Details for: HLA DQB2

Gene ID: 3120

Symbol: HLA DQB2

Ensembl ID: ENSG00000232629

Description: major histocompatibility complex, class II, DQ beta 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.66
    Marker Score: 1086
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7650
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.9
    Marker Score: 2321
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.71
    Marker Score: 1157
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.7
    Marker Score: 209
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.66
    Marker Score: 401
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.61
    Marker Score: 616
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.58
    Marker Score: 14961
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.47
    Marker Score: 124
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 189
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.43
    Marker Score: 494
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.43
    Marker Score: 892
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.4
    Marker Score: 275
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.3
    Marker Score: 857
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.29
    Marker Score: 1077
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.29
    Marker Score: 164
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.28
    Marker Score: 165
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.28
    Marker Score: 554
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.26
    Marker Score: 1550
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.25
    Marker Score: 252
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.24
    Marker Score: 87
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 387
  • Cell Name: myeloid dendritic cell, human (CL0001057)
    Fold Change: 0.24
    Marker Score: 86
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.23
    Marker Score: 133
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.22
    Marker Score: 102
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.21
    Marker Score: 73.5
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.21
    Marker Score: 160
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.21
    Marker Score: 152
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.21
    Marker Score: 121.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.2
    Marker Score: 357
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.2
    Marker Score: 177
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.19
    Marker Score: 135
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.19
    Marker Score: 2565
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.19
    Marker Score: 231
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 128
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.18
    Marker Score: 749
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.18
    Marker Score: 171
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 96
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.18
    Marker Score: 444
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.16
    Marker Score: 154
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.16
    Marker Score: 37
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.16
    Marker Score: 461
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.15
    Marker Score: 202
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.15
    Marker Score: 957
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.15
    Marker Score: 91
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.15
    Marker Score: 164
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.14
    Marker Score: 740
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.14
    Marker Score: 903
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.12
    Marker Score: 114
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.12
    Marker Score: 141
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.12
    Marker Score: 67
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.12
    Marker Score: 117
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.12
    Marker Score: 28
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.11
    Marker Score: 72
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.11
    Marker Score: 1303
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.11
    Marker Score: 28
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.11
    Marker Score: 6089
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.11
    Marker Score: 117
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.11
    Marker Score: 133
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.11
    Marker Score: 95
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.1
    Marker Score: 116
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.1
    Marker Score: 149
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.1
    Marker Score: 29
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.1
    Marker Score: 28
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 44
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1
    Marker Score: 38
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 48

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Other Information

**Key characteristics** * The DQB2 gene is located on chromosome 15q21.1. * It is a member of the HLA class II antigen complex. * The DQB2 protein is a heterodimeric structure, consisting of two alpha-helices and two beta-sheets. * The protein is expressed on the surface of antigen-presenting cells, including macrophages, dendritic cells, and B cells. * The DQB2 protein is a key antigen for T-helper 17 cells and is involved in the regulation of immune responses. **Pathways and functions** * The DQB2 protein is involved in the adaptive immune response and the activation of T-helper 17 cells. * The protein binds to peptide antigens derived from extracellular bacteria, viruses, and parasites. * Upon binding, the DQB2 protein is internalized by antigen-presenting cells. * The DQB2 protein is then processed and presented on the surface of the APC, where it can be recognized by T-helper 17 cells. * The DQB2 protein also plays a role in the regulation of immune responses by interacting with other immune molecules, such as PD-1 and CD80. **Clinical significance** Mutations in the DQB2 gene have been linked to several human diseases, including autoimmune disorders, inflammatory bowel disease, and cancer. These findings have led to the development of antibodies that are used in clinical practice to treat these diseases.

Genular Protein ID: 817666625

Symbol: DQB2_HUMAN

Name: HLA class II histocompatibility antigen, DQ beta 2 chain

UniProtKB Accession Codes:

P05538 A6NIA5 Q29826 Q29870 Q29871 Q29872 Q29873 Q5SR06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 8 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3036828

Title: Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.

PubMed ID: 3036828

DOI: 10.1016/s0021-9258(18)47482-0

PubMed ID: 8568858

Title: Evolutionary dynamics of non-coding sequences within the class II region of the human MHC.

PubMed ID: 8568858

DOI: 10.1006/jmbi.1996.0001

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3858830

Title: Gene organization of DC and DX subregions of the human major histocompatibility complex.

PubMed ID: 3858830

DOI: 10.1073/pnas.82.10.3410

PubMed ID: 2564844

Title: Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC.

PubMed ID: 2564844

DOI: 10.1007/bf00717908

PubMed ID: 9036956

Title: The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells.

PubMed ID: 9036956

PubMed ID: 11334674

Title: Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions.

PubMed ID: 11334674

DOI: 10.1016/s0198-8859(01)00236-1

PubMed ID: 8598037

Title: Invariant chain structure and MHC class II function.

PubMed ID: 8598037

DOI: 10.1016/s0092-8674(00)81025-9

PubMed ID: 11684289

Title: Presentation of antigens by MHC class II molecules: getting the most out of them.

PubMed ID: 11684289

DOI: 10.1016/s0161-5890(01)00069-4

PubMed ID: 18046453

Title: MHC class II molecules on the move for successful antigen presentation.

PubMed ID: 18046453

DOI: 10.1038/sj.emboj.7601945

PubMed ID: 17241953

Title: Autophagy in MHC class II presentation: sampling from within.

PubMed ID: 17241953

DOI: 10.1016/j.immuni.2007.01.005

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19533806

Title: CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract.

PubMed ID: 19533806

DOI: 10.3748/wjg.15.2855

PubMed ID: 22407913

Title: HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule.

PubMed ID: 22407913

DOI: 10.4049/jimmunol.1103048

Sequence Information:

  • Length: 268
  • Mass: 30387
  • Checksum: 2746ED6CC5D44AF2
  • Sequence:
    • MSWKMALQIP GGFWAAAVTV MLVMLSTPVA EARDFPKDFL VQFKGMCYFT NGTERVRGVA 
RYIYNREEYG RFDSDVGEFQ AVTELGRSIE DWNNYKDFLE QERAAVDKVC RHNYEAELRT 
TLQRQVEPTV TISPSRTEAL NHHNLLVCSV TDFYPAQIKV RWFRNDQEET AGVVSTSLIR 
NGDWTFQILV MLEITPQRGD IYTCQVEHPS LQSPITVEWR AQSESAQSKM LSGIGGFVLG 
LIFLGLGLII RHRGQKGPRG PPPAGLLH

Genular Protein ID: 1080849774

Symbol: Q5SR05_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5SR05

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 6 GO 17 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 8 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 264
  • Mass: 29854
  • Checksum: 26E9B8B769A9D55A
  • Sequence:
    • MALQIPGGFW AAAVTVMLVM LSTPVAEARD FPKDFLVQFK GMCYFTNGTE RVRGVARYIY 
NREEYGRFDS DVGEFQAVTE LGRSIEDWNN YKDFLEQERA AVDKVCRHNY EAELRTTLQR 
QVEPTVTISP SRTEALNHHN LLVCSVTDFY PAQIKVRWFR NDQEETAGVV STSLIRNGDW 
TFQILVMLEI TPQRGDIYTC QVEHPSLQSP ITVEWRAQSE SAQSKMLSGI GGFVLGLIFL 
GLGLIIRHRG QKGPRGPPPA GLLH

Genular Protein ID: 2918179020

Symbol: A0A2H4Z4R5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A2H4Z4R5

Database IDs:

ARBA 11 AlphaFoldDB 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 15 GO 5 Gene3D 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 219
  • Mass: 25302
  • Checksum: 76F9BEF894C6AAED
  • Sequence:
    • MALQIPGGFW AAAVTVMLVM LSTPVAEARD FPKDFLVQFK GMCYFTNGTE RVRGVARYIY 
NREEYGRFDS DVGEFQAVTE LGRSIEDWNN YKDFLEQERA AVDKVCRHNY EAELRTTLQR 
QVEPTVTISP SRTEALNHHN LLVCSVTDFY PAQIKVRWFR NDQEETAGVV STSLIRNGDW 
TFQILVMLEI TPQRGDIYTC QVEHPSLQSP ITVEWRLLH

Genular Protein ID: 807657653

Symbol: A2ADX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A2ADX3

Database IDs:

ARBA 11 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 7 Ensembl 6 GO 5 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 3 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 275
  • Mass: 30948
  • Checksum: 6E1A385D96839EE0
  • Sequence:
    • MALQIPGGFW AAAVTVMLVM LSTPVAEARD FPKDFLVQFK GMCYFTNGTE RVRGVARYIY 
NREEYGRFDS DVGEFQAVTE LGRSIEDWNN YKDFLEQERA AVDKVCRHNY EAELRTTLQR 
QVEPTVTISP SRTEALNHHN LLVCSVTDFY PAQIKVRWFR NDQEETAGVV STSLIRNGDW 
TFQILVMLEI TPQRGDIYTC QVEHPSLQSP ITVEWRAQSE SAQSKMLSGI GGFVLGLIFL 
GLGLIIRHRG QKGPRGPPPA GNISAMIQSG ERAQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.