cell homeostasis. **Clinical Significance:** 1. **Cancer immunotherapy:** CD274 is a target for cancer immunotherapy, as its expression on tumor cells makes it a potential target for antibody-based therapies. 2. **Autoimmune disorders:** CD274 dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and type 1 diabetes, where it contributes to immune dysregulation. 3. **Infectious diseases:** CD274 plays a role in regulating the immune response to infectious diseases, such as HIV and tuberculosis. 4. **Stem cell transplantation:** CD274 expression on stem cells has implications for stem cell transplantation, as it may influence the engraftment and differentiation of stem cells. 5. **Cancer diagnosis:** CD274 expression on tumor cells has implications for cancer diagnosis, as it may serve as a biomarker for tumor detection and prognosis. In conclusion, the CD274 gene plays a critical role in regulating the adaptive immune response, particularly in the context of tumor immunosurveillance. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. Further research is needed to fully understand the mechanisms of CD274 and its clinical significance.

Genular Protein ID: 250149872

Symbol: PD1L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10581077

Title: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.

PubMed ID: 10581077

DOI: 10.1038/70932

PubMed ID: 11015443

Title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.

PubMed ID: 11015443

DOI: 10.1084/jem.192.7.1027

PubMed ID: 15780196

Title: Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain.

PubMed ID: 15780196

DOI: 10.1111/j.1745-7254.2005.00086.x

PubMed ID: 30564891

Title: A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression.

PubMed ID: 30564891

DOI: 10.1007/s00262-018-2282-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 27281199

Title: Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.

PubMed ID: 27281199

DOI: 10.1038/nature18294

PubMed ID: 28813410

Title: Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

PubMed ID: 28813410

DOI: 10.1038/nature23669

PubMed ID: 31399419

Title: USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.

PubMed ID: 31399419

DOI: 10.1158/2326-6066.cir-18-0910

PubMed ID: 32929201

Title: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

PubMed ID: 32929201

DOI: 10.1038/s41556-020-0575-z

PubMed ID: 34183449

Title: Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.

PubMed ID: 34183449

DOI: 10.1158/1541-7786.mcr-21-0147

PubMed ID: 36232715

Title: PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway.

PubMed ID: 36232715

DOI: 10.3390/ijms231911414

PubMed ID: 36727298

Title: The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80.

PubMed ID: 36727298

DOI: 10.15252/embj.2022111556

PubMed ID: 18287011

Title: The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.

PubMed ID: 18287011

DOI: 10.1073/pnas.0712278105

PubMed ID: 26602187

Title: Structure of the complex of human programmed death 1, PD-1, and its ligand PD-L1.

PubMed ID: 26602187

DOI: 10.1016/j.str.2015.09.010

Sequence Information:

  • Length: 290
  • Mass: 33275
  • Checksum: FE957086E62A31A8
  • Sequence:
  • MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME 
    DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VYRCMISYGG 
    ADYKRITVKV NAPYNKINQR ILVVDPVTSE HELTCQAEGY PKAEVIWTSS DHQVLSGKTT 
    TTNSKREEKL FNVTSTLRIN TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH 
    LVILGAILLC LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET

Genular Protein ID: 3275674497

Symbol: Q0GN75_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 127
  • Mass: 14775
  • Checksum: 7BE13D4ADE4884BE
  • Sequence:
  • MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME 
    DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VFRCMISYGG 
    ADYKRIT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.