Details for: CD274

Gene ID: 29126

Symbol: CD274

Ensembl ID: ENSG00000120217

Description: CD274 molecule

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,160
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.42
    Marker Score: 2,949
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.33
    Marker Score: 4,937
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 846
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.08
    Marker Score: 2,205
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 15,019
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,218
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,735
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,282
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.87
    Marker Score: 360
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.82
    Marker Score: 10,866
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,254
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.75
    Marker Score: 755
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.75
    Marker Score: 1,905
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 673
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,980
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 453
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.64
    Marker Score: 1,796
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 194
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 291
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.43
    Marker Score: 139
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 704
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.38
    Marker Score: 478
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.38
    Marker Score: 119
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.35
    Marker Score: 168
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.35
    Marker Score: 147
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.34
    Marker Score: 8,628
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.33
    Marker Score: 404
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.33
    Marker Score: 87
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.32
    Marker Score: 763
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.32
    Marker Score: 491
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.31
    Marker Score: 455
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3
    Marker Score: 301
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 542
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.29
    Marker Score: 146
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 160
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.26
    Marker Score: 383
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.26
    Marker Score: 124
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.26
    Marker Score: 223
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.26
    Marker Score: 171
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.26
    Marker Score: 1,081
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.26
    Marker Score: 163
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.25
    Marker Score: 110
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.24
    Marker Score: 95
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.23
    Marker Score: 210
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.23
    Marker Score: 5,182
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.23
    Marker Score: 149
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.22
    Marker Score: 66
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.22
    Marker Score: 249
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.22
    Marker Score: 174
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.22
    Marker Score: 1,326
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.22
    Marker Score: 236
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.21
    Marker Score: 146
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 71
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.21
    Marker Score: 542
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.21
    Marker Score: 50
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.21
    Marker Score: 435
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2
    Marker Score: 246
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.2
    Marker Score: 217
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2
    Marker Score: 379
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.19
    Marker Score: 63
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.19
    Marker Score: 7,134
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.19
    Marker Score: 751
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.19
    Marker Score: 114
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.18
    Marker Score: 185
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.18
    Marker Score: 36
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.18
    Marker Score: 63
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.18
    Marker Score: 180
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.18
    Marker Score: 73
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.18
    Marker Score: 150
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.18
    Marker Score: 286
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.17
    Marker Score: 158
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.17
    Marker Score: 3,398
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.17
    Marker Score: 34
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.17
    Marker Score: 418
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.17
    Marker Score: 1,712
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.17
    Marker Score: 672
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.16
    Marker Score: 2,604
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.16
    Marker Score: 1,019

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane protein:** CD274 is a transmembrane protein, meaning it spans the cell membrane and is exposed to both the extracellular and intracellular environments. 2. **Ligand for PD-1:** CD274 interacts with its receptor, PD-1, on activated T cells, leading to their downregulation and apoptosis. 3. **Costimulatory molecule:** CD274 is a costimulatory molecule, meaning it provides a second signal necessary for T cell activation and proliferation. 4. **Regulator of immune response:** CD274 plays a critical role in regulating the adaptive immune response, particularly in the context of tumor immunosurveillance. 5. **Tumor-associated antigen:** CD274 is overexpressed in various types of cancer, making it a potential target for cancer immunotherapy. **Pathways and Functions:** 1. **Immune response:** CD274 regulates the adaptive immune response by interacting with PD-1 on activated T cells, leading to their downregulation and apoptosis. 2. **Tumor immunosurveillance:** CD274 plays a critical role in tumor immunosurveillance, as its expression is often downregulated in cancer cells, allowing them to evade immune detection. 3. **Costimulation:** CD274 provides a second signal necessary for T cell activation and proliferation, enhancing the immune response against antigens. 4. **Apoptosis:** CD274 induces apoptosis in activated T cells, regulating the immune response and preventing excessive inflammation. 5. **Stem cell maintenance:** CD274 is expressed in stem cells, including intestinal crypt stem cells, suggesting its role in maintaining stem cell homeostasis. **Clinical Significance:** 1. **Cancer immunotherapy:** CD274 is a target for cancer immunotherapy, as its expression on tumor cells makes it a potential target for antibody-based therapies. 2. **Autoimmune disorders:** CD274 dysregulation has been implicated in autoimmune disorders, such as multiple sclerosis and type 1 diabetes, where it contributes to immune dysregulation. 3. **Infectious diseases:** CD274 plays a role in regulating the immune response to infectious diseases, such as HIV and tuberculosis. 4. **Stem cell transplantation:** CD274 expression on stem cells has implications for stem cell transplantation, as it may influence the engraftment and differentiation of stem cells. 5. **Cancer diagnosis:** CD274 expression on tumor cells has implications for cancer diagnosis, as it may serve as a biomarker for tumor detection and prognosis. In conclusion, the CD274 gene plays a critical role in regulating the adaptive immune response, particularly in the context of tumor immunosurveillance. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and infectious diseases. Further research is needed to fully understand the mechanisms of CD274 and its clinical significance.

Genular Protein ID: 250149872

Symbol: PD1L1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9NZQ7 B2RBA2 B4DU27 Q14CJ2 Q2V8D5 Q66RK1 Q6WEX4 Q9NUZ5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EMBL 15 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 64 PDBsum 56 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10581077

Title: B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion.

PubMed ID: 10581077

DOI: 10.1038/70932

PubMed ID: 11015443

Title: Engagement of the PD-1 immunoinhibitory receptor by a novel B7-family member leads to negative regulation of lymphocyte activation.

PubMed ID: 11015443

DOI: 10.1084/jem.192.7.1027

PubMed ID: 15780196

Title: Identification of a novel splice variant of human PD-L1 mRNA encoding an isoform-lacking Igv-like domain.

PubMed ID: 15780196

DOI: 10.1111/j.1745-7254.2005.00086.x

PubMed ID: 30564891

Title: A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression.

PubMed ID: 30564891

DOI: 10.1007/s00262-018-2282-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 28813417

Title: CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity.

PubMed ID: 28813417

DOI: 10.1038/nature23643

PubMed ID: 27281199

Title: Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers.

PubMed ID: 27281199

DOI: 10.1038/nature18294

PubMed ID: 28813410

Title: Identification of CMTM6 and CMTM4 as PD-L1 protein regulators.

PubMed ID: 28813410

DOI: 10.1038/nature23669

PubMed ID: 32929201

Title: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.

PubMed ID: 32929201

DOI: 10.1038/s41556-020-0575-z

PubMed ID: 34183449

Title: Membrane-Associated RING-CH 8 Functions as a Novel PD-L1 E3 Ligase to Mediate PD-L1 Degradation Induced by EGFR Inhibitors.

PubMed ID: 34183449

DOI: 10.1158/1541-7786.mcr-21-0147

PubMed ID: 36232715

Title: PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-kappaB Signaling Pathway.

PubMed ID: 36232715

DOI: 10.3390/ijms231911414

PubMed ID: 18287011

Title: The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors.

PubMed ID: 18287011

DOI: 10.1073/pnas.0712278105

PubMed ID: 26602187

Title: Structure of the complex of human programmed death 1, PD-1, and its ligand PD-L1.

PubMed ID: 26602187

DOI: 10.1016/j.str.2015.09.010

Sequence Information:

  • Length: 290
  • Mass: 33275
  • Checksum: FE957086E62A31A8
  • Sequence:
    • MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME 
DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VYRCMISYGG 
ADYKRITVKV NAPYNKINQR ILVVDPVTSE HELTCQAEGY PKAEVIWTSS DHQVLSGKTT 
TTNSKREEKL FNVTSTLRIN TTTNEIFYCT FRRLDPEENH TAELVIPELP LAHPPNERTH 
LVILGAILLC LGVALTFIFR LRKGRMMDVK KCGIQDTNSK KQSDTHLEET

Genular Protein ID: 3275674497

Symbol: Q0GN75_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q0GN75

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 RefSeq 2 SAM 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 127
  • Mass: 14775
  • Checksum: 7BE13D4ADE4884BE
  • Sequence:
    • MRIFAVFIFM TYWHLLNAFT VTVPKDLYVV EYGSNMTIEC KFPVEKQLDL AALIVYWEME 
DKNIIQFVHG EEDLKVQHSS YRQRARLLKD QLSLGNAALQ ITDVKLQDAG VFRCMISYGG 
ADYKRIT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.