Details for: SPIB

Gene ID: 6689

Symbol: SPIB

Ensembl ID: ENSG00000269404

Description: Spi-B transcription factor

Associated with

  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Nucleus
    (GO:0005634)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.1660
    Cell Significance Index: -4.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.8884
    Cell Significance Index: -4.0300
  • Cell Name: centroblast (CL0009112)
    Fold Change: 10.4284
    Cell Significance Index: 24.3300
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 3.3925
    Cell Significance Index: 10.4600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3172
    Cell Significance Index: -4.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.7090
    Cell Significance Index: 58.6900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.6908
    Cell Significance Index: 27.1500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 2.6702
    Cell Significance Index: 40.0100
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.2921
    Cell Significance Index: 37.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.2002
    Cell Significance Index: 418.7100
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.0930
    Cell Significance Index: 9.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7748
    Cell Significance Index: 209.3000
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.7087
    Cell Significance Index: 10.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6394
    Cell Significance Index: 162.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5844
    Cell Significance Index: 172.3300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.5448
    Cell Significance Index: 23.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8815
    Cell Significance Index: 56.8700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.8139
    Cell Significance Index: 8.4300
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.7217
    Cell Significance Index: 9.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6616
    Cell Significance Index: 29.9900
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.2402
    Cell Significance Index: 2.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1788
    Cell Significance Index: 111.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1645
    Cell Significance Index: 4.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1586
    Cell Significance Index: 5.0800
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.1459
    Cell Significance Index: 0.7300
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.1345
    Cell Significance Index: 1.0200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0893
    Cell Significance Index: 2.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0683
    Cell Significance Index: 7.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0676
    Cell Significance Index: 1.6900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0394
    Cell Significance Index: 0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0299
    Cell Significance Index: 1.0500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0155
    Cell Significance Index: 3.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0099
    Cell Significance Index: 1.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0083
    Cell Significance Index: 2.9900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0062
    Cell Significance Index: 0.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0029
    Cell Significance Index: -4.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0036
    Cell Significance Index: -4.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0049
    Cell Significance Index: -2.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0053
    Cell Significance Index: -3.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0071
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0073
    Cell Significance Index: -1.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0074
    Cell Significance Index: -1.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0087
    Cell Significance Index: -6.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0094
    Cell Significance Index: -5.9800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0109
    Cell Significance Index: -1.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0120
    Cell Significance Index: -5.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0157
    Cell Significance Index: -4.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0193
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0209
    Cell Significance Index: -2.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0287
    Cell Significance Index: -3.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0297
    Cell Significance Index: -1.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0317
    Cell Significance Index: -1.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0328
    Cell Significance Index: -2.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0379
    Cell Significance Index: -4.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0385
    Cell Significance Index: -5.6000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0393
    Cell Significance Index: -1.0100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0396
    Cell Significance Index: -1.6200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0405
    Cell Significance Index: -4.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0436
    Cell Significance Index: -5.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0479
    Cell Significance Index: -4.8900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0532
    Cell Significance Index: -0.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0536
    Cell Significance Index: -4.1200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0541
    Cell Significance Index: -1.3900
  • Cell Name: memory B cell (CL0000787)
    Fold Change: -0.0573
    Cell Significance Index: -0.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0601
    Cell Significance Index: -0.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0637
    Cell Significance Index: -3.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0648
    Cell Significance Index: -1.8100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0656
    Cell Significance Index: -3.0600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0667
    Cell Significance Index: -3.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0699
    Cell Significance Index: -4.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0743
    Cell Significance Index: -4.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0788
    Cell Significance Index: -4.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0802
    Cell Significance Index: -5.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0808
    Cell Significance Index: -2.8300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0822
    Cell Significance Index: -2.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0829
    Cell Significance Index: -2.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0903
    Cell Significance Index: -4.2500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0908
    Cell Significance Index: -1.9000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0926
    Cell Significance Index: -1.9200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0927
    Cell Significance Index: -1.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0952
    Cell Significance Index: -5.8500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0969
    Cell Significance Index: -4.2900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1002
    Cell Significance Index: -1.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1119
    Cell Significance Index: -1.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1138
    Cell Significance Index: -4.3100
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: -0.1160
    Cell Significance Index: -0.8200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1163
    Cell Significance Index: -2.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1168
    Cell Significance Index: -3.1800
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.1211
    Cell Significance Index: -1.1100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1264
    Cell Significance Index: -4.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1271
    Cell Significance Index: -1.8500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.1285
    Cell Significance Index: -1.8800
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1286
    Cell Significance Index: -1.5200
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.1301
    Cell Significance Index: -1.3700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1367
    Cell Significance Index: -1.5000
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1378
    Cell Significance Index: -1.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Spi-B is a transcription factor that belongs to the E2A family of proteins. It is primarily expressed in B cells and is involved in the regulation of gene expression during the transition from the early stages of B cell development to the mature B cell stage. Spi-B exhibits high specificity for the promoter regions of genes involved in B cell development and differentiation. It is also capable of interacting with other transcription factors and co-regulators to modulate gene expression. **Pathways and Functions:** Spi-B is involved in several key pathways, including: 1. **Cell Differentiation**: Spi-B plays a crucial role in the transition from the early stages of B cell development to the mature B cell stage. It regulates the expression of genes involved in B cell differentiation, including those involved in the development of IgM and IgG antibodies. 2. **Chromatin Remodeling**: Spi-B interacts with chromatin remodeling complexes to modulate the structure and accessibility of chromatin, allowing for the regulation of gene expression. 3. **DNA Binding**: Spi-B exhibits high specificity for the promoter regions of genes involved in B cell development and differentiation, and can bind to specific DNA sequences to regulate gene expression. 4. **Positive Regulation of Transcription**: Spi-B acts as a transcriptional activator, stimulating the expression of genes involved in B cell development and differentiation. **Clinical Significance:** Abnormalities in Spi-B expression have been implicated in various B cell-related disorders, including: 1. **B Cell Lymphomas**: Spi-B is overexpressed in some B cell lymphomas, including Burkitt lymphoma and follicular lymphoma. 2. **Autoimmune Diseases**: Spi-B has been implicated in the pathogenesis of autoimmune diseases, including autoimmune hemolytic anemia and rheumatoid arthritis. 3. **Immunodeficiency Disorders**: Spi-B is involved in the regulation of B cell development and differentiation, and abnormalities in Spi-B expression have been implicated in immunodeficiency disorders, including X-linked lymphoma protein (XLP) syndrome. In conclusion, Spi-B is a critical transcription factor involved in the regulation of B cell development and differentiation. Its expression is tightly regulated during the germinal center reaction, and abnormalities in Spi-B expression have been implicated in various B cell-related disorders. Further research is needed to fully understand the role of Spi-B in B cell development and differentiation, and to explore its potential as a therapeutic target in B cell-related disorders.

Genular Protein ID: 1761856289

Symbol: SPIB_HUMAN

Name: Transcription factor Spi-B

UniProtKB Accession Codes:

Q01892 A8K9C9 B4DUG6 Q15359

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 2 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1406622

Title: Characterization of Spi-B, a transcription factor related to the putative oncoprotein Spi-1/PU.1.

PubMed ID: 1406622

DOI: 10.1128/mcb.12.10.4297-4304.1992

PubMed ID: 8670269

Title: An alternatively spliced isoform of the Spi-B transcription factor.

PubMed ID: 8670269

DOI: 10.1006/bbrc.1996.0881

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10196196

Title: SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1.

PubMed ID: 10196196

DOI: 10.1074/jbc.274.16.11115

PubMed ID: 11841448

Title: Expression of transcription factors Pu.1, Spi-B, Blimp-1, BSAP and oct-2 in normal human plasma cells and in multiple myeloma cells.

PubMed ID: 11841448

DOI: 10.1046/j.1365-2141.2002.03271.x

PubMed ID: 11864910

Title: Interaction between the hematopoietic Ets transcription factor Spi-B and the coactivator CREB-binding protein associated with negative cross-talk with c-Myb.

PubMed ID: 11864910

PubMed ID: 12393575

Title: The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development.

PubMed ID: 12393575

DOI: 10.1182/blood-2002-02-0438

PubMed ID: 15583020

Title: The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development.

PubMed ID: 15583020

DOI: 10.1084/jem.20041231

Sequence Information:

  • Length: 262
  • Mass: 28819
  • Checksum: A6C21DA1BBF61B6F
  • Sequence:
    • MLALEAAQLD GPHFSCLYPD GVFYDLDSCK HSSYPDSEGA PDSLWDWTVA PPVPATPYEA 
FDPAAAAFSH PQAAQLCYEP PTYSPAGNLE LAPSLEAPGP GLPAYPTENF ASQTLVPPAY 
APYPSPVLSE EEDLPLDSPA LEVSDSESDE ALVAGPEGKG SEAGTRKKLR LYQFLLGLLT 
RGDMRECVWW VEPGAGVFQF SSKHKELLAR RWGQQKGNRK RMTYQKLARA LRNYAKTGEI 
RKVKRKLTYQ FDSALLPAVR RA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.