Details for: CD274
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 28.8662
Cell Significance Index: -4.4900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 17.8597
Cell Significance Index: -4.5300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 10.6583
Cell Significance Index: -4.3300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 3.6822
Cell Significance Index: -4.5400 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 2.4944
Cell Significance Index: 36.2200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 2.3894
Cell Significance Index: 76.5300 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.8427
Cell Significance Index: 15.2400 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 1.3213
Cell Significance Index: 8.2100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 1.0484
Cell Significance Index: -3.2200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.9963
Cell Significance Index: 45.1600 - Cell Name: epithelial cell of thymus (CL0002293)
Fold Change: 0.8961
Cell Significance Index: 6.8900 - Cell Name: monocyte-derived dendritic cell (CL0011031)
Fold Change: 0.8341
Cell Significance Index: 14.3300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7936
Cell Significance Index: 151.0300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.5769
Cell Significance Index: 15.4100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5236
Cell Significance Index: 51.8000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4601
Cell Significance Index: 415.4800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.4275
Cell Significance Index: 11.4400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4057
Cell Significance Index: 8.6400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2899
Cell Significance Index: 47.1600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2821
Cell Significance Index: 30.6800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2595
Cell Significance Index: 19.9200 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: 0.1862
Cell Significance Index: 2.5500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1850
Cell Significance Index: 11.1100 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.1751
Cell Significance Index: 1.2700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1560
Cell Significance Index: 10.7900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1371
Cell Significance Index: 7.1200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.0865
Cell Significance Index: 1.1800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0595
Cell Significance Index: 1.6200 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 0.0461
Cell Significance Index: 0.4900 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.0451
Cell Significance Index: 2.3500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0380
Cell Significance Index: 7.6200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0329
Cell Significance Index: 0.9700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0231
Cell Significance Index: 8.2800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0215
Cell Significance Index: 0.6200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0196
Cell Significance Index: 0.6900 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0175
Cell Significance Index: 32.9100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0152
Cell Significance Index: 9.6700 - Cell Name: suprabasal keratinocyte (CL4033013)
Fold Change: 0.0143
Cell Significance Index: 0.2300 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0132
Cell Significance Index: 0.3300 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.0089
Cell Significance Index: 0.0700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0079
Cell Significance Index: 0.2200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0052
Cell Significance Index: 0.1500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0021
Cell Significance Index: 1.4200 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.0020
Cell Significance Index: 0.0300 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0018
Cell Significance Index: 0.0400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0013
Cell Significance Index: 0.7200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0005
Cell Significance Index: -0.2000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0017
Cell Significance Index: -3.1000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0023
Cell Significance Index: -3.5300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0028
Cell Significance Index: -0.4100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0035
Cell Significance Index: -4.8200 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0039
Cell Significance Index: -0.5000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0040
Cell Significance Index: -3.0500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0041
Cell Significance Index: -0.5000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0047
Cell Significance Index: -0.8500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0061
Cell Significance Index: -4.4500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0061
Cell Significance Index: -4.4900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0063
Cell Significance Index: -1.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0064
Cell Significance Index: -0.4800 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0078
Cell Significance Index: -4.3900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0083
Cell Significance Index: -2.4000 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0089
Cell Significance Index: -4.0300 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0093
Cell Significance Index: -5.7900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0096
Cell Significance Index: -1.9100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0161
Cell Significance Index: -0.8100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0162
Cell Significance Index: -1.6500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0180
Cell Significance Index: -0.8400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0181
Cell Significance Index: -2.1100 - Cell Name: trophoblast giant cell (CL0002488)
Fold Change: -0.0194
Cell Significance Index: -0.1400 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.0200
Cell Significance Index: -0.1900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0255
Cell Significance Index: -5.3800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0258
Cell Significance Index: -2.9600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0262
Cell Significance Index: -3.6000 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0278
Cell Significance Index: -1.2300 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0281
Cell Significance Index: -0.1700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0302
Cell Significance Index: -1.4200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0313
Cell Significance Index: -4.0500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0337
Cell Significance Index: -0.7000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0344
Cell Significance Index: -2.1100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0388
Cell Significance Index: -2.6100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0407
Cell Significance Index: -4.8000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0416
Cell Significance Index: -4.3300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0444
Cell Significance Index: -2.8000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0510
Cell Significance Index: -0.7300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0512
Cell Significance Index: -1.9400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.0632
Cell Significance Index: -1.2500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.0654
Cell Significance Index: -0.9700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0678
Cell Significance Index: -4.1700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0702
Cell Significance Index: -4.5300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0707
Cell Significance Index: -3.9700 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.0750
Cell Significance Index: -1.3300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0769
Cell Significance Index: -3.1500 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0809
Cell Significance Index: -4.2500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0860
Cell Significance Index: -2.2100 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.0913
Cell Significance Index: -1.3000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0914
Cell Significance Index: -1.9400 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0922
Cell Significance Index: -4.0100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0948
Cell Significance Index: -3.0200 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0956
Cell Significance Index: -3.1300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0971
Cell Significance Index: -3.4000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 250149872
Symbol: PD1L1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10581077
Title: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.
PubMed ID: 10581077
DOI: 10.1038/70932
PubMed ID: 11015443
Title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.
PubMed ID: 11015443
PubMed ID: 15780196
Title: Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain.
PubMed ID: 15780196
PubMed ID: 30564891
Title: A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression.
PubMed ID: 30564891
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 28813417
Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.
PubMed ID: 28813417
DOI: 10.1038/nature23643
PubMed ID: 27281199
Title: Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.
PubMed ID: 27281199
DOI: 10.1038/nature18294
PubMed ID: 28813410
Title: Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.
PubMed ID: 28813410
DOI: 10.1038/nature23669
PubMed ID: 31399419
Title: USP22 Deubiquitinates CD274 to Suppress Anticancer Immunity.
PubMed ID: 31399419
PubMed ID: 32929201
Title: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
PubMed ID: 32929201
PubMed ID: 34183449
Title: Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.
PubMed ID: 34183449
PubMed ID: 36232715
Title: PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway.
PubMed ID: 36232715
PubMed ID: 36727298
Title: The CTLA-4 immune checkpoint protein regulates PD-L1:PD-1 interaction via transendocytosis of its ligand CD80.
PubMed ID: 36727298
PubMed ID: 18287011
Title: The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.
PubMed ID: 18287011
PubMed ID: 26602187
Title: Structure of the complex of human programmed death 1, PD-1, and its ligand PD-L1.
PubMed ID: 26602187
Sequence Information:
- Length: 290
- Mass: 33275
- Checksum: FE957086E62A31A8
- Sequence:
MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VYRCMISYGG ADYKRITVKV NAPYNKINQR ILVVDPVTSE HELTCQAEGY PKAEVIWTSS DHQVLSGKTT TTNSKREEKL FNVTSTLRIN TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH LVILGAILLC LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET
Genular Protein ID: 3275674497
Symbol: Q0GN75_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 127
- Mass: 14775
- Checksum: 7BE13D4ADE4884BE
- Sequence:
MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VFRCMISYGG ADYKRIT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.