Details for: RNASE2

Gene ID: 6036

Symbol: RNASE2

Ensembl ID: ENSG00000169385

Description: ribonuclease A family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 60.2397
    Cell Significance Index: -9.3700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 33.8664
    Cell Significance Index: -8.5900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 11.2253
    Cell Significance Index: 74.4700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 8.9539
    Cell Significance Index: 23.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.5510
    Cell Significance Index: -9.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 6.6278
    Cell Significance Index: 177.2900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.7418
    Cell Significance Index: 30.2700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.2201
    Cell Significance Index: 49.8200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4404
    Cell Significance Index: -9.6300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5755
    Cell Significance Index: 29.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0055
    Cell Significance Index: -0.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0132
    Cell Significance Index: -9.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0212
    Cell Significance Index: -0.3100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0215
    Cell Significance Index: -9.7400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0238
    Cell Significance Index: -6.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0307
    Cell Significance Index: -11.0200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0316
    Cell Significance Index: -0.4600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0390
    Cell Significance Index: -7.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0399
    Cell Significance Index: -4.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0423
    Cell Significance Index: -2.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0426
    Cell Significance Index: -8.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0504
    Cell Significance Index: -8.6000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0508
    Cell Significance Index: -7.3900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0524
    Cell Significance Index: -2.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0583
    Cell Significance Index: -1.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0609
    Cell Significance Index: -7.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0654
    Cell Significance Index: -1.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0657
    Cell Significance Index: -13.1800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0678
    Cell Significance Index: -1.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0757
    Cell Significance Index: -10.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1056
    Cell Significance Index: -12.1000
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1086
    Cell Significance Index: -1.4200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1144
    Cell Significance Index: -1.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1293
    Cell Significance Index: -16.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1294
    Cell Significance Index: -9.9300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1384
    Cell Significance Index: -2.3500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.1420
    Cell Significance Index: -1.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1451
    Cell Significance Index: -8.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1591
    Cell Significance Index: -8.2700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1649
    Cell Significance Index: -1.8700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1682
    Cell Significance Index: -10.6000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1694
    Cell Significance Index: -2.9200
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1854
    Cell Significance Index: -1.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1860
    Cell Significance Index: -8.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1961
    Cell Significance Index: -12.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2023
    Cell Significance Index: -15.0800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2102
    Cell Significance Index: -2.9500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: -0.2499
    Cell Significance Index: -1.0400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2500
    Cell Significance Index: -11.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2535
    Cell Significance Index: -6.1400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2725
    Cell Significance Index: -8.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2883
    Cell Significance Index: -13.5500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2987
    Cell Significance Index: -7.6300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3005
    Cell Significance Index: -2.5400
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.3061
    Cell Significance Index: -2.8500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.3106
    Cell Significance Index: -3.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3138
    Cell Significance Index: -8.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3240
    Cell Significance Index: -8.5200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3258
    Cell Significance Index: -8.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3276
    Cell Significance Index: -5.5100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3306
    Cell Significance Index: -4.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3310
    Cell Significance Index: -12.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3460
    Cell Significance Index: -16.1300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3537
    Cell Significance Index: -11.5800
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.3624
    Cell Significance Index: -5.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3636
    Cell Significance Index: -11.5800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3709
    Cell Significance Index: -9.2500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3714
    Cell Significance Index: -1.6200
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.3742
    Cell Significance Index: -4.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3795
    Cell Significance Index: -8.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3857
    Cell Significance Index: -9.2500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4107
    Cell Significance Index: -5.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4169
    Cell Significance Index: -11.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4240
    Cell Significance Index: -12.1000
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.4248
    Cell Significance Index: -6.3600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.4363
    Cell Significance Index: -5.6500
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.4526
    Cell Significance Index: -5.4700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.4537
    Cell Significance Index: -5.2200
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.4763
    Cell Significance Index: -5.0600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4782
    Cell Significance Index: -8.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.4885
    Cell Significance Index: -8.3500
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.4904
    Cell Significance Index: -5.2400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.4911
    Cell Significance Index: -4.4400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4930
    Cell Significance Index: -6.7600
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: -0.4977
    Cell Significance Index: -4.5900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4983
    Cell Significance Index: -12.4300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5000
    Cell Significance Index: -7.3800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.5009
    Cell Significance Index: -5.9200
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.5019
    Cell Significance Index: -5.9100
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.5074
    Cell Significance Index: -5.1800
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.5140
    Cell Significance Index: -5.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5279
    Cell Significance Index: -11.0500
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.5347
    Cell Significance Index: -6.4500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5398
    Cell Significance Index: -13.1700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5405
    Cell Significance Index: -9.0500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.5456
    Cell Significance Index: -7.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** RNASE2 is a member of the ribonuclease A family, which consists of enzymes that catalyze the hydrolysis of RNA into smaller fragments. Unlike other ribonucleases, RNASE2 is non-secretory, meaning it is not released into the extracellular environment. Instead, it is retained within cells and is thought to play a localized role in the regulation of immune responses. RNASE2 has a high degree of specificity for RNA, with a preference for double-stranded RNA (dsRNA). **Pathways and Functions** RNASE2 is involved in several key pathways and functions, including: 1. **Degradation of RNA**: RNASE2 degrades RNA into smaller fragments, which can be used by the cell to regulate gene expression and immune responses. 2. **Induction of bacterial agglutination**: RNASE2 induces the agglutination of bacteria, which can help to remove them from the extracellular environment and prevent their entry into the host cell. 3. **Regulation of immune responses**: RNASE2 regulates immune responses by modulating the activity of immune cells, such as neutrophils and monocytes. 4. **Lipopolysaccharide binding**: RNASE2 binds to lipopolysaccharides (LPS), which are components of the outer membrane of Gram-negative bacteria. 5. **Neutrophil degranulation**: RNASE2 is involved in the regulation of neutrophil degranulation, which is the process by which neutrophils release their granules to kill pathogens. **Clinical Significance** RNASE2 has several potential clinical applications, including: 1. **Innate immune response disorders**: RNASE2 dysfunction has been implicated in various innate immune response disorders, including chronic granulomatous disease and autoimmune disorders. 2. **Bacterial infections**: RNASE2 may play a role in the defense against bacterial infections, particularly those caused by Gram-negative bacteria. 3. **Cancer therapy**: RNASE2 may be used as a target for cancer therapy, as it is involved in the regulation of immune responses and the degradation of RNA. 4. **Inflammation**: RNASE2 may be involved in the regulation of inflammation, which is a key component of the innate immune response. In conclusion, RNASE2 is a non-secretory ribonuclease that plays a crucial role in the innate immune response. Its involvement in various pathways and functions, including the degradation of RNA and the regulation of immune responses, makes it an important target for the study of innate immune response disorders and the development of new therapeutic strategies.

Genular Protein ID: 909132583

Symbol: RNAS2_HUMAN

Name: Non-secretory ribonuclease

UniProtKB Accession Codes:

P10153 Q52M39 Q9H2B7 Q9UCG7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 ELM 1 EMBL 18 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2591744

Title: Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases.

PubMed ID: 2591744

DOI: 10.1016/0378-1119(89)90414-9

PubMed ID: 2745977

Title: Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases.

PubMed ID: 2745977

PubMed ID: 2734298

Title: Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family.

PubMed ID: 2734298

DOI: 10.1073/pnas.86.12.4460

PubMed ID: 2387583

Title: Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily.

PubMed ID: 2387583

DOI: 10.1016/0888-7543(90)90197-3

PubMed ID: 11102386

Title: Sequence variation at two eosinophil-associated ribonuclease loci in humans.

PubMed ID: 11102386

DOI: 10.1093/genetics/156.4.1949

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3166997

Title: Amino acid sequence of the nonsecretory ribonuclease of human urine.

PubMed ID: 3166997

DOI: 10.1021/bi00412a046

PubMed ID: 3458170

Title: Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease.

PubMed ID: 3458170

DOI: 10.1073/pnas.83.10.3146

PubMed ID: 3926759

Title: Purification and properties of bovine kidney ribonucleases.

PubMed ID: 3926759

DOI: 10.1093/oxfordjournals.jbchem.a135134

PubMed ID: 3182786

Title: Purification and characterization of a ribonuclease from human liver.

PubMed ID: 3182786

DOI: 10.1016/s0021-9258(18)37567-7

PubMed ID: 1587793

Title: Characterization of a unique nonsecretory ribonuclease from urine of pregnant women.

PubMed ID: 1587793

DOI: 10.1093/oxfordjournals.jbchem.a123757

PubMed ID: 8471426

Title: Characterisation of UGP and its relationship with beta-core fragment.

PubMed ID: 8471426

DOI: 10.1038/bjc.1993.127

PubMed ID: 7947762

Title: New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us.

PubMed ID: 7947762

DOI: 10.1021/bi00250a003

PubMed ID: 7547911

Title: The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose.

PubMed ID: 7547911

DOI: 10.1021/bi00037a016

PubMed ID: 9450956

Title: Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp.

PubMed ID: 9450956

DOI: 10.1091/mbc.9.2.301

PubMed ID: 12578357

Title: Mutational analysis of the complex of human RNase inhibitor and human eosinophil-derived neurotoxin (RNase 2).

PubMed ID: 12578357

DOI: 10.1021/bi026852o

PubMed ID: 12855582

Title: Eosinophil-derived neurotoxin (EDN), an antimicrobial protein with chemotactic activities for dendritic cells.

PubMed ID: 12855582

DOI: 10.1182/blood-2003-01-0151

PubMed ID: 18694936

Title: Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase.

PubMed ID: 18694936

DOI: 10.1074/jbc.m801196200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 8759319

Title: X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83-A resolution.

PubMed ID: 8759319

DOI: 10.1006/jmbi.1996.0420

PubMed ID: 11154698

Title: Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors.

PubMed ID: 11154698

DOI: 10.1074/jbc.m010585200

PubMed ID: 15755456

Title: Molecular recognition of human eosinophil-derived neurotoxin (RNase 2) by placental ribonuclease inhibitor.

PubMed ID: 15755456

DOI: 10.1016/j.jmb.2005.01.035

PubMed ID: 16401072

Title: Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A.

PubMed ID: 16401072

DOI: 10.1021/bi0518592

Sequence Information:

  • Length: 161
  • Mass: 18354
  • Checksum: 9406C4596CA69038
  • Sequence:
    • MVPKLFTSQI CLLLLLGLLA VEGSLHVKPP QFTWAQWFET QHINMTSQQC TNAMQVINNY 
QRRCKNQNTF LLTTFANVVN VCGNPNMTCP SNKTRKNCHH SGSQVPLIHC NLTTPSPQNI 
SNCRYAQTPA NMFYIVACDN RDQRRDPPQY PVVPVHLDRI I

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.