Details for: FCN1

Gene ID: 2219

Symbol: FCN1

Ensembl ID: ENSG00000085265

Description: ficolin 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.33
    Marker Score: 242192
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.87
    Marker Score: 7537
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.24
    Marker Score: 8072
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.16
    Marker Score: 7628
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.05
    Marker Score: 1319
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.67
    Marker Score: 31075
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 2.61
    Marker Score: 2660
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.03
    Marker Score: 8441
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.8
    Marker Score: 4658.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.61
    Marker Score: 3051.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1163
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 1.38
    Marker Score: 714
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.25
    Marker Score: 2551
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.19
    Marker Score: 1357
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 481
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.13
    Marker Score: 284
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 497
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 790
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48031
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.9
    Marker Score: 5488
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 321
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.88
    Marker Score: 1148
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.88
    Marker Score: 880
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.84
    Marker Score: 3508
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 704
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 305
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.73
    Marker Score: 11395
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 456
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.71
    Marker Score: 1136
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.62
    Marker Score: 213
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.61
    Marker Score: 304
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.57
    Marker Score: 365
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.56
    Marker Score: 171
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.55
    Marker Score: 333
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.52
    Marker Score: 394
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 0.52
    Marker Score: 180
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.5
    Marker Score: 663
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.49
    Marker Score: 595
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.49
    Marker Score: 391
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.48
    Marker Score: 200.5
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.41
    Marker Score: 179
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.41
    Marker Score: 364
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.41
    Marker Score: 340
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.41
    Marker Score: 108
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.4
    Marker Score: 105
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.37
    Marker Score: 254
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.34
    Marker Score: 247
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.34
    Marker Score: 224
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 200
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.33
    Marker Score: 249
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.33
    Marker Score: 1009
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.33
    Marker Score: 90
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.32
    Marker Score: 219
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.32
    Marker Score: 142
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.32
    Marker Score: 301
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.32
    Marker Score: 98
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.31
    Marker Score: 407
  • Cell Name: platelet (CL0000233)
    Fold Change: 0.31
    Marker Score: 140
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.31
    Marker Score: 102
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.31
    Marker Score: 424
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.31
    Marker Score: 237
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.31
    Marker Score: 169
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 0.3
    Marker Score: 109
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.3
    Marker Score: 329
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.3
    Marker Score: 141
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.29
    Marker Score: 280
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.28
    Marker Score: 196
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.28
    Marker Score: 478
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.27
    Marker Score: 180
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.27
    Marker Score: 118
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.27
    Marker Score: 240
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 160
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 114
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 0.26
    Marker Score: 240
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.25
    Marker Score: 85
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 99
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.24
    Marker Score: 124
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.23
    Marker Score: 63
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.22
    Marker Score: 225
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.22
    Marker Score: 47
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.22
    Marker Score: 429
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.22
    Marker Score: 77
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.22
    Marker Score: 108

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Other Information

**Key characteristics**: - FCN1 is a cell surface receptor that is expressed on a variety of cell types. - It is a glycoprotein that is composed of 14 extracellular repeats of a type I transmembrane domain. - FCN1 is a ligand for G protein-coupled receptors and is involved in the regulation of cell signaling pathways. - It is also involved in the regulation of inflammation and immune responses. **Pathways and functions**: - FCN1 is involved in a variety of cellular processes, including cell adhesion, migration, and signaling. - It is involved in the regulation of inflammation and immune responses. - It is involved in the binding of complement proteins to cell surfaces, which can lead to the activation of the complement system. - It is also involved in the binding of G protein-coupled receptors, which can activate intracellular signaling pathways. **Clinical significance**: - Mutations in the FCN1 gene have been linked to a number of human diseases, including systemic sclerosis, rheumatoid arthritis, and inflammatory bowel disease. - FCN1 is a potential target for therapeutic intervention in these diseases.

Genular Protein ID: 3505721304

Symbol: FCN1_HUMAN

Name: Ficolin-1

UniProtKB Accession Codes:

O00602 Q5VYV5 Q92596

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ComplexPortal 2 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 7 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8573080

Title: Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9.

PubMed ID: 8573080

DOI: 10.1042/bj3130473

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8947836

Title: Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1.

PubMed ID: 8947836

DOI: 10.1093/oxfordjournals.jbchem.a021474

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 21037097

Title: Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.

PubMed ID: 21037097

DOI: 10.4049/jimmunol.1001225

PubMed ID: 20400674

Title: Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain.

PubMed ID: 20400674

DOI: 10.1189/jlb.1209802

PubMed ID: 17148457

Title: Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain.

PubMed ID: 17148457

DOI: 10.1074/jbc.m608627200

PubMed ID: 17897951

Title: Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.

PubMed ID: 17897951

DOI: 10.1074/jbc.m705741200

PubMed ID: 20032467

Title: Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin.

PubMed ID: 20032467

DOI: 10.1074/jbc.m109.065854

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 326
  • Mass: 35078
  • Checksum: 184D24B371B251AB
  • Sequence:
    • MELSGATMAR GLAVLLVLFL HIKNLPAQAA DTCPEVKVVG LEGSDKLTIL RGCPGLPGAP 
GPKGEAGVIG ERGERGLPGA PGKAGPVGPK GDRGEKGMRG EKGDAGQSQS CATGPRNCKD 
LLDRGYFLSG WHTIYLPDCR PLTVLCDMDT DGGGWTVFQR RMDGSVDFYR DWAAYKQGFG 
SQLGEFWLGN DNIHALTAQG SSELRVDLVD FEGNHQFAKY KSFKVADEAE KYKLVLGAFV 
GGSAGNSLTG HNNNFFSTKD QDNDVSSSNC AEKFQGAWWY ADCHASNLNG LYLMGPHESY 
ANGINWSAAK GYKYSYKVSE MKVRPA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.