Details for: FCN1

Gene ID: 2219

Symbol: FCN1

Ensembl ID: ENSG00000085265

Description: ficolin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 48.6032
    Cell Significance Index: -7.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.9022
    Cell Significance Index: -9.3600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 22.6615
    Cell Significance Index: 59.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 19.4018
    Cell Significance Index: -9.9800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 11.8560
    Cell Significance Index: 219.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9856
    Cell Significance Index: -7.3800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.4431
    Cell Significance Index: 53.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3821
    Cell Significance Index: -9.4000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.8525
    Cell Significance Index: 7.7100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.4712
    Cell Significance Index: 9.7600
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: 0.8659
    Cell Significance Index: 8.3300
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.7896
    Cell Significance Index: 6.7300
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.3093
    Cell Significance Index: 3.0200
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.2372
    Cell Significance Index: 2.2100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.2037
    Cell Significance Index: 1.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1825
    Cell Significance Index: 4.4200
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.1611
    Cell Significance Index: 1.5000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.1171
    Cell Significance Index: 2.2900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0060
    Cell Significance Index: -11.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0072
    Cell Significance Index: -11.0700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0073
    Cell Significance Index: -5.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0083
    Cell Significance Index: -11.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0093
    Cell Significance Index: -1.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0118
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0146
    Cell Significance Index: -10.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0164
    Cell Significance Index: -10.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0167
    Cell Significance Index: -9.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0177
    Cell Significance Index: -1.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0190
    Cell Significance Index: -6.8300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0222
    Cell Significance Index: -0.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0233
    Cell Significance Index: -10.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0253
    Cell Significance Index: -3.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0274
    Cell Significance Index: -5.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0332
    Cell Significance Index: -9.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0335
    Cell Significance Index: -1.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0375
    Cell Significance Index: -7.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0471
    Cell Significance Index: -9.9300
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0487
    Cell Significance Index: -0.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0496
    Cell Significance Index: -8.9400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0534
    Cell Significance Index: -0.6600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0542
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0565
    Cell Significance Index: -9.6400
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0580
    Cell Significance Index: -0.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0674
    Cell Significance Index: -9.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0675
    Cell Significance Index: -7.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0690
    Cell Significance Index: -10.0300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0745
    Cell Significance Index: -9.6200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0771
    Cell Significance Index: -9.4800
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0818
    Cell Significance Index: -1.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0833
    Cell Significance Index: -9.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0929
    Cell Significance Index: -4.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1027
    Cell Significance Index: -2.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1093
    Cell Significance Index: -2.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1101
    Cell Significance Index: -8.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1208
    Cell Significance Index: -3.8700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1209
    Cell Significance Index: -7.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1257
    Cell Significance Index: -5.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1289
    Cell Significance Index: -9.6100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1379
    Cell Significance Index: -3.6900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1436
    Cell Significance Index: -9.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1494
    Cell Significance Index: -9.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1527
    Cell Significance Index: -10.2700
  • Cell Name: promonocyte (CL0000559)
    Fold Change: -0.1582
    Cell Significance Index: -1.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1883
    Cell Significance Index: -9.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1893
    Cell Significance Index: -10.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1926
    Cell Significance Index: -5.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1960
    Cell Significance Index: -9.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2056
    Cell Significance Index: -9.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2110
    Cell Significance Index: -11.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2241
    Cell Significance Index: -4.6900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.2312
    Cell Significance Index: -2.5600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2333
    Cell Significance Index: -3.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2359
    Cell Significance Index: -2.6800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2381
    Cell Significance Index: -4.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2446
    Cell Significance Index: -8.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2493
    Cell Significance Index: -8.7400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2525
    Cell Significance Index: -11.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2564
    Cell Significance Index: -9.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2737
    Cell Significance Index: -8.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2796
    Cell Significance Index: -8.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2821
    Cell Significance Index: -5.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2923
    Cell Significance Index: -11.0700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3009
    Cell Significance Index: -2.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3094
    Cell Significance Index: -10.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.3134
    Cell Significance Index: -9.0300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3237
    Cell Significance Index: -9.2800
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.3243
    Cell Significance Index: -4.4100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3283
    Cell Significance Index: -4.6700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3348
    Cell Significance Index: -9.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3354
    Cell Significance Index: -8.8200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.3374
    Cell Significance Index: -4.7400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3464
    Cell Significance Index: -8.6400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3603
    Cell Significance Index: -9.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3606
    Cell Significance Index: -10.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3607
    Cell Significance Index: -9.6300
  • Cell Name: phagocyte (CL0000234)
    Fold Change: -0.3610
    Cell Significance Index: -2.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3630
    Cell Significance Index: -11.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3715
    Cell Significance Index: -9.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Ficolin 1 is a member of the ficolin family of PRRs, which are characterized by their ability to bind to specific carbohydrate structures on the surface of pathogens. The FCN1 gene product is a pentameric protein that consists of five identical subunits, each with a distinct N-terminal domain that is responsible for binding to carbohydrate structures. Ficolin 1 is widely expressed on the surface of various immune cells, including monocytes and dendritic cells, as well as on endothelial cells and myeloid dendritic cells. **Pathways and Functions** Ficolin 1 plays a critical role in the lectin pathway of complement activation, which is a key component of the innate immune response. Upon binding to carbohydrate structures on the surface of pathogens, ficolin 1 triggers the assembly of the lectin pathway, leading to the activation of the complement system and the subsequent elimination of the pathogen. The FCN1 gene product also interacts with other immune cells, such as neutrophils, to regulate their degranulation and the production of pro-inflammatory cytokines. Additionally, ficolin 1 has been shown to regulate the clearance of apoptotic cells, which is essential for maintaining tissue homeostasis. **Clinical Significance** Dysregulation of ficolin 1 has been implicated in various diseases, including autoimmune disorders, such as lupus and rheumatoid arthritis. Mutations in the FCN1 gene have been associated with increased susceptibility to infections, particularly those caused by gram-negative bacteria. Furthermore, ficolin 1 has been shown to play a role in the clearance of apoptotic cells, which is essential for maintaining tissue homeostasis. Dysregulation of ficolin 1 has been implicated in various diseases, including: * Autoimmune disorders, such as lupus and rheumatoid arthritis * Increased susceptibility to infections, particularly those caused by gram-negative bacteria * Clearance of apoptotic cells, which is essential for maintaining tissue homeostasis In conclusion, ficolin 1 is a critical component of the innate immune system that plays a key role in the recognition and elimination of pathogens. Dysregulation of ficolin 1 has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis.

Genular Protein ID: 3505721304

Symbol: FCN1_HUMAN

Name: Ficolin-1

UniProtKB Accession Codes:

O00602 Q5VYV5 Q92596

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8573080

Title: Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9.

PubMed ID: 8573080

DOI: 10.1042/bj3130473

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8947836

Title: Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1.

PubMed ID: 8947836

DOI: 10.1093/oxfordjournals.jbchem.a021474

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 21037097

Title: Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.

PubMed ID: 21037097

DOI: 10.4049/jimmunol.1001225

PubMed ID: 20400674

Title: Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain.

PubMed ID: 20400674

DOI: 10.1189/jlb.1209802

PubMed ID: 17148457

Title: Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain.

PubMed ID: 17148457

DOI: 10.1074/jbc.m608627200

PubMed ID: 17897951

Title: Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.

PubMed ID: 17897951

DOI: 10.1074/jbc.m705741200

PubMed ID: 20032467

Title: Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.

PubMed ID: 20032467

DOI: 10.1074/jbc.m109.065854

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 326
  • Mass: 35078
  • Checksum: 184D24B371B251AB
  • Sequence:
    • MELSGATMAR GLAVLLVLFL HIKNLPAQAA DTCPEVKVVG LEGSDKLTIL RGCPGLPGAP 
GPKGEAGVIG ERGERGLPGA PGKAGPVGPK GDRGEKGMRG EKGDAGQSQS CATGPRNCKD 
LLDRGYFLSG WHTIYLPDCR PLTVLCDMDT DGGGWTVFQR RMDGSVDFYR DWAAYKQGFG 
SQLGEFWLGN DNIHALTAQG SSELRVDLVD FEGNHQFAKY KSFKVADEAE KYKLVLGAFV 
GGSAGNSLTG HNNNFFSTKD QDNDVSSSNC AEKFQGAWWY ADCHASNLNG LYLMGPHESY 
ANGINWSAAK GYKYSYKVSE MKVRPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.